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    Small cell lung cancer associated antigens and uses therefor
    21.
    发明授权
    Small cell lung cancer associated antigens and uses therefor 有权
    小细胞肺癌相关抗原及其用途

    公开(公告)号：US07314721B2

    公开(公告)日：2008-01-01

    申请号：US10761169

    申请日：2004-01-20

    申请人： Ali O. Gure ,  Elisabeth Stockert ,  Matthew J. Scanlan ,  Dirk Jager ,  Lloyd J. Old ,  Yao-Tseng Chen

    发明人： Ali O. Gure ,  Elisabeth Stockert ,  Matthew J. Scanlan ,  Dirk Jager ,  Lloyd J. Old ,  Yao-Tseng Chen

    IPC分类号： G01N33/53 ,  C07K1/00 ,  C07K16/00

    CPC分类号： G01N33/574 ,  A61K38/00 ,  A61K39/00 ,  C07K14/4748 ,  G01N33/57423

    摘要： Cancer associated antigens have been identified by autologous antibody screening of libraries of nucleic acids expressed in small cell lung cancer cells using antisera from cancer patients. The invention relates to nucleic acids and encoded polypeptides which are cancer associated antigens expressed in patients afflicted with small cell lung cancer. The invention provides, among other things, isolated nucleic acid molecules, expression vectors containing those molecules and host cells transfected with those molecules. The invention also provides isolated proteins and peptides, antibodies to those proteins and peptides and cytotoxic T lymphocytes which recognize the proteins and peptides. Fragments of the foregoing including functional fragments and variants also are provided. Kits containing the foregoing molecules additionally are provided. The molecules provided by the invention can be used in the diagnosis, monitoring, research, or treatment of conditions characterized by the expression of one or more cancer associated antigens.

    摘要翻译： 已经通过使用来自癌症患者的抗血清的小细胞肺癌细胞中表达的核酸文库的自身抗体筛选来鉴定癌症相关抗原。 本发明涉及在患有小细胞肺癌的患者中表达的癌症相关抗原的核酸和编码多肽。 本发明尤其提供了分离的核酸分子，含有这些分子的表达载体和用这些分子转染的宿主细胞。 本发明还提供分离的蛋白质和肽，这些蛋白质和肽的抗体以及识别蛋白质和肽的细胞毒性T淋巴细胞。 还提供了前述的片段，包括功能片段和变体。 另外提供了含有上述分子的试剂盒。 本发明提供的分子可用于诊断，监测，研究或治疗以一种或多种癌症相关抗原表达为特征的病症。

    Recombinant human anti-Lewis Y antibodies
    28.
    发明授权
    Recombinant human anti-Lewis Y antibodies 失效
    重组人抗Lewis Y抗体

    公开(公告)号：US06310185B1

    公开(公告)日：2001-10-30

    申请号：US08207861

    申请日：1994-03-08

    申请人： Thomas P. Wallace ,  Kathryn Lesley Armour ,  Francis Joseph Carr ,  Lloyd J. Old ,  Elisabeth Stockert ,  Sydney Welt ,  Kunio Kitamura ,  Pilar Garin-Chesa

    发明人： Thomas P. Wallace ,  Kathryn Lesley Armour ,  Francis Joseph Carr ,  Lloyd J. Old ,  Elisabeth Stockert ,  Sydney Welt ,  Kunio Kitamura ,  Pilar Garin-Chesa

    IPC分类号： C07K1630

    CPC分类号： C07K16/34 ,  C07K16/30 ,  C07K2317/24 ,  C07K2319/00

    摘要： The invention provides for the production of several humanized murine antibodies specific for the antigen Lewis Y, which is recognized by murine atibodies specific for the Lewis Y antigen. The Lewis Y antigen is expressed in normal tissues but the level of expression is higher in certain tumour types so that the antigen can be used as a marker for cells of some breast, colon, gastric, esophageal, pancreatic, duodenal, lung, bladder and renal carcinomas and gastric and islet cell neuroendocrine tumours. The invention also provides for numerous polynucleotide encoding humanized Lewis Y specific antibodies, expression vectors for producing humanized Lewis Y specific antibodies, and host cells for the recombinant production of the humanized antibodies. The invention also provides methods for detecting cancerous cells (in vitro and in vivo) using humanized Lewis Y specific antibodies. Additionally, the invention provides methods of treating cancer using humanized Lewis Y specific antibodies.

    摘要翻译： 本发明提供了对抗原Lewis Y特异性的几种人源化鼠抗体的产生，其被Lewis Y抗原特异性的鼠抗体识别。 Lewis Y抗原在正常组织中表达，但在某些肿瘤类型中表达水平较高，因此抗原可用作乳腺癌，结肠癌，胃癌，食管癌，胰腺癌，十二指肠癌，肺癌，膀胱癌， 肾癌和胃和胰岛细胞神经内分泌肿瘤。 本发明还提供编码人源化Lewis Y特异性抗体的许多多核苷酸，用于产生人源化Lewis Y特异性抗体的表达载体和用于重组产生人源化抗体的宿主细胞。 本发明还提供使用人源化Lewis Y特异性抗体检测癌细胞（体外和体内）的方法。 另外，本发明提供使用人源化Lewis Y特异性抗体治疗癌症的方法。