公开(公告)号：US20190071404A1

公开(公告)日：2019-03-07

申请号：US16181228

申请日：2018-11-05

Applicant: Genentech, Inc.

Inventor： James John Crawford ,  Mark Zak ,  Terry Kellar ,  Yun-Xing Cheng ,  Wei Li ,  F. Anthony Romero ,  Paul Gibbons ,  Guiling Zhao ,  Gregory Hamilton ,  Simon Charles Goodacre

IPC: C07D231/40 ,  C07D401/04 ,  C07D405/04 ,  C07D403/08 ,  C07D409/14 ,  C07D401/14 ,  C07D405/12

Abstract: Compounds of Formula (I): and salts thereof, and methods of use as Janus kinase inhibitors are described herein.

公开(公告)号：US20180339998A1

公开(公告)日：2018-11-29

申请号：US15936086

申请日：2018-03-26

Applicant: Forma TM, LLC ,  Genentech, Inc.

Inventor： Kenneth W. Bair ,  Timm R. Baumeister ,  Peter Dragovich ,  Xiongcai Liu ,  Snahel Patel ,  Po-Wai Yuen ,  Mark Zak ,  Guiling Zhao ,  Yamin Zhang ,  Xiaozhang Zheng

IPC: C07D519/00 ,  A61K45/06 ,  C07D471/04 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/496 ,  A61K31/497 ,  A61K31/513 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/438 ,  C07D495/04 ,  C07D491/048 ,  C07D487/04 ,  A61K31/501

Abstract: Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

公开(公告)号：US20160279260A1

公开(公告)日：2016-09-29

申请号：US15181825

申请日：2016-06-14

Applicant: Genentech, Inc.

Inventor： John Flygare ,  Janet Gunzner-Toste ,  Thomas Pillow ,  Brian Safina ,  Vishal Verma ,  Binqing Wei ,  Guiling Zhao ,  Leanna Staben

IPC: A61K47/48 ,  C07K16/30 ,  C07K16/28

CPC classification number: A61K47/6803 ,  A61K47/6809 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6889 ,  C07K16/28 ,  C07K16/2851 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/76

Abstract: This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof, to pharmaceutical compositions containing them, and to their use in therapy for the prevention or treatment of cancer.

Abstract translation: 本发明涉及肽模拟接头及其抗体药物偶联物，含有它们的药物组合物及其在治疗中用于预防或治疗癌症的用途。

公开(公告)号：US20130345215A1

公开(公告)日：2013-12-26

申请号：US13911585

申请日：2013-06-06

Applicant: Genentech, Inc.

Inventor： Jianwen Feng ,  Nancy-Ellen Haynes ,  Johannes Cornelius Hermann ,  Kyungjin Kim ,  Jin-Jun Liu ,  Nathan Robert Scott ,  Lin Yi ,  Mark Edward Zak ,  Guiling Zhao

IPC: C07D487/04 ,  C07D471/04

CPC classification number: C07D487/04 ,  C07D471/04

Abstract: There are provided compounds of the formula or a pharmaceutically acceptable salt thereof, wherein Q, R1 and R2 are as defined herein.The compounds of formula I are useful in the treatment of cancer.

Abstract translation: 提供下式的化合物或其药学上可接受的盐，其中Q，R 1和R 2如本文所定义。 式I化合物可用于治疗癌症。

公开(公告)号：US20130157999A1

公开(公告)日：2013-06-20

申请号：US13687437

申请日：2012-11-28

Applicant: Genentech, Inc.

Inventor： Charles Baker-Glenn ,  Daniel Jon Burdick ,  Mark Chambers ,  Bryan K. Chan ,  Huifen Chen ,  Anthony Estrada ,  Gunzner-Toste Janet ,  Daniel Shore ,  Zachary Kevin Sweeney ,  Shumei Wang ,  Guiling Zhao

IPC: C07D498/18 ,  C07D498/10 ,  C07D405/12 ,  C07D239/48 ,  C07D487/04

CPC classification number: C07D498/18 ,  C07D239/47 ,  C07D239/48 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D487/04 ,  C07D491/107 ,  C07D498/08 ,  C07D498/10

Abstract: Specific Compounds of formula I: or pharmaceutically acceptable salts thereof, wherein m, X, R1, R2, R3, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.

Abstract translation: 式I的具体化合物或其药学上可接受的盐，其中m，X，R 1，R 2，R 3，R 5，R 6和R 7如本文所定义。 还公开了制备化合物和使用该化合物治疗与LRRK2受体（例如帕金森病）相关的疾病的方法。

公开(公告)号：US12281101B2

公开(公告)日：2025-04-22

申请号：US17198238

申请日：2021-03-10

Applicant: Genentech, Inc.

Inventor： Snahel Patel ,  Gregory Hamilton ,  Craig Stivala ,  Huifen Chen ,  Guiling Zhao

IPC: C07D403/12 ,  A61K31/55 ,  A61K31/553 ,  A61P1/00 ,  A61P1/04 ,  A61P1/16 ,  A61P1/18 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P13/12 ,  A61P17/06 ,  A61P25/00 ,  A61P27/02 ,  A61P29/00 ,  A61P31/00 ,  A61P31/04 ,  A61P35/00 ,  A61P43/00 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D491/044 ,  C07D491/048 ,  C07D491/052 ,  C07D491/10 ,  C07D495/04 ,  C07D495/14 ,  C07D498/04 ,  C07D498/16 ,  C07D519/00

Abstract: The invention provides novel compounds having the general formula I: wherein R1, X, Z1, L, n, the A ring, the B ring, and the C ring are as described herein, pharmaceutical compositions including the compounds and methods of using the compounds.

公开(公告)号：US11607396B2

公开(公告)日：2023-03-21

申请号：US17141070

申请日：2021-01-04

Applicant: Genentech, Inc.

Inventor： Snahel Patel ,  Gregory Hamilton ,  Guiling Zhao ,  Huifen Chen

IPC: A61K31/16 ,  A61P9/10 ,  C07D519/00 ,  A61P9/00 ,  A61P29/00 ,  A61P43/00 ,  A61K31/396 ,  A61K31/397 ,  A61K31/4025 ,  A61K31/416 ,  A61K31/4196 ,  A61K31/44 ,  A61K31/5383 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D491/048

Abstract: The invention provides novel compounds having the general formula I: wherein R1, R2, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds and methods of using the compounds.

公开(公告)号：US11098058B2

公开(公告)日：2021-08-24

申请号：US16034207

申请日：2018-07-12

Applicant: Genentech, Inc.

Inventor： Snahel Patel ,  Gregory Hamilton ,  Guiling Zhao ,  Huifen Chen ,  Blake Daniels ,  Craig Stivala

IPC: C07D498/04 ,  C07D487/04 ,  A61P25/16 ,  A61P25/28 ,  C07D235/12 ,  C07D471/04 ,  A61P17/06 ,  A61P21/00 ,  A61P19/02 ,  A61P1/00

Abstract: The invention provides novel compounds having the general formula I: wherein R1, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.

公开(公告)号：US11071721B2

公开(公告)日：2021-07-27

申请号：US15828271

申请日：2017-11-30

Applicant: Genentech, Inc.

Inventor： Snahel Patel ,  Gregory Hamilton ,  Guiling Zhao ,  Huifen Chen

IPC: C07D471/04 ,  A61K31/16 ,  A61P9/10 ,  C07D519/00 ,  A61P9/00 ,  A61P29/00 ,  A61P43/00 ,  A61K31/396 ,  A61K31/397 ,  A61K31/4025 ,  A61K31/416 ,  A61K31/4196 ,  A61K31/44 ,  A61K31/5383 ,  C07D487/04 ,  C07D491/04 ,  C07D491/048

Abstract: The invention provides novel compounds having the general formula I: wherein R1, R2, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds and methods of using the compounds.

公开(公告)号：US10988459B2

公开(公告)日：2021-04-27

申请号：US15200058

申请日：2016-07-01

Applicant: Genentech, Inc.

Inventor： Snahel Patel ,  Gregory Hamilton ,  Craig Stivala ,  Huifen Chen ,  Guiling Zhao

IPC: A61K31/551 ,  C07D487/04 ,  C07D403/12 ,  C07D413/12 ,  C07D471/04 ,  C07D498/04 ,  C07D495/04 ,  C07D491/04 ,  C07D491/10 ,  C07D413/14 ,  C07D491/044 ,  C07D491/048 ,  C07D491/052 ,  C07D519/00

Abstract: The invention provides novel compounds having the general formula I: wherein R1, X, Z1, L, n, the A ring, the B ring, and the C ring are as described herein, pharmaceutical compositions including the compounds and methods of using the compounds.