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公开(公告)号：US20150284457A1
公开(公告)日：2015-10-08
申请号：US14731277
申请日：2015-06-04
发明人： Ulrich Brinkmann , Remko Albert Griep , Klaus Kaluza , Anita Kavlie , Christian Klein , Joerg Thomas Regula , Werner Scheuer
IPC分类号： C07K16/22
CPC分类号： C07K16/22 , A61K39/00 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/85
摘要： The present invention relates to antibodies against human Angiopoietin 2 (anti-ANG-2 antibodies), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及抗人血管生成素2（抗ANG-2抗体）的抗体，其生产方法，含有所述抗体的药物组合物及其应用。
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公开(公告)号：US20220144963A9
公开(公告)日：2022-05-12
申请号：US17130477
申请日：2020-12-22
发明人： Harald Duerr , Sebastian Fenn , Ulrich Goepfert , Sabine Imhof-Jung , Christian Klein , Laurent Lariviere , Michael Molhoj , Joerg Thomas Regula , Petra Rueger , Wolfgang Schaefer
摘要： Herein are provided bispecific anti-human A-betalhuman transferrin receptor antibodies and methods of using the same.
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公开(公告)号：US11267903B2
公开(公告)日：2022-03-08
申请号：US16522412
申请日：2019-07-25
发明人： Maria Amann , Peter Bruenker , Christina Claus , Claudia Ferrara Koller , Sandra Grau-Richards , Christian Klein , Viktor Levitski , Ekkehard Moessner , Joerg Thomas Regula , Pablo Umana
IPC分类号： C07K16/28 , C07K14/705 , A61K39/395 , A61K38/00 , C07K16/40 , C07K16/30
摘要： The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to a target cell antigen and (b) a first and a second polypeptide that are linked to each other by a disulfide bond, characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand family member or a fragment thereof.
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公开(公告)号：US10941205B2
公开(公告)日：2021-03-09
申请号：US15941655
申请日：2018-03-30
发明人： Harald Duerr , Sebastian Fenn , Ulrich Goepfert , Sabine Imhof-Jung , Christian Klein , Laurent Lariviere , Michael Molhoj , Joerg Thomas Regula , Petra Rueger , Wolfgang Schaefer
摘要： Herein are provided bispecific anti-human A-beta/human transferrin receptor antibodies and methods of using the same.
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公开(公告)号：US20210047394A1
公开(公告)日：2021-02-18
申请号：US16817993
申请日：2020-03-13
发明人： Monika Baehner , Ulrich Brinkmann , Guy Georges , Remko Albert Griep , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Stefan Seeber , Markus Thomas
IPC分类号： C07K16/22
摘要： The present invention relates to bispecific antibodies against human VEGF and against human ANG-2, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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公开(公告)号：US10766967B2
公开(公告)日：2020-09-08
申请号：US15281484
申请日：2016-09-30
发明人： Marina Bacac , Tanja Fauti , Sabine Imhof-Jung , Christian Klein , Stefan Klostermann , Ekkehard Moessner , Michael Molhoj , Christiane Neumann , Joerg Thomas Regula , Wolfgang Schaefer , Pablo Umana
摘要： The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
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公开(公告)号：US20200262904A1
公开(公告)日：2020-08-20
申请号：US16583839
申请日：2019-09-26
发明人： Ulrich Brinkmann , Remko Albert Griep , Klaus Kaluza , Anita Kavlie , Christian Klein , Joerg Thomas Regula , Werner Scheuer
摘要： The present invention relates to antibodies against human Angiopoietin 2 (anti-ANG-2 antibodies), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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公开(公告)号：US20190382507A1
公开(公告)日：2019-12-19
申请号：US16522412
申请日：2019-07-25
发明人： Maria Amann , Peter Bruenker , Christina Claus , Claudia Ferrara Koller , Sandra Grau-Richards , Christian Klein , Viktor Levitski , Ekkehard Moessner , Joerg Thomas Regula , Pablo Umana
IPC分类号： C07K16/40 , C07K16/28 , C07K14/705 , A61K39/395 , C07K16/30
摘要： The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to a target cell antigen and (b) a first and a second polypeptide that are linked to each other by a disulfide bond, characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand family member or a fragment thereof.
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公开(公告)号：US20170240629A1
公开(公告)日：2017-08-24
申请号：US15590176
申请日：2017-05-09
发明人： Marc Bedoucha , Sebastian Breuer , Stefan Dengl , Christian Gassner , Guy Georges , Sabine Gruener , Guido Hartmann , Peter Michael Huelsmann , Hubert Kettenberger , Joerg Moelleken , Michael Molhoj , Olaf Mundigl , Joerg Thomas Regula , Ralf Schumacher , Barbara Weiser
摘要： Herein are reported novel bispecific antibodies that specifically bind to two different antigens selected from the group consisting of human ANG2, human VEGF, human IL-1beta and human PDGF-B.
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公开(公告)号：US20170190783A1
公开(公告)日：2017-07-06
申请号：US15281484
申请日：2016-09-30
发明人： Marina Bacac , Tanja Fauti , Sabine Imhof-Jung , Christian Klein , Stefan Klostermann , Ekkehard Moessner , Michael Molhoj , Christianne Neumann , Joerg Thomas Regula , Wolfgang Schaefer , Pablo Umana
摘要： The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
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