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公开(公告)号:US20120230980A1
公开(公告)日:2012-09-13
申请号:US13346604
申请日:2012-01-09
申请人: Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John Rudolph Desjarlais , Stephen Kohl Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
发明人: Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John Rudolph Desjarlais , Stephen Kohl Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
IPC分类号: C07K16/28 , C12N15/13 , C12N5/10 , A61P37/04 , C12N1/19 , C12P21/02 , A61K39/395 , C07K17/00 , C12N1/21
CPC分类号: C07K16/283 , A61K39/395 , A61K39/3955 , A61K39/39566 , A61K2039/505 , C07K16/00 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/2887 , C07K16/2893 , C07K16/2896 , C07K16/32 , C07K16/4291 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/51 , C07K2317/52 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/56 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12P21/005 , C40B30/02 , G06F19/12 , G06F19/16 , G06F19/22
摘要: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
摘要翻译: 本发明涉及优化的Fc变体,其产生方法,以及包含优化的Fc变体的抗体和Fc融合体。
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公开(公告)号:US20140370021A1
公开(公告)日:2014-12-18
申请号:US13918782
申请日:2013-06-14
申请人: Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John Desjarlais , Stephen K. Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
发明人: Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John Desjarlais , Stephen K. Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
IPC分类号: C07K16/32
CPC分类号: C07K16/2893 , C07K16/2887 , C07K2317/41 , C07K2317/52 , C07K2317/732
摘要: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
摘要翻译: 本发明涉及优化的Fc变体,其产生方法,以及包含优化的Fc变体的抗体和Fc融合体。
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公开(公告)号:US20090081208A1
公开(公告)日:2009-03-26
申请号:US11981596
申请日:2007-10-31
申请人: Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John Rudolph Desjarlais , Stephen Kohl Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
发明人: Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John Rudolph Desjarlais , Stephen Kohl Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
IPC分类号: A61K39/395 , C07K16/00 , A61P35/00 , A61P9/00 , A61P29/00
CPC分类号: C07K16/283 , A61K39/395 , A61K39/3955 , A61K39/39566 , A61K2039/505 , C07K16/00 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/2887 , C07K16/2893 , C07K16/2896 , C07K16/32 , C07K16/4291 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/51 , C07K2317/52 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/56 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12P21/005 , G16B5/00 , G16B15/00 , G16B30/00 , G16B35/00 , G16C20/60
摘要: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
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公开(公告)号:US20110021755A1
公开(公告)日:2011-01-27
申请号:US12896610
申请日:2010-10-01
申请人: Gregory Alan Lazar , Wei Dang , John R. Desjarlais , Sher Bahadur Karki , Omid Vafa , Robert Hayes , Jost Vielmetter
发明人: Gregory Alan Lazar , Wei Dang , John R. Desjarlais , Sher Bahadur Karki , Omid Vafa , Robert Hayes , Jost Vielmetter
IPC分类号: C07K16/00
CPC分类号: C07K16/2893 , A61K2039/505 , C07K16/00 , C07K16/18 , C07K16/2863 , C07K16/2887 , C07K16/2896 , C07K16/30 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/40 , C07K2317/41 , C07K2317/52 , C07K2317/56 , C07K2317/64 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92 , C07K2317/94
摘要: The present invention relates to Fc variants having decreased affinity for FcγRIIb, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
摘要翻译: 本发明涉及对FcγRIIb具有降低的亲和力的Fc变体,其产生方法,包含优化的Fc变体的Fc多肽,以及使用优化的Fc变体的方法。
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公开(公告)号:US20080154025A1
公开(公告)日:2008-06-26
申请号:US11841654
申请日:2007-08-20
申请人: Gregory Alan Lazar , Wei Dang , John R. Desjarlais , Sher Bahadur Karki , Omid Vafa , Robert Hayes
发明人: Gregory Alan Lazar , Wei Dang , John R. Desjarlais , Sher Bahadur Karki , Omid Vafa , Robert Hayes
IPC分类号: C07K14/00
CPC分类号: C07K16/2893 , A61K2039/505 , C07K16/00 , C07K16/18 , C07K16/2863 , C07K16/2887 , C07K16/2896 , C07K16/30 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/40 , C07K2317/41 , C07K2317/52 , C07K2317/56 , C07K2317/64 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92 , C07K2317/94
摘要: The present invention relates to Fc variants having increased affinity for FcγRIIc, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
摘要翻译: 本发明涉及对FcgammaRIIc具有增加的亲和力的Fc变体,其产生方法,包含优化的Fc变体的Fc多肽和使用优化的Fc变体的方法。
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公开(公告)号:US20080161541A1
公开(公告)日:2008-07-03
申请号:US11841843
申请日:2007-08-20
申请人: Gregory Alan Lazar , Wei Dang , John R. Desjarlais , Sher Bahadur Karki , Omid Vafa , Robert Hayes
发明人: Gregory Alan Lazar , Wei Dang , John R. Desjarlais , Sher Bahadur Karki , Omid Vafa , Robert Hayes
IPC分类号: C07K16/00
CPC分类号: C07K16/2893 , A61K2039/505 , C07K16/00 , C07K16/18 , C07K16/2863 , C07K16/2887 , C07K16/2896 , C07K16/30 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/40 , C07K2317/41 , C07K2317/52 , C07K2317/56 , C07K2317/64 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92 , C07K2317/94
摘要: The present invention relates to Fc variants having increased affinity for FcγRIIc, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
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公开(公告)号:US08388955B2
公开(公告)日:2013-03-05
申请号:US11764001
申请日:2007-06-15
申请人: Gregory Alan Lazar , Wei Dang , John R. Desjarlais , Sher Bahadur Karki , Omid Vafa , Robert Hayes , Jost Vielmetter
发明人: Gregory Alan Lazar , Wei Dang , John R. Desjarlais , Sher Bahadur Karki , Omid Vafa , Robert Hayes , Jost Vielmetter
IPC分类号: A61K39/40 , A61K39/395 , C07K16/00
CPC分类号: C07K16/18 , A61K2039/505 , C07K16/2863 , C07K16/2887 , C07K16/2893 , C07K16/32 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/52 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77
摘要: The present invention relates to Fc variants having increased affinity for FcγRIIb, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
摘要翻译: 本发明涉及对FcγRIIb具有增加的亲和力的Fc变体,其产生方法,包含优化的Fc变体的Fc多肽和使用优化的Fc变体的方法。
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公开(公告)号:US08937158B2
公开(公告)日:2015-01-20
申请号:US11841654
申请日:2007-08-20
申请人: Gregory Alan Lazar , Wei Dang , John R. Desjarlais , Sher Bahadur Karki , Omid Vafa , Robert Hayes
发明人: Gregory Alan Lazar , Wei Dang , John R. Desjarlais , Sher Bahadur Karki , Omid Vafa , Robert Hayes
CPC分类号: C07K16/2893 , A61K2039/505 , C07K16/00 , C07K16/18 , C07K16/2863 , C07K16/2887 , C07K16/2896 , C07K16/30 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/40 , C07K2317/41 , C07K2317/52 , C07K2317/56 , C07K2317/64 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92 , C07K2317/94
摘要: The present invention relates to Fc variants having increased affinity for FcγRIIc, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
摘要翻译: 本发明涉及对FcγRIIc具有增加的亲和力的Fc变体,其产生方法,包含优化的Fc变体的Fc多肽和使用优化的Fc变体的方法。
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公开(公告)号:US08188231B2
公开(公告)日:2012-05-29
申请号:US11124620
申请日:2005-05-05
申请人: Gregory Alan Lazar , Wei Dang , John R. Desjarlais , Sher Bahadur Karki , Omid Vafa , Robert Hayes , Jost Vielmetter
发明人: Gregory Alan Lazar , Wei Dang , John R. Desjarlais , Sher Bahadur Karki , Omid Vafa , Robert Hayes , Jost Vielmetter
IPC分类号: C07K16/00 , C12P21/08 , A61K39/395 , A61K39/40 , C07K1/00
CPC分类号: C07K16/2893 , C07K2317/34 , C07K2317/52 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要: The present invention relates to optimized Fc variants, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
摘要翻译: 本发明涉及优化的Fc变体,其生成方法,包含优化的Fc变体的Fc多肽和使用优化的Fc变体的方法。
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公开(公告)号:US20090215991A1
公开(公告)日:2009-08-27
申请号:US11841755
申请日:2007-08-20
申请人: Gregory Alan Lazar , Wei Dang , John R. Desjarlais , Sher Bahadur Karki , Omid Vafa , Robert Hayes
发明人: Gregory Alan Lazar , Wei Dang , John R. Desjarlais , Sher Bahadur Karki , Omid Vafa , Robert Hayes
IPC分类号: C07K16/00
CPC分类号: C07K16/2893 , A61K2039/505 , C07K16/00 , C07K16/18 , C07K16/2863 , C07K16/2887 , C07K16/2896 , C07K16/30 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/40 , C07K2317/41 , C07K2317/52 , C07K2317/56 , C07K2317/64 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92 , C07K2317/94
摘要: The present invention relates to Fc variants having increased affinity for FcγRIIc, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
摘要翻译: 本发明涉及对FcgammaRIIc具有增加的亲和力的Fc变体,其产生方法,包含优化的Fc变体的Fc多肽和使用优化的Fc变体的方法。
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