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37 条记录 (耗时 0.018 秒)

    MANUFACTURING METHOD OF MAGNETIC PARTICLES
    4.
    发明公开
    MANUFACTURING METHOD OF MAGNETIC PARTICLES 审中-公开

    公开(公告)号：US20230245808A1

    公开(公告)日：2023-08-03

    申请号：US18185346

    申请日：2023-03-16

    申请人： Industrial Technology Research Institute

    发明人： Chien-An Chen ,  Cheng-Tai Chen ,  Pei-Shin Jiang

    IPC分类号： H01F1/26 ,  H01F1/00 ,  H01F1/37

    CPC分类号： H01F1/26 ,  H01F1/0054 ,  H01F1/37 ,  G01N2446/10 ,  G01N33/5434

    摘要： Described herein is a manufacturing method of a magnetic particle. First, deionized water, an organic solvent, a hydrophilic polymer, a lipid-soluble initiator, and at least two monomers are placed in a reactor and then stirred for polymerizing the at least two monomers into a copolymer to form a knobby copolymer core. Next, a polymer layer is formed to cover the knobby copolymer core, wherein the polymer layer has at least one functional group. Thereafter, a magnetic substance precursor is adsorbed by the knobby copolymer core covered with the polymer layer to form a magnetic substance layer. Further, a silicon-based layer may be additionally formed to cover the magnetic substance layer.

    Method to use fluorescent magnetic polymer particles as markers in an immunoassay
    8.
    发明授权
    Method to use fluorescent magnetic polymer particles as markers in an immunoassay 失效
    荧光磁性聚合物颗粒作为免疫测定中的标记物的方法

    公开(公告)号：US06013531A

    公开(公告)日：2000-01-11

    申请号：US518135

    申请日：1995-08-22

    申请人： Chaeo-Huej J. Wang ,  Dinesh O. Shah

    发明人： Chaeo-Huej J. Wang ,  Dinesh O. Shah

    IPC分类号： C08F257/02 ,  C08F285/00 ,  C12Q1/68 ,  G01N33/543 ,  G01N33/58 ,  G01N33/553 ,  G01N33/546

    CPC分类号： C12Q1/6834 ,  C08F257/02 ,  C08F285/00 ,  G01N33/54326 ,  G01N33/582 ,  G01N33/585 ,  G01N2446/10 ,  G01N2446/40 ,  G01N2446/84 ,  G01N2446/86 ,  Y10S435/967

    摘要： This invention provides a novel process of using magnetically responsive fluorescent polymer particles comprising polymeric core particles coated evenly with a layer of polymer containing magnetically responsive metal oxide as highly sensitive quantitative reagents for biochemical and immunological studies, wherein the fluorescent magnetic particles can serve as a marker for the number of particles. A wide variety of polymeric particles with sizes ranging from 1 to 100 microns can be used a core particles and transformed into magnetically responsive polymer particles. The surface of these magnetically responsive polymer particles can be coated further with another layer of functionalized polymer. These magnetically responsive fluorescent polymer particles can be used for passive or covalent coupling of biological material such as antigens, antibodies, enzymes or DNA/RNA hybridization and used as solid phase for various types of immunoassays, DNA/RNA hybridization probes assays, affinity purification, cell separation and other medical, diagnostic, and industrial applications.

    摘要翻译： 本发明提供了一种使用磁响应荧光聚合物颗粒的新方法，其包括均匀包被含有磁响应金属氧化物的聚合物层的聚合物芯颗粒，作为生物化学和免疫学研究的高灵敏度定量试剂，其中荧光磁性颗粒可以作为标记 对于颗粒数量。 尺寸范围为1至100微米的多种聚合物颗粒可用于核心颗粒并转化为磁响应聚合物颗粒。 这些磁响应聚合物颗粒的表面可以进一步被另一层官能化聚合物涂覆。 这些磁响应荧光聚合物颗粒可用于生物材料如抗原，抗体，酶或DNA / RNA杂交的被动或共价偶联，并用作各种类型的免疫测定的固相，DNA / RNA杂交探针测定，亲和纯化， 细胞分离等医疗，诊断和工业应用。

    Process for preparing magnetic polymer particles
    9.
    发明授权
    Process for preparing magnetic polymer particles 失效
    制备磁性聚合物颗粒的方法

    公开(公告)号：US4774265A

    公开(公告)日：1988-09-27

    申请号：US890221

    申请日：1986-07-29

    申请人： John Ugelstad ,  Turid Ellingsen ,  Arvid Berge ,  Oskar B. Helgee

    发明人： John Ugelstad ,  Turid Ellingsen ,  Arvid Berge ,  Oskar B. Helgee

    IPC分类号： H01G2/00 ,  B03C1/01 ,  G01N33/543 ,  H01F1/10 ,  H01F1/11 ,  H01F1/42 ,  H01G4/38 ,  H01G9/08 ,  H01L31/02 ,  H01L31/04 ,  H01L31/042 ,  H01M2/20 ,  H01M2/22 ,  H01M2/26 ,  H01M2/30 ,  H01M6/42 ,  H02N11/00 ,  C08J9/22 ,  C08K3/10

    CPC分类号： H01F1/42 ,  B03C1/01 ,  G01N33/5434 ,  H01F1/111 ,  G01N2446/10 ,  Y10S428/90 ,  Y10T428/2998

    摘要： Magnetic polymer particles prepared by treating compact or porous polymer particles with a solution of iron salts and, if desired, salts of other metals which are capable of forming magnetic ferrites, in which the solution swells or penetrates into the particles. Iron hydroxide and possible other metal hydroxides are precipitated, for instance by raising the pH value, and the particles are optionally heated. In the iron salts used the ratio between di- and trivalent iron is suitably such that magnetic iron oxide is formed directly. It is also possible to use oxidizing or reducing groups or additives to obtain such a ratio. When other metal salts are used in addition to iron salts, the operation is carried out in the same manner. For instance, when Mn.sup.++, Co.sup.++ or Ni.sup.++ salts are used in addition to Fe.sup.++ salts, the divalent iron is oxidized to trivalent so that magnetic ferrite is obtained. The polymer particles which are treated with metal salts preferably contain metal-binding groups. Such groups are incorporated for instance by using monomers which contain said groups for the preparation of the polymer particles, or the groups are incorporated in the polymer particles prepared.The magnetic polymer particles are spherical and have a uniform concentration of magnetic material. They may be used for medical, diagnostic or other purposes.

    摘要翻译： 通过用铁盐溶液处理紧密或多孔的聚合物颗粒制备的磁性聚合物颗粒，以及如果需要，能够形成磁性铁氧体的其它金属的盐，其中溶液溶胀或渗入颗粒中。 例如通过提高pH值来沉淀氢氧化铁和可能的其它金属氢氧化物，任选地加热颗粒。 在使用的铁盐中，二价和三价铁之间的比例适当地使得直接形成磁性氧化铁。 也可以使用氧化或还原基团或添加剂来获得这种比例。 除了铁盐之外，当使用其它金属盐时，以相同的方式进行操作。 例如，除了Fe ++盐之外，当使用Mn ++，Co ++或Ni ++盐时，二价铁被氧化成三价，从而得到磁性铁氧体。 用金属盐处理的聚合物颗粒优选含有金属结合基团。 这样的基团例如通过使用含有所述基团的单体来制备聚合物颗粒，或将这些基团引入所制备的聚合物颗粒中。 磁性聚合物颗粒是球形的并且具有均匀的磁性材料浓度。 它们可用于医疗，诊断或其他目的。

    Magnetic polymer particles and process for the preparation thereof
    10.
    发明授权
    Magnetic polymer particles and process for the preparation thereof 失效
    磁性聚合物颗粒及其制备方法

    公开(公告)号：US4654267A

    公开(公告)日：1987-03-31

    申请号：US571878

    申请日：1983-12-23

    申请人： John Ugelstad ,  Turid Ellingsen ,  Arvid Berge ,  Oskar B. Helgee

    发明人： John Ugelstad ,  Turid Ellingsen ,  Arvid Berge ,  Oskar B. Helgee

    IPC分类号： H01G2/00 ,  B03C1/01 ,  G01N33/543 ,  H01F1/10 ,  H01F1/11 ,  H01F1/42 ,  H01G4/38 ,  H01G9/08 ,  H01L31/02 ,  H01L31/04 ,  H01L31/042 ,  H01M2/20 ,  H01M2/22 ,  H01M2/26 ,  H01M2/30 ,  H01M6/42 ,  H02N11/00 ,  H01F1/20 ,  B32B15/08

    CPC分类号： H01F1/42 ,  B03C1/01 ,  G01N33/5434 ,  H01F1/111 ,  G01N2446/10 ,  Y10S428/90 ,  Y10T428/2998

    摘要： Magnetic polymer particles prepared by treating compact or porous polymer particles with a solution of iron salts and, if desired, salts of other metals which are capable of forming magnetic ferrites, in which the solution swells or penetrates into the particles. Iron hydroxide and other metal hydroxides, if employed, are precipitated, e.g. by raising the pH value, and the particles are optionally heated. In the iron salts used, the ratio between di- and trivalent iron is suitably such that magnetic iron oxide is formed directly. It is also possible to use oxidizing or reducing groups or additives to obtain such a ratio. When other metal salts are used in addition to iron salts, the operation is carried out in the same manner. For instance, when Mn.sup.++, Co.sup.++ or Ni.sup.++ salts are used in addition to Fe.sup.++ salts, the divalent iron is oxidized to trivalent so that magnetic ferrite is obtained. The polymer particles which are treated with metal salts preferably contain metal-binding groups. Such groups are incorporated e.g. by using monomers which contain said groups for the preparation of the polymer particles, or the groups are incorporated in the polymer particles prepared.The magnetic polymer particles are spherical and have a uniform concentration of magnetic material. They may be used for medical, diagnostic or other purposes.

    摘要翻译： PCT No.PCT / NO83 / 00014 Sec。 371日期1983年12月23日 102（e）1983年12月23日日期PCT提交1983年4月22日PCT公布。 公开号WO83 / 03920 日期：1983年11月10日。磁性聚合物颗粒通过用铁盐溶液处理紧密或多孔的聚合物颗粒，并且如果需要，可以形成能够形成磁性铁氧体的其它金属的盐，其中溶液溶胀或渗入 粒子。 氢氧化铁和其它金属氢氧化物（如果使用）沉淀，如 通过提高pH值，并且任选地加热颗粒。 在所用的铁盐中，二价和三价铁之间的比例适宜地直接形成磁性氧化铁。 也可以使用氧化或还原基团或添加剂来获得这种比例。 除了铁盐之外，当使用其它金属盐时，以相同的方式进行操作。 例如，除了Fe ++盐之外，当使用Mn ++，Co ++或Ni ++盐时，二价铁被氧化成三价，从而得到磁性铁氧体。 用金属盐处理的聚合物颗粒优选含有金属结合基团。 这样的组合例如 通过使用含有所述基团的单体制备聚合物颗粒，或将这些基团引入制备的聚合物颗粒中。 磁性聚合物颗粒是球形的并且具有均匀的磁性材料浓度。 它们可用于医疗，诊断或其他目的。