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公开(公告)号:US20160279261A1
公开(公告)日:2016-09-29
申请号:US15182429
申请日:2016-06-14
申请人: Ho Huat Lee , Moana Tercel , Genentech, Inc.
发明人: Ho Huat Lee , Moana Tercel , John A. Flygare , Janet Gunzner-Toste , Thomas H. Pillow , Brian Safina , Leanna Staben , Vishal Verma , BinQing Wei , Guiling Zhao
CPC分类号: C07K16/30 , A61K47/6803 , A61K47/6851 , A61K47/6889 , A61K2039/505 , C07K16/28 , C07K16/2851 , C07K16/2863 , C07K2317/24 , C07K2317/56 , C07K2317/76
摘要: This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof, to pharmaceutical compositions containing them, and to their use in therapy for the prevention or treatment of cancer.
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公开(公告)号:US10533058B2
公开(公告)日:2020-01-14
申请号:US15104388
申请日:2014-12-16
申请人: GENENTECH INC. , MEDIMMUNE LIMITED
发明人: John Flygare , Janet Gunzner-Toste , Thomas Pillow , Brian Safina , Vishal Verma , Binqing Wei , Guiling Zhao , Leanna Staben , Philip Wilson Howard , Luke Masterson
IPC分类号: A61K47/68 , A61K31/5517 , C07K16/30 , C07K16/28
摘要: This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof, pharmaceutical compositions containing them, and to their use in therapy for the prevention treatment of cancer.
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公开(公告)号:US20190083643A1
公开(公告)日:2019-03-21
申请号:US16150623
申请日:2018-10-03
申请人: Genentech, Inc.
发明人: Ho Huat Lee , Moana Tercel , John A. Flygare , Janet Gunzner-Toste , Thomas H. Pillow , Brian Safina , Leanna Staben , Vishal Verma , BinQing Wei , Guiling Zhao
摘要: This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof, to pharmaceutical compositions containing them, and to their use in therapy for the prevention or treatment of cancer.
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公开(公告)号:US10696692B2
公开(公告)日:2020-06-30
申请号:US14382141
申请日:2013-03-01
申请人: Forma TM, LLC , Genentech, Inc.
发明人: Kenneth W Bair , Timm R Baumeister , Alexandre J Buckmelter , Karl H Clodfelter , Peter Dragovich , Francis Gosselin , Janet Gunzner-Toste , Bingsong Han , Jian Lin , Xiongcai Liu , Dominic J Reynolds , Chase C Smith , Zhongguo Wang , Mark Zak , Yamin Zhang , Guiling Zhao , Xiaozhang Zheng , Po-Wai Yuen
IPC分类号: A61K51/00 , A61M36/14 , C07D519/00 , C07D471/04 , C07D495/04 , C07D487/04 , C07D491/048 , A61K31/454 , A61K31/4545 , A61K31/46 , A61K31/496 , A61K31/5025 , A61K31/5377 , A61K31/5386 , A61K31/551 , A61K45/06
摘要: The present invention relates to certain amido-benzyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.
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公开(公告)号:US20160279260A1
公开(公告)日:2016-09-29
申请号:US15181825
申请日:2016-06-14
申请人: Genentech, Inc.
发明人: John Flygare , Janet Gunzner-Toste , Thomas Pillow , Brian Safina , Vishal Verma , Binqing Wei , Guiling Zhao , Leanna Staben
CPC分类号: A61K47/6803 , A61K47/6809 , A61K47/6849 , A61K47/6851 , A61K47/6889 , C07K16/28 , C07K16/2851 , C07K16/30 , C07K2317/24 , C07K2317/56 , C07K2317/76
摘要: This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof, to pharmaceutical compositions containing them, and to their use in therapy for the prevention or treatment of cancer.
摘要翻译: 本发明涉及肽模拟接头及其抗体药物偶联物,含有它们的药物组合物及其在治疗中用于预防或治疗癌症的用途。
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公开(公告)号:US10124069B2
公开(公告)日:2018-11-13
申请号:US15182429
申请日:2016-06-14
申请人: Genentech, Inc.
发明人: Ho Huat Lee , Moana Tercel , John A. Flygare , Janet Gunzner-Toste , Thomas H. Pillow , Brian Safina , Leanna Staben , Vishal Verma , BinQing Wei , Guiling Zhao
摘要: This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof, to pharmaceutical compositions containing them, and to their use in therapy for the prevention or treatment of cancer.
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公开(公告)号:US09999681B2
公开(公告)日:2018-06-19
申请号:US15181825
申请日:2016-06-14
申请人: Genentech, Inc.
发明人: John Flygare , Janet Gunzner-Toste , Thomas Pillow , Brian Safina , Vishal Verma , Binqing Wei , Guiling Zhao , Leanna Staben
CPC分类号: A61K47/6803 , A61K47/6809 , A61K47/6849 , A61K47/6851 , A61K47/6889 , C07K16/28 , C07K16/2851 , C07K16/30 , C07K2317/24 , C07K2317/56 , C07K2317/76
摘要: This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof, to pharmaceutical compositions containing them, and to their use in therapy for the prevention or treatment of cancer.
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公开(公告)号:US20130096102A1
公开(公告)日:2013-04-18
申请号:US13712015
申请日:2012-12-12
申请人: Genentech, Inc.
发明人: Charles Baker-Glenn , Daniel Jon Burdick , Mark Chambers , Bryan K. Chan , Huifen Chen , Anthony Estrada , Janet Gunzner-Toste , Daniel Shore , Zachary Kevin Sweeney , Shumei Wang , Guiling Zhao
IPC分类号: C07D413/14 , C07D498/08 , C07D413/12
CPC分类号: C07D413/14 , C07D403/14 , C07D413/12 , C07D473/16 , C07D498/06 , C07D498/08
摘要: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n. X, R1, R2, R3, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.
摘要翻译: 式I化合物或其药学上可接受的盐,其中m,n。 X,R 1,R 2,R 3,R 5,R 6和R 7如本文所定义。 还公开了制备化合物和使用该化合物治疗与LRRK2受体(例如帕金森病)相关的疾病的方法。
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