Methods and compositions for treating diseases associated with excesses in ACE

    公开(公告)号:US20060111397A1

    公开(公告)日:2006-05-25

    申请号:US11284227

    申请日:2005-11-21

    Inventor: David Moskowitz

    Abstract: Over 40 common diseases, in addition to congestive heart failure (CHF) due to hypertension (HTN) or non-insulin dependent diabetes mellitus (type II diabetes mellitus) (NIDDM), atherosclerotic peripheral vascular disease (ASPVD) due to HTN or NIDDM, and chronic obstructive pulmonary disease; emphysema (COPD), are associated with the ACE D/D genotype and should also respond to an adequate tissue-inhibitory dose of ACE inhibitors such as quinapril. Several of these diseases have now been successfully treated using higher than normal dosages of ACE inhibitors, especially hydrophobic ACE inhibitors, with good outcomes. ACE inhibitors have also been found to be useful in inhibiting apoptosis and aging in general. Dosages that have been utilized are typically greater than quinapril at a dose of 40 to 80 mg/day, i.e. up to 1 mg/kg per day for a “typical” 80 kg patient. New formulations of ACE inhibitors have been developed for these higher dosages, including 80 mg tablets, controlled and/or sustained release formulations, and formulations containing a second active agent such as a diuretic, or a compound such as furosemide 20 mg/day (for creatinine 2.5 mg/dl), to prevent fluid retention and congestive heart failure in patients with renal failure. The ACE inhibitors can also be combined with an angiotensin receptor blocker.

    Method of cutting using a titanium diboride body
    3.
    发明授权
    Method of cutting using a titanium diboride body 失效
    使用二硼化钛体切割的方法

    公开(公告)号:US4859124A

    公开(公告)日:1989-08-22

    申请号:US220126

    申请日:1988-07-15

    CPC classification number: C22C29/14 Y10T407/27 Y10T408/03 Y10T409/30

    Abstract: Methods are disclosed of making and of using a high density high strength titanium diboride comprising material. The method of making comprises (a) compacting a mixture of titanium diboride, 5-20% by weight of a metal group binder, and up to 1% oxygen and up to 2% graphite, the mixture having a maximum particle size of 5 microns, and (b) sintering the compact to substantially full density. The TiB.sub.2 may be replaced by up to 10% TiC. The method of use is as a cutting tool at relatively high speeds against aluminum based materials.

    Abstract translation: 公开了制造和使用包含高密度高强度二硼化钛的材料的方法。 制备方法包括(a)压制二硼化钛的混合物,5-20重量%的金属粘合剂和至多1%的氧气和至多2%的石墨,该混合物的最大粒度为5微米 ,和(b)将压坯烧结至基本全密度。 TiB2可以被最多10%的TiC代替。 使用的方法是相对于铝基材料的相对高的速度的切削工具。

    Safety covers for electrical outlets (II)
    4.
    发明授权
    Safety covers for electrical outlets (II) 失效
    电源插座安全盖(二)

    公开(公告)号:US4718856A

    公开(公告)日:1988-01-12

    申请号:US897083

    申请日:1986-08-18

    CPC classification number: H01R13/447

    Abstract: A protective cover for restricting access to the female sockets or connectors of an electrical outlet, thereby protecting infants and small children and others of limited understanding against electrical shock. The cover includes a base plate bearing an externally threaded boss which replaces the conventional outlet cover; a safety cap of the push-and-twist type threaded on the boss; protective members which are clamped by the safety cap against the boss overlying the socket being protected to deny access to the socket, both when the socket is in use and when it is not in service; and a platelike shield which normally overlies, and denies access to, a second female socket of the typical double socket wall outlet. This shield can be swung aside after backing off the safety cap to furnish unprotected, but controlled, and typically temporary, access to that second female socket.

    Abstract translation: 一个保护盖,用于限制进入电源插座的阴插座或连接器,从而保护婴儿和小孩,以及其他对电击的理解有限。 该盖包括一个带有外螺纹凸起部的基板,该外螺纹凸台取代了传统的出口盖; 螺母上的推 - 扭型安全帽; 当插座正在使用时以及不在使用时,保护构件被安全帽夹紧抵靠插座上的凸起被保护以拒绝进入插座; 以及通常覆盖并拒绝进入典型双插座墙壁插座的第二母插座的平板式屏蔽。 这个防护罩可以从安全帽上取下来摆放,以提供无保护的,但可以控制的,通常是临时的接入第二个母插座。

    Process for producing Si.sub.3 N.sub.4 base articles by the cold press
sinter method
    5.
    发明授权
    Process for producing Si.sub.3 N.sub.4 base articles by the cold press sinter method 失效
    通过冷压烧结法生产Si3N4基底制品的方法

    公开(公告)号:US4280973A

    公开(公告)日:1981-07-28

    申请号:US94248

    申请日:1979-11-14

    CPC classification number: C04B35/584 C04B35/597

    Abstract: A method of making Si.sub.3 N.sub.4 based cutting tools (and the resulting product) is disclosed. A mixture is formed of three powders: a first powder of at least 75% crystalline Si.sub.3 N.sub.4, a second powder selected from the group Y.sub.2 O.sub.3, MgO, CeO.sub.2 and ZrO.sub.2, and a third powder selected from the group consisting of Al.sub.2 O.sub.3, WC, Wsi.sub.2, W and TiC. The mixture is cold pressed to a density of 50-70% of theoretical and then sintered to full density without the application of pressure.

    Abstract translation: 公开了制造Si 3 N 4基切削工具(以及所得产品)的方法。 混合物由三种粉末形成:第一粉末为至少75%的结晶Si 3 N 4,第二粉末,其选自Y 2 O 3,MgO,CeO 2和ZrO 2,以及选自Al 2 O 3,WC,Wsi 2, W和TiC。 将混合物冷压至理论值的50-70%的密度,然后在不施加压力的情况下烧结至全密度。

    Method of improving tool life of TiC base tools
    6.
    发明授权
    Method of improving tool life of TiC base tools 失效
    提高TiC基础工具刀具寿命的方法

    公开(公告)号:US4230462A

    公开(公告)日:1980-10-28

    申请号:US967925

    申请日:1978-12-08

    Inventor: David Moskowitz

    CPC classification number: C22C1/051 C22C29/067 C22C29/10

    Abstract: A method of making cemented titanium carbide base cutting tools with increased tool life is disclosed. Substantially unoxidized carbide and binder metal powders are ground to a sub-micron particle size in the presence of a low-boiling oxidation-inhibiting ingredient covering the particles of said powders. A low-boiling pressing aid is added. The ground powders are then subjected to air drying to evaporate said oxidation inhibiting liquid ingredient and the pressing aid consisting preferably of polyethylene glycol. After compacting the waxed ground particles to a predetermined configuration, the compact is first heated to volatize the wax at an appropriate temperature and critically in the presence of a nitrogen based atmosphere which may contain 0-10% H.sub.2. The dewaxed compact is then heated to a higher second temperature level for effecting sintering in the presence of a vacuum.

    Abstract translation: 公开了一种制造具有增加的刀具寿命的胶结碳化钛底切刀的方法。 在覆盖所述粉末的颗粒的低沸点氧化抑制成分的存在下,将基本上未氧化的碳化物和粘结剂金属粉末研磨成亚微米级的粒度。 加入低沸点加压助剂。 然后将研磨的粉末进行空气干燥以蒸发所述氧化抑制液体成分,并且优选由聚乙二醇组成的加压助剂。 将打蜡的研磨颗粒压实到预定的构型之后,首先将该压块加热至适当温度下的蜡挥发,并在可能含有0-10%H 2的氮气气氛存在下进行临界定影。 然后将脱蜡的压块加热至较高的第二温度水平,以在真空存在下进行烧结。

    Ceramic cutting tool
    8.
    发明授权
    Ceramic cutting tool 失效
    陶瓷切割工具

    公开(公告)号:US5017524A

    公开(公告)日:1991-05-21

    申请号:US507968

    申请日:1990-04-11

    CPC classification number: C04B35/111

    Abstract: A composition for a ceramic cutting tool which enjoys long tool life at high speed machining of ferrous alloys. The composition consists essentially of 60-80% alpha aluminum oxide (Al.sub.2 O.sub.3) having a hexagonal crystal structure and the remainder of titanium carbonitride (TiCN). The titanium carbonitride has a mixture of 30-70% titanium carbide and the remainder titanium nitride. The mixture is compacted and hot pressed, sintered or pressure sintered to form the tool.

    Abstract translation: 一种陶瓷切削工具的组合物,在铁合金的高速加工中具有较长的刀具寿命。 该组合物基本上由具有六方晶系结构的60-80%的α氧化铝(Al 2 O 3)和剩余的碳氮化钛(TiCN)组成。 碳氮化钛具有30-70%的碳化钛和其余的氮化钛的混合物。 将混合物压实并热压,烧结或加压烧结以形成工具。

    Night Light
    9.
    发明授权
    Night Light 失效
    小夜灯

    公开(公告)号:US4723823A

    公开(公告)日:1988-02-09

    申请号:US899894

    申请日:1986-08-25

    CPC classification number: H01R13/447

    Abstract: Devices for protecting the bulb of a night light against damage and for denying access to the sockets of an electrical outlet into which the night light is plugged and for also denying access to those parts of the night light which might produce an electrical shock if touched. One component of the protective arrangement is a cover with externally threaded bosses which are apertured so that the night light can be plugged into a socket which a boss overlies by installing the night light through the aperture. The night light includes a bulb surrounding protective shield which is clamped against the boss by a safety cap of the push-and-twist type, thereby protecting the bulb and isolating the socket and electrically charged parts of the night light. Safety caps are also used to deny access to any othe sockets of the outlet servicing the night light, and these safety caps may be designed so that they will perform this function when the protected socket is in use as well as when it is out of service.

    Abstract translation: 用于保护夜灯的灯泡免受损坏并且拒绝进入夜间灯被插入的电源插座的插座的设备,并且还拒绝进入可能在触摸时可能产生电击的那些部分夜间灯。 保护装置的一个组成部分是具有外螺纹凸起部的盖,该凸起是有孔的,使得夜间灯可以插入插座中,该插座通过安装通过该孔的夜光而覆盖。 夜灯包括围绕保护罩的灯泡,其通过推 - 扭型安全帽夹紧在凸台上,从而保护灯泡并隔离插座和夜灯的带电部分。 安全帽也用于拒绝访问夜间灯具的插座的任何插座,并且这些安全帽可以设计成当保护的插座在使用中以及在停止使用时它们将执行此功能 。

    Safety covers for electric outlets
    10.
    发明授权
    Safety covers for electric outlets 失效
    电源插座安全盖

    公开(公告)号:US4691974A

    公开(公告)日:1987-09-08

    申请号:US815528

    申请日:1986-03-17

    CPC classification number: H01R13/447

    Abstract: A cover for restricting access to the female sockets of an electrical outlet, thereby protecting infants and small children and others of limited understanding against electrical shock. The cover includes a plate bearing externally threaded bosses which replaces the conventional outlet cover, safety caps of the push-and-twist type, and protective members which are clamped against the boss overlying the socket being protected by the safety cap to deny access to the socket, both when the socket is in use and when it is not in service.

    Abstract translation: 用于限制进入电源插座的插座的盖子,从而保护婴儿和小孩以及其他对电击的理解有限。 该盖包括一个板轴承外螺纹凸台,其代替常规的出口盖,推 - 扭型的安全盖,以及保护构件,该保护构件被夹在盖上的凸台上,该凸台被安全盖保护,以便不允许进入 套接字,当插座正在使用时以及何时不使用。

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