公开(公告)号：US20230332206A1

公开(公告)日：2023-10-19

申请号：US18061898

申请日：2022-12-05

Applicant: GUARDANT HEALTH, INC.

Inventor： Andrew KENNEDY ,  Stefanie Ann Ward MORTIMER ,  Helmy ELTOUKHY ,  AmirAli TALASAZ ,  DIANA ABDUEVA

IPC: C12Q1/6806 ,  C12N15/10 ,  C12Q1/6874 ,  C12Q1/6886

CPC classification number: C12Q1/6806 ,  C12N15/1065 ,  C12Q1/6874 ,  C12Q1/6886 ,  C12Q2600/154

Abstract: The disclosure provides methods for processing nucleic acid populations containing different forms (e.g., RNA and DNA, single-stranded or double-stranded) and/or extents of modification (e.g., cytosine methylation, association with proteins). These methods accommodate multiple forms and/or modifications of nucleic acid in a sample, such that sequence information can be obtained for multiple forms. The methods also preserve the identity of multiple forms or modified states through processing and analysis, such that analysis of sequence can be combined with epigenetic analysis.

公开(公告)号：US20230197284A1

公开(公告)日：2023-06-22

申请号：US18173361

申请日：2023-02-23

Applicant: GUARDANT HEALTH, INC.

Inventor： Helmy ELTOUKHY ,  AmirAli TALASAZ

IPC: G16H50/30 ,  G16B40/00 ,  G16B20/00 ,  C12Q1/6886 ,  G16H50/20 ,  G16B20/10 ,  G16B20/20

CPC classification number: G16H50/30 ,  G16B40/00 ,  G16B20/00 ,  C12Q1/6886 ,  G16H50/20 ,  G16B20/10 ,  G16B20/20 ,  C12Q2535/122 ,  C12Q2600/156

Abstract: The present disclosure provides methods for determining a probability that after any of a number of therapeutic interventions, an initial state of a subject, such as somatic cell mutational status of a subject with cancer, will develop a subsequent state. Such probabilities can be used to inform a health care provider as to particular courses of treatment to maximize probability of a desired outcome for the subject.

公开(公告)号：US20220359085A1

公开(公告)日：2022-11-10

申请号：US17814768

申请日：2022-07-25

Applicant: GUARDANT HEALTH, INC.

Inventor： Helmy ELTOUKHY ,  AmirAli TALASAZ

IPC: G16H50/30 ,  G16B40/00 ,  G16B20/00 ,  C12Q1/6886 ,  G16H50/20 ,  G16B20/10 ,  G16B20/20

Abstract: The present disclosure provides methods for determining a probability that after any of a number of therapeutic interventions, an initial state of a subject, such as somatic cell mutational status of a subject with cancer, will develop a subsequent state. Such probabilities can be used to inform a health care provider as to particular courses of treatment to maximize probability of a desired outcome for the subject.

公开(公告)号：US20220170082A9

公开(公告)日：2022-06-02

申请号：US16711892

申请日：2019-12-12

Applicant: GUARDANT HEALTH, INC.

Inventor： AmirAli TALASAZ ,  Stefanie Ann Ward MORTIMER

IPC: C12Q1/6827 ,  C12Q1/6806 ,  G16B30/00

Abstract: The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. The systems and methods also may contain a database or collection of different rare mutations or copy number variation profiles of different diseases, to be used as additional references in aiding detection of rare mutations, copy number variation profiling or general genetic profiling of a disease.

公开(公告)号：US20200299756A1

公开(公告)日：2020-09-24

申请号：US16870476

申请日：2020-05-08

Applicant: GUARDANT HEALTH, INC.

Inventor： AmirAli TALASAZ ,  Stefanie Ann Ward MORTIMER

IPC: C12Q1/6827 ,  C12Q1/6806 ,  G16B30/00

Abstract: The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. The systems and methods also may contain a database or collection of different rare mutations or copy number variation profiles of different diseases, to be used as additional references in aiding detection of rare mutations, copy number variation profiling or general genetic profiling of a disease.

公开(公告)号：US20190185940A1

公开(公告)日：2019-06-20

申请号：US16283629

申请日：2019-02-22

Applicant: GUARDANT HEALTH, INC.

Inventor： AmirAli TALASAZ

IPC: C12Q1/6886 ,  G16B30/00 ,  C12Q1/6806 ,  C12Q1/6874 ,  C12N15/10 ,  C12Q1/6869

CPC classification number: C12Q1/6886 ,  C12N15/1065 ,  C12Q1/6806 ,  C12Q1/6869 ,  C12Q1/6874 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  G16B30/00 ,  C12Q2537/165 ,  C12Q2545/114

Abstract: The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. The systems and methods also may contain a database or collection of different rare mutations or copy number variation profiles of different diseases, to be used as additional references in aiding detection of rare mutations, copy number variation profiling or general genetic profiling of a disease.

公开(公告)号：US20170218460A1

公开(公告)日：2017-08-03

申请号：US15492659

申请日：2017-04-20

Applicant: Guardant Health, Inc.

Inventor： AmirAli TALASAZ

IPC: C12Q1/68 ,  G06F19/22

CPC classification number: C12Q1/6886 ,  C12N15/1065 ,  C12Q1/6806 ,  C12Q1/6869 ,  C12Q1/6874 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  G06F19/22 ,  C12Q2537/165 ,  C12Q2545/114

Abstract: The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. The systems and methods also may contain a database or collection of different rare mutations or copy number variation profiles of different diseases, to be used as additional references in aiding detection of rare mutations, copy number variation profiling or general genetic profiling of a disease.

公开(公告)号：US20170218459A1

公开(公告)日：2017-08-03

申请号：US15467570

申请日：2017-03-23

Applicant: Guardant Health, Inc.

Inventor： AmirAli TALASAZ ,  Helmy ELTOUKHY

IPC: C12Q1/68 ,  G06F19/22

CPC classification number: C12Q1/6886 ,  C12N15/1065 ,  C12Q1/6806 ,  C12Q1/6869 ,  C12Q1/6874 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  G06F19/22 ,  C12Q2537/165 ,  C12Q2545/114

Abstract: The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. The systems and methods also may contain a database or collection of different rare mutations or copy number variation profiles of different diseases, to be used as additional references in aiding detection of rare mutations, copy number variation profiling or general genetic profiling of a disease.

公开(公告)号：US20250051858A1

公开(公告)日：2025-02-13

申请号：US18930072

申请日：2024-10-29

Applicant: GUARDANT HEALTH, INC.

Inventor： AmirAli TALASAZ

IPC: C12Q1/6886 ,  C12N15/10 ,  C12Q1/6806 ,  C12Q1/6869 ,  C12Q1/6874 ,  G16B30/00 ,  G16B30/10

Abstract: The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. The systems and methods also may contain a database or collection of different rare mutations or copy number variation profiles of different diseases, to be used as additional references in aiding detection of rare mutations, copy number variation profiling or general genetic profiling of a disease.

公开(公告)号：US20240263246A1

公开(公告)日：2024-08-08

申请号：US18620056

申请日：2024-03-28

Applicant: GUARDANT HEALTH, INC.

Inventor： Stefanie Ann Ward MORTIMER ,  AmirAli TALASAZ ,  Darya CHUDOVA ,  Helmy ELTOUKHY

IPC: C12Q1/6886 ,  C12M1/00 ,  C12M1/34 ,  C12Q1/6806 ,  C12Q1/6855 ,  C12Q1/6869 ,  G01N33/574 ,  G16B20/20 ,  G16B30/10 ,  G16H50/20 ,  G16H50/30

CPC classification number: C12Q1/6886 ,  C12M1/00 ,  C12M1/34 ,  C12Q1/6806 ,  C12Q1/6855 ,  C12Q1/6869 ,  G01N33/57407 ,  G16B20/20 ,  G16B30/10 ,  G16H50/20 ,  G16H50/30 ,  C12Q2600/118 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/166

Abstract: Disclosed herein are methods, compositions, and devices for use in the early detection of cancer. The methods include preparing cell-free nucleic acid molecules from a subject for sequencing, sequencing a panel of regions in the cell-free nucleic acid molecules, and detecting one or more markers that are indicative of a cancer.