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公开(公告)号：US20240087680A1
公开(公告)日：2024-03-14
申请号：US18503392
申请日：2023-11-07
IPC分类号： G16B30/00 , C12Q1/6806 , C12Q1/6827 , G16B5/00 , G16B25/10 , G16B40/30
CPC分类号： G16B30/00 , C12Q1/6806 , C12Q1/6827 , G16B5/00 , G16B25/10 , G16B40/30 , C12Q2535/122 , C12Q2537/159
摘要： The present disclosure provides a method for enriching for multiple genomic regions using a first bait set that selectively hybridizes to a first set of genomic regions of a nucleic acid sample and a second bait set that selectively hybridizes to a second set of genomic regions of the nucleic acid sample. These bait set panels can selectively enrich for one or more nucleosome-associated regions of a genome, said nucleosome-associated regions comprising genomic regions having one or more genomic base positions with differential nucleosomal occupancy, wherein the differential nucleosomal occupancy is characteristic of a cell or tissue type of origin or disease state.
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公开(公告)号：US20240087681A1
公开(公告)日：2024-03-14
申请号：US18506734
申请日：2023-11-10
IPC分类号： G16B30/00 , C12Q1/6806 , C12Q1/6827 , G16B5/00 , G16B25/10 , G16B40/30
CPC分类号： G16B30/00 , C12Q1/6806 , C12Q1/6827 , G16B5/00 , G16B25/10 , G16B40/30 , C12Q2535/122 , C12Q2537/159
摘要： The present disclosure provides a method for enriching for multiple genomic regions using a first bait set that selectively hybridizes to a first set of genomic regions of a nucleic acid sample and a second bait set that selectively hybridizes to a second set of genomic regions of the nucleic acid sample. These bait set panels can selectively enrich for one or more nucleosome-associated regions of a genome, said nucleosome-associated regions comprising genomic regions having one or more genomic base positions with differential nucleosomal occupancy, wherein the differential nucleosomal occupancy is characteristic of a cell or tissue type of origin or disease state.
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公开(公告)号：US20190352695A1
公开(公告)日：2019-11-21
申请号：US16244966
申请日：2019-01-10
发明人： DIANA ABDUEVA
摘要： The present disclosure contemplates various uses of cell-free DNA. Methods provided herein may use sequence information in a macroscale and global manner, with or without somatic variant information, to assess a fragmentome profile that can be representative of a tissue of origin, disease, progression, etc. In an aspect, disclosed herein is a method for determining a presence or absence of a genetic aberration in deoxyribonucleic acid (DNA) fragments from cell-free DNA obtained from a subject, the method comprising: (a) constructing a multi-parametric distribution of the DNA fragments over a plurality of base positions in a genome; and (b) without taking into account a base identity of each base position in a first locus, using the multi-parametric distribution to determine the presence or absence of the genetic aberration in the first locus in the subject
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公开(公告)号：US20230332206A1
公开(公告)日：2023-10-19
申请号：US18061898
申请日：2022-12-05
IPC分类号： C12Q1/6806 , C12N15/10 , C12Q1/6874 , C12Q1/6886
CPC分类号： C12Q1/6806 , C12N15/1065 , C12Q1/6874 , C12Q1/6886 , C12Q2600/154
摘要： The disclosure provides methods for processing nucleic acid populations containing different forms (e.g., RNA and DNA, single-stranded or double-stranded) and/or extents of modification (e.g., cytosine methylation, association with proteins). These methods accommodate multiple forms and/or modifications of nucleic acid in a sample, such that sequence information can be obtained for multiple forms. The methods also preserve the identity of multiple forms or modified states through processing and analysis, such that analysis of sequence can be combined with epigenetic analysis.
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公开(公告)号：US20230253071A1
公开(公告)日：2023-08-10
申请号：US18055298
申请日：2022-11-14
IPC分类号： G16B30/00 , G16B5/00 , G16B40/30 , C12Q1/6806 , G16B25/10
CPC分类号： G16B30/00 , G16B5/00 , G16B40/30 , C12Q1/6806 , G16B25/10 , C12Q2537/159 , C12Q2535/122
摘要： The present disclosure provides a method for enriching for multiple genomic regions using a first bait set that selectively hybridizes to a first set of genomic regions of a nucleic acid sample and a second bait set that selectively hybridizes to a second set of genomic regions of the nucleic acid sample. These bait set panels can selectively enrich for one or more nucleosome-associated regions of a genome, said nucleosome-associated regions comprising genomic regions having one or more genomic base positions with differential nucleosomal occupancy, wherein the differential nucleosomal occupancy is characteristic of a cell or tissue type of origin or disease state.
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公开(公告)号：US20240279714A1
公开(公告)日：2024-08-22
申请号：US18625882
申请日：2024-04-03
IPC分类号： C12Q1/6806 , C12N15/10 , C12Q1/6874 , C12Q1/6886
CPC分类号： C12Q1/6806 , C12N15/1065 , C12Q1/6874 , C12Q1/6886 , C12Q2600/154
摘要： The disclosure provides methods for processing nucleic acid populations containing different forms (e.g., RNA and DNA, single-stranded or double-stranded) and/or extents of modification (e.g., cytosine methylation, association with proteins). These methods accommodate multiple forms and/or modifications of nucleic acid in a sample, such that sequence information can be obtained for multiple forms. The methods also preserve the identity of multiple forms or modified states through processing and analysis, such that analysis of sequence can be combined with epigenetic analysis.
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公开(公告)号：US20230260596A1
公开(公告)日：2023-08-17
申请号：US18155523
申请日：2023-01-17
IPC分类号： G16B30/00 , G16B5/00 , G16B40/30 , G16B25/10 , C12Q1/6806
CPC分类号： G16B30/00 , G16B5/00 , G16B40/30 , G16B25/10 , C12Q1/6806 , C12Q2537/159 , C12Q2535/122
摘要： The present disclosure provides a method for enriching for multiple genomic regions using a first bait set that selectively hybridizes to a first set of genomic regions of a nucleic acid sample and a second bait set that selectively hybridizes to a second set of genomic regions of the nucleic acid sample. These bait set panels can selectively enrich for one or more nucleosome-associated regions of a genome, said nucleosome-associated regions comprising genomic regions having one or more genomic base positions with differential nucleosomal occupancy, wherein the differential nucleosomal occupancy is characteristic of a cell or tissue type of origin or disease state.
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公开(公告)号：US20190287645A1
公开(公告)日：2019-09-19
申请号：US16315573
申请日：2017-07-06
发明人： DIANA ABDUEVA
摘要： The present disclosure contemplates various uses of cell-free DNA. Methods provided herein may use sequence information in a macroscale and global manner, with or without somatic variant information, to assess a fragmentome profile that can be representative of a tissue of origin, disease, progression, etc. In an aspect, disclosed herein is a method for determining a presence or absence of a genetic aberration in deoxyribonucleic acid (DNA) fragments from cell-free DNA obtained from a subject, the method comprising: (a) constructing a multi-parametric distribution of the DNA fragments over a plurality of base positions in a genome; and (b) without taking into account a base identity of each base position in a first locus, using the multi-parametric distribution to determine the presence or absence of the genetic aberration in the first locus in the subject.
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