公开(公告)号：US10441419B2

公开(公告)日：2019-10-15

申请号：US16197245

申请日：2018-11-20

Applicant: Edwards Lifesciences Corporation

Inventor： Thanh Huy Le ,  Tri D. Tran ,  Ronaldo C. Cayabyab ,  David M. Taylor ,  Antonio O. Vidal ,  Robert Bowes

IPC: A61F2/24 ,  A61M25/10 ,  A61M25/01 ,  A61F2/95 ,  A61M25/06

Abstract: A method of delivery a prosthetic heart valve includes inserting a delivery apparatus and a prosthetic heart valve into a patient's vasculature. The delivery apparatus includes a steerable guide catheter, a balloon catheter, and a flex indicator. The balloon catheter extends coaxially through the guide catheter, the prosthetic heart valve is mounted on a distal end portion of the balloon catheter, and the flex indicator is movably coupled to a handle of the guide catheter. The method further includes adjusting flexion of a steerable section of the guide catheter to position the prosthetic heart valve. The flex indicator moves relative to the handle of the guide catheter as the flexion of the steerable section is adjusted, and the handle comprises one or more visual indicators adjacent the flex indicator to provide visual indication of an amount of flexion of the steerable section of the guide catheter.

公开(公告)号：US10307250B2

公开(公告)日：2019-06-04

申请号：US15063319

申请日：2016-03-07

Applicant: Edwards Lifesciences Corporation

Inventor： David Maimon ,  Ron Sharoni ,  Tamir S. Levi ,  Emil Karapetian ,  Tri D. Tran ,  Tung T. Le

IPC: B21D39/04 ,  A61F2/24 ,  B21D41/04 ,  A61B50/30 ,  A61B17/06 ,  B23P11/00 ,  B21D41/00 ,  A61F2/00 ,  B25B27/10 ,  B23P19/04 ,  A61F2/95

Abstract: A device for crimping a radially expandable and collapsible prosthetic valve comprises a coiled wire frame having a longitudinal opening extending from a proximal end to a distal end thereof. The opening has a first state and a second state, the opening in the first state having a first diameter dimensioned to receive the prosthetic valve in an expanded or partially crimped configuration therein, and the opening in the second state having a second diameter dimensioned to receive the prosthetic valve in a crimped configuration. The coiled wire frame has a first end coupled to a first member and a second end coupled to a second member. The first member is movable relative to the second member to convert the coiled wire frame from the first state to the second state.

公开(公告)号：US10278819B2

公开(公告)日：2019-05-07

申请号：US15167760

申请日：2016-05-27

Applicant: Edwards Lifesciences Corporation

Inventor： David M. Taylor ,  Tri D. Tran ,  Sean Chow ,  David L. Hauser ,  Pui Tong Ho ,  Alexander H. Cooper

IPC: A61F2/24

Abstract: Disclosed herein are devices for improving coaption of the mitral valve leaflets to reduce or eliminate mitral valve regurgitation. The devices may be used to perform mitral valve annuloplasty, or to serve as a docking station for a transcatheter prosthetic heart valve. The various embodiments of devices are configured for percutaneous and, in some cases, transvascular delivery. Delivery systems useful for routing the devices to the mitral valve are also disclosed, including catheters, balloons and/or mechanical expansion systems. The devices themselves include at least one tissue penetrating member. Methods of delivery include partially embedding the devices in the mitral valve annulus via at least one tissue penetrating member. Tissue penetrating members may be embedded into the tissue in a simultaneous or a nearly simultaneous fashion. Upon embedding, the devices employ various expansion and/or contraction features to adjust the mitral valve diameter. Adjustments may continue until the leaflets fully coapt and the problem of mitral regurgitation is reduced or eliminated.

公开(公告)号：US20180126124A1

公开(公告)日：2018-05-10

申请号：US15796436

申请日：2017-10-27

Applicant: Edwards Lifesciences Corporation

Inventor： Matthew T. Winston ,  Christopher J. Olson ,  Asher L. Metchik ,  Tri D. Tran ,  Alexander J. Siegel

IPC: A61M25/01 ,  A61M25/06 ,  A61M25/00 ,  A61F2/24

CPC classification number: A61M25/0147 ,  A61F2/2427 ,  A61F2/2433 ,  A61F2/2436 ,  A61M25/005 ,  A61M25/0662 ,  A61M2025/015

Abstract: A delivery apparatus includes a steerable shaft having a proximal portion, a distal portion, and a pull-wire conduit that extends through the proximal and distal portions. A pull wire extends through the conduit and has a distal portion that is fixed to the shaft. An adjustment mechanism is connected to the proximal end portion of the pull wire and configured to increase and decrease tension in the pull wire to adjust the curvature of the shaft. The distal portion of the shaft has a steerable portion including one or more layers. A compression-resistance portion is incorporated into a layer of the steerable portion, and extends angularly along a portion of a cross-section of the layer. The layer of the steerable portion into which the compression-resistance portion is incorporated has a first hardness, and the compression-resistance portion has a second hardness that is greater than the first hardness.

公开(公告)号：US20130152659A1

公开(公告)日：2013-06-20

申请号：US13715605

申请日：2012-12-14

Applicant: Edwards Lifesciences Corporation

Inventor： David Maimon ,  Ron Sharoni ,  Tamir S. Levi ,  Emil Karapetian ,  Tri D. Tran ,  Tung Le

IPC: B21D41/04

CPC classification number: A61F2/2427 ,  A61B50/30 ,  A61F2/0095 ,  A61F2/243 ,  A61F2/2433 ,  A61F2002/9522 ,  B21D41/04 ,  B23P19/04 ,  B25B27/10 ,  Y10T29/53552 ,  Y10T29/53578 ,  Y10T29/5367

Abstract: An exemplary system for crimping a prosthetic valve comprises a radially expandable and compressible prosthetic valve, a crimping device positioned around the valve and configured to reduce the diameter of the valve to a delivery configuration, and a sterile package enclosing the valve and the crimping device. The valve can be pre-assembled in a partially crimped configuration within the crimping device. After removing the sterile packaging, the crimping device can be used to crimp the valve from the partially crimped configuration to the delivery configuration, such as by twisting a knob on the crimping device. The system can further comprise at least a portion of a delivery catheter within the sterile package, wherein the valve is pre-mounted on or adjacent to an inflatable balloon of the delivery catheter, such that the valve can be crimped onto the delivery catheter using the crimping device.

公开(公告)号：US20250114088A1

公开(公告)日：2025-04-10

申请号：US18984170

申请日：2024-12-17

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Kurt Kelly Reed ,  Tri D. Tran

IPC: A61B17/04

Abstract: Suture lock assemblies with suture tensioners are disclosed herein. A suture lock assembly can comprise a suture tensioner configured to be selectively rotated to collect a length of a suture. The suture tensioner comprises a pair of spaced-apart posts and a connecting body coupled to each of the posts. A suture lock assembly also can comprise a suture tensioner, a tensioner housing, and a quick release suture mechanism. The tensioner housing at least partially receives the suture tensioner and includes a suture entry port and a suture exit port. The suture tensioner is configured to be selectively rotated relative to the tensioner housing to selectively increase a length of a suture that is enclosed by the tensioner housing. The quick release suture mechanism comprises a quick release dock port and a suture anchor cap configured to be selectively coupled to and uncoupled from the quick release dock port.

公开(公告)号：US20230329863A1

公开(公告)日：2023-10-19

申请号：US18210568

申请日：2023-06-15

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Gilbert Madrid ,  Matthew T. Winston ,  Sam Sok ,  Thanh Huy Le ,  Tri D. Tran ,  Kim Le ,  Michael D. Franklin

IPC: A61F2/24 ,  A61M25/01 ,  A61M25/10 ,  A61M25/00

CPC classification number: A61F2/2427 ,  A61F2/2433 ,  A61M25/0147 ,  A61M25/1011 ,  A61M25/0052 ,  A61F2/2412 ,  A61F2002/9583

Abstract: A method of implanting a prosthetic heart valve includes advancing a distal end portion of a catheter shaft through a patient's vasculature. The distal end portion of the catheter shaft includes an expansion device. A prosthetic heart valve is mounted on the expansion device with the expansion device and the prosthetic heart valve in a compressed configuration. The method further includes positioning the distal end portion of the catheter shaft and the prosthetic heart valve to an implantation location and expanding the prosthetic heart valve and the expansion device to an expanded configuration. The expansion device includes a main body and a plurality of projections extending radially from the main body. The projections are spaced apart relative to each such that there are grooves extending between adjacent projections providing perfusion passageways between the expansion device and the prosthetic heart valve when the expansion device is in the expanded configuration.

公开(公告)号：US11666436B2

公开(公告)日：2023-06-06

申请号：US16415590

申请日：2019-05-17

Applicant: Edwards Lifesciences Corporation

Inventor： David Maimon ,  Ron Sharoni ,  Tamir S. Levi ,  Emil Karapetian ,  Tri D. Tran ,  Tung Le

IPC: B21D41/04 ,  B21D41/00 ,  A61F2/24 ,  A61B50/30 ,  A61B17/06 ,  B23P11/00 ,  A61F2/00 ,  B25B27/10 ,  B23P19/04 ,  A61F2/95

CPC classification number: A61F2/2427 ,  A61B17/06 ,  A61B50/30 ,  A61F2/0095 ,  A61F2/243 ,  A61F2/2433 ,  B21D41/00 ,  B21D41/04 ,  B23P11/00 ,  B23P19/04 ,  B25B27/10 ,  A61F2/9522 ,  Y10T29/5367 ,  Y10T29/53552 ,  Y10T29/53578

Abstract: A device for crimping a radially expandable and collapsible prosthetic valve comprises a crimping loop having a first end portion, a second end portion, and a loop portion extending between the first and second end portions and defining an opening configured to receive the prosthetic valve. The crimping loop is movable between a first state in which the opening has a first diameter and a second state in which the opening has a second diameter smaller than the first diameter such that when the prosthetic valve is positioned within the loop portion, movement of the crimping loop from the first state to the second state is effective to reduce a diameter of the prosthetic valve. A method for crimping a prosthetic valve comprises reducing a diameter of an opening of a crimping loop, thereby radially compressing an at least partially expanded prosthetic valve disposed within the opening.

公开(公告)号：US20230080273A1

公开(公告)日：2023-03-16

申请号：US17992427

申请日：2022-11-22

Applicant: Edwards Lifesciences Corporation

Inventor： Matthew T. Winston ,  Christopher J. Olson ,  Asher L. Metchik ,  Tri D. Tran ,  Alexander J. Siegel

IPC: A61M25/01 ,  A61F2/24 ,  A61M25/06

Abstract: A delivery apparatus includes a steerable guide sheath. The steerable guide sheath has a steerable portion, a pull ring located in the distal portion, and a pull wire coupled at one end to the pull ring and coupled at the opposite end to a control handle. The pull wire extends longitudinally through a pull-wire conduit. The steerable guide sheath further includes a compression-resistance portion made of metal and located in the distal portion.

公开(公告)号：US11166817B2

公开(公告)日：2021-11-09

申请号：US16358480

申请日：2019-03-19

Applicant: Edwards Lifesciences Corporation

Inventor： David M. Taylor ,  Tri D. Tran ,  Sean Chow ,  David L. Hauser ,  Pui Tong Ho ,  Alexander H. Cooper

IPC: A61F2/24

Abstract: Disclosed herein are devices for improving coaption of the mitral valve leaflets to reduce or eliminate mitral valve regurgitation. The devices may be used to perform mitral valve annuloplasty, or to serve as a docking station for a transcatheter prosthetic heart valve. The various embodiments of devices are configured for percutaneous and, in some cases, transvascular delivery. Delivery systems useful for routing the devices to the mitral valve are also disclosed, including catheters, balloons and/or mechanical expansion systems. The devices themselves include at least one tissue penetrating member. Methods of delivery include partially embedding the devices in the mitral valve annulus via at least one tissue penetrating member. Tissue penetrating members may be embedded into the tissue in a simultaneous or a nearly simultaneous fashion. Upon embedding, the devices employ various expansion and/or contraction features to adjust the mitral valve diameter. Adjustments may continue until the leaflets fully coapt and the problem of mitral regurgitation is reduced or eliminated.