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公开(公告)号：US20120195879A1
公开(公告)日：2012-08-02
申请号：US13258668
申请日：2010-03-19
申请人： Kenneth W. Walker , Yue-Sheng Li , Thomas C. Boone , Frederick W. Jacobsen , HoSung Min , Jane Talvenheimo , Taruna Arora , George Doellgast , Janet Doellgast
发明人： Kenneth W. Walker , Yue-Sheng Li , Thomas C. Boone , Frederick W. Jacobsen , HoSung Min , Jane Talvenheimo , Taruna Arora , George Doellgast , Janet Doellgast
CPC分类号： C07K16/44 , A61K39/39591 , A61K47/6817 , A61K47/6843 , C07K14/43504 , C07K14/575 , C07K14/605 , C07K14/66 , C07K16/00 , C07K16/18 , C07K16/248 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/30 , C07K2319/55
摘要： Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors, host cells, and hybridomas useful in methods of making it. In some embodiments the antigen binding protein comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.
摘要翻译： 公开了分离的抗原结合蛋白，例如但不限于抗体或抗体片段。 还公开了包含抗原结合蛋白，编码它的分离的核酸，载体，宿主细胞和用于制备它的方法中的杂交瘤的药物组合物和药物。 在一些实施方案中，抗原结合蛋白包含与其结合的1-24个药理活性化学部分，例如药理学活性多肽。
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公开(公告)号：US20090137483A1
公开(公告)日：2009-05-28
申请号：US12082224
申请日：2008-04-08
申请人： Gordon Ng , Yue-Sheng Li , Colin V. Gegg , Benny C. Askew, JR. , Thomas Storz , Yuelie Lu , Derin C. D'Amico , Mark A. Jarosinski , Chuan-Fa Liu , Qi Huang
发明人： Gordon Ng , Yue-Sheng Li , Colin V. Gegg , Benny C. Askew, JR. , Thomas Storz , Yuelie Lu , Derin C. D'Amico , Mark A. Jarosinski , Chuan-Fa Liu , Qi Huang
摘要： The present invention relates to composition of matter involving bradykinin B1 receptor antagonist peptides conjugated to a univalent vehicle, including peptides conjugated to univalent PEG. These compositions can be used as therapeutics or prophylactics against diseases or conditions, such as inflammation or pain, linked to the bradykinin B1 receptor.
摘要翻译： 本发明涉及与单价载体缀合的缓激肽B1受体拮抗剂肽的物质组合物，包括与一价PEG缀合的肽。 这些组合物可用作与缓激肽B1受体连接的疾病或病症例如炎症或疼痛的治疗剂或预防剂。
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23.发明申请HUMAN ANTI-IFN-GAMMA NEUTRALIZING ANTIBODIES AS SELECTIVE IFN-GAMMA PATHWAY INHIBITORS 有权人类抗IFN-GAMMA作为选择性IFN-GAMMA途径抑制剂中和抗体公开(公告)号：US20080107655A1
公开(公告)日：2008-05-08
申请号：US11962594
申请日：2007-12-21
申请人： Andrew Welcher , Hilary Chute , Yue-Sheng Li , Haichun Huang
发明人： Andrew Welcher , Hilary Chute , Yue-Sheng Li , Haichun Huang
IPC分类号： A61K39/395 , C07K16/18 , A61P25/00 , A61P1/00
CPC分类号： C07K16/249 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： This invention provides antibodies that interact with or bind to human interferon-gamma (IFN-γ) and methods for treating IFN-γ mediated diseases by administering a pharmaceutically effective amount of antibodies to IFN-γ. Methods of detecting the amount of IFN-γ in a sample using antibodies to IFN-γ are also provided.
摘要翻译： 本发明提供了与人类干扰素-γ（IFN-γ）相互作用或与之结合的抗体以及通过向IFN-γ施用药学上有效量的抗体来治疗IFN-γ介导的疾病的方法。 还提供了使用针对IFN-γ的抗体检测样品中IFN-γ量的方法。
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公开(公告)号：US20050215470A1
公开(公告)日：2005-09-29
申请号：US10972236
申请日：2004-10-21
申请人： Gordon Ng , Yue-Sheng Li , Colin Gegg , Benny Askew , Thomas Storz , Yuelie Lu , Derin D'Amico
发明人： Gordon Ng , Yue-Sheng Li , Colin Gegg , Benny Askew , Thomas Storz , Yuelie Lu , Derin D'Amico
摘要： The present invention relates to certain biologically active peptides and conjugated peptides which can be used as therapeutics or prophylactics against diseases or conditions linked to B1 as the causative agent. In a preferred embodiment of the invention biologically active PEG-conjugated peptides are provided. In one aspect of the present invention, pharmacologically active PEG-conjugated peptides of the present invention are useful to treat inflammation or pain.
摘要翻译： 本发明涉及某些生物活性肽和缀合肽，其可以用作治疗剂或预防药物，其与作为致病剂的B1连接的疾病或病症。 在本发明的优选实施方案中，提供生物活性PEG-缀合的肽。 在本发明的一个方面，本发明的药理学活性的PEG-缀合的肽可用于治疗炎症或疼痛。
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公开(公告)号：US06448381B1
公开(公告)日：2002-09-10
申请号：US07542232
申请日：1990-06-21
申请人： Thomas F. Deuel , Yue-Sheng Li , Ned R. Siegel , Peter G. Milner
发明人： Thomas F. Deuel , Yue-Sheng Li , Ned R. Siegel , Peter G. Milner
IPC分类号： A61K3824
CPC分类号： C07K14/475
摘要： A novel heparin-binding growth factor of 18.9 kDa mol. wt. is disclosed which is purified from bovine uterus and human placenta and has a unique 25 N-terminal amino acid sequence as follows: Gly-Lys-Lys-Glu-Lys-Pro-Glu-Lys-Lys-Val-Lys-Lys-Ser-Asp-Cys-Gly-Glu-Trp-Gln-Trp-Ser-Val-Cys-Val-Pro.
摘要翻译： 18.9 kDa mol的新型肝素结合生长因子。 重量 公开了其从牛子宫和人胎盘中纯化，并具有如下独特的25个N-末端氨基酸序列：Gly-Lys-Lys-Glu-Lys-Pro-Glu-Lys-Lys-Val-Lys-Lys-Ser -Asp-Cys-Gly-Glu-Trp-Gln-Trp-Ser-Val-Cys-Val-Pro。
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公开(公告)号：US08278280B2
公开(公告)日：2012-10-02
申请号：US12082219
申请日：2008-04-08
申请人： Gordon Ng , Yue-Sheng Li , Colin V. Gegg , Benny C. Askew, Jr. , Thomas Storz , Yuelie Lu , Derin C. D'Amico , Mark A. Jarosinski , Chuan-Fa Liu , Qi Huang
发明人： Gordon Ng , Yue-Sheng Li , Colin V. Gegg , Benny C. Askew, Jr. , Thomas Storz , Yuelie Lu , Derin C. D'Amico , Mark A. Jarosinski , Chuan-Fa Liu , Qi Huang
IPC分类号： C07K7/18
摘要： The present invention relates to composition of matter involving bradykinin B1 receptor antagonist peptides conjugated to a multivalent vehicle, including peptides conjugated to multivalent PEG. These compositions can be used as therapeutics or prophylactics against diseases or conditions, such as inflammation or pain, linked to the bradykinin B1 receptor.
摘要翻译： 本发明涉及涉及与多价载体缀合的缓激肽B1受体拮抗剂肽的物质组合物，包括与多价PEG缀合的肽。 这些组合物可用作与缓激肽B1受体连接的疾病或病症例如炎症或疼痛的治疗剂或预防剂。
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公开(公告)号：US20090048149A1
公开(公告)日：2009-02-19
申请号：US12082395
申请日：2008-04-09
申请人： Gordon Ng , Yue-Sheng Li , Colin V. Gegg , Benny C. Askew, JR. , Thomas Storz , Yuelie Lu , Derin C. D'Amico , Mark A. Jarosinski , Chuan-Fa Liu , Qi Huang
发明人： Gordon Ng , Yue-Sheng Li , Colin V. Gegg , Benny C. Askew, JR. , Thomas Storz , Yuelie Lu , Derin C. D'Amico , Mark A. Jarosinski , Chuan-Fa Liu , Qi Huang
摘要： The present invention relates to a method of treating, preventing, or ameliorating a disease or condition associated with or mediated by B1 activity that involves administering a composition of matter containing bradykinin B1 receptor antagonist peptides conjugated to a multivalent vehicle, including peptides conjugated to multivalent PEG. The method can be used therapeutically or prophylactically against diseases or conditions, such as inflammation or pain, linked to the bradykinin B1 receptor.
摘要翻译： 本发明涉及一种治疗，预防或改善与B1活性相关或介导的疾病或病症的方法，该方法包括给予包含与多价载体缀合的缓激肽B1受体拮抗剂肽的物质组合物，包括与多价PEG缀合的肽 。 该方法可以治疗性或预防性地用于与缓激肽B1受体连接的疾病或病症，例如炎症或疼痛。
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公开(公告)号：US08734796B2
公开(公告)日：2014-05-27
申请号：US13258668
申请日：2010-03-19
申请人： Kenneth W. Walker , Yue-Sheng Li , Thomas C. Boone , Frederick W. Jacobsen , HoSung Min , Jane Talvenheimo , Taruna Arora , Janet Doellgast
发明人： Kenneth W. Walker , Yue-Sheng Li , Thomas C. Boone , Frederick W. Jacobsen , HoSung Min , Jane Talvenheimo , Taruna Arora , George Doellgast
IPC分类号： A61K39/395 , C07K16/00 , C12N5/12
CPC分类号： C07K16/44 , A61K39/39591 , A61K47/6817 , A61K47/6843 , C07K14/43504 , C07K14/575 , C07K14/605 , C07K14/66 , C07K16/00 , C07K16/18 , C07K16/248 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/30 , C07K2319/55
摘要： Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors, host cells, and hybridomas useful in methods of making it. In some embodiments the antigen binding protein comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.
摘要翻译： 公开了分离的抗原结合蛋白，例如但不限于抗体或抗体片段。 还公开了包含抗原结合蛋白，编码它的分离的核酸，载体，宿主细胞和用于制备它的方法中的杂交瘤的药物组合物和药物。 在一些实施方案中，抗原结合蛋白包含与其结合的1-24个药理活性化学部分，例如药理学活性多肽。
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29.发明申请Human Anti-IFN-gamma Neutralizing Antibodies as Selective IFN-gamma Pathway Inhibitors 有权人抗IFN-γ中和抗体作为选择性IFN-γ途径抑制剂公开(公告)号：US20140004127A1
公开(公告)日：2014-01-02
申请号：US13966185
申请日：2013-08-13
IPC分类号： C07K16/24
CPC分类号： C07K16/249 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： This invention provides antibodies that interact with or bind to human interferon-gamma (IFN-γ) and methods for treating IFN-γ mediated diseases by administering a pharmaceutically effective amount of antibodies to IFN-γ. Methods of detecting the amount of IFN-γ in a sample using antibodies to IFN-γ are also provided.
摘要翻译： 本发明提供了与人类干扰素-γ（IFN-γ）相互作用或与之结合的抗体以及通过向IFN-γ施用药学上有效量的抗体来治疗IFN-γ介导的疾病的方法。 还提供了使用针对IFN-γ的抗体检测样品中IFN-γ量的方法。
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30.发明授权Methods for treating IFN-γ mediated diseases using human anti-IFN-γ neutralizing antibodies as selective IFN-gamma pathway inhibitors 有权使用人抗-γ-γ中和抗体作为选择性IFN-γ途径抑制剂治疗IFN-γ介导的疾病的方法公开(公告)号：US08529893B2
公开(公告)日：2013-09-10
申请号：US13476317
申请日：2012-05-21
IPC分类号： A61K39/395
CPC分类号： C07K16/249 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： This invention provides antibodies that interact with or bind to human interferon-gamma (IFN-γ) and methods for treating IFN-γ mediated diseases by administering a pharmaceutically effective amount of antibodies to IFN-γ. Methods of detecting the amount of IFN-γ in a sample using antibodies to IFN-γ are also provided.
摘要翻译： 本发明提供了与人类干扰素-γ（IFN-γ）相互作用或与之结合的抗体以及通过向IFN-γ施用药学上有效量的抗体来治疗IFN-γ介导的疾病的方法。 还提供了使用针对IFN-γ的抗体检测样品中IFN-γ量的方法。
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