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1.发明申请HUMAN ANTI-IFN-GAMMA NEUTRALIZING ANTIBODIES AS SELECTIVE IFN-GAMMA PATHWAY INHIBITORS 有权人类抗IFN-GAMMA作为选择性IFN-GAMMA途径抑制剂中和抗体公开(公告)号：US20080107655A1
公开(公告)日：2008-05-08
申请号：US11962594
申请日：2007-12-21
申请人： Andrew Welcher , Hilary Chute , Yue-Sheng Li , Haichun Huang
发明人： Andrew Welcher , Hilary Chute , Yue-Sheng Li , Haichun Huang
IPC分类号： A61K39/395 , C07K16/18 , A61P25/00 , A61P1/00
CPC分类号： C07K16/249 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： This invention provides antibodies that interact with or bind to human interferon-gamma (IFN-γ) and methods for treating IFN-γ mediated diseases by administering a pharmaceutically effective amount of antibodies to IFN-γ. Methods of detecting the amount of IFN-γ in a sample using antibodies to IFN-γ are also provided.
摘要翻译： 本发明提供了与人类干扰素-γ（IFN-γ）相互作用或与之结合的抗体以及通过向IFN-γ施用药学上有效量的抗体来治疗IFN-γ介导的疾病的方法。 还提供了使用针对IFN-γ的抗体检测样品中IFN-γ量的方法。
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2.发明申请Human anti-IFN-gamma neutralizing antibodies as selective IFN-gamma pathway inhibitors 有权人抗IFN-γ中和抗体作为选择性IFN-γ途径抑制剂公开(公告)号：US20050004353A1
公开(公告)日：2005-01-06
申请号：US10684957
申请日：2003-10-14
CPC分类号： C07K16/249 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： This invention provides antibodies that interact with or bind to human interferon-gamma (IFN-γ) and methods for treating IFN-γ mediated diseases by administering a pharmaceutically effective amount of antibodies to IFN-γ. Methods of detecting the amount of IFN-γ in a sample using antibodies to IFN-γ are also provided.
摘要翻译： 本发明提供了与人类干扰素-γ（IFN-γ）相互作用或与之结合的抗体以及通过向IFN-γ施用药学上有效量的抗体来治疗IFN-γ介导的疾病的方法。 还提供了使用针对IFN-γ的抗体检测样品中IFN-γ量的方法。
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公开(公告)号：US20060168672A1
公开(公告)日：2006-07-27
申请号：US11241836
申请日：2005-09-30
申请人： Andrew Welcher , Ulla Sarmiento , Henry Schultz , Hilary Chute
发明人： Andrew Welcher , Ulla Sarmiento , Henry Schultz , Hilary Chute
IPC分类号： A01K67/027 , C12Q1/68 , A61K38/17 , C07K14/705 , C07K16/28 , C07H21/04 , C12P21/06
CPC分类号： C07K14/70532
摘要： Novel B7-like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, selective binding agents, and methods for producing B7-like polypeptides. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with B7-like polypeptides.
摘要翻译： 新型B7样多肽和编码其的核酸分子。 本发明还提供载体，宿主细胞，选择性结合剂和用于产生B7样多肽的方法。 还提供用于治疗，诊断，改善或预防B7样多肽的疾病的方法。
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公开(公告)号：US5599920A
公开(公告)日：1997-02-04
申请号：US518474
申请日：1995-08-21
申请人： Pragna I. Patel , Ueli Suter , G. Jackson Snipes , Andrew Welcher , Marino DeLeon , James R. Lupski , Eric M. Shooter
发明人： Pragna I. Patel , Ueli Suter , G. Jackson Snipes , Andrew Welcher , Marino DeLeon , James R. Lupski , Eric M. Shooter
CPC分类号： C12Q1/6883 , C07K14/47 , C12Q1/683 , C12Q1/6858 , C12Q2600/156 , C12Q2600/158
摘要： The disclosed invention includes a a peripheral myelin protein, PMP-22, which is present predominantly in the peripheral nervous system and purified nucleic acids which encode the protein. Also included are oligonucleotide probes and primers derived from such sequences, and methods for the use of such sequences, probes and primers in detecting peripheral neuropathies.
摘要翻译： 所公开的发明包括主要存在于外周神经系统中的外周髓鞘蛋白PMP-22和编码该蛋白质的纯化核酸。 还包括衍生自这些序列的寡核苷酸探针和引物，以及在检测周围神经病中使用这些序列，探针和引物的方法。
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公开(公告)号：US08148109B2
公开(公告)日：2012-04-03
申请号：US11200389
申请日：2005-08-08
申请人： Andrew Welcher , Duanzhi Wen , Michael Kelley
发明人： Andrew Welcher , Duanzhi Wen , Michael Kelley
CPC分类号： G01N33/6866 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K14/555 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C12N2799/021
摘要： The present invention provides Interferon-Like (IFN-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing IFN-L polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with IFN-L polypeptides.
摘要翻译： 本发明提供了干扰素样（IFN-L）多肽和编码该多肽的核酸分子。 本发明还提供选择性结合剂，载体，宿主细胞和用于产生IFN-L多肽的方法。 本发明进一步提供用于诊断，治疗，改善和/或预防与IFN-L多肽相关的疾病，病症和病症的药物组合物和方法。
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公开(公告)号：US20060216287A1
公开(公告)日：2006-09-28
申请号：US11201407
申请日：2005-08-09
申请人： Gary Fox , Andrew Welcher , Shuqian Jing
发明人： Gary Fox , Andrew Welcher , Shuqian Jing
IPC分类号： A61K39/395 , G01N33/567 , A61K48/00 , A61K38/17 , C07K14/705 , C07K16/28
CPC分类号： C07K14/705 , C07K14/71 , C07K16/2863 , C12Q1/485 , G01N33/5082 , G01N33/574
摘要： Four novel members of the EPH sub-family of receptor protein tyrosine kinases are disclosed. Nucleic acid sequences encoding receptor proteins, recombinant plasmids and host cells for expression, and methods of producing and using such receptors are also disclosed.
摘要翻译： 公开了受体蛋白酪氨酸激酶的EPH亚家族的四个新成员。 还公开了编码受体蛋白质的核酸序列，用于表达的重组质粒和宿主细胞，以及产生和使用这些受体的方法。
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公开(公告)号：US20060030005A1
公开(公告)日：2006-02-09
申请号：US11235732
申请日：2005-09-26
申请人： Andrew Welcher , Gary Elliott
发明人： Andrew Welcher , Gary Elliott
CPC分类号： C07K14/70596 , A61K38/00 , C07K2319/00
摘要： Novel C3b/C4b CR-like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, selective binding agents, and methods for producing C3b/C4b CR-like polypeptides. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with C3b/C4b CR-like polypeptides.
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公开(公告)号：US20060024795A1
公开(公告)日：2006-02-02
申请号：US11200389
申请日：2005-08-08
申请人： Andrew Welcher , Duanzhi Wen , Michael Kelley
发明人： Andrew Welcher , Duanzhi Wen , Michael Kelley
IPC分类号： C07H21/04 , C12P21/04 , C07K14/555
CPC分类号： G01N33/6866 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K14/555 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C12N2799/021
摘要： The present invention provides Interferon-Like (IFN-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing IFN-L polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with IFN-L polypeptides.
摘要翻译： 本发明提供了干扰素样（IFN-L）多肽和编码该多肽的核酸分子。 本发明还提供选择性结合剂，载体，宿主细胞和用于产生IFN-L多肽的方法。 本发明进一步提供用于诊断，治疗，改善和/或预防与IFN-L多肽相关的疾病，病症和病症的药物组合物和方法。
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公开(公告)号：US07811791B2
公开(公告)日：2010-10-12
申请号：US10977680
申请日：2004-10-29
申请人： Andrew Welcher , Duanzhi Wen , Michael Kelly
发明人： Andrew Welcher , Duanzhi Wen , Michael Kelly
CPC分类号： G01N33/6866 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K14/555 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C12N2799/021
摘要： The present invention provides Interferon-Like (IFN-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing IFN-L polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with IFN-L polypeptides.
摘要翻译： 本发明提供了干扰素样（IFN-L）多肽和编码该多肽的核酸分子。 本发明还提供选择性结合剂，载体，宿主细胞和用于产生IFN-L多肽的方法。 本发明进一步提供用于诊断，治疗，改善和/或预防与IFN-L多肽相关的疾病，病症和病症的药物组合物和方法。
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公开(公告)号：US20060287502A1
公开(公告)日：2006-12-21
申请号：US11429673
申请日：2006-05-05
申请人： Andrew Welcher , Gary Elliott
发明人： Andrew Welcher , Gary Elliott
IPC分类号： A61K39/395 , A61K38/17 , A01K67/027 , C07K14/74 , C07K16/28 , G01N33/567 , C07H21/04 , C12P21/06 , C12N5/06
CPC分类号： C07K14/705 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K14/70596 , C07K2319/00
摘要： Novel C3b/C4b CR-like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, selective binding agents, and methods for producing C3b/C4b CR-like polypeptides. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with C3b/C4b CR-like polypeptides.
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