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公开(公告)号：US06423507B1
公开(公告)日：2002-07-23
申请号：US08798095
申请日：1997-02-12
申请人： Gregg A. Hastings , Mark D. Adams , Claire M. Fraser , Norman H. Lee , Ewen F. Kirkness , Judith A. Blake , Lisa M. Fitzgerald , Fred H. Drake , Maxine Gowan
发明人： Gregg A. Hastings , Mark D. Adams , Claire M. Fraser , Norman H. Lee , Ewen F. Kirkness , Judith A. Blake , Lisa M. Fitzgerald , Fred H. Drake , Maxine Gowan
IPC分类号： C12Q137
CPC分类号： C12N9/6472 , A61K38/00 , C07K16/40
摘要： Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.
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公开(公告)号：US6103871A
公开(公告)日：2000-08-15
申请号：US916989
申请日：1997-08-21
申请人： Ying-Fei Wei , Ewen F. Kirkness
发明人： Ying-Fei Wei , Ewen F. Kirkness
CPC分类号： C12N9/16 , A61K38/00 , Y10S530/809
摘要： A human hMutT2 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for hydrolyzing and eliminating oxidized guanine nucleotides from the nucleotide pool to ensure correct DNA synthesis. Diagnostic assays are also disclosed which detect the presence of a mutated form of hMutT2 and over-expression of the hMutT2 protein.
摘要翻译： 公开了编码这种多肽的人hMutT2多肽和DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽从核苷酸库水解和消除氧化的鸟嘌呤核苷酸以确保正确的DNA合成的方法。 还公开了诊断测定法，其检测突变形式的hMutT2的存在和hMutT2蛋白的过表达。
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公开(公告)号：US06344547B1
公开(公告)日：2002-02-05
申请号：US09432253
申请日：1999-11-02
申请人： Ying-Fei Wei , Ewen F. Kirkness
发明人： Ying-Fei Wei , Ewen F. Kirkness
IPC分类号： C07H1900
CPC分类号： C12N9/16 , A61K38/00 , Y10S530/809
摘要： A human hMutT2 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for hydrolyzing and eliminating oxidized guanine nucleotides from the nucleotide pool to ensure correct DNA synthesis. Diagnostic assays are also disclosed which detect the presence of a mutated form of hMutT2 and over-expression of the hMutT2 protein.
摘要翻译： 公开了编码这种多肽的人hMutT2多肽和DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽从核苷酸库水解和消除氧化的鸟嘌呤核苷酸以确保正确的DNA合成的方法。 还公开了诊断测定法，其检测突变形式的hMutT2的存在和hMutT2蛋白的过表达。
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公开(公告)号：US5654172A
公开(公告)日：1997-08-05
申请号：US459100
申请日：1995-06-02
申请人： Yi Li , Ewen F. Kirkness
发明人： Yi Li , Ewen F. Kirkness
CPC分类号： C07K14/70571 , A61K38/00
摘要： Disclosed is a human GABA.sub.A epsilon subunit receptor and DNA (RNA) encoding such polypeptides (RNA). Also provided is a procedure for producing such polypeptides by recombinant techniques and agonists and antagonists for such polypeptides. Also provided are methods of using the agonists, for example, to treat anxiety, Huntington's Chorea, muscular spasms and rigidity, and sleep and seizure disorders. Antagonists may be used, for example, to diagnose and treat anxiety, Huntington's Chorea, sleep and seizure disorders, Alzheimer's disease, Parkinson's disease and overdoses with benzodiazepine and for enhancing cognition and reversing sedation after application of general anesthesia during surgery. Also disclosed are diagnostic methods for detecting mutations in the polynucleotides of the present invention and for detecting levels of the soluble polypeptides in samples derived from a host.
摘要翻译： 披露了人类GABAAε亚基受体和编码这种多肽（RNA）的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及用于这种多肽的激动剂和拮抗剂。 还提供了使用激动剂的方法，例如治疗焦虑症，亨廷顿舞蹈病，肌肉痉挛和僵硬，以及睡眠和发作障碍。 例如，可以使用拮抗剂来诊断和治疗焦虑症，亨廷顿舞蹈病，睡眠和癫痫发作，阿尔茨海默病，帕金森氏病和苯二氮卓类药物过量，并且在手术中应用全身麻醉后增强认知和反转镇静作用。 还公开了用于检测本发明的多核苷酸中的突变并用于检测衍生自宿主的样品中可溶性多肽的水平的诊断方法。
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公开(公告)号：US07365163B2
公开(公告)日：2008-04-29
申请号：US11346326
申请日：2006-02-03
申请人： Michael C. Hanna , Ewen F. Kirkness
发明人： Michael C. Hanna , Ewen F. Kirkness
CPC分类号： C07K14/70571 , A61K38/00
摘要： The present invention relates to a novel GABAA receptor ε subunit (GABRE) and an alternative transcript thereof (ET2). More specifically, isolated nucleic acid molecules are provided encoding human GABRE and ET2 receptor subunits. ET2 and GABRE polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of ET2 and GABRE activities. Also provided are diagnostic methods for detecting aberrant GABRE and ET2 expression, as well as therapeutic methods for treating disorders involving ET2 and GABRE.
摘要翻译： 本发明涉及一种新的GABA A受体ε亚基（GABRE）及其替代转录物（ET2）。 更具体地，提供编码人GABRE和ET2受体亚单位的分离的核酸分子。 还提供了ET2和GABRE多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 本发明还涉及用于鉴定ET2和GABRE活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测异常GABRE和ET2表达的诊断方法，以及用于治疗涉及ET2和GABRE的疾病的治疗方法。
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公开(公告)号：US07029870B1
公开(公告)日：2006-04-18
申请号：US09030832
申请日：1998-02-26
申请人： Michael C. Hanna , Ewen F. Kirkness
发明人： Michael C. Hanna , Ewen F. Kirkness
CPC分类号： C07K14/70571 , A61K38/00
摘要： The present invention relates to a novel GABAA receptor ε subunit (GABRE) and an alternative transcript thereof (ET2). More specifically, isolated nucleic acid molecules are provided encoding human GABRE and ET2 receptor subunits. ET2 and GABRE polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of ET2 and GABRE activities. Also provided are diagnostic methods for detecting aberrant GABRE and ET2 expression, as well as therapeutic methods for treating disorders involving ET2 and GABRE.
摘要翻译： 本发明涉及一种新的GABA A受体ε亚基（GABRE）及其替代转录物（ET2）。 更具体地，提供编码人GABRE和ET2受体亚单位的分离的核酸分子。 还提供了ET2和GABRE多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 本发明还涉及用于鉴定ET2和GABRE活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测异常GABRE和ET2表达的诊断方法，以及用于治疗涉及ET2和GABRE的疾病的治疗方法。
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公开(公告)号：US06552174B2
公开(公告)日：2003-04-22
申请号：US09974800
申请日：2001-10-12
申请人： Ying-Fei Wei , Ewen F. Kirkness
发明人： Ying-Fei Wei , Ewen F. Kirkness
IPC分类号： C07K1640
CPC分类号： C12N9/16 , A61K38/00 , Y10S530/809
摘要： A human hMutT2 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for hydrolyzing and eliminating oxidized guanine nucleotides from the nucleotide pool to ensure correct DNA synthesis. Diagnostic assays are also disclosed which detect the presence of a mutated form of hMutT2 and over-expression of the hMutT2 protein.
摘要翻译： 公开了编码这种多肽的人hMutT2多肽和DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽从核苷酸库水解和消除氧化的鸟嘌呤核苷酸以确保正确的DNA合成的方法。 还公开了诊断测定法，其检测突变形式的hMutT2的存在和hMutT2蛋白的过表达。
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公开(公告)号：US06462188B1
公开(公告)日：2002-10-08
申请号：US09061154
申请日：1998-04-16
申请人： Ewen F. Kirkness
发明人： Ewen F. Kirkness
IPC分类号： C07H2104
CPC分类号： C07K14/70571
摘要： Recombinant materials for preparation of a new form of human 5-HT3 receptor are provided. These materials permit the production of said receptor, display of said receptor on host cells, and compositions of diagnostic and therapeutic utility.
摘要翻译： 提供了用于制备新形式的人5-HT 3受体的重组材料。 这些材料允许产生所述受体，在宿主细胞上显示所述受体，以及诊断和治疗效用的组合物。
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公开(公告)号：US06063376A
公开(公告)日：2000-05-16
申请号：US860995
申请日：1997-10-16
申请人： Ying-Fei Wei , Ewen F. Kirkness
发明人： Ying-Fei Wei , Ewen F. Kirkness
CPC分类号： C12N9/1205 , A61K38/00
摘要： A human deoxycytidine kinase 2 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of malignancies and viral infections. Antagonist against such polypeptides and their use as a therapeutic to treat immunodeficiency disorders are also disclosed. Diagnostic assays for detecting diseases related to mutations in the hdCK2 nucleic acid sequence and the concentration of the polypeptide encoded by such nucleic acid sequence is also disclosed.
摘要翻译： PCT No.PCT / US95 / 00532 Sec。 371日期：1997年10月16日 102（e）日期1997年10月16日PCT提交1995年1月13日PCT公布。 出版物WO96 / 21724 日期1996年7月18日公开了一种编码这种多肽的人脱氧胞苷激酶2多肽和DNA（RNA），以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽治疗恶性肿瘤和病毒感染的方法。 还公开了抗这些多肽的拮抗剂及其作为治疗性免疫缺陷病症治疗剂的用途。 还公开了用于检测与hdCK2核酸序列中的突变有关的疾病的诊断测定和由该核酸序列编码的多肽的浓度。
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公开(公告)号：US5914258A
公开(公告)日：1999-06-22
申请号：US458657
申请日：1995-06-02
申请人： Ying-Fei Wei , Ewen F. Kirkness
发明人： Ying-Fei Wei , Ewen F. Kirkness
CPC分类号： C12N9/1205 , B32B5/26 , A61K38/00
摘要： A human deoxycytidine kinase 2 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of malignancies and viral infections. Antagonist against such polypeptides and their use as a therapeutic to treat immunodeficiency disorders are also disclosed. Diagnostic assays for detecting diseases related to mutations in the hdCK2 nucleic acid sequence and the concentration of the polypeptide encoded by such nucleic acid sequence is also disclosed.
摘要翻译： 公开了人脱氧胞苷激酶2多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽治疗恶性肿瘤和病毒感染的方法。 还公开了抗这些多肽的拮抗剂及其作为治疗性免疫缺陷病症治疗剂的用途。 还公开了用于检测与hdCK2核酸序列中的突变有关的疾病的诊断测定和由该核酸序列编码的多肽的浓度。
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