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1.发明公开公开(公告)号：US20230212277A1
公开(公告)日：2023-07-06
申请号：US18146044
申请日：2022-12-23
发明人： Harald Duerr , Frank Herting , Christian Klein , Joerg Thomas Regula , Matthias Rueth , Kay-Gunnar Stubenrauch
CPC分类号： C07K16/22 , A61P27/02 , C07K2317/52 , C07K2317/31 , C07K2317/35 , A61K2039/505
摘要： The present invention relates to bispecific antibody against human vascular endothelial growth factor (VEGF/VEGF-A) and against human angiopoietin-2 (ANG-2) of human IgG1 or IgG4 subclass with mutations I253A, H310A, and H435A, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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公开(公告)号：US11603411B2
公开(公告)日：2023-03-14
申请号：US15941524
申请日：2018-03-30
发明人： Harald Duerr , Sebastian Fenn , Ulrich Goepfert , Sabine Imhof-Jung , Christian Klein , Laurent Lariviere , Michael Molhoj , Joerg Thomas Regula , Petra Rueger , Wolfgang Schaefer
摘要： Herein are provided bispecific anti-human CD20/human transferrin receptor antibodies and methods of using the same.
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公开(公告)号：US11306154B2
公开(公告)日：2022-04-19
申请号：US16522391
申请日：2019-07-25
发明人： Maria Amann , Peter Bruenker , Christina Claus , Claudia Ferrara Koller , Sandra Grau-Richards , Christian Klein , Viktor Levitski , Ekkehard Moessner , Joerg Thomas Regula , Pablo Umana
IPC分类号： C07K16/40 , C07K16/28 , C07K14/705 , A61K39/395 , A61K38/00 , C07K16/30
摘要： The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to a target cell antigen and (b) a first and a second polypeptide that are linked to each other by a disulfide bond, characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand family member or a fragment thereof.
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公开(公告)号：US20210301030A1
公开(公告)日：2021-09-30
申请号：US17130477
申请日：2020-12-22
发明人： Harald Duerr , Sebastian Fenn , Ulrich Goepfert , Sabine Imhof-Jung , Christian Klein , Laurent Lariviere , Michael Molhoj , Joerg Thomas Regula , Petra Rueger , Wolfgang Schaefer
摘要： Herein are provided bispecific anti-human A-betalhuman transferrin receptor antibodies and methods of using the same.
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公开(公告)号：US20200247904A1
公开(公告)日：2020-08-06
申请号：US16522391
申请日：2019-07-25
发明人： Maria Amann , Peter Bruenker , Christina Claus , Claudia Ferrara Koller , Sandra Grau-Richards , Christian Klein , Viktor Levitski , Ekkehard Moessner , Joerg Thomas Regula , Pablo Umana
IPC分类号： C07K16/40 , C07K16/28 , C07K14/705 , A61K39/395 , C07K16/30
摘要： The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to a target cell antigen and (b) a first and a second polypeptide that are linked to each other by a disulfide bond, characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand family member or a fragment thereof.
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公开(公告)号：US10287352B2
公开(公告)日：2019-05-14
申请号：US15280372
申请日：2016-09-29
发明人： Laura Codarri-Deak , Georg Fertig , Jens Fischer , Christian Klein , Viktor Levitski , Valeria Lifke , Mario Perro , Joerg Thomas Regula , Tilman Schlothauer , Stefan Seeber , Pablo Umana , Ildiko Wuensche , Adrian Zwick
摘要： The invention relates to bispecific antibodies comprising a first antigen-binding site that specifically binds to PD1 and a second antigen-binding site that specifically binds to TIM3, in particular to bispecific antibodies, wherein the bispecific antibody binds to TIM3 with a lower binding affinity when compared to the binding to PD1. The invention further relates to methods of producing these molecules and to methods of using the same.
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公开(公告)号：US20170369566A1
公开(公告)日：2017-12-28
申请号：US15603124
申请日：2017-05-23
发明人： Monika Baehner , Ulrich Brinkmann , Guy Georges , Remko Albert Griep , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Stefan Seeber , Markus Thomas
CPC分类号： C07K16/22 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to bispecific antibodies against human VEGF and against human ANG-2, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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公开(公告)号：US09708396B2
公开(公告)日：2017-07-18
申请号：US14192213
申请日：2014-02-27
发明人： Monika Baehner , Ulrich Brinkmann , Guy Georges , Remko Albert Griep , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Stefan Seeber , Markus Thomas
IPC分类号： A61K39/395 , C07K16/22 , A61K39/00
CPC分类号： C07K16/22 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to bispecific antibodies against human VEGF and against human ANG-2, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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公开(公告)号：US20170174786A1
公开(公告)日：2017-06-22
申请号：US15281493
申请日：2016-09-30
发明人： Marina Bacac , Christian Klein , Wolfgang Schaefer , Stefan Klostermann , Sabine Imhof-Jung , Michael Molhoj , Joerg Thomas Regula , Pablo Umana , Sylvia Herter , Christiane Neumann
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/2803 , C07K16/2809 , C07K16/2863 , C07K16/3007 , C07K16/3053 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/35 , C07K2317/52 , C07K2317/526 , C07K2317/55 , C07K2317/626 , C07K2317/64 , C07K2317/66 , C07K2317/73 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
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10.发明申请公开(公告)号：US20160194389A1
公开(公告)日：2016-07-07
申请号：US14927022
申请日：2015-10-29
IPC分类号： C07K16/22
CPC分类号： C07K16/22 , A61K2039/505 , A61K2039/54 , C07K16/00 , C07K16/2863 , C07K16/468 , C07K2317/31 , C07K2317/33 , C07K2317/35 , C07K2317/41 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to antibodies and Fc-region fusion polypeptides which are asymmetrically modified with respect to their Fc-receptor, especially their FcRn, and methods of using the same.
摘要翻译： 本发明涉及相对于其Fc受体，特别是其FcRn不对称修饰的抗体和Fc区融合多肽及其使用方法。
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