公开(公告)号：US20070161663A1

公开(公告)日：2007-07-12

申请号：US10587264

申请日：2005-01-28

申请人： Megumi Takeuchi ,  Makoto Takayama ,  Shiro Shirakura ,  Hiroshi Kase

发明人： Megumi Takeuchi ,  Makoto Takayama ,  Shiro Shirakura ,  Hiroshi Kase

IPC分类号： A61K31/522

CPC分类号： A61K31/522 ,  C07D473/08

摘要： (wherein R1, R2 and R3 are the same or different, and represent a hydrogen atom, lower alkyl, lower alkenyl or lower alkynyl; R4 represents cycloalkyl, —(CH2)n—R5 or a group represented by the above formula (II); and X1 and X2 are the same or different, and represent an oxygen atom or a sulfur atom) The present invention provides, for example, agents for treating migraine comprising, as an active ingredient, a xanthine derivative represented by the above formula (I) or a pharmaceutically acceptable salt thereof.

摘要翻译： （其中R 1，R 2和R 3相同或不同，表示氢原子，低级烷基，低级烯基或低级 炔基; R 4表示环烷基， - （CH 2 CH 2）n -R 5或由下式表示的基团： 上述式（II）; X 1和X 2相同或不同，表示氧原子或硫原子）本发明提供例如， 用于治疗偏头痛的药剂，其包含作为活性成分的由上式（I）表示的黄嘌呤衍生物或其药学上可接受的盐。

公开(公告)号：US20060178379A1

公开(公告)日：2006-08-10

申请号：US11326414

申请日：2006-01-06

申请人： Hiroshi Kase ,  Akihisa Mori ,  Yutaka Waki ,  Yutaka Ohsawa ,  Akira Karasawa ,  Yoshihisa Kuwana

发明人： Hiroshi Kase ,  Akihisa Mori ,  Yutaka Waki ,  Yutaka Ohsawa ,  Akira Karasawa ,  Yoshihisa Kuwana

IPC分类号： A61K31/522 ,  A61K31/198 ,  A61K31/137

CPC分类号： A61K31/522 ,  A61K9/0019 ,  A61K9/20 ,  A61K9/48 ,  A61K31/198 ,  A61K45/06

摘要： The present invention is directed to methods of treating movement disorders by administering an effective amount of one or more adenosine A2A receptor antagonists to a patient in need thereof. The present invention also provides methods of decreasing the adverse effects of L-DOPA in patients receiving L-DOPA therapy in the treatment of Parkinson's disease. The present invention further provides methods and compositions for treating Parkinson's disease patients with sub-clinically effective doses of L-DOPA by combining L-DOPA treatment with an effective amount of one or more adenosine A2A receptor antagonists (i.e., L-DOPA sparing effect). The present invention further provides methods of effective treatment of Parkinson's disease by co-administering at least one adenosine A2A receptor antagonist, L-DOPA and a dopamine agonist and/or a COMT inhibitor and/or a MAO inhibitor. The present invention further provides methods of prolonging effective treatment of Parkinson's disease by administering an adenosine A2A receptor antagonist singly or together with a dopamine agonist, and/or a COMT inhibitor, and/or a MAO inhibitor without prior or subsequent administration of L-DOPA, delaying or removing on-set of L-DOPA motor complication.

公开(公告)号：US20050238314A1

公开(公告)日：2005-10-27

申请号：US11089964

申请日：2005-03-25

申请人： Sako Asayama ,  Hiroshi Kase ,  Keiko Tanaka ,  Yasuhiro Kubo ,  Kevin La Chapelle ,  Ian Mercer ,  Brian Walker

发明人： Sako Asayama ,  Hiroshi Kase ,  Keiko Tanaka ,  Yasuhiro Kubo ,  Kevin La Chapelle ,  Ian Mercer ,  Brian Walker

IPC分类号： G11B27/034 ,  G06F17/00

CPC分类号： G11B27/034

摘要： A recording apparatus reads a content management file from a file information obtaining means, and a data analysis and search means searches for a specified digital content information storing portions from the read content management file and searches for a play list file including specified digital contents in reproduction order based on reference play list information of the content information storing portions. The file information obtaining means reads a relevant play list file, and the data analysis and search means searches for an updated location and notifies a play list file creation means thereof so that the play list file creation means correctly updates the play list file.

摘要翻译： 记录装置从文件信息获取装置读取内容管理文件，并且数据分析和搜索装置从读取的内容管理文件中搜索指定的数字内容信息存储部分，并在再现中搜索包括指定的数字内容的播放列表文件 基于内容信息存储部分的参考播放列表信息的顺序。 文件信息获取装置读取相关的播放列表文件，并且数据分析和搜索装置搜索更新的位置并通知播放列表文件创建装置，使得播放列表文件创建装置正确地更新播放列表文件。

公开(公告)号：US20050234858A1

公开(公告)日：2005-10-20

申请号：US11090543

申请日：2005-03-25

申请人： Yasuyuki Torii ,  Nobuyasu Takeguchi ,  Hiroshi Kase ,  Kevin La Chapelle ,  Ian Mercer ,  Brian Walker

发明人： Yasuyuki Torii ,  Nobuyasu Takeguchi ,  Hiroshi Kase ,  Kevin La Chapelle ,  Ian Mercer ,  Brian Walker

IPC分类号： G11B27/034 ,  G11B27/10 ,  G11B27/32 ,  G06F7/00

CPC分类号： G11B27/034 ,  G11B27/105 ,  G11B27/329

摘要： [Object] When additional recording is performed by a recording apparatus and a program of a different method of management information construction to a recording medium having recorded thereon management information data such as a content parameter, a menu, a play list and a menu display image together with content data such as an audio, a static image and a video, consistency of the management information data is lost. [Solution] It is possible to record in a file header portion 31 of a management information file group 2 an editor identifier 33 for identifying an apparatus and a program having edited that file, trace update history of the file with a file management device 14 and update information with a management information file creation device 15 by reflecting an intention of management information already recorded so as to keep the consistency of the management information.

摘要翻译： [对象]当由记录装置执行附加记录和对管理信息构造的不同方法的程序记录在其上记录了诸如内容参数，菜单，播放列表和菜单显示图像的管理信息数据的记录介质时 与诸如音频，静态图像和视频的内容数据一起，丢失了管理信息数据的一致性。 [解决方案]可以在管理信息文件组2的文件头部分31中记录用于识别装置的编辑器标识符33和已经编辑该文件的程序，具有文件管理装置14的文件的跟踪更新历史，以及 通过反映已经记录的管理信息的意图来更新与管理信息文件创建装置15的信息，以保持管理信息的一致性。

公开(公告)号：US20050220442A1

公开(公告)日：2005-10-06

申请号：US11083283

申请日：2005-03-17

申请人： Hiroshi Kase ,  Yoshiho Gotoh

发明人： Hiroshi Kase ,  Yoshiho Gotoh

IPC分类号： G11B20/00 ,  G11B20/12 ,  G11B20/18 ,  G11B27/36 ,  H04N5/91

CPC分类号： G11B20/00086 ,  G11B27/36

摘要： To record video data or audio data on an optical disc on which a defective area exists, there is a method of determining an allowable number of defects in proportion to a recording size and skipping the defective area to use an adjacent area thereto. This method has a problem that a time is required to start reproduction if the defective area exists at the top of a file. The size of the defective area allowed in a recording area is limited regardless of the size of the recording area, and recording on the optical disc is performed so that a normal area preceding a first defect in the recording area has a predetermined size.

摘要翻译： 为了在存在缺陷区域的光盘上记录视频数据或音频数据，存在与记录尺寸成比例地确定允许的缺陷数量并跳过缺陷区域以使用相邻区域的方法。 该方法存在如果缺陷区域存在于文件顶部时需要时间开始再现的问题。 在记录区域中允许的缺陷区域的大小受限于记录区域的大小，并且执行光盘上的记录，使得记录区域中的第一缺陷之前的正常区域具有预定的尺寸。

公开(公告)号：US5698560A

公开(公告)日：1997-12-16

申请号：US727598

申请日：1996-10-23

申请人： Yasuo Onoda ,  Shin-ichi Sasaki ,  Daisuke Machii ,  Haruki Takai ,  Tetsuji Ohno ,  Koji Yamada ,  Michio Ichimura ,  Hiroshi Kase

发明人： Yasuo Onoda ,  Shin-ichi Sasaki ,  Daisuke Machii ,  Haruki Takai ,  Tetsuji Ohno ,  Koji Yamada ,  Michio Ichimura ,  Hiroshi Kase

IPC分类号： C07D487/04 ,  A61K31/505 ,  A61K31/535 ,  C07D417/02 ,  C07D487/02

CPC分类号： C07D487/04

摘要： The present invention relates to imidazoquinazoline derivatives represented by formula (I): ##STR1## wherein R.sup.1 represents hydrogen, substituted or unsubstituted lower alkyl, cycloalkyl, lower alkenyl, substituted or unsubstituted aralkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroarylalkyl, or substituted or unsubstituted heteroaryl, R.sup.2 and R.sup.3 represent independently hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroarylalkyl, or substituted or unsubstituted heteroaryl, or R.sup.2 and R.sup.3 are combined to represent a heterocyclic group containing a nitrogen atom, R.sup.4 represents hydrogen or substituted or unsubstituted lower alkyl, X represents O or S, Y represents a single bond or O, n represents 0, 1, 2, or 3, and pharmaceutically acceptable salts thereof.

摘要翻译： PCT No.PCT / JP96 / 00497 Sec。 371日期：1996年10月23日 102（e）日期1996年10月23日PCT 1996年3月1日PCT公布。 第WO96 / 26940号公报 日本1996年9月6日本发明涉及由式（I）表示的咪唑并喹唑啉衍生物：其中R1表示氢，取代或未取代的低级烷基，环烷基，低级烯基，取代或未取代的芳烷基，取代或未取代的芳基 取代或未取代的芳基，取代或未取代的杂芳基，或取代或未取代的杂芳基，或者取代或未取代的杂芳基，或者取代或未取代的杂芳基，或R 2和R 3 合并表示含有氮原子的杂环基，R4表示氢或取代或未取代的低级烷基，X表示O或S，Y表示单键或O，n表示0,1,2或3，以及药学上可接受的 的盐。

公开(公告)号：US5605900A

公开(公告)日：1997-02-25

申请号：US430227

申请日：1995-04-28

申请人： Shigeki Fujiwara ,  Daisuke Machii ,  Haruki Takai ,  Hiromi Nonaka ,  Hiroshi Kase ,  Kozo Yao ,  Michiyo Kawakage ,  Hideaki Kusaka ,  Akira Karasawa

发明人： Shigeki Fujiwara ,  Daisuke Machii ,  Haruki Takai ,  Hiromi Nonaka ,  Hiroshi Kase ,  Kozo Yao ,  Michiyo Kawakage ,  Hideaki Kusaka ,  Akira Karasawa

IPC分类号： C07D401/14 ,  C07D491/04 ,  C07D401/04 ,  A61K31/445 ,  A61K31/50 ,  A61K31/53

CPC分类号： C07D401/14 ,  C07D491/04

摘要： The present invention relates to an adenosine uptake inhibitor and an agent for the myocardium protection or the prevention or treatment of inflammatory edema, comprising a 1,2,3,4-tetrahydro-2,4-dioxoquinazoline derivative represented by formula (I): ##STR1## wherein R.sup.1 represents hydrogen, substituted or unsubstituted lower alkyl, alkenyl, or substituted or unsubstituted aralkyl; R.sup.2, R.sup.3, R.sup.4, and R.sup.5 independently represent hydrogen, halogen, amino, mono- or di(lower alkyl)amino, lower alkanoylamino, nitro, cyano, substituted or unsubstituted lower alkyl, hydroxy, lower alkoxy, lower alkylthio, carboxy, lower alkoxycarbonyl, lower alkanoyl, aralkyloxy, or lower alkanoyloxy; R.sup.6, R.sup.7, R.sup.8, and R.sup.9 independently represent hydrogen, hydroxy, substituted or unsubstituted lower alkoxy, or aralkyloxy, or any adjoining two of them are combined to form methylenedioxy; R.sup.10 represents hydrogen or lower alkyl; and Y and Z independently represent N or C-R.sup.11 (wherein R.sup.11 represents hydrogen, substituted or unsubstituted lower alkyl, or halogen),or a pharmaceutically acceptable salt thereof as an active ingredient.

摘要翻译： 本发明涉及腺苷摄取抑制剂和用于心肌保护或预防或治疗炎性水肿的药剂，其包含由式（I）表示的1,2,3,4-四氢-2,4-二氧代喹唑啉衍生物： （I）其中R 1表示氢，取代或未取代的低级烷基，烯基或取代或未取代的芳烷基; R2，R3，R4和R5独立地表示氢，卤素，氨基，一或二（低级烷基）氨基，低级烷酰基氨基，硝基，氰基，取代或未取代的低级烷基，羟基，低级烷氧基，低级烷硫基，羧基，低级 烷氧基羰基，低级烷酰基，芳烷氧基或低级烷酰氧基; R 6，R 7，R 8和R 9独立地表示氢，羟基，取代或未取代的低级烷氧基或芳烷氧基，或者它们中的任何相邻的两个被结合形成亚甲二氧基; R 10表示氢或低级烷基; 并且Y和Z独立地表示作为活性成分的N或C-R11（其中R11表示氢，取代或未取代的低级烷基或卤素）或其药学上可接受的盐。

公开(公告)号：US4618613A

公开(公告)日：1986-10-21

申请号：US749716

申请日：1985-06-28

申请人： Kazuko Hashizume ,  Hiroshi Kase ,  Shigeto Kitamura ,  Takao Iida ,  Kunikatsu Shirahata ,  Kenji Omori ,  Katsuichi Shuto

发明人： Kazuko Hashizume ,  Hiroshi Kase ,  Shigeto Kitamura ,  Takao Iida ,  Kunikatsu Shirahata ,  Kenji Omori ,  Katsuichi Shuto

IPC分类号： C07D215/60 ,  A61K31/47 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P29/00 ,  A61P37/08

CPC分类号： A61K31/47 ,  Y10S514/826

摘要： A preventive and healing composition for diseases due to lipoxygenase metabolic products, which comprises an effective amount of a compound represented by the formula: ##STR1## wherein R is an alkyl group having 1 to 15 carbon atoms and at least one pharmaceutically acceptable carrier.

摘要翻译： 一种用于由脂氧合酶代谢产物引起的疾病的预防和治疗组合物，其包含有效量的由下式表示的化合物：其中R是具有1至15个碳原子的烷基和至少一种药学上可接受的载体。

公开(公告)号：US08233634B2

公开(公告)日：2012-07-31

申请号：US13205788

申请日：2011-08-09

申请人： Sako Asayama ,  Hiroshi Kase ,  Mitsuteru Kataoka ,  Akihiro Mitani ,  Toshiki Murakami ,  Masahiko Mizoguchi ,  Masazumi Yamada

发明人： Sako Asayama ,  Hiroshi Kase ,  Mitsuteru Kataoka ,  Akihiro Mitani ,  Toshiki Murakami ,  Masahiko Mizoguchi ,  Masazumi Yamada

IPC分类号： H04B3/00

CPC分类号： H04N5/60 ,  H04N5/4403 ,  H04N5/642 ,  H04N5/765 ,  H04N5/775 ,  H04N21/4104 ,  H04N21/42204 ,  H04N21/485 ,  H04N21/4852 ,  H04R5/04 ,  H04R2420/03 ,  H04R2499/15

摘要： A television set includes: an internal speaker which outputs sound; a memory which holds information; a remote controller receiver which receives an instruction from the outside of the television set; a microcomputer which causes, based on a mode specifying instruction for specifying a sound output mode received by the remote controller receiver, the memory to hold any one of (a) information that indicates a first sound output mode in which sound is outputted from the internal speaker and (b) information that indicates a second sound output mode in which sound is outputted from an external speaker that is a speaker outside the television set; and an HDMI/CEC communication unit which outputs the information that indicates the sound output mode and that is held by the memory, to an amplifier which controls to operate or not operate the speaker outside the television set.

摘要翻译： 电视机包括：输出声音的内部扬声器; 一个保存信息的记忆体; 遥控器接收器，其从电视机的外部接收指令; 微型计算机，其基于用于指定由遥控器接收器接收的声音输出模式的模式指定指令，使得存储器保持（a）指示从内部输出声音的第一声音输出模式的信息 扬声器和（b）指示从作为电视机外的扬声器的外部扬声器输出声音的第二声音输出模式的信息; 以及HDMI / CEC通信单元，其将指示声音输出模式的信息和由存储器保持的信息输出到控制在电视机外部操作或不操作扬声器的放大器。

公开(公告)号：US20120122897A1

公开(公告)日：2012-05-17

申请号：US13297341

申请日：2011-11-16

申请人： Hiroshi Kase ,  Akihisa Mori ,  Yutaka Waki ,  Yutaka Ohsawa ,  Akira Karasawa ,  Yoshihisa Kuwana

发明人： Hiroshi Kase ,  Akihisa Mori ,  Yutaka Waki ,  Yutaka Ohsawa ,  Akira Karasawa ,  Yoshihisa Kuwana

IPC分类号： A61K31/522 ,  A61P25/00 ,  A61P25/14 ,  A61P25/16

CPC分类号： A61K31/522 ,  A61K9/0019 ,  A61K9/20 ,  A61K9/48 ,  A61K31/198 ,  A61K45/06

摘要： Methods of treating movement disorders by administering an effective amount of one or more adenosine A2A receptor antagonists to a patient in need thereof and methods of decreasing the adverse effects of L-DOPA in patients receiving L-DOPA therapy in the treatment of Parkinson's disease. Also, methods and compositions for treating Parkinson's disease patients with sub-clinically effective doses of L-DOPA with an effective amount of one or more adenosine A2A receptor antagonists, optionally with a dopamine agonist and/or a COMT inhibitor and/or a MAO inhibitor.

摘要翻译： 通过向有需要的患者施用有效量的一种或多种腺苷A2A受体拮抗剂和降低L-DOPA在接受L-DOPA治疗帕金森病的患者中的不利影响的方法来治疗运动障碍的方法。 此外，用有效量的一种或多种腺苷A2A受体拮抗剂，任选地与多巴胺激动剂和/或COMT抑制剂和/或MAO抑制剂治疗具有亚临床有效剂量的L-DOPA的帕金森病患者的方法和组合物 。