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公开(公告)号：US20070297945A1
公开(公告)日：2007-12-27
申请号：US11473867
申请日：2006-06-23
申请人： Andrew Michael Leach
发明人： Andrew Michael Leach
IPC分类号： G01N21/00
CPC分类号： G01N21/31 , G01N21/53 , G01N33/1853
摘要： A sensor including a substrate and a sensing element disposed on a substrate is provided. The sensing element includes a sensing matrix in contact with a flow of water, an indicator for one or more chemical species in the flow of water, and a selectivity component that reacts reversibly with the one or more chemical species. The sensor also includes a light source configured to direct light through the substrate and the sensing element. The sensor further includes a light detector configured to receive transmitted light from the substrate and the sensing matrix and to generate a signal representative of selective wavelengths of the light indicative of the one or more chemical species in the flow of water.
摘要翻译： 提供了包括基板和设置在基板上的感测元件的传感器。 感测元件包括与水流接触的感测矩阵，水流中的一种或多种化学物质的指示剂以及与一种或多种化学物质可逆地反应的选择性成分。 传感器还包括被配置为将光引导通过基板和感测元件的光源。 传感器还包括光检测器，其被配置为从基板和感测矩阵接收透射光，并且产生代表在水流中指示一种或多种化学物质的光的选择波长的信号。
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22.发明申请FLUID PATH SYSTEM FOR DISSOLUTION AND TRANSPORT OF A HYPERPOLARIZED MATERIAL 有权用于溶解和运输超高分子材料的流体路径系统公开(公告)号：US20120117985A1
公开(公告)日：2012-05-17
申请号：US13350189
申请日：2012-01-13
申请人： John Arthur Urbahn , Jan Henrik Ardenkjaer-Larsen , Andrew Michael Leach , Eric John Telfeyan , David Key Dietrich , David Brandon Whitt , Peter Miller , Ernst Wolfgang Stautner
发明人： John Arthur Urbahn , Jan Henrik Ardenkjaer-Larsen , Andrew Michael Leach , Eric John Telfeyan , David Key Dietrich , David Brandon Whitt , Peter Miller , Ernst Wolfgang Stautner
CPC分类号： G01N13/00 , G01N33/15 , G01N2013/006 , G01R33/282 , Y10T29/49826 , Y10T137/8593 , Y10T436/24 , Y10T436/25
摘要： A fluid path system includes a vial containing a pharmaceutical product therein. A dissolution fluid path is also included in the fluid path system, the dissolution fluid path having an output end in fluid communication with the vial and an input end attached to a pressure vessel containing a dissolution medium. A delivery fluid path is also included in the system having a first end hermetically attached to the vial to transport therefrom a mixture of dissolved pharmaceutical product and dissolution medium and a second end connected to a receiving vessel to receive the mixture. A dissolution fluid path valve is positioned between the pressure vessel and the dissolution fluid path to control flow of the dissolution medium, and a delivery fluid path valve is also included in the fluid path system to control flow of the mixture from the delivery fluid path to the receiving vessel.
摘要翻译： 流体路径系统包括其中含有药物产品的小瓶。 溶解流体路径也包括在流体路径系统中，溶解流体路径具有与小瓶流体连通的输出端和连接到包含溶解介质的压力容器的输入端。 输送流体路径还包括在系统中，其具有气密地附接到小瓶以从其中输送溶解的药物产物和溶出介质的混合物的第一端和连接到接收容器的第二端以接收混合物。 溶解流体通道阀定位在压力容器和溶解流体路径之间以控制溶解介质的流动，并且输送流体通道阀也包括在流体路径系统中以控制混合物从输送流体路径到 接收船。
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公开(公告)号：US20120053364A1
公开(公告)日：2012-03-01
申请号：US13292468
申请日：2011-11-09
IPC分类号： C07C51/487
CPC分类号： B01J20/261 , A61M5/165 , B01D15/00 , B01D15/322 , B01D15/327 , B01J20/103 , B01J20/3204 , B01J20/3242 , B01J47/15
摘要： A method for dynamic filtration of a pharmaceutical product is provided. The method includes using an unconditioned resin configured to selectively retain one or more components from a mixture having the pharmaceutical product and where the unconditioned resin is configured to be activated by a medium of the mixture. The method further includes the use of at least one positioning material disposed adjacent to the unconditioned resin, where the positioning material is configured to provide mechanical support to the resin to at least partially retain the resin in position.
摘要翻译： 提供了药物动态过滤的方法。 该方法包括使用非条件树脂，其构造成从具有药物产品的混合物中选择性地保留一种或多种组分，并且其中未条件化的树脂被配置为由混合物的介质活化。 该方法还包括使用邻近未条件化树脂设置的至少一个定位材料，其中定位材料构造成为树脂提供机械支撑以至少部分地将树脂保持在适当位置。
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24.发明申请公开(公告)号：US20110180482A1
公开(公告)日：2011-07-28
申请号：US13081572
申请日：2011-04-07
IPC分类号： B01J47/00
CPC分类号： A61M5/165 , B01D15/00 , B01D15/08 , B01D15/322 , B01D15/327 , B01J20/103 , B01J20/26 , B01J20/3242
摘要： A device for dynamic filtration of a pharmaceutical product is provided. The device includes a resin configured to selectively retain one or more components from a mixture having the pharmaceutical product, where the resin is configured to be activated by a medium of the mixture. The device further includes at least one positioning material disposed adjacent to the resin, where the positioning material is configured to provide mechanical support to the resin to at least partially retain the resin in position. In certain embodiments, the device does not require conditioning immediately prior to filtration.
摘要翻译： 提供了用于药物动力过滤的装置。 该装置包括被配置为从具有药物产品的混合物中选择性地保持一种或多种组分的树脂，其中树脂被配置为由混合物的介质活化。 该装置还包括邻近树脂设置的至少一个定位材料，其中定位材料构造成为树脂提供机械支撑以至少部分地将树脂保持在适当位置。 在某些实施方案中，该装置在过滤之前不需要立即进行调节。
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25.发明申请公开(公告)号：US20100251732A1
公开(公告)日：2010-10-07
申请号：US12418649
申请日：2009-04-06
CPC分类号： G01R33/282 , G01R33/307 , G01R33/31 , G01R33/62
摘要： Provided is an apparatus and method for introducing a sample into a cryogenic system comprising, an airlock chamber, a sample path having a first end connected to the airlock chamber and a second end connected to a cryogenic helium bath, an equilibrator, inserted into the sample path and positioned between the airlock and the cryogenic bath and which allows for passage of a sample to the cryogenic helium bath, and a cooling unit to coupled to the equilibration to control the temperature of the equilibrator. A machine-readable medium, comprising instructions which when executed by a controller causes a sample to be positioned within the cryogenic system, is also provided.
摘要翻译： 提供了一种用于将样品引入低温系统的装置和方法，该低温系统包括气闸室，具有连接到气闸室的第一端的样品路径和连接到低温氦浴的第二端，插入样品中的平衡器 路径并且定位在气锁和低温浴之间并且允许样品通过低温氦浴，以及冷却单元以耦合到平衡以控制平衡器的温度。 一种机器可读介质，包括当由控制器执行时使得样品定位在低温系统内的指令。
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26.发明授权Methods for deposition of sensor regions onto optical storage media substrates and resulting devices 失效将传感器区域沉积到光学存储介质基板和所得到的装置上的方法公开(公告)号：US07524455B2
公开(公告)日：2009-04-28
申请号：US10723536
申请日：2003-11-24
申请人： Radislav Alexandrovich Potyrailo , Marc Brian Wisnudel , Scott Martell Boyette , Andrew Michael Leach , Kasiraman Krishnan
发明人： Radislav Alexandrovich Potyrailo , Marc Brian Wisnudel , Scott Martell Boyette , Andrew Michael Leach , Kasiraman Krishnan
IPC分类号： G01N33/00
CPC分类号： B82Y5/00 , B82Y10/00 , B82Y30/00 , G01N33/54366 , G01N33/54393 , Y10T428/249994 , Y10T428/31935
摘要： Methods for applying sensor materials to optical storage media substrates are disclosed. After exposure to a sample of interest, the resulting sensors may be read in optical storage media drives for quantitative analysis of physical, chemical and biological parameters of the sample.
摘要翻译： 公开了将传感器材料应用于光学存储介质基板的方法。 在暴露于感兴趣的样品之后，所得到的传感器可以在光学存储介质驱动器中读取，用于定量分析样品的物理，化学和生物学参数。
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27.发明授权Apparatus and method for fully automated closed system quality control of a substance 有权物质全自动封闭系统质量控制的装置和方法公开(公告)号：US07519492B2
公开(公告)日：2009-04-14
申请号：US11743288
申请日：2007-05-02
申请人： Peter Miller , Jan Henrik Ardenkjaer-Larsen , Martin John Bradney , Andrew Michael Leach , Per Christian Sontum , Eric John Telfeyan , David Brandon Whitt , Jan Wolber
发明人： Peter Miller , Jan Henrik Ardenkjaer-Larsen , Martin John Bradney , Andrew Michael Leach , Per Christian Sontum , Eric John Telfeyan , David Brandon Whitt , Jan Wolber
CPC分类号： G01N21/33 , G01N21/21 , G01N21/35 , G01N21/3577 , G01N2021/8416 , G01R33/282 , G01R33/60
摘要： The present invention provides an apparatus and method for automated quality control of a substance comprising a compartment wherein a substance is located, a monitoring device coupled to the compartment and configured to monitor at least one quality control parameter prior to an end-use of the substance, and a processor coupled to the monitoring device, wherein the monitoring device is configured to communicate data to the processor for comparing at least one quality control parameter to an end-use value, and wherein the processor is further configured to control the release of the substance from the compartment to its end-use.
摘要翻译： 本发明提供了一种用于对物质进行自动质量控制的装置和方法，所述物质包括物质位于其中的隔间，耦合到隔室的监测装置，并且被配置为在物质的最终使用之前监测至少一个质量控制参数 以及耦合到所述监视设备的处理器，其中所述监视设备被配置为将数据传送到所述处理器，用于将至少一个质量控制参数与最终使用值进行比较，并且其中所述处理器还被配置为控制所述处理器的释放 物质从隔间到最终用途。
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28.发明申请公开(公告)号：US20080314836A1
公开(公告)日：2008-12-25
申请号：US11766881
申请日：2007-06-22
CPC分类号： A61M5/165 , B01D15/00 , B01D15/08 , B01D15/322 , B01D15/327 , B01J20/103 , B01J20/26 , B01J20/3242
摘要： A device for dynamic filtration of a pharmaceutical product is provided. The device includes a resin configured to selectively retain one or more components from a mixture having the pharmaceutical product, where the resin is configured to be activated by a medium of the mixture. The device further includes at least one positioning material disposed adjacent to the resin, where the positioning material is configured to provide mechanical support to the resin to at least partially retain the resin in position. In certain embodiments, the device does not require conditioning immediately prior to filtration.
摘要翻译： 提供了用于药物动力过滤的装置。 该装置包括被配置为从具有药物产品的混合物中选择性地保持一种或多种组分的树脂，其中树脂被配置为由混合物的介质活化。 该装置还包括邻近树脂设置的至少一个定位材料，其中定位材料构造成为树脂提供机械支撑以至少部分地将树脂保持在适当位置。 在某些实施方案中，该装置在过滤之前不需要立即进行调节。
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29.发明申请APPARATUS AND METHOD FOR FULLY AUTOMATED CLOSED SYSTEM OPTICAL MEASUREMENT OF VOLUME 审中-公开全自动封闭系统的光学测量装置和方法公开(公告)号：US20080275668A1
公开(公告)日：2008-11-06
申请号：US11872880
申请日：2007-10-16
申请人： Peter Miller , Andrew Michael Leach
发明人： Peter Miller , Andrew Michael Leach
CPC分类号： G01N21/31 , G01F23/292 , G01N21/0303
摘要： The present invention provides an apparatus and method for a noninvasive optical determination of the volume of a fluid in a compartment within a closed system comprising a compartment wherein a fluid resides which is permeable to at least one wavelength of light, a light source and light detecting device configured to obtain spectral data for a fluid for at least one wavelength, a processor adapted to determine the volume of the fluid by correlating the spectral data for a fluid at a known path length with the spectral data for the fluid at an unknown path length and wherein the processor is further configured to control the release of the substance from the compartment to its end use.
摘要翻译： 本发明提供了一种用于非封闭光学确定封闭系统内的隔室中的流体体积的装置和方法，所述封闭系统包括隔室，其中流体存在，所述隔室可透过至少一个波长的光，光源和光检测 被配置为获得用于至少一个波长的流体的光谱数据的处理器，适于通过将已知路径长度处的流体的光谱数据与未知路径长度的流体的光谱数据相关联来确定流体的体积的处理器 并且其中所述处理器还被配置为控制所述物质从所述隔室到其最终用途的释放。
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