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公开(公告)号：US11787868B2
公开(公告)日：2023-10-17
申请号：US17130477
申请日：2020-12-22
发明人： Harald Duerr , Sebastian Fenn , Ulrich Goepfert , Sabine Imhof-Jung , Christian Klein , Laurent Lariviere , Michael Molhoj , Joerg Thomas Regula , Petra Rueger , Wolfgang Schaefer
CPC分类号： C07K16/2881 , A61P25/28 , C07K16/18 , C07K16/468 , A61K2039/505 , C07K2317/31 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/522 , C07K2317/55 , C07K2317/56 , C07K2317/64
摘要： Herein are provided bispecific anti-human A-betalhuman transferrin receptor antibodies and methods of using the same.
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公开(公告)号：US11685790B2
公开(公告)日：2023-06-27
申请号：US17399988
申请日：2021-08-11
发明人： Thomas Hofer , Maximiliane Koenig , Ekkehard Moessner , Jens Niewoehner , Tina Weinzierl , Laurent Lariviere
CPC分类号： C07K16/3069 , A61P35/00 , C07K16/2809 , C07K2317/31 , C07K2317/55 , C07K2317/565
摘要： The present invention generally relates to antibodies that bind to STEAP-1, including bispecific antigen binding molecules e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.
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公开(公告)号：US11668722B2
公开(公告)日：2023-06-06
申请号：US16657753
申请日：2019-10-18
CPC分类号： G01N33/686 , C07K16/18 , C07K16/2863
摘要： Herein is reported a method for selecting an antibody with a systematic clearance in cynomolgus monkeys of less than 8 mL/kg/day comprising the steps of measuring the retention time of the antibody on performing an FcRn affinity chromatography with a positive linear pH gradient and on a heparin affinity chromatography with a positive linear conductivity/salt gradient, and selecting an antibody that has a relative retention time on the FcRn affinity chromatography column is less than 1.78 times the retention time difference between peaks 2 and 3 the retention time of preparation of an oxidized anti-Her3 antibody of SEQ ID NO: 03 and 04, and a relative retention time on the heparin affinity chromatography column is less than 0.87 times the retention time of an anti-pTau antibody of SEQ ID NO: 01 and 02.
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公开(公告)号：US11180571B2
公开(公告)日：2021-11-23
申请号：US16587606
申请日：2019-09-30
发明人： Thomas Hofer , Maximiliane Koenig , Ekkehard Moessner , Jens Niewoehner , Tina Weinzierl , Laurent Lariviere
摘要： The present invention generally relates to antibodies that bind to STEAP-1, including bispecific antigen binding molecules e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.
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公开(公告)号：US20200217851A1
公开(公告)日：2020-07-09
申请号：US16657753
申请日：2019-10-18
摘要： Herein is reported a method for selecting an antibody with a systematic clearance in cynomolgus monkeys of less than 8 mL/kg/day comprising the steps of measuring the retention time of the antibody on performing an FcRn affinity chromatography with a positive linear pH gradient and on a heparin affinity chromatography with a positive linear conductivity/salt gradient, and selecting an antibody that has a relative retention time on the FcRn affinity chromatography column is less than 1.78 times the retention time difference between peaks 2 and 3 the retention time of preparation of an oxidized anti-Her3 antibody of SEQ ID NO: 03 and 04, and a relative retention time on the heparin affinity chromatography column is less than 0.87 times the retention time of an anti-pTau antibody of SEQ ID NO: 01 and 02.
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公开(公告)号：US20180222992A1
公开(公告)日：2018-08-09
申请号：US15941655
申请日：2018-03-30
发明人： Harald Duerr , Sebastian Fenn , Ulrich Goepfert , Sabine Imhof-Jung , Christian Klein , Laurent Lariviere , Michael Molhoj , Joerg Thomas Regula , Petra Rueger , Wolfgang Schaefer
CPC分类号： C07K16/2881 , A61K2039/505 , A61P25/28 , C07K16/18 , C07K2317/31 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/522 , C07K2317/55 , C07K2317/56 , C07K2317/64
摘要： Herein are provided bispecific anti-human A-beta/human transferrin receptor antibodies and methods of using the same.
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公开(公告)号：US20230251270A1
公开(公告)日：2023-08-10
申请号：US18305158
申请日：2023-04-21
CPC分类号： G01N33/686 , C07K16/18 , C07K16/2863
摘要： Herein is reported a method for selecting an antibody with a systematic clearance in cynomolgus monkeys of less than 8 mL/kg/day comprising the steps of measuring the retention time of the antibody on performing an FcRn affinity chromatography with a positive linear pH gradient and on a heparin affinity chromatography with a positive linear conductivity/salt gradient, and selecting an antibody that has a relative retention time on the FcRn affinity chromatography column is less than 1.78 times the retention time difference between peaks 2 and 3 the retention time of preparation of an oxidized anti-Her3 antibody of SEQ ID NO: 03 and 04, and a relative retention time on the heparin affinity chromatography column is less than 0.87 times the retention time of an anti-pTau antibody of SEQ ID NO: 01 and 02.
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公开(公告)号：US11603411B2
公开(公告)日：2023-03-14
申请号：US15941524
申请日：2018-03-30
发明人： Harald Duerr , Sebastian Fenn , Ulrich Goepfert , Sabine Imhof-Jung , Christian Klein , Laurent Lariviere , Michael Molhoj , Joerg Thomas Regula , Petra Rueger , Wolfgang Schaefer
摘要： Herein are provided bispecific anti-human CD20/human transferrin receptor antibodies and methods of using the same.
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公开(公告)号：US11440942B2
公开(公告)日：2022-09-13
申请号：US16354627
申请日：2019-03-15
摘要： Herein is reported a fusion polypeptide according to formula I (TAG-X1-C1qA-X2-C1qB-X3-C1qC-X4), comprising a fragment of SEQ ID NO: 01 (C1qA), a fragment of SEQ ID NO: 03 (C1qB), a fragment of SEQ ID NO: 05 (C1qC) and optionally a tag (TAG).
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公开(公告)号：US20220204616A1
公开(公告)日：2022-06-30
申请号：US17578655
申请日：2022-01-19
发明人： Claudia Ferrara Koller , Guy Georges , Alexander Haas , Hubert Kettenberger , Ekkehard Moessner , Tilman Schlothauer , Michael Molhoj , Laurent Lariviere
IPC分类号： C07K16/28
摘要： Herein is reported an antibody that specifically hinds to human CD 19, wherein the antibody comprises (a) HVR-H1 comprising the amino acid sequence of SEQ ID NO: 03, (b) HVR-H2 comprising the amino acid sequence of SEQ ID NO: 11, (c) HVR-H3 comprising the amino acid sequence of SEQ ID NO: 05, (d) HVR-L1 comprising the amino acid sequence of SEQ ID NO: 20 or 28, (e) HVR-L2 comprising the amino acid sequence of SEQ ID NO: 07, and (f) HVR-L3 comprising the amino acid sequence of SEQ ID NO: 08, as well as methods of using the same.
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