Method to use fluorescent magnetic polymer particles as markers in an
immunoassay
    22.
    发明授权
    Method to use fluorescent magnetic polymer particles as markers in an immunoassay 失效
    荧光磁性聚合物颗粒作为免疫测定中的标记物的方法

    公开(公告)号:US06013531A

    公开(公告)日:2000-01-11

    申请号:US518135

    申请日:1995-08-22

    摘要: This invention provides a novel process of using magnetically responsive fluorescent polymer particles comprising polymeric core particles coated evenly with a layer of polymer containing magnetically responsive metal oxide as highly sensitive quantitative reagents for biochemical and immunological studies, wherein the fluorescent magnetic particles can serve as a marker for the number of particles. A wide variety of polymeric particles with sizes ranging from 1 to 100 microns can be used a core particles and transformed into magnetically responsive polymer particles. The surface of these magnetically responsive polymer particles can be coated further with another layer of functionalized polymer. These magnetically responsive fluorescent polymer particles can be used for passive or covalent coupling of biological material such as antigens, antibodies, enzymes or DNA/RNA hybridization and used as solid phase for various types of immunoassays, DNA/RNA hybridization probes assays, affinity purification, cell separation and other medical, diagnostic, and industrial applications.

    摘要翻译: 本发明提供了一种使用磁响应荧光聚合物颗粒的新方法,其包括均匀包被含有磁响应金属氧化物的聚合物层的聚合物芯颗粒,作为生物化学和免疫学研究的高灵敏度定量试剂,其中荧光磁性颗粒可以作为标记 对于颗粒数量。 尺寸范围为1至100微米的多种聚合物颗粒可用于核心颗粒并转化为磁响应聚合物颗粒。 这些磁响应聚合物颗粒的表面可以进一步被另一层官能化聚合物涂覆。 这些磁响应荧光聚合物颗粒可用于生物材料如抗原,抗体,酶或DNA / RNA杂交的被动或共价偶联,并用作各种类型的免疫测定的固相,DNA / RNA杂交探针测定,亲和纯化, 细胞分离等医疗,诊断和工业应用。

    Treatment of dry eye
    23.
    发明授权
    Treatment of dry eye 失效
    干眼症治疗

    公开(公告)号:US4131651A

    公开(公告)日:1978-12-26

    申请号:US844555

    申请日:1977-10-25

    IPC分类号: A61K9/00 A61K31/765 A61K31/74

    CPC分类号: A61K31/765 A61K9/0048

    摘要: Methods and compositions are provided for the treatment of dry eye and discontinuous tear films. The ophthalmic solution for maintaining a continuous tear film employs a combination of hydroxyalkylcellulose and polyvinyl alcohol in a predetermined ratio in an aqueous isotonic medium.

    摘要翻译: 提供了用于治疗干眼和不连续泪液膜的方法和组合物。 用于保持连续泪膜的眼用溶液在水性等渗介质中采用预定比例的羟烷基纤维素和聚乙烯醇的组合。