公开(公告)号：US20150203597A1

公开(公告)日：2015-07-23

申请号：US14420985

申请日：2013-08-15

Applicant: Dow Global Technologies LLC

Inventor： Meinolf Brackhagen ,  Nicholas S. Grasman ,  Yongfu Li ,  David M. Meunier ,  Oliver Petermann ,  Matthias Sprehe

IPC: C08B13/00 ,  C08B11/20 ,  A61K9/10

CPC classification number: C08B13/00 ,  A61K9/10 ,  A61K9/146 ,  A61K9/2866 ,  C08B11/20

Abstract: A partially cross-linked esterified cellulose ether having A) groups of the formula —C(O)—R—COOA or a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, and B) having a molecular weight distribution such that [Wf(>100 k)−Wf(>100 k)XL]/Wf(>100 k)XL is at least 0.20, wherein Wf(>100 k) is the total weight fraction of the esterified cellulose ether that exceeds 100,000 g/mol, and Wf(>100 k)XL is the weight fraction that exceeds 100,000 g/mol of the methylated esterified cellulose ether is useful as enteric polymer for pharmaceutical dosage forms.

Abstract translation: 具有A）基团的式-C（O）-R-COOA或脂族一价酰基和式-C（O）-R-COOA基团的部分交联的酯化纤维素醚，其中R为 二价脂族或芳族烃基，A是氢或阳离子，B）分子量分布使得[Wf（> 100k）-Wf（> 100k）XL] / Wf（> 100k）XL为 至少0.20，其中Wf（> 100k）是超过100,000g / mol的酯化纤维素醚的总重量分数，Wf（> 100k）XL是甲基化酯化的超过100,000g / mol的重量分数 纤维素醚可用作药物剂型的肠溶性聚合物。

公开(公告)号：US20220127381A1

公开(公告)日：2022-04-28

申请号：US17310470

申请日：2020-04-17

Applicant: Dow Global Technologies LLC

Inventor： Alexandra Hild ,  Jöerg Neubauer ,  Sonja Menz ,  Matthias Sprehe ,  Michael Schreck

IPC: C08B15/00 ,  C08B11/08 ,  C04B24/38

Abstract: A process for producing a crosslinked cellulose ether including the steps of (i) contacting at least one cellulose material with a mixture comprising (ia) at least one crosslinking agent and (ib) at least one alkalization reagent to form an activated cellulose material; and (ii) contacting the activated cellulose material of step (i) with at least one etherification reagent; wherein the at least one etherification reagent reacts with the activated cellulose material to form the crosslinked cellulose ether; and a crosslinked cellulose ether produced by the above process.

公开(公告)号：US20210115161A1

公开(公告)日：2021-04-22

申请号：US16493770

申请日：2018-03-14

Applicant: DOW GLOBAL TECHNOLOGIES LLC

Inventor： Oliver O. Petermann ,  Robert L Louis Schmitt ,  Rene Kelling ,  Matthias Sprehe

IPC: C08B13/00

Abstract: A process for recovering an esterified cellulose ether from a reaction product mixture obtained from a reaction of (a) a cellulose ether with (b) an aliphatic monocarboxylic acid anhydride or a di- or tricarboxylic acid anhydride or a combination of an aliphatic monocarboxylic acid anhydride and a di- or tricarboxylic acid anhydride, comprises the steps of (i) contacting the reaction product mixture with an aqueous liquid and precipitating the esterified cellulose ether from the reaction product mixture, and (ii) isolating the precipitated esterified cellulose ether from the mixture obtained in step (i), Tackiness of the esterified cellulose ether can be reduced when before or in step (i) a particulate silicon oxide or metal oxide is dispersed or suspended in the reaction product mixture, the aqueous liquid or a combination thereof.

公开(公告)号：US10196461B2

公开(公告)日：2019-02-05

申请号：US15521088

申请日：2015-10-21

Applicant: Dow Global Technologies LLC

Inventor： Oliver Petermann ,  Matthias Sprehe ,  Robert B. Appell

IPC: C08B13/00 ,  C08L1/32 ,  C09D101/32

Abstract: A process for producing an esterified cellulose ether can be efficiently be produced by reacting a moist cellulose ether having a water content of at least 10 percent, based on the weight of the moist cellulose ether, with an aliphatic monocarboxylic acid anhydride, a dicarboxylic acid anhydride or a combination thereof. Further improvements in efficiency and reduction in process steps are achieved in a process for producing an esterified cellulose ether which comprises the steps of a) reacting cellulose with an alkaline material to produce alkali cellulose, b) reacting the produced alkali cellulose with one or more etherifying agents and washing the produced cellulose ether to obtain a moist cellulose ether having a water content of at least 10 weight percent, and c) reacting the moist cellulose ether with an aliphatic monocarboxylic acid anhydride and/or a dicarboxylic acid anhydride and with a depolymerizing agent.

公开(公告)号：US20170355783A1

公开(公告)日：2017-12-14

申请号：US15521088

申请日：2015-10-21

Applicant: Dow Global Technologies LLC

Inventor： Oliver Petermann ,  Matthias Sprehe ,  Robert B. Appell

IPC: C08B13/00

CPC classification number: C08B13/00 ,  C08L1/32 ,  C09D101/32

Abstract: A process for producing an esterified cellulose ether can be efficiently be produced by reacting a moist cellulose ether having a water content of at least 10 percent, based on the weight of the moist cellulose ether, with an aliphatic monocarboxylic acid anhydride, a dicarboxylic acid anhydride or a combination thereof. Further improvements in efficiency and reduction in process steps are achieved in a process for producing an esterified cellulose ether which comprises the steps of a) reacting cellulose with an alkaline material to produce alkali cellulose, b) reacting the produced alkali cellulose with one or more etherifying agents and washing the produced cellulose ether to obtain a moist cellulose ether having a water content of at least 10 weight percent, and c) reacting the moist cellulose ether with an aliphatic monocarboxylic acid anhydride and/or a dicarboxylic acid anhydride and with a depolymerizing agent.

公开(公告)号：US20170335019A1

公开(公告)日：2017-11-23

申请号：US15521065

申请日：2015-10-21

Applicant: Dow Global Technologies LLC

Inventor： Oliver Petermann ,  Matthias Sprehe

IPC: C08B13/00

CPC classification number: C08B13/00 ,  A61K9/2866 ,  A61K47/38 ,  C08L1/32 ,  C09D101/32

Abstract: A process for producing an esterified cellulose ether comprises the step of reacting a cellulose ether with an aliphatic monocarboxylic acid anhydride and/or a dicarboxylic acid anhydride and with a depolymerizing agent, wherein the cellulose ether has an initial viscosity of at least 500 mPa·s, measured as a 2 weight-% solution in water at 20° C., and the reaction of the cellulose ether with the aliphatic monocarboxylic acid anhydride and/or the dicarboxylic acid anhydride and with the depolymerizing agent is conducted simultaneously or in sequence in one reaction device.

公开(公告)号：US09587037B2

公开(公告)日：2017-03-07

申请号：US15022418

申请日：2014-09-15

Applicant: Dow Global Technologies LLC

Inventor： Oliver Petermann ,  Matthias Sprehe ,  Robert Appell ,  Robert Nilsson

IPC: C08B13/00 ,  A61K8/28 ,  G03C1/835 ,  C08B11/20 ,  C08B11/22 ,  C08B17/00

CPC classification number: C08B13/00 ,  C08B11/20 ,  C08B11/22 ,  C08B17/00

Abstract: A process for recovering an esterified cellulose ether from a reaction product mixture obtained from a reaction of (a) a cellulose ether with (b) an aliphatic monocarboxylic acid anhydride or a di- or tricarboxylic acid anhydride or a combination of an aliphatic monocarboxylic acid anhydride and a di- or tricarboxylic acid anhydride, comprises the steps of (i) contacting the reaction product mixture with an aqueous liquid to precipitate the esterified cellulose ether from the reaction product mixture, (ii) isolating the precipitated esterified cellulose ether from the mixture obtained in step (i), and (iii) suspending the isolated esterified cellulose ether in an aqueous liquid to provide a suspension having a temperature of at least 28° C., and (iv) recovering the esterified cellulose ether from the suspension of step (iii).

Abstract translation: 从（a）纤维素醚与（b）脂肪族一元羧酸酐或二羧酸或三羧酸酐的反应得到的反应产物混合物或脂肪族单羧酸酐的组合中回收酯化纤维素醚的方法 和二羧酸或三羧酸酐包括以下步骤：（i）使反应产物混合物与水性液体接触，以使反应产物混合物中的酯化纤维素醚沉淀，（ii）从得到的混合物中分离沉淀的酯化纤维素醚 在步骤（i）中，和（iii）将分离的酯化纤维素醚悬浮在水性液体中以提供温度至少为28℃的悬浮液，和（iv）从步骤（i）的悬浮液中回收酯化的纤维素醚 iii）。

公开(公告)号：US09486532B2

公开(公告)日：2016-11-08

申请号：US14766997

申请日：2014-02-28

Applicant: Dow Global Technologies LLC

Inventor： Meinolf Brackhagen ,  Steven J. Guillaudeu ,  Nicholas S. Grasman ,  Oliver Petermann ,  Robert L. Schmitt ,  Matthias Sprehe

IPC: A61K47/38 ,  C08B13/00 ,  A61K9/28 ,  A61K9/48

CPC classification number: A61K47/38 ,  A61K9/2866 ,  A61K9/4891 ,  C08B13/00

Abstract: Esterified cellulose ethers which comprise (i) aliphatic monovalent acyl groups or (ii) groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, or (iii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, which have a viscosity of up to 2.33 mPa·s, measured as a 2.0 wt % solution of the esterified cellulose ether in 0.43 wt % aqueous NaOH at 20° C., and which have a viscosity of up to 13 mPao·s, measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20° C. are useful for preparing solid dispersions comprising drugs.

Abstract translation: 酯化纤维素醚，其包含（i）脂族一价酰基或（ii）式-C（O）-R-COOA的基团，其中R是二价脂族或芳族烃基，A是氢或阳离子，或（ iii）脂族一价酰基和式-C（O）-R-COOA基团的组合，其粘度高达2.33mPa·s，以2.0重量％的酯化纤维素醚溶液测量为0.43 20℃下的重量％NaOH水溶液，其粘度高达13mPao·s，以20wt％的酯化纤维素醚在丙酮中的10wt％溶液测量可用于制备包含药物的固体分散体 。

公开(公告)号：US20160222133A1

公开(公告)日：2016-08-04

申请号：US15022418

申请日：2014-09-15

Applicant: DOW GLOBAL TECHNOLOGIES LLC

Inventor： Oliver Petermann ,  Matthias Sprehe ,  Robert Appell ,  Robert Nilsson

IPC: C08B13/00

CPC classification number: C08B13/00 ,  C08B11/20 ,  C08B11/22 ,  C08B17/00

Abstract: A process for recovering an esterified cellulose ether from a reaction product mixture obtained from a reaction of (a) a cellulose ether with (b) an aliphatic monocarboxylic acid anhydride or a di- or tricarboxylic acid anhydride or a combination of an aliphatic monocarboxylic acid anhydride and a di- or tricarboxylic acid anhydride, comprises the steps of (i) contacting the reaction product mixture with an aqueous liquid to precipitate the esterified cellulose ether from the reaction product mixture, (ii) isolating the precipitated esterified cellulose ether from the mixture obtained in step (i), and (iii) suspending the isolated esterified cellulose ether in an aqueous liquid to provide a suspension having a temperature of at least 28° C., and (iv) recovering the esterified cellulose ether from the suspension of step (iii).

Abstract translation: 从（a）纤维素醚与（b）脂肪族一元羧酸酐或二羧酸或三羧酸酐的反应得到的反应产物混合物或脂肪族单羧酸酐的组合中回收酯化纤维素醚的方法 和二羧酸或三羧酸酐包括以下步骤：（i）使反应产物混合物与水性液体接触，以使反应产物混合物中的酯化纤维素醚沉淀，（ii）从得到的混合物中分离沉淀的酯化纤维素醚 在步骤（i）中，和（iii）将分离的酯化纤维素醚悬浮在水性液体中以提供温度至少为28℃的悬浮液，和（iv）从步骤（i）的悬浮液中回收酯化的纤维素醚 iii）。

公开(公告)号：US20150368365A1

公开(公告)日：2015-12-24

申请号：US14766569

申请日：2014-02-28

Applicant: DOW GLOBAL TECHNOLOGIES LLC

Inventor： Oliver Petermann ,  Meinolf Brackhagen ,  Matthias Sprehe ,  Robert B. Appell

IPC: C08B13/00 ,  A61K47/38

CPC classification number: C08B13/00 ,  A61K9/2866 ,  A61K9/4816 ,  A61K47/38

Abstract: Esterified cellulose ethers which comprise (i) aliphatic monovalent acyl groups or (ii) groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, or (iii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, which have a viscosity of up 19 mPa·s, measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20° C., and which have a weight average molecular weight Mw of at least 90,000 Dalton, are useful for preparing solid dispersions comprising drugs.

Abstract translation: 酯化纤维素醚，其包含（i）脂族一价酰基或（ii）式-C（O）-R-COOA的基团，其中R是二价脂族或芳族烃基，A是氢或阳离子，或（ iii）脂族一价酰基和式-C（O）-R-COOA基团的组合，其粘度为19mPa·s，以酯化纤维素醚在丙酮中的10wt％溶液测量 20℃，其重均分子量Mw至少为90,000道尔顿，可用于制备包含药物的固体分散体。