公开(公告)号：US20110137244A1

公开(公告)日：2011-06-09

申请号：US12963621

申请日：2010-12-08

申请人： Heejin Lee ,  Karen Daniel ,  Grace Kim ,  Cheryl Larrivee-Elkins ,  Michael J. Cima

发明人： Heejin Lee ,  Karen Daniel ,  Grace Kim ,  Cheryl Larrivee-Elkins ,  Michael J. Cima

IPC分类号： A61M29/00 ,  A61L31/16 ,  A61F2/12

CPC分类号： A61L31/16 ,  A61B90/02 ,  A61F2/12 ,  A61L31/10 ,  A61L2300/402 ,  A61L2430/04 ,  A61M2025/105 ,  C08L83/04

摘要： A device includes a tissue expanding portion and an enclosure positioned on a surface of the tissue expanding portion. The enclosure includes an enclosure wall and a drug formulation pocket defined by the enclosure wall. A solid drug formulation that includes a drug is housed within the drug formulation pocket

摘要翻译： 一种装置包括组织扩张部分和位于组织扩张部分的表面上的外壳。 外壳包括外壳壁和由外壳壁限定的药物制剂口袋。 包含药物的固体药物制剂容纳在药物制剂口袋内

公开(公告)号：US09586035B2

公开(公告)日：2017-03-07

申请号：US12333182

申请日：2008-12-11

申请人： Michael J. Cima ,  Heejin Lee

发明人： Michael J. Cima ,  Heejin Lee

IPC分类号： A61M31/00 ,  A61K9/00 ,  A61K31/167

CPC分类号： A61M25/0102 ,  A61F2250/0068 ,  A61K9/0024 ,  A61K9/0034 ,  A61K31/167 ,  A61M25/0108 ,  A61M31/002 ,  A61M2205/0216 ,  A61M2210/1085

摘要： An implantable medical device is provided for controlled drug delivery within the bladder, or other body vesicle. The device may include at least one drug reservoir component comprising a drug; and a vesicle retention frame which comprises an elastic wire having a first end, an opposing second end, and an intermediate region therebetween, wherein the drug reservoir component is attached to the intermediate region of the vesicle retention frame. The retention frame prevents accidental voiding of the device from the bladder, and it preferably has a spring constant selected for the device to effectively stay in the bladder during urination while minimizing the irritation of the bladder.

摘要翻译： 提供可植入的医疗装置用于膀胱或其他体内囊泡内的受控药物输送。 该装置可以包括至少一个包含药物的药物储存器部件; 以及囊泡保持框架，其包括具有第一端，相对的第二端和在其间的中间区域的弹性线，其中所述药物储存部件附接到所述囊泡保持框架的中间区域。 保持框架防止装置从膀胱意外排空，并且其优选地具有选择用于装置的弹簧常数，以在排尿期间有效地停留在膀胱中，同时使膀胱的刺激最小化。

公开(公告)号：US20110202036A1

公开(公告)日：2011-08-18

申请号：US12879638

申请日：2010-09-10

申请人： Jim Boyko ,  Grace Kim ,  Heejin Lee ,  Michael J. Cima ,  Jennie Kwo

发明人： Jim Boyko ,  Grace Kim ,  Heejin Lee ,  Michael J. Cima ,  Jennie Kwo

IPC分类号： A61M31/00 ,  A61M25/00 ,  A61M5/32

CPC分类号： A61L29/16 ,  A61M25/007 ,  A61M25/0662 ,  A61M31/002 ,  A61M31/007 ,  A61M2210/1085

摘要： A method delivers an implantable device through the urethra and into the bladder. A deployment instrument is inserted into the urethra, the implantable device is inserted into the deployment instrument, and a stream of fluid is injected into the deployment instrument. The stream of fluid drives the implantable device from the deployment instrument into the bladder. The deployment instrument is removed from the urethra, leaving the implantable device wholly implanted in the bladder.

摘要翻译： 一种方法通过尿道递送可植入装置并进入膀胱。 将部署仪器插入到尿道中，将可植入装置插入到展开仪器中，并将流体流注入到展开仪器中。 流体流将可植入装置从展开器械驱动到膀胱中。 将部署仪器从尿道中取出，将可植入装置完全植入膀胱。

公开(公告)号：US20110060309A1

公开(公告)日：2011-03-10

申请号：US12851494

申请日：2010-08-05

申请人： Heejin Lee ,  Michael J. Cima ,  Karen Daniel ,  Cheryl Larrivee-Elkins

发明人： Heejin Lee ,  Michael J. Cima ,  Karen Daniel ,  Cheryl Larrivee-Elkins

IPC分类号： A61M25/00 ,  A61F2/00 ,  A61K31/16

CPC分类号： A61K9/0092 ,  A61K9/0004 ,  A61K9/0034 ,  A61K31/167 ,  A61M31/002

摘要： Implantable devices and methods for delivery of lidocaine or other drugs to a patient are provided. In one embodiment, the device includes a first drug portion which has a first drug housing which contains a first drug formulation in a solid form which includes a pharmaceutically acceptable salt of lidocaine; and a second drug portion which includes a second drug housing which contains a second drug formulation which includes lidocaine base. In another embodiment, the device includes a drug reservoir component which has an elastic tube having at least one lumen bounded by a porous sidewall having an open-cell structure, a closed-cell structure, or a combination thereof; and a drug formulation contained within the at least one lumen, wherein the device is deformable between a low-profile deployment shape and a relatively expanded retention shape.

摘要翻译： 提供了用于将利多卡因或其他药物递送给患者的可植入装置和方法。 在一个实施方案中，该装置包括第一药物部分，其具有第一药物外壳，其包含固体形式的第一药物制剂，其包含利多卡因的药学上可接受的盐; 和第二药物部分，其包括含有包含利多卡因碱的第二药物制剂的第二药物外壳。 在另一个实施方案中，该装置包括药物储存器部件，该药物储存器部件具有弹性管，该弹性管具有由具有开孔结构，闭孔结构或其组合的多孔侧壁限定的至少一个内腔; 以及包含在所述至少一个内腔内的药物制剂，其中所述装置可在低轮廓展开形状和相对扩张的保留形状之间变形。

公开(公告)号：US20100331770A1

公开(公告)日：2010-12-30

申请号：US12825215

申请日：2010-06-28

申请人： Heejin Lee ,  Cheryl Larrivee-Elkins

发明人： Heejin Lee ,  Cheryl Larrivee-Elkins

IPC分类号： A61M31/00 ,  B65D83/04

CPC分类号： A61K9/0004 ,  A61K9/0034 ,  A61K9/2004 ,  A61K9/2027 ,  A61K9/2031 ,  A61K9/2072 ,  A61K9/2095 ,  A61K31/16 ,  A61K31/165 ,  A61K31/167 ,  A61M31/002 ,  A61M31/007 ,  A61M2202/06 ,  B65B1/16

摘要： A drug delivery device is provided that includes a device body, a number of solid, compressed drug tablets, and a retention frame. The device body includes a drug reservoir lumen and a retention frame lumen. The number of solid, compressed drug tablets are positioned in the drug reservoir lumen, and the retention frame is positioned in the retention frame lumen. The drug tablets may be mini-tablets aligned in the drug reservoir lumen, with an interstice formed between any two adjacent drug tablets facilitating deformation of the device body. Systems and method are also provided for loading a drug delivery device. In one embodiment, the method includes positioning one or more solid drug units upstream of the drug delivery device; and driving the drug units into the drug delivery device with a flow of pressurized gas.

摘要翻译： 提供了一种药物递送装置，其包括装置主体，多个固体，压缩药片和保留框架。 装置主体包括药物储存器腔和保持框架内腔。 固体压缩药片的数量位于药物储存器腔中，并且保持框架位于保持框架腔中。 药物片剂可以是在药物储存器腔中排列的微型药片，在任何两个相邻的药物片剂之间形成有促进器官体变形的间隙。 还提供了用于装载药物递送装置的系统和方法。 在一个实施方案中，该方法包括将药物递送装置上游的一个或多个固体药物单元定位; 并用加压气体流将药物单元驱入药物输送装置。

公开(公告)号：US20100330149A1

公开(公告)日：2010-12-30

申请号：US12825238

申请日：2010-06-28

申请人： Karen Danielle Daniel ,  Burleigh M. Hutchins, III ,  Cheryl Larrivee-Elkins ,  Heejin Lee

发明人： Karen Danielle Daniel ,  Burleigh M. Hutchins, III ,  Cheryl Larrivee-Elkins ,  Heejin Lee

IPC分类号： A61K31/167 ,  A61K9/00 ,  A61P13/10

CPC分类号： A61K9/0004 ,  A61K9/0034 ,  A61K9/2004 ,  A61K9/2027 ,  A61K9/2031 ,  A61K9/2072 ,  A61K9/2095 ,  A61K31/16 ,  A61K31/165 ,  A61K31/167 ,  A61M31/002 ,  A61M31/007 ,  A61M2202/06 ,  B65B1/16

摘要： A drug dosage form is provided in the form of a solid tablet which is greater than 50% by weight the local anesthetic agent. The local anesthetic agent may be selected from the group consisting of an aminoamide, an aminoester, and a combination thereof. The drug tablet may be in the form of a mini-tablet which is greater than 70 wt % drug, with the balance being excipient. For example, the anesethetic agent may include lidocaine, in a salt or base form, combined with binder and lubricant excipients. Implantable drug delivery devices including the tablets are also provided, e.g., one or more of the drug tablets may be contained in a biocompatible housing. The drug tablets may be substantially cylindrical with flat end faces, and the device may have from 10 to 100 drug tablets aligned in the housing with the flat end faces of adjacent tablets abutting one another.

摘要翻译： 以固体片剂的形式提供药物剂型，其大于当量麻醉剂的50重量％。 局部麻醉剂可以选自氨基酰胺，氨基酯及其组合。 药片可以是大于70重量％的药物的微型片剂，其余为赋形剂。 例如，麻醉剂可以包括盐或碱形式的利多卡因，与粘合剂和润滑剂赋形剂组合。 还提供了包括片剂在内的可植入药物递送装置，例如药物片剂中的一种或多种可以包含在生物相容的壳体中。 药物片剂可以是具有平坦端面的大致圆柱形，并且该装置可以具有在壳体中对齐的10至100个药物片剂，相邻片剂的平坦端面彼此邻接。

公开(公告)号：US20090149833A1

公开(公告)日：2009-06-11

申请号：US12333182

申请日：2008-12-11

申请人： Michael J. Cima ,  Heejin Lee

发明人： Michael J. Cima ,  Heejin Lee

IPC分类号： A61M25/00 ,  A61K31/167

CPC分类号： A61M25/0102 ,  A61F2250/0068 ,  A61K9/0024 ,  A61K9/0034 ,  A61K31/167 ,  A61M25/0108 ,  A61M31/002 ,  A61M2205/0216 ,  A61M2210/1085

摘要： An implantable medical device is provided for controlled drug delivery within the bladder, or other body vesicle. The device may include at least one drug reservoir component comprising a drug; and a vesicle retention frame which comprises an elastic wire having a first end, an opposing second end, and an intermediate region therebetween, wherein the drug reservoir component is attached to the intermediate region of the vesicle retention frame. The retention frame prevents accidental voiding of the device from the bladder, and it preferably has a spring constant selected for the device to effectively stay in the bladder during urination while minimizing the irritation of the bladder.

摘要翻译： 提供可植入的医疗装置用于膀胱或其他体内囊泡内的受控药物输送。 该装置可以包括至少一个包含药物的药物储存器部件; 以及囊泡保持框架，其包括具有第一端，相对的第二端和在其间的中间区域的弹性线，其中所述药物储存部件附接到所述囊泡保持框架的中间区域。 保持框架防止装置从膀胱意外排空，并且其优选地具有选择用于装置的弹簧常数，以在排尿期间有效地停留在膀胱中，同时使膀胱的刺激最小化。

公开(公告)号：US20070202151A1

公开(公告)日：2007-08-30

申请号：US11463956

申请日：2006-08-11

申请人： Heejin Lee ,  Karen Daniel ,  Hong Ho Duc ,  Michael Cima ,  Mario Casillo-Ortiz ,  Steven Floelich ,  Jordan Dimitrakov

发明人： Heejin Lee ,  Karen Daniel ,  Hong Ho Duc ,  Michael Cima ,  Mario Casillo-Ortiz ,  Steven Floelich ,  Jordan Dimitrakov

IPC分类号： A61F2/02

CPC分类号： A61M31/002 ,  A61K9/0034 ,  A61L29/06 ,  A61L29/16 ,  A61L2300/402 ,  A61L2300/406 ,  A61L2300/45 ,  A61L2300/63 ,  A61M2202/06 ,  A61M2205/0216 ,  A61M2210/1085 ,  C08L83/04

摘要： Implant devices for intravesical administration and local drug delivery. The device has a body which includes a hollow tube formed of a biocompatible material; at least one reservoir in the tube which contains a drug; and one or more apertures through which the drug can be released. The device is configured for minimally invasive insertion into a body cavity, such as the bladder. The hollow tube may be elastomeric to permit the device to be elastically deformed from its initial shape into an elongated shape for passage through a catheter, where following such passage the device can return to or toward its initial shape to facilitate retention of the device in the body cavity. The body may have a narrow, elongated shape effective to permit insertion of the drug delivery device through a catheter without necessarily deforming the body, yet include flexible projections which effect retention within the body cavity.

摘要翻译： 用于膀胱内给药和局部药物输送的植入装置。 该装置具有包括由生物相容性材料形成的中空管的主体; 管中含有药物的至少一个储存器; 以及可以释放药物的一个或多个孔。 该装置构造成用于微创地插入诸如膀胱的体腔中。 中空管可以是弹性的，以允许该装置从其初始形状弹性变形成细长形状以便通过导管，其中随后通过该装置可以返回或朝向其初始形状，以便于将装置保持在 体腔。 身体可以具有有效的狭窄的细长形状，以允许药物递送装置通过导管插入，而不必使身体变形，而包括有效地保持在体腔内的弹性突起。

公开(公告)号：US06617554B2

公开(公告)日：2003-09-09

申请号：US09966805

申请日：2001-09-28

申请人： Jung S. Moon ,  Heejin Lee ,  Rong Liu ,  Kitak Chae

发明人： Jung S. Moon ,  Heejin Lee ,  Rong Liu ,  Kitak Chae

IPC分类号： H05B102

CPC分类号： A47J37/0623 ,  A47J37/0635 ,  A47J37/0641

摘要： A counter-top electric oven includes a base, an oven housing supported on the base, and a power head detachably connected to the oven housing. The power head includes a heating unit for generating and directing heat into the oven housing. At least one handle is formed on the power head, and a power interrupting device is operatively provided in the handle for disconnecting power to the power head. The power interrupting device is activated when the handle is grasped by a user.

摘要翻译： 台面电烤箱包括底座，支撑在基座上的烤箱壳体和可拆卸地连接到烤箱壳体的动力头。 动力头包括用于产生和引导热量进入烤箱壳体的加热单元。 在动力头上形成至少一个手柄，并且在手柄中可操作地设置动力中断装置，以断开动力头的动力。 当手柄被用户抓住时，电源中断装置被激活。

公开(公告)号：US10543166B2

公开(公告)日：2020-01-28

申请号：US12825215

申请日：2010-06-28

申请人： Heejin Lee ,  Cheryl Larrivee-Elkins

发明人： Heejin Lee ,  Cheryl Larrivee-Elkins

IPC分类号： A61K9/00 ,  A61K9/20 ,  A61K31/167 ,  A61M31/00 ,  A61K31/165 ,  B65B1/16 ,  A61K31/16

摘要： A drug delivery device is provided that includes a device body, a number of solid, compressed drug tablets, and a retention frame. The device body includes a drug reservoir lumen and a retention frame lumen. The number of solid, compressed drug tablets are positioned in the drug reservoir lumen, and the retention frame is positioned in the retention frame lumen. The drug tablets may be mini-tablets aligned in the drug reservoir lumen, with an interstice formed between any two adjacent drug tablets facilitating deformation of the device body. Systems and method are also provided for loading a drug delivery device. In one embodiment, the method includes positioning one or more solid drug units upstream of the drug delivery device; and driving the drug units into the drug delivery device with a flow of pressurized gas.