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公开(公告)号：US20050009016A1
公开(公告)日：2005-01-13
申请号：US10275098
申请日：2001-05-04
Applicant: David Moskowitz , Lee Henderson
Inventor： David Moskowitz , Lee Henderson
IPC: C12Q1/68 , C12Q1/6886 , C07H21/04 , C07K14/475
CPC classification number: C12Q1/6886 , C12Q2600/106 , C12Q2600/156
Abstract: Disclosed are single nucleotide polymorphisms (SNPs) associated with end stage renal disease, breast cancer, lung cancer, and prostate cancer. Also disclosed are methods for using SNPs to determine susceptibility to these diseases; nucleotide sequences containing SNPs; kits for determining the presence of SNPs; and methods of treatment or prophylaxis based on the presence of SNPs.
Abstract translation: 公开了与终末期肾病，乳腺癌，肺癌和前列腺癌相关的单核苷酸多态性（SNPs）。 还公开了使用SNP来确定对这些疾病的易感性的方法; 含有SNP的核苷酸序列; 用于确定SNP存在的试剂盒; 以及基于SNP存在的治疗或预防方法。
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Patent Agency Ranking
公开(公告)号：US4925346A
公开(公告)日：1990-05-15
申请号：US332127
申请日：1989-04-03
Applicant: David Moskowitz , David W. Hoffman , Duane J. Schmatz
Inventor： David Moskowitz , David W. Hoffman , Duane J. Schmatz
CPC classification number: C23C14/46 , C23C14/022 , Y10T407/27 , Y10T408/03 , Y10T408/78 , Y10T82/10
Abstract: The wear life of a high-speed tool steel cutting bit is increased by (a) cleansing the bit by subjection to an ion beam; (b) while preventing the temperature of said cleansed from rising above 350.degree. C., coating the cleansed bit by condensing sputtered atoms of titanium and boron thereonto, the condensation being carried out to provide a coating thickness of 2-6 microns. An argon or krypton beam of ions is accelerated to 1300-1800 volts as a broad-beam ion source to sputter a titanium diboride target arranged as a cathode. The sputtering is carried out for 5-10 minutes while the bit is heated to about 200.degree. C., and a soft vacuum of about 4-6 milli-torr is used during the process.
Abstract translation: 高速工具钢切削刀头的磨损寿命通过以下方式增加：（a）通过置于离子束上清洁钻头; （b）在防止所述清洁温度升高到高于350℃的同时，通过将其上的钛和硼的溅射原子凝结来涂覆清洁的钻头，进行冷凝以提供2-6微米的涂层厚度。 将氩离子或氪离子束作为宽束离子源加速至1300-1800伏，以溅射作为阴极布置的二硼化钛靶。 溅射进行5-10分钟，同时加热至约200℃，并且在该过程中使用约4-6毫乇的软真空。
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公开(公告)号：US4880600A
公开(公告)日：1989-11-14
申请号：US124383
申请日：1987-11-20
Applicant: David Moskowitz , Charles W. Phillips
Inventor： David Moskowitz , Charles W. Phillips
IPC: C22C29/14
CPC classification number: C22C29/14
Abstract: Methods are disclosed of making and of using a high density high strength titanium diboride comprising material. The method of making comprises (a) compacting a mixture of titanium diboride, 5-20% by weight of a metal group binder, and up to 1% oxygen and up to 2% graphite, the mixture having a maximum particle size of 5 microns, and (b) sintering the compact to substantially full density. The TiB.sub.2 may be replaced by up to 10% TiC. The method of use is as a cutting tool at relatively high speeds against aluminum based materials.
Abstract translation: 公开了制造和使用包含高密度高强度二硼化钛的材料的方法。 制备方法包括（a）压制二硼化钛的混合物，5-20重量％的金属粘合剂和至多1％的氧气和至多2％的石墨，该混合物的最大粒度为5微米 ，和（b）将压坯烧结至基本全密度。 TiB2可以被最多10％的TiC代替。 使用的方法是相对于铝基材料的相对高的速度的切削工具。
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公开(公告)号：US4820392A
公开(公告)日：1989-04-11
申请号：US135881
申请日：1987-12-21
Applicant: David Moskowitz , David W. Hoffman , Duane J. Schmatz
Inventor： David Moskowitz , David W. Hoffman , Duane J. Schmatz
CPC classification number: C23C14/022 , C23C14/46
Abstract: The wear life of a high-speed tool steel cutting bit is increased by (a) cleansing the bit by subjection to an ion beam; (b) while preventing the temperature of said cleansed from rising above 350.degree. C., coating the cleansed bit by condensing sputtered atoms of titanium and boron thereonto, the condensation being carried out to provide a coating thickness of 2-6 microns. An argon or krypton beam of ions is accelerated to 1300-1800 volts as a broad-beam ion source to sputter a titanium diboride target arranged as a cathode. The sputtering is carried out for 5-10 minutes while the bit is heated to about 200.degree. C. and a soft vacuum of about 4-6 milli-torr is used during the process.
Abstract translation: 高速工具钢切削刀头的磨损寿命通过以下方式增加：（a）通过置于离子束上清洁钻头; （b）在防止所述清洁温度升高到高于350℃的同时，通过将其上的钛和硼的溅射原子凝结来涂覆清洁的钻头，进行冷凝以提供2-6微米的涂层厚度。 将氩离子或氪离子束作为宽束离子源加速至1300-1800伏，以溅射作为阴极布置的二硼化钛靶。 溅射进行5-10分钟，同时加热至约200℃，并且在该过程中使用约4-6毫乇的软真空。
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公开(公告)号：US4288495A
公开(公告)日：1981-09-08
申请号：US118709
申请日：1980-02-04
Applicant: Leslie L. Terner , Roy L. Van Alsten , David Moskowitz
Inventor： Leslie L. Terner , Roy L. Van Alsten , David Moskowitz
CPC classification number: C23C4/04 , B23B27/148 , C04B41/5059 , C23C4/06 , Y10S60/909
Abstract: This application discloses a new powder composition which may be plasma sprayed onto the surface of an article to provide a protective coating therefor. The protective coating may be resistant to heat, wear, and corrosion. The coating may also provide a thermal or radiation barrier.In particular, the coating composition for arc plasma spraying consists of finely divided silicon carbide mixed with finely divided silicon. This coating composition is applied to a substrate by developing a plasma spray, feeding the coating composition to the plasma spray and directing the plasma spray at an exposed surface of the substrate so that the exposed substrate is coated with a coating which consists essentially of beta silicon carbide and silicon.The new article of manufacture disclosed in this application, is a substrate with a tightly adherent coating thereon consisting essentially of beta silicon carbide and silicon. The substrate may be any material, either metallic or non-metallic, to which the coating adheres. The coating may provide the substrate with wear resistant characteristics as, for example, if the substrate is to be used for machining metals or as a valve seat in an aluminum engine. The substrate, with the coating thereon, may be used to withstand severe temperatures as, for example, in rocket nozzles and other areas where a substrate would be subjected to extreme temperatures.
Abstract translation: 本申请公开了一种新的粉末组合物，其可以被等离子体喷涂在制品的表面上以提供其保护涂层。 保护涂层可以耐热，耐磨和耐腐蚀。 涂层还可以提供热或辐射屏障。 特别地，用于电弧等离子体喷涂的涂料组合物是由精细分散的碳化硅与细分散的硅混合。 通过显影等离子喷涂将该涂料组合物施加到基材上，将涂料组合物进料到等离子喷涂中，并将等离子喷涂引导到基板的暴露表面，使得暴露的基材涂覆有基本上由β硅 碳化物和硅。 本申请中公开的新制品是其上具有紧密粘附的基材，其基本上由β碳化硅和硅组成。 衬底可以是涂层粘附到的任何金属或非金属材料。 涂层可以为基材提供耐磨特性，例如，如果基材用于加工金属或作为铝发动机中的阀座。 具有其上的涂层的基底可以用于承受诸如火箭喷嘴和基板将经受极端温度的其它区域的严酷的温度。
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公开(公告)号：US4019874A
公开(公告)日：1977-04-26
申请号：US634972
申请日：1975-11-24
Applicant: David Moskowitz
Inventor： David Moskowitz
CPC classification number: C22C29/10 , C22C29/02 , C22C29/067
Abstract: A hard sintered carbide composition and the method of making such composition for use as a cutting material or for use as wear parts or dies and the like, is disclosed. The composition consists essentially of a titanium carbide phase bound together by a binding alloy principally composed of molybdenum and nickel; the titanium carbide contains controlled amounts of dissolved vanadium carbide and/or titanium nitride. The binding alloy is characterized by the addition of aluminum in controlled amounts and chromium may be added to the binding alloy as a partial substitute for some of the aluminum. The presence of the dissolved vanadium carbide and/or titanium nitride produces a grain refinement in the carbide phase and the presence of the aluminum tends to form a nickel aluminide in the binding alloy which is of a finely divided character. The presence of two or more of the elements: vanadium carbide, titanium nitride and aluminum produce an unprecedented improvement in the deformation resistance of a TiC-Ni-Mo composition.The method requires that the binding alloy powder and the carbide powders be selected as to size (about 3-4 microns) be milled with the additive powders and the compacted charge then be sintered at about 1400.degree. C in closed graphite trays in a furnace evacuated to less than 1 micron of mercury pressure.
Abstract translation: 公开了一种硬质烧结碳化物组合物以及用作切削材料或用作磨损部件或模具等的这种组合物的方法。 该组合物基本上由通过主要由钼和镍组成的结合合金结合在一起的碳化钛相组成; 碳化钛含有受控量的溶解的碳化钒和/或氮化钛。 结合合金的特征在于加入受控量的铝，并且可以将铬加入到粘合合金中作为一些铝的部分替代物。 溶解的碳化钒和/或氮化钛的存在在碳化物相中产生晶粒细化，并且铝的存在倾向于在具有细碎特性的结合合金中形成镍铝化物。 两种或更多种元素的存在：碳化钒，氮化钛和铝在TiC-Ni-Mo组合物的抗变形性方面产生了前所未有的改善。
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