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公开(公告)号：US20220396629A1
公开(公告)日：2022-12-15
申请号：US17825202
申请日：2022-05-26
Applicant: GENMAB A/S
Inventor： Paul PARREN , Janine Schuurman , Tom Vink , Willem Karel Bleeker , Jan Van De Winkel , Patrick Van Berkel , Frank Beurskens
IPC: C07K16/28
Abstract: The present invention provides monovalent antibodies with a long half-life when administered in vivo, methods of making such monovalent antibodies, pharmaceutical compositions comprising such antibodies, and uses of the monovalent antibodies.
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公开(公告)号：US11091553B2
公开(公告)日：2021-08-17
申请号：US15832337
申请日：2017-12-05
Applicant: GENMAB A/S
Inventor： Bart De Goeij , Simone De Haij , Thilo Riedl , Rene Hoet , Ole Baadsgaard , Jan Van De Winkel , David Satijn , Paul Parren , Aran Frank Labrijn , Joyce Meesters , Janine Schuurman , Edward N. Van Den Brink
Abstract: Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
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公开(公告)号：US10752695B2
公开(公告)日：2020-08-25
申请号：US15197496
申请日：2016-06-29
Applicant: GENMAB A/S
Inventor： Jan Van De Winkel , Tom Vink , Janine Schuurman , Paul Parren , Rob Aalberse , Marijn Van Der Neut Kolfschoten
IPC: C07K16/00 , C12P21/08 , C07K16/28 , A61K51/10 , A61K47/68 , C07K16/16 , C07K16/18 , C07K1/00 , A61K39/00
Abstract: The present invention relates to novel stabilized IgG4 antibodies, to methods of producing such antibodies and to uses of such antibodies as a medicament. In a main aspect, the invention relates to a stabilized IgG4 antibody, comprising a heavy chain and a light chain, wherein said heavy chain comprises a human IgG4 constant region having a substitution of the Arg residue at position (409), the Phe residue at position (405) or the Lys residue at position (370).
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公开(公告)号：US10703818B2
公开(公告)日：2020-07-07
申请号：US15420824
申请日：2017-01-31
Applicant: GENMAB A/S
Inventor： Janine Schuurman , Catharina Emanuele Gerarda Havenith , Paul Parren , Jan G. J. Van De Winkel , Denise Leah Williams , Jørgen Petersen , Ole Baadsgaard
IPC: C07K16/20 , C07K16/30 , C07K16/40 , C07K16/28 , G01N33/68 , A61K39/395 , A61K45/06 , A61N5/06 , C07K16/42 , C07K16/46 , G01N33/574 , G01N33/569 , A61K39/00
Abstract: Isolated human monoclonal antibodies which bind to and inhibit human CD25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a hybridoma, a transfectoma or in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals, hybridomas and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
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公开(公告)号：US10590206B2
公开(公告)日：2020-03-17
申请号：US14760157
申请日：2014-01-09
Applicant: GENMAB A/S
Inventor： Aran Frank Labrijn , Joyce Meesters , Joost J. Neijssen , Edward Norbert Van Den Brink , Janine Schuurman , Paul Parren
Abstract: Described herein are, proteins comprising amino acid substitutions in at least one of a first and a second polypeptide chain. Furthermore, is described the uses and methods related to said proteins.
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Patent Agency Ranking
公开(公告)号：US10344050B2
公开(公告)日：2019-07-09
申请号：US14353962
申请日：2012-10-26
Applicant: GENMAB A/S
Inventor： Michael Gramer , Amitava Kundu , Ewald T. J. Van Den Bremer , Muriel Van Kampen , Patrick Priem , Aran Frank Labrijn , Joyce I. Meesters , Joost J. Neijssen , Janine Schuurman , Paul Parren , Patrick Van Berkel , Werner L. Vos , Arnout Gerritsen
Abstract: The present invention relates to an in vitro method for production of heterodimeric proteins.
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公开(公告)号：US09598493B2
公开(公告)日：2017-03-21
申请号：US14592558
申请日：2015-01-08
Applicant: GENMAB A/S
Inventor： Janine Schuurman , Catharina Emanuele Gerarda Havenith , Paul Parren , Jan G. J. Van De Winkel , Denise Leah Williams , Jørgen Petersen , Ole Baadsgaard
IPC: C07K16/28 , G01N33/68 , A61K39/395 , A61K45/06 , A61N5/06 , C07K16/42 , C07K16/46 , G01N33/574 , A61K39/00
CPC classification number: C07K16/2866 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61N5/062 , C07K16/4258 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/56966 , G01N33/57492 , G01N33/6854 , G01N33/6869 , G01N2333/70596 , G01N2333/715 , G01N2333/7155
Abstract: Isolated human monoclonal antibodies which bind to and inhibit human CD25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a hybridoma, a transfectoma or in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals, hybridomas and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
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公开(公告)号：US20150368345A1
公开(公告)日：2015-12-24
申请号：US14739771
申请日：2015-06-15
Applicant: Genmab A/S
Inventor： Aran Frank Labrijn , Stefan Loverix , Paul Parren , Jan Van De Winkel , Janine Schuurman , Ignace Laster
IPC: C07K16/28
Abstract: The present invention relates to positions in the constant region of antibodies, in particular the CH3 region of lgG4, which affect the strength of CH3-CH3 interactions. Mutations that either stabilize or destabilize this interaction are disclosed.
Abstract translation: 本发明涉及抗体的恒定区，特别是1gG4的CH3区，其影响CH3-CH3相互作用强度的位置。 公开了稳定或不稳定这种相互作用的突变。
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公开(公告)号：US20130345406A1
公开(公告)日：2013-12-26
申请号：US13912581
申请日：2013-06-07
Applicant: Genmab A/S
Inventor： Jan Van De Winkel , Tom Vink , Janine Schuurman , Paul Parren , Rob Aalberse , Marijn Van Der Neut Kolfschoten
CPC classification number: C07K16/2887 , A61K47/6803 , A61K47/6813 , A61K47/6835 , A61K47/6839 , A61K47/6845 , A61K47/6849 , A61K51/10 , A61K51/1006 , A61K51/1021 , A61K51/1027 , A61K51/103 , A61K51/1039 , A61K2039/505 , C07K16/00 , C07K16/16 , C07K16/18 , C07K16/28 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/94
Abstract: The present invention relates to stabilized IgG4 antibodies, to methods of producing such antibodies and to uses of such antibodies as a medicament. In a main aspect, the invention relates to a stabilized IgG4 antibody, comprising a heavy chain and a light chain, wherein said heavy chain comprises a human IgG4 constant region having a substitution of the Arg residue at position (409), the Phe residue at position (405) or the Lys residue at position (370).
Abstract translation: 本发明涉及稳定的IgG4抗体，涉及产生此类抗体的方法以及此类抗体作为药物的用途。 在一个主要方面，本发明涉及一种稳定的IgG4抗体，其包含重链和轻链，其中所述重链包含具有在位置（409）处的Arg残基取代的人IgG4恒定区， 位置（405）或位置（370）处的Lys残基。
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公开(公告)号：US11866514B2
公开(公告)日：2024-01-09
申请号：US16777053
申请日：2020-01-30
Applicant: GENMAB A/S
Inventor： Aran Frank Labrijn , Joyce I. Meesters , Ewald T. J. Van Den Bremer , Joost J. Neijssen , Patrick Van Berkel , Bart De Goeij , Tom Vink , Jan Van De Winkel , Janine Schuurman , Paul Parren
CPC classification number: C07K16/468 , C07K16/1063 , C07K16/2809 , C07K16/2863 , C07K16/2887 , C07K16/32 , C07K16/40 , G01N33/6854 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94
Abstract: Novel heterodimeric antibody-Fc-containing proteins, such as bispecific antibodies, and novel methods for producing such proteins.
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