公开(公告)号：US4107486A

公开(公告)日：1978-08-15

申请号：US701064

申请日：1976-06-30

申请人： David M. Evans

发明人： David M. Evans

IPC分类号： H01H3/22 ,  H01H31/00

CPC分类号： H01H3/227

摘要： A three-phase, high voltage switch arrangement is operated through a connected drive shaft by a switch operating mechanism that can be either driven by motor power or manually operated. When manual operation is desired, a crank handle is folded out of a stored position to an operating position. An improved mechanism is provided to prevent the crank handle from operably engaging the switch operating mechanism until stored torsional energy (i.e., the potential energy due to torsional strain) in the drive shaft has been released thereby avoiding improper operation, such as unexpected whipping of the handle. In addition, when the crank handle is folded out to its operating position, the motor is disabled so that the motor can not be operated while the handle is engaged with the mechanism so that the handle cannot be driven by the motor. When it is desired to disconnect the switch operating mechanism from the switch so that maintenance and testing can be performed, a selector handle may be operated that disconnects the drive shaft from the operating mechanism and locks the drive shaft so that the switch cannot be accidentally opened or closed due to wind or vibrational forces. Also, while the selector handle is being operated, the motor cannot be operated while the drive shaft is being disconnected and locked.

摘要翻译： 三相高压开关装置通过连接的驱动轴由开关操作机构操作，开关操作机构可以由电机驱动或手动操作。 当需要手动操作时，将曲柄手柄从存储位置折叠到操作位置。 提供改进的机构以防止曲柄手柄可操作地接合开关操作机构，直到已经释放驱动轴中存储的扭转能量（即，由于扭转应变引起的潜在能量），从而避免不正确的操作，例如不期望的鞭打 处理。 此外，当曲柄手柄折叠到其操作位置时，电动机被禁用，使得电动机在手柄与机构接合时不能被操作，使得手柄不能被电动机驱动。 当需要将开关操作机构与开关断开以进行维护和测试时，可以操作选择器手柄，其将驱动轴与操作机构断开并锁定驱动轴，使得开关不会被意外打开 或由于风或振动力而关闭。 此外，当选择器手柄被操作时，在驱动轴被断开和锁定时，电机不能被操作。

公开(公告)号：US4103129A

公开(公告)日：1978-07-25

申请号：US775904

申请日：1977-03-09

申请人： David M. Evans ,  Joel A. Ramos

发明人： David M. Evans ,  Joel A. Ramos

IPC分类号： H01H33/02

CPC分类号： H01H33/02

摘要： A high voltage circuit interrupter is enclosed within an integral insulating housing that includes an operating mechanism enclosing portion, an insulator portion, and a muffler portion. The integrally formed insulating housing is formed to provide a groove in one interior wall of the operating mechanism enclosing portion and a similar groove is formed on the housing cover immediately opposite the groove in the wall so that a portion of the operating mechanism can ride in the grooves thereby eliminating certain internal metallic components. The operating shaft of the interrupter is hexagonal in cross section thereby eliminating the need for special machining, keys, and cross pins to attach operating levers to the shaft. Operating triggers having round bearing surfaces are inserted over the ends of the hexagonal shaft to provide a smooth running bearing fit with openings in the housing wall. A unique locking arrangement is utilized to lock the lever arm of the operating mechanism to the hexagonal shaft. Also, a bayonet type connection at the exhaust end of the interrupter unit permits a rain cap to be easily and conveniently attached to the interrupter unit.

公开(公告)号：US3980977A

公开(公告)日：1976-09-14

申请号：US563964

申请日：1975-04-01

申请人： David M. Evans

发明人： David M. Evans

IPC分类号： H01H3/22 ,  H01H3/00 ,  H01H9/00 ,  H01H51/00

CPC分类号： H01H3/227

摘要： A spiral spring interconnects a pivotably mounted drive lever that may be pivoted either by hand or by a motor, and a pivotably mounted toggle lever that is operably connected to a switch. The toggle lever is held in the switch-closed or the switch-opened positions by main latches which hold the toggle lever in position while the drive lever is pivoted to bias the spring. Once the spring is biased, stop latches engage the drive lever holding it in a spring biased position. The main latches may then be either manually operated or operated by solenoids connected to control circuitry to release the toggle lever so that the spring will react against the toggle lever to either open or close the switch depending on the position of the switch at the initiation of operation. Once the switch has either opened or closed, the spring may be either recharged automatically by the motor, or if manual operation is desired, the motor can be disabled so that the spring can be biased by manual rotation of the drive lever. A clutch mechanism is provided to disconnect the motor from the mechanism when a manual tool is inserted into the mechanism. Also provided is a shutter bolt that locks out automatic operation of the main latches when the manual tool is inserted, electrically disconnects the motor, and prevents manual operation of the main latches when the tool is inserted into the mechanism. Also, if it is desirable to test the solenoids without tripping the main latches, a mechanism is provided to manually disconnect solenoids from the main latches. In addition, in case the switch blade is welded or stuck in the closed position, an automatic pry-out mechanism is provided to assure contact separation during switch opening.

摘要翻译： 螺旋弹簧将可枢转地安装的驱动杆互相连接，所述驱动杆可以由手或马达枢转，以及可枢转地安装的可操作地连接到开关的肘节杆。 肘节杆通过主闩锁保持在开关闭合或开关位置，主闩锁将肘节杆保持在适当位置，同时驱动杆枢转以偏置弹簧。 一旦弹簧被偏压，止动闩锁接合驱动杆，将其保持在弹簧偏压位置。 然后，主闩锁可以手动操作或由连接到控制电路的螺线管操作以释放肘杆，使得弹簧将响应于肘杆而反作用，以根据开关在起动时的位置打开或关闭开关 操作。 一旦开关已经打开或关闭，弹簧可以由电机自动重新充电，或者如果需要手动操作，则电机可以被禁用，使得可以通过驱动杆的手动旋转来偏置弹簧。 离合器机构设置成当手动工具插入机构时将电机与机构断开。 还提供了一种快门螺栓，当插入手动工具时，锁定主闩锁的自动操作，电动断开电动机，并且当工具插入机构时防止主闩锁的手动操作。 此外，如果希望在不跳闸主闩锁的情况下测试螺线管，则提供机构以手动地从主闩锁断开螺线管。 另外，在开关刀片被焊接或者卡在闭合位置的情况下，提供自动撬出机构以确保开关打开期间的接触分离。

公开(公告)号：US20130345284A1

公开(公告)日：2013-12-26

申请号：US13752568

申请日：2013-01-29

申请人： Alan Y. Lu ,  Patrick Y. Lu ,  David M. Evans ,  John J. Xu

发明人： Alan Y. Lu ,  Patrick Y. Lu ,  David M. Evans ,  John J. Xu

IPC分类号： C12N15/113

CPC分类号： C12N15/1131 ,  C12N2310/14 ,  C12N2310/17 ,  C12N2320/31

摘要： The invention provides siRNA compositions that (1) interfere with viral replication of human papillomavirus (HPV), herpes simplex virus (HSV), and human immunodeficiency virus (HIV) in mucosal tissues, such as genital tissues, and (2) treat fungal infections. The compositions include siRNA molecules that target HPV, complexed with a dendrimer that treats and prevents genital herpes (HSV) and HIV. The compositions also include siRNA molecules that target HPV, complexed with a histidine-lysine (HK) polymer that treats and prevent fungus infection. The combined formulations of siRNA and dendrimer provide treatment of the infections from HPVs, HSVs, and HIVs. The combined formulations of siRNA and HK polymer provide treatment of HPVs and fungus infections.

摘要翻译： 本发明提供了siRNA组合物，其（1）干扰人乳头状瘤病毒（HPV），单纯疱疹病毒（HSV）和人类免疫缺陷病毒（HIV）在粘膜组织如生殖器官组织中的病毒复制，和（2）治疗真菌感染 。 组合物包括靶向HPV的siRNA分子，与治疗和预防生殖器疱疹（HSV）和HIV的树突状细胞复合。 组合物还包括靶向HPV的siRNA分子，与治疗和预防真菌感染的组氨酸 - 赖氨酸（HK）聚合物复合。 siRNA和树枝状大分子的组合制剂提供了对HPV，HSV和HIV感染的治疗。 siRNA和HK聚合物的组合制剂提供对HPV和真菌感染的治疗。

公开(公告)号：US20080255126A1

公开(公告)日：2008-10-16

申请号：US12004054

申请日：2007-12-20

申请人： David M. Evans ,  Doreen M. Ashworth

发明人： David M. Evans ,  Doreen M. Ashworth

IPC分类号： A61K31/53 ,  A61K31/40 ,  C07D207/16 ,  C07D277/04 ,  C07D417/12 ,  A61K31/426 ,  A61K31/4439 ,  C07D401/12

CPC分类号： C07D207/335 ,  C07D207/10 ,  C07D207/16 ,  C07D211/14 ,  C07D211/38 ,  C07D211/62 ,  C07D213/38 ,  C07D213/74 ,  C07D213/82 ,  C07D215/12 ,  C07D251/50 ,  C07D251/52 ,  C07D277/04 ,  C07D295/185 ,  C07D307/06 ,  C07D307/81 ,  C07D317/66 ,  C07D333/20 ,  C07D401/12 ,  C07D401/14 ,  C07D407/12 ,  C07D409/12 ,  C07D417/12 ,  C07D417/14

摘要： Novel compounds that are inhibitors of one or most post-proline cleaving proteases, e.g. dipeptidyl peptidase IV, according to general formula (1). R1 is H or CN, X1 is O, S, CH2, CHF, CF2, CH(CH3), C(CH3)2 or CH(CN), and b is 1 or 2. G1 is H or a group according to the formula —CH2—X2—(CH2)a-G3 and G2 is H or a group according to the formula —CH2—(CH29a-G3, provided that one of G1 and G2 is H and the other is not H. X2 is O, S, or CH2, and a is 0, 1 or 2, provided that when a is 1 then X2 is CH2. G3 is a group according to one of general formulae 2-4, where the variables have meaning given in the description. The compounds are useful in the treatment of i.a. type 2 diabetes and impaired glucose tolerance.

摘要翻译： 一种或多种后脯氨酸切割蛋白酶的抑制剂的新型化合物，例如 二肽基肽酶IV，根据通式（1）。 R 1是H或CN，X 1是O，S，CH 2，CHF，CF 2， CH（CH 3）3，C（CH 3）2或CH（CN），b为1或2.G < 1是H或根据式-CH 2的基团-X 2 - （CH 2）2 G 2和H 2是H或根据式-CH 2 - （CH 2）2的基团， 只要G 1和G 2中的一个是H，且< 另一个不是H.X 2是O，S或CH 2，并且a是0,1或2，条件是当a是1时，X _{2 是CH 2，G 3是根据通式2-4之一的基团，其中变量具有在说明书中给出的含义。 化合物可用于治疗2型糖尿病和糖耐量异常。}

公开(公告)号：US07144886B2

公开(公告)日：2006-12-05

申请号：US10491288

申请日：2002-10-23

申请人： David M. Evans ,  Andre Tartar

发明人： David M. Evans ,  Andre Tartar

IPC分类号： A61K31/497 ,  A61K31/4439 ,  C07D241/12 ,  C07D401/12

CPC分类号： C07D213/82 ,  C07D277/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12

摘要： The present invention relates to a series of prodrugs of inhibitors of DP-IV with improved properties. The compounds can be used for the treatment of a number of human diseases, including impaired glucose tolerance and type II diabetes. The compounds of the invention are described by general formula (1); wherein R1 is H or CN; R2 is selected from CH2R5, CH2CH2R5 and C(R3)(R4)—X2—(CH2)aR5; R3 and R4 are each independently selected from H and Me; R5 is selected from CON(R6)(R7), N(R8)C(═O)R9, N(R8)C(═S)R9, N(R8)SO2R10 and N(R8)R10; R6 and R7 are each independently R11(CH2)b or together they are —(CH2)2—Z—(CH2)2— or CH2—o—C6H4—Z—CH2—; R8 is H or Me; R9 is selected from R11(CH2)b, R11(CH2)bO and N(R6)(R7); R10 is R11(CH2)b; R11 is selected from H, alkyl, optionally substituted aryl, optionally substituted aroyl, optionally substituted arylsulphonyl and optionally substituted heteroaryl; R12 is selected from H2NCH(R13)CO, H2NCH(R14)CONHCH(R15)CO, C(R16)═C(R17)COR18 and R19OCO; R13, R14 and R15 are selected from the side chains of the proteinaceous amino acids; R16 is selected from H, lower alkyl (C1–C6) and phenyl; R17 is selected from H and lower alkyl (C1–C6); R18 is selected from H, lower alkyl (C1–C6), OH, O-(lower alkyl (C1–C6)) and phenyl; R19 is selected from lower alkyl (C1–C6), optionally substituted phenyl and R20C(═O)OC(R21)(R22); R20, R21 and R22 are each independently selected from H and lower alkyl (C1–C6); Z is selected from a covalent bond, —(CH2)c—, —O—, —SOd— and —N(R10)—; X1 is S or CH2; X2 is O, S or CH2; a is 1, 2 or 3; b is 0–3; c is 1 or 2; and d is 0, 1 or 2.

公开(公告)号：US06622696B2

公开(公告)日：2003-09-23

申请号：US10066840

申请日：2002-02-04

申请人： Donald G. Witzel ,  David M. Evans

发明人： Donald G. Witzel ,  David M. Evans

IPC分类号： F02D916

CPC分类号： F02D9/16

摘要： A rotary throttle valve having a first cylindrical bore for flow of air between an inlet and an outlet and a second cylindrical bore orthogonal to the first bore and being substantially the same diameter as the first bore. A flow modulator rotatably disposed in the second bore has first and second cylindrical portions disposed respectively on opposite sides of the first bore and separated by a central plate such that when the modulator is rotated to place the plate transverse to the first bore, the edges of the plate are fully engaged with the wall of the second bore and the valve is closed. As the modulator is rotated from the closed position to open the valve, the edges of the plate become progressively less engaged with the wall of the second bore, the edge of the open area following the juncture lines of the first and second bores.

摘要翻译： 一种旋转节流阀，具有用于在入口和出口之间流动的第一圆柱形孔和与第一孔垂直的第二圆柱孔，并且与第一孔基本相同的直径。 可旋转地设置在第二孔中的流动调节器具有分别设置在第一孔的相对侧上的第一和第二圆柱形部分，并由中心板分隔开，使得当调制器旋转以使板横向于第一孔时，边缘 板与第二孔的壁完全接合，并且阀被关闭。 当调制器从关闭位置旋转以打开阀时，板的边缘逐渐地与第二孔的壁接合，开口区域的边缘跟随第一和第二孔的接合线。

公开(公告)号：US06263917B1

公开(公告)日：2001-07-24

申请号：US09373145

申请日：1999-08-12

申请人： David M. Evans

发明人： David M. Evans

IPC分类号： E03B100

CPC分类号： F16K11/0525 ,  F02D9/101 ,  F02D9/107 ,  F02D9/1095 ,  F02D2009/0276 ,  F02D2009/0279 ,  F02M26/70 ,  F16K1/223 ,  Y10T137/87161 ,  Y10T137/87877 ,  Y10T137/87909

摘要： A multiple-bore throttle valve wherein the valve shaft is restrained from end play at a point between two of the flow bores. A passageway in the valve body between the flow bores intersects the valve shaft bore non-diametrically. The valve shaft has a circumferential groove at the point of intersection. A pin pressed into both the passageway and the groove axially restrains the shaft at that location. Since thermal expansion or contraction of the shaft in its axial direction can proceed only from the point of restraint, a dual-bore valve in accordance with the invention exhibits length changes in each bore equivalent to that of a single bore valve, which is less than half the shaft length change exhibited in at least one bore of a prior art dual-bore throttle valve. Similarly, a triple-bore valve exhibits expansion comparable to individual prior art single-bore and dual-bore valves, and a quadruple-bore valve exhibits expansion comparable to a prior art dual-bore valve.

摘要翻译： 一种多孔节流阀，其中阀轴在两个流动孔之间的点处被限制在末端游隙。 流体孔之间的阀体中的通道非直径地与阀轴孔相交。 阀轴在交点处具有圆周槽。 压入通道和槽中的销轴在该位置轴向地限制轴。 由于轴在其轴向上的热膨胀或收缩只能从约束的角度进行，所以根据本发明的双孔阀显示出相当于单孔阀的孔的长度变化，其小于 在现有技术的双孔节流阀的至少一个孔中显示出一半的轴长变化。 类似地，三孔阀具有与单独的现有技术的单孔和双孔阀类似的膨胀，并且四缸阀具有与现有技术的双孔阀类似的膨胀。

公开(公告)号：US4366353A

公开(公告)日：1982-12-28

申请号：US237228

申请日：1981-02-23

申请人： David M. Evans

发明人： David M. Evans

IPC分类号： H01H31/10 ,  H01H31/00

CPC分类号： H01H31/10

摘要： Apparatus for preventing two switches from being simultaneously closed. A pair of rollers are each movable in, and between the ends of, respective curved tracks. The rollers are each linked to a respective switch so that when its switch is closed, each roller is at the bottom of its track, and when its switch is open, each roller is at the top of its track. Each switch cannot operate if its roller cannot move. A yoke maintains the rollers a fixed distance apart so that each roller may be at the top of its track, one roller may be at the top of its track while the other roller is at the bottom of its track, and vice versa, but one roller cannot move away from the top of its track if the other roller is not at the top of its track and vice versa. If one switch attempts to close while the other switch is closed, the roller of the closed switch is pulled into a detent at the bottom of its track; the roller remains in the detent as long as the other switch attempts closure. The closed switch may reopen while its roller remains in the detent, preventing closure of the one switch until its attempt at closure ceases. If the switches attempt simultaneous closure, one roller is preferentially held at the top of its track, while the other roller moves to the bottom of its track.

摘要翻译： 用于防止两个开关同时闭合的装置。 一对辊子各自可以在相应的弯曲轨道内部和之间移动。 辊子各自连接到相应的开关，使得当其开关闭合时，每个辊子在其轨道的底部，并且当其开关打开时，每个辊子在其轨道的顶部。 每个开关如果其滚轮不能移动，则无法操作。 磁轭将辊保持固定距离，使得每个辊可以在其轨道的顶部，一个辊可以在其轨道的顶部，而另一个辊位于其轨道的底部，反之亦然，但是一个 如果另一个辊子不在其轨道的顶部，则辊子不能从其轨道的顶部移开，反之亦然。 如果一个开关在另一个开关闭合时尝试关闭，则闭合开关的滚轮被拉入其轨道底部的定位器; 只要另一个开关试图闭合，滚子就保持在制动器中。 闭合的开关可以在其辊保持在制动器中时重新打开，防止一个开关的闭合直到其关闭的尝试停止。 如果开关同时闭合，则一个滚轮优先保持在其轨道的顶部，而另一个滚轮移动到其轨道的底部。

公开(公告)号：US4351994A

公开(公告)日：1982-09-28

申请号：US136632

申请日：1980-04-01

申请人： David M. Evans ,  Roy T. Swanson

发明人： David M. Evans ,  Roy T. Swanson

IPC分类号： H01H3/30 ,  H01H3/32

CPC分类号： H01H3/3042

摘要： Disclosed in a high voltage switch operating mechanism which utilizes energy stored in a spiral spring to drive the high voltage switches from either the open to the closed or the closed to the open position. The spring can be charged either by a manual tool or by an electric motor. The switch can be tripped by either electric or manual trip mechanisms. Manual and electric trip interlock assemblies are provided to prevent the switch operating mechanism from being tripped either manually or electrically while the spring is being charged. A mechanism is provided to prevent the charging of the spring by the electric motor when the manual tool is used to charge the spring. Another mechanism is provided to decouple the operating mechanism from the switch. To allow testing of the operating mechanism without change of the switch state. The decoupling mechanism locks the switch to its present position before the decoupling is complete allowing the energy in the operating spring to be dissipated.

摘要翻译： 公开在高压开关操作机构中，其利用存储在螺旋弹簧中的能量来驱动高压开关从开启到关闭或关闭到打开位置。 弹簧可以由手动工具或电动马达充电。 开关可以通过电动或手动跳闸机构跳闸。 提供手动和电动跳闸互锁组件，以防止开关操作机构在弹簧充电时手动或电动跳闸。 提供了一种机构，用于当使用手动工具对弹簧充电时，防止电动机对弹簧的充电。 提供另一种机制来将操作机构与开关分离。 允许测试操作机构而不改变开关状态。 去耦机构在去耦合完成之前将开关锁定到其当前位置，从而使操作弹簧中的能量消散。