摘要:
Compounds of Formula 1 where X is S and the variables have the meaning defined in the specification are specific or selective to alpha2B and/or alpha2C adrenergic receptors in preference over alpha2A adrenergic receptors, and as such have no or only minimal cardivascular and/or sedatory activity. These compounds of Formula 1 are useful as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha2B adrenergic receptors. Compounds of Formula 1 where X is O also have the advantageous property that they have no or only minimal cardivascular and/or sedatory activity and are useful for treating pain and other conditions with no or only minimal cardivascular and/or sedatory activity.
摘要:
Compounds of Formula 1 where the variables have the meaning defined in the specification are agonists of alpha2 adrenergic receptors. Several compounds of the disclosure are specific or selective to alpha2B and/or alpha2C adrenergic receptors in preference over alpha2A adrenergic receptors. Additionally some of the claimed compounds have no or only minimal cardivascular and/or sedatory activity. The compounds of Formula 1 are useful as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha2 adrenergic receptors. Compounds of Formula 1 which have no significant cardiovascular and/or sedatory activity are useful for treating pain and other conditions with minimal side effects.
摘要:
This invention relates aryl substituted pyridines, pyrimidines, pyrazines and triazines of Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein A1, A2, A3, R1-R4, X and Y are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
摘要:
A sensor for measuring a current passing through a load. The sensor has a power transistor having a first terminal connected to substantially constant voltage and a second terminal connected to the load. The sensor can sample a voltage difference with a variable capacitor, and a controller can be configured to cause a variable capacitor in the current sensor to have a capacitance inversely proportional to a resistance of the power transistor, whereby a charge stored on the variable capacitor is proportional to the current passing through the power transistor when the sampling switches are opened. A comparator can compare the current through the power transistor to a known reference current to generate a digital output signal. The sensor can include a power transistor, reference transistor and amplifier connected and configured so as to generate a signal on a reference line having a current of known proportion to the current passing through the load.
摘要:
A method of providing a packetized data transmission service to a mobile terminal (108) in a spread spectrum communication network (100), includes: at a transmitter (102), broadcasting an indication message to a cell on a downlink broadcast channel (114), the indication message providing notification of an available packetized data transmission service intended for the mobile terminal (108); at the mobile terminal (108), monitoring the broadcast channel (114) for the indication message, and upon receipt, acknowledging detection of the indication message to the transmitter (102) on an uplink contention channel (116); and at the transmitter (102), upon contention completion, transmitting packetized data transmission service configuration information to the mobile terminal (108) on the broadcast channel (114).
摘要:
A method and system for using Threat Imaging Projection (TIP) technology, and the operator testing data that it generates, in order to certify x-ray inspection system operators and thereby assure an acceptable and uniform level of operator performance. In a preferred configuration, the operator views x-ray images of objects on a screening system equipped with TIP technology. When the operator believes that a threat item image appears on the screening system, the operator indicates such via an indicating means. The system is capable of recording, storing and transmitting individual operator performance data relating to proper detections, missed detections, and false alarms, i.e., when an operator indicates that a threat item image appears when no such image actually appears on the screening system. The system preferably contains a library of various threat item images, e.g., guns, bombs, knives, etc., which are classified according to type of threat and difficulty of detection.
摘要:
A method of providing a packetized data transmission service to a mobile terminal (108) in a spread spectrum communication network (100), includes: at a transmitter (102), broadcasting an indication message to a cell on a downlink broadcast channel (114), the indication message providing notification of an available packetized data transmission service intended for the mobile terminal (108); at the mobile terminal (108), monitoring the broadcast channel (114) for the indication message, and upon receipt, acknowledging detection of the indication message to the transmitter (102) on an uplink contention channel (116); and at the transmitter (102), upon contention completion, transmitting packetized data transmission service configuration information to the mobile terminal (108) on the broadcast channel (114).
摘要:
A method and system for using Threat Imaging Projection (TIP) technology, and the operator testing data that it generates, in order to certify x-ray inspection system operators and thereby assure an acceptable and uniform level of operator performance. In a preferred configuration, the operator views x-ray images of objects on a screening system equipped with TIP technology. When the operator believes that a threat item image appears on the screening system, the operator indicates such via an indicating means. The system is capable of recording, storing and transmitting individual operator performance data relating to proper detections, missed detections, and false alarms, i.e., when an operator indicates that a threat item image appears when no such image actually appears on the screening system. The system preferably contains a library of various threat item images, e.g., guns, bombs, knives, etc., which are classified according to type of threat and difficulty of detection.
摘要:
A compound having a structure or a pharmaceutically acceptable salt, or a prodrug thereof is disclosed herein. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
摘要:
A compound is disclosed herein comprising or a pharmaceutically acceptable salt or a prodrug thereof; wherein R is OH or NH2. Methods, compositions, and medicaments related thereto are also disclosed.