公开(公告)号：US20160183843A1

公开(公告)日：2016-06-30

申请号：US15063353

申请日：2016-03-07

Applicant: Edwards Lifesciences Corporation

Inventor： Brian S. Conklin ,  Da-Yu Chang

IPC: A61B5/107 ,  A61B5/02 ,  A61B5/00 ,  A61F2/24

CPC classification number: A61B5/1076 ,  A61B5/02028 ,  A61B5/6859 ,  A61B2090/064 ,  A61B2090/065 ,  A61B2090/066 ,  A61F2/243 ,  A61F2/2496

Abstract: A valve sizer for determining an appropriate replacement valve size when performing a heart valve replacement procedure is provided. In one version the valve sizer has a hollow shaft with proximal and distal ends. A movable sizing element couples to the distal end of the shaft and is radially expandable between first, contracted and second, expanded positions. An actuator assembly on a handle includes an actuator coupled to a clutch member via a ball-spring-detent clutch. A rod extends through the shaft and maintains a fixed distance between the handle and a distal hub in the sizing element. Movement of the actuator causes axial movement of the shaft, thereby causing radial expansion of sizing petals relative to the hub. The clutch slips when a predetermined reaction force from the surrounding valve annulus is met by the petals.

Abstract translation: 提供了一种用于在执行心脏瓣膜置换过程时确定适当的更换瓣膜尺寸的瓣膜分选机。 在一个版本中，阀门分级器具有中空轴，其具有近端和远端。 可移动的施胶元件联接到轴的远端并且可在第一，收缩和第二扩展位置之间径向扩张。 手柄上的致动器组件包括经由球弹簧止动离合器联接到离合器构件的致动器。 杆延伸穿过轴并且在手柄和施胶元件中的远侧轮毂之间保持固定的距离。 致动器的运动导致轴的轴向移动，从而引起尺寸花瓣相对于毂的径向膨胀。 当来自周围的瓣膜环的预定反作用力被花瓣满足时，离合器滑动。

公开(公告)号：US20150366664A1

公开(公告)日：2015-12-24

申请号：US14745287

申请日：2015-06-19

Applicant: Edwards Lifesciences Corporation

Inventor： Jessica Guttenberg ,  Da-Yu Chang ,  Derrick Johnson ,  Brian S. Conklin ,  Qinggang Zeng ,  Myron Howanec, JR. ,  Grace M. Kim

IPC: A61F2/24 ,  A61F2/91

CPC classification number: A61F2/2418 ,  A61F2/2409 ,  A61F2250/0085 ,  A61F2250/0089 ,  A61F2250/0098

Abstract: A prosthetic heart valve configured to replace a native heart valve and for post-implant expansion and having a valve-type indicator thereon visible from outside the body post-implant. The indicator communicates information about the valve, such as the size or orifice diameter of the valve, and/or that the valve has the capacity for post-implant expansion. The indicator can be an alphanumeric symbol or other symbol or combination of symbols that represent information about the characteristics of the valve such as the valve size. The capacity for post-implant expansion facilitates a valve-in-valve procedure, where the valve-type indicator conveys information to the surgeon about whether the implanted valve is suitable for the procedure and informs the choice of the secondary valve.

Abstract translation: 一种假体心脏瓣膜，其构造成代替天然心脏瓣膜并用于植入后扩张，并且在体外植入物后面具有可从其上观察到的瓣膜型指示器。 指示器传达关于阀的信息，例如阀的尺寸或孔直径，和/或阀具有用于植入物扩张的能力。 指示符可以是代表关于阀的特性的信息的字母数字符号或其他符号或符号的组合，例如阀的尺寸。 植入后扩张的能力有利于瓣膜瓣膜手术，其中瓣膜型指示器向外科医生传达关于植入的瓣膜是否适于手术并且通知二次瓣膜的选择的信息。

公开(公告)号：US20150313711A1

公开(公告)日：2015-11-05

申请号：US14700007

申请日：2015-04-29

Applicant: Edwards Lifesciences Corporation

Inventor： Da-Yu Chang ,  Hilda Z. Fann

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2427 ,  A61F2/243 ,  A61F2/2439 ,  A61F2210/00 ,  A61F2210/0014 ,  A61F2220/0075 ,  A61F2230/0069

Abstract: A holder for a hybrid heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The hybrid heart valve includes a non-expandable, non-compressible prosthetic valve and a self-expandable anchoring stent, thereby enabling attachment to the annulus without sutures. A first suture connects the holder to the valve and constricts an inflow end of the anchoring stent. A second suture connects the holder to the valve and extends down three holder legs to loop through fabric on the valve. Both sutures may loop over a single cutting well on the holder so that severing the first and second sutures at the single cutting well simultaneously releases the tension in the first suture, permitting the inflow end of the anchoring stent to expand, and disconnects the valve holder from the prosthetic heart valve.

Abstract translation: 提供了一种用于混合式心脏瓣膜假体的保持器，其可以在手术过程中快速且容易地植入。 混合心脏瓣膜包括不可膨​​胀的不可压缩的人造瓣膜和自膨胀的锚固支架，从而使得能够连接到环状物而不缝合。 第一缝合线将支架连接到阀并且收缩锚固支架的流入端。 第二缝合线将支架连接到阀上，并且向下延伸三个保持器腿以环绕阀上的织物。 两个缝合线可以环绕保持器上的单个切割井，使得在单个切割井处切断第一和第二缝合线同时释放第一缝合线中的张力，允许锚固支架的流入端膨胀，并且断开阀座 从假体心脏瓣膜。

公开(公告)号：US20150066137A1

公开(公告)日：2015-03-05

申请号：US14469978

申请日：2014-08-27

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Harvey H. Chen ,  Andrew Phung ,  Thomas Chien ,  Da-Yu Chang

IPC: A61M25/10 ,  A61F2/24

CPC classification number: A61M25/10185 ,  A61F2/2433 ,  A61M25/0097 ,  A61M25/10181 ,  A61M25/10184

Abstract: An inflation system having two pressure vessels integrated into a balloon catheter. A pressurized chamber and a vacuum chamber are integrally attached to proximal end of the balloon catheter and activated by a common valve or switch. Pressure or vacuum is selectively transmitted to the balloon depending on the valve/switch position. The working fluid may be air, or a combination of air and saline with an intermediate piston/cylinder assembly. The balloon catheter may be a part of a heart valve delivery system with a balloon-expandable heart valve crimped onto the balloon.

Abstract translation: 具有两个压力容器的充气系统整合到球囊导管中。 加压室和真空室一体地附接到气囊导管的近端并由公共阀或开关激活。 取决于阀/开关位置，压力或真空选择性地传递到气囊。 工作流体可以是空气，也可以是空气和盐水与中间活塞/气缸组件的组合。 气囊导管可以是心脏瓣膜输送系统的一部分，其中气囊可扩张的心脏瓣膜卷曲到气囊上。

公开(公告)号：US20230125047A1

公开(公告)日：2023-04-20

申请号：US18069082

申请日：2022-12-20

Applicant: Edwards Lifesciences Corporation

Inventor： Brian S. Conklin ,  Louis A. Campbell ,  Salvador Marquez ,  James R. Yamada ,  Rodolfo Rodriguez ,  Da-Yu Chang ,  Steven M. Ford

IPC: A61F2/24

Abstract: A minimally-invasive annuloplasty ring for implant at a mitral annulus. The annuloplasty ring has an inner core member with a C-shaped plan view that generally defines an oval with a major axis and a minor axis, and is symmetric about the minor axis. A posterior portion of the core member bisected by the minor axis has a thicker radial dimension than a pair of free end regions terminating on an anterior side of the core member. The radial thickness smoothly transitions between the posterior portion and the end regions. The inner core member may be covered with a fabric, and is a superelastic metal so that it can be straightened out and delivered through an access tube. The curvatures and thicknesses around the core member are selected so that the strain experienced when straightened does not exceed 7-8%.

公开(公告)号：US20220362014A1

公开(公告)日：2022-11-17

申请号：US17810182

申请日：2022-06-30

Applicant: Edwards Lifesciences Corporation

Inventor： Da-Yu Chang ,  Hilda Z. Fann

IPC: A61F2/24

Abstract: A holder for a hybrid heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The hybrid heart valve includes a non-expandable, non-compressible prosthetic valve and a self-expandable anchoring stent, thereby enabling attachment to the annulus without sutures. A first suture connects the holder to the valve and constricts an inflow end of the anchoring stent. A second suture connects the holder to the valve and extends down three holder legs to loop through fabric on the valve. Both sutures may loop over a single cutting well on the holder so that severing the first and second sutures at the single cutting well simultaneously releases the tension in the first suture, permitting the inflow end of the anchoring stent to expand, and disconnects the valve holder from the prosthetic heart valve.

公开(公告)号：US11376122B2

公开(公告)日：2022-07-05

申请号：US16429651

申请日：2019-06-03

Applicant: Edwards Lifesciences Corporation

Inventor： Da-Yu Chang ,  Hilda Z. Fann

IPC: A61F2/24

Abstract: A holder for a hybrid heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The hybrid heart valve includes a non-expandable, non-compressible prosthetic valve and a self-expandable anchoring stent, thereby enabling attachment to the annulus without sutures. A first suture connects the holder to the valve and constricts an inflow end of the anchoring stent. A second suture connects the holder to the valve and extends down three holder legs to loop through fabric on the valve. Both sutures may loop over a single cutting well on the holder so that severing the first and second sutures at the single cutting well simultaneously releases the tension in the first suture, permitting the inflow end of the anchoring stent to expand, and disconnects the valve holder from the prosthetic heart valve.

公开(公告)号：US10751174B2

公开(公告)日：2020-08-25

申请号：US16141604

申请日：2018-09-25

Applicant: Edwards Lifesciences Corporation

Inventor： Brian S. Conklin ,  Da-Yu Chang

IPC: A61F2/24

Abstract: A prosthetic heart valve configured to replace a native heart valve and having a support frame configured to be reshaped into an expanded form in order to receive and/or support an expandable prosthetic heart valve therein is disclosed, together with methods of using same. Interlocking members or flexible loops are included to limit expansion of the valve to one or two valve sizes, for example, with a 2-mm gap between each valve size. The valve may include an internal structural band with overlapped free ends having structure for limiting expansion, or external loops of suture may be added to the fabric covering which limits expansion.

公开(公告)号：US10702680B2

公开(公告)日：2020-07-07

申请号：US15925086

申请日：2018-03-19

Applicant: Edwards Lifesciences Corporation

Inventor： Harvey H. Chen ,  Andrew Phung ,  Thomas H. Chien ,  Da-Yu Chang

IPC: A61M25/10 ,  A61F2/24 ,  A61M25/00

Abstract: An inflation system having two pressure vessels integrated into a balloon catheter. A pressurized chamber and a vacuum chamber are integrally attached to proximal end of the balloon catheter and activated by a common valve or switch. Pressure or vacuum is selectively transmitted to the balloon depending on the valve/switch position. The working fluid may be air, or a combination of air and saline with an intermediate piston/cylinder assembly. The balloon catheter may be a part of a heart valve delivery system with a balloon-expandable heart valve crimped onto the balloon.

公开(公告)号：US20200155309A1

公开(公告)日：2020-05-21

申请号：US16773802

申请日：2020-01-27

Applicant: Edwards Lifesciences Corporation

Inventor： Visith Chung ,  Da-Yu Chang ,  Brian S. Conklin ,  Grace Myong Kim ,  Louis A. Campbell ,  Donald E. Bobo, JR. ,  Myron Howanec, JR. ,  David S. Lin ,  Peng Norasing ,  Francis M. Tran ,  Mark Van Nest ,  Thomas Chien ,  Harvey H. Chen ,  Isidro L. Guerrero ,  Derrick Johnson ,  Paul A. Schmidt

IPC: A61F2/24

Abstract: A prosthetic heart valve configured to replace a native heart valve and having a support frame configured to be reshaped into an expanded form in order to receive and/or support an expandable prosthetic heart valve therein is disclosed, together with methods of using same. The prosthetic heart valve may be configured to have a generally rigid and/or expansion-resistant configuration when initially implanted to replace a native valve (or other prosthetic heart valve), but to assume a generally expanded form when subjected to an outward force such as that provided by a dilation balloon or other mechanical expander.