公开(公告)号：US08445200B2

公开(公告)日：2013-05-21

申请号：US12761330

申请日：2010-04-15

申请人： Aya M. Westbrook ,  Robert H. Schiestl ,  Bo Wei ,  Jonathan Braun

发明人： Aya M. Westbrook ,  Robert H. Schiestl ,  Bo Wei ,  Jonathan Braun

IPC分类号： C12Q1/68

CPC分类号： C12Q1/686 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N27/447 ,  G01N33/5014 ,  G01N33/6875

摘要： The invention provides a method for detection of inflammatory disease in a subject that comprises assaying a test sample of peripheral blood from the subject for a marker of DNA damage. An elevated amount of marker present in the test sample compared to control sample is indicative of inflammatory disease activity, including sub-clinical inflammation. The method can be adapted for quantitatively monitoring the efficacy of treatment of inflammatory disease in a subject. Markers of DNA damage include single- and/or double-stranded breaks in leukocytes, oxidative DNA damage in leukocytes, or a marker of nitric oxide oxidative activity (protein nitrosylation in leukocytes). The inflammatory disease can be inflammatory bowel disease (ulcerative colitis or Crohn's disease). The invention may also be used for detection of other types of inflammatory disease, such as non-immune intestinal inflammatory disease (diverticulitis, pseudomembranous colitis), autoimmune diseases (rheumatoid arthritis, lupus, multiple sclerosis, psoriasis, uveitis, vasculitis), or non-immune lung diseases (asthma, chronic obstructive lung disease, and interstitial pneumonitis). This unexpected discovery of markers of genotoxicity present in circulating leukocytes enables detection of inflammation occurring at a localized site with a relatively simple and minimally invasive assay using peripheral blood.

公开(公告)号：US20130117475A1

公开(公告)日：2013-05-09

申请号：US13291894

申请日：2011-11-08

申请人： Bo Wei ,  Tse Jen Lee ,  Steven TianChye Cheok ,  Jian Qiang

发明人： Bo Wei ,  Tse Jen Lee ,  Steven TianChye Cheok ,  Jian Qiang

IPC分类号： G06F13/14

CPC分类号： G06F13/1694 ,  Y02D10/14 ,  Y02D10/151

摘要： The disclosure is related to systems and methods for data detection and device optimization. In one example, a device may include an interface circuit for data transmission, and an interface detection module adapted to determine a characteristic of a data transfer over the interface circuit. The device may implement an optimization profile for the device based upon the determined characteristic. Further, a device may be configured to measure a data transfer rate, determine an interface type based on the data transfer rate, and implement an optimization profile based on the interface type. The optimization profile may optimize a system for power consumption, performance, or other benefits.

摘要翻译： 本公开涉及用于数据检测和设备优化的系统和方法。 在一个示例中，设备可以包括用于数据传输的接口电路，以及适于确定接口电路上的数据传输的特性的接口检测模块。 该设备可以基于所确定的特性来实现该设备的优化简档。 此外，设备可以被配置为测量数据传输速率，基于数据传输速率来确定接口类型，并且基于接口类型实现优化简档。 优化配置文件可以优化系统的功耗，性能或其他优点。

公开(公告)号：US07965726B2

公开(公告)日：2011-06-21

申请号：US11401246

申请日：2006-04-11

申请人： Bo Wei ,  Lin Ma ,  Zhigang Rong ,  Steven Craig Greer

发明人： Bo Wei ,  Lin Ma ,  Zhigang Rong ,  Steven Craig Greer

IPC分类号： H04L12/28

CPC分类号： H04L47/10 ,  H04L47/14 ,  H04L47/2433 ,  H04L47/283 ,  H04L47/50 ,  H04L47/527 ,  H04L47/56 ,  H04W72/1242

摘要： A method, apparatus and system for scheduling data packets in a wireless communications system. The invention includes determining a priority for at least one data packet, wherein determining the priority of the data packet is based at least on a plurality of quality of service factors, wherein each of the plurality of QoS factors has a corresponding weighting factor and the determined priority includes minimum-performance guarantees. The invention further includes scheduling transmission of the at least one data packet based at least on the determined priority.

摘要翻译： 一种用于在无线通信系统中调度数据分组的方法，装置和系统。 本发明包括确定至少一个数据分组的优先级，其中确定数据分组的优先级至少基于多个服务质量因素，其中多个QoS因子中的每一个具有对应的加权因子，并且确定 优先级包括最低性能保证。 本发明还包括至少基于所确定的优先级来调度所述至少一个数据分组的传输。

公开(公告)号：US20100313076A1

公开(公告)日：2010-12-09

申请号：US12480087

申请日：2009-06-08

申请人： Bo Wei ,  Patrick Tai Heng Wong ,  MingZhong Ding

发明人： Bo Wei ,  Patrick Tai Heng Wong ,  MingZhong Ding

IPC分类号： G06F11/00

CPC分类号： G11B20/1883 ,  G11B20/1816 ,  G11B20/1879 ,  G11B2020/1893 ,  G11B2220/20 ,  G11B2220/2516 ,  G11B2220/63

摘要： An aspect of the present disclosure relates to scanning reassigned data storage locations. In one example, a reassignment table is accessed to identify a deallocated data storage location and scan the deallocated data storage location for media defects.

摘要翻译： 本公开的一个方面涉及扫描重新分配的数据存储位置。 在一个示例中，访问重新分配表以识别解除分配的数据存储位置，并扫描解除分配的数据存储位置以进行媒体缺陷。

公开(公告)号：US20050058650A1

公开(公告)日：2005-03-17

申请号：US10962126

申请日：2004-10-08

申请人： Ralf Luche ,  Bo Wei

发明人： Ralf Luche ,  Bo Wei

IPC分类号： C12N9/16 ,  C12N15/55 ,  C12Q1/68 ,  A61K39/395 ,  C07H21/04

CPC分类号： C12N9/16

摘要： Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatases DSP-12 and DSP-13, and polypeptide variants thereof, that stimulate dephosphorylation of DSP-12 and DSP-13 substrates are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-12 and/or DSP-13 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.

摘要翻译： 提供组合物和方法用于治疗与细胞增殖，细胞分化和细胞存活相关的病症。 特别地，提供了刺激DSP-12和DSP-13底物去磷酸化的双特异性磷酸酶DSP-12和DSP-13及其多肽变体。 多肽可用于例如鉴定抑制DSP-12和/或DSP-13活性的抗体和其它试剂。 多肽和试剂可用于调节细胞增殖，分化和存活。

公开(公告)号：US06844042B1

公开(公告)日：2005-01-18

申请号：US09543281

申请日：2000-04-05

申请人： Guolin Ma ,  Easen Ho ,  Theodore Rees ,  Bo Wei

发明人： Guolin Ma ,  Easen Ho ,  Theodore Rees ,  Bo Wei

IPC分类号： B32B3/02 ,  G11B7/12 ,  G11B7/135 ,  G11B7/24

CPC分类号： G11B7/122 ,  G11B7/1387 ,  Y10T428/21

摘要： An air-incident optical recording medium for use with flying heads has a system of layers, which thermally isolate the disk surface from the active, recording layer.

摘要翻译： 与飞头一起使用的空气入射光记录介质具有层，其将盘表面与活性记录层热隔离。

公开(公告)号：US06492157B1

公开(公告)日：2002-12-10

申请号：US09544716

申请日：2000-04-06

申请人： Ralf M. Luche ,  Bo Wei

发明人： Ralf M. Luche ,  Bo Wei

IPC分类号： C12N916

CPC分类号： C12Y301/03016 ,  C12N9/16 ,  C12Y301/03048

摘要： Compositions and methods are provided for the treatment of conditions associated with cells proliferation, cells differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-9, and polypeptide variants thereof that stimulate dephosphorylation of DSP-9 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-9 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.

摘要翻译： 提供组合物和方法用于治疗与细胞增殖，细胞分化和细胞存活相关的病症。 特别地，提供了刺激DSP-9底物去磷酸化的双重特异性磷酸酶DSP-9及其多肽变体。 多肽可用于例如鉴定抑制DSP-9活性的抗体和其它试剂。 多肽和试剂可用于调节细胞增殖，分化和存活。

公开(公告)号：US06483666B2

公开(公告)日：2002-11-19

申请号：US09799840

申请日：2001-03-06

申请人： Bo Wei ,  Dallas W. Meyer ,  Zhengda Pan ,  Jialuo J. Xuan ,  Chung Y. Shih

发明人： Bo Wei ,  Dallas W. Meyer ,  Zhengda Pan ,  Jialuo J. Xuan ,  Chung Y. Shih

IPC分类号： G11B582

CPC分类号： G11B5/82 ,  B23K26/06 ,  B23K26/064 ,  B23K26/0648 ,  B23K26/0652 ,  B23K26/0665 ,  B23K26/073 ,  G11B5/74

摘要： Magnetic data storage disks, particularly along dedicated transducing head contact regions, are laser textured according to a process in which beam shaping optical components impart an elliptical or otherwise elongated cross-section to the laser beam. Consequently, individual texturing features such as rims and nodules are elliptical or elongate, with more gradual height gradients in directions parallel to their major axes. The texturing features further are oriented with respect to the direction of transducing head accelerations and decelerations, which yields high performance in terms of reduced dynamic friction, reduced stiction and better wear characteristics. Texturing features are formed in a variety of patterns, including patterns with adjacent features contacting one another. A further refinement involves forming features with substantially different slopes on opposites sides of a maximum height region.

摘要翻译： 磁性数据存储盘，特别是沿着专用的传感头接触区域，根据波束整形光学部件赋予激光束的椭圆形或其他细长横截面的过程被激光纹理化。 因此，诸如轮辋和结节的单个纹理特征是椭圆形或细长的，在与它们的主轴平行的方向上具有更渐进的高度梯度。 纹理特征进一步相对于头部加速度和减速度的转向的方向定向，这在减少的动态摩擦，降低的静摩擦和更好的磨损特性方面产生高性能。 纹理特征以各种图案形成，包括具有彼此接触的相邻特征的图案。 进一步的细化包括在最大高度区域的相对侧上形成具有基本不同斜率的特征。

公开(公告)号：US06225595B1

公开(公告)日：2001-05-01

申请号：US08849001

申请日：1999-08-13

申请人： Bo Wei ,  Dallas W. Meyer ,  Zhengda Pan ,  Jialuo J. Xuan ,  Chung Y. Shih

发明人： Bo Wei ,  Dallas W. Meyer ,  Zhengda Pan ,  Jialuo J. Xuan ,  Chung Y. Shih

IPC分类号： B23K2600

CPC分类号： G11B5/82 ,  B23K26/06 ,  B23K26/064 ,  B23K26/0648 ,  B23K26/0652 ,  B23K26/0665 ,  B23K26/073 ,  G11B5/74

摘要： Magnetic data storage disks, particularly along dedicated transducing head contact regions, are laser textured according to a process in which beam shaping optical components impart an elliptical or otherwise elongated cross-section to the laser beam. Consequently, individual texturing features such as rims and nodules are elliptical or elongate, with more gradual height gradients in directions parallel to their major axes. The texturing features further are oriented with respect to the direction of transducing head accelerations and decelerations, which yields high performance in terms of reduced flying height, improved glide avalanche, reduced dynamic friction, reduced stiction and better wear characteristics. Texturing features are formed in a variety of patterns, including patterns with adjacent features contacting one another. A further refinement involves forming features with substantially different slopes on opposites sides of a maximum height region.

摘要翻译： 磁性数据存储盘，特别是沿着专用的传感头接触区域，根据波束整形光学部件赋予激光束的椭圆形或其他细长横截面的过程被激光纹理化。 因此，诸如轮辋和结节的单个纹理特征是椭圆形或细长的，在与它们的主轴平行的方向上具有更渐进的高度梯度。 纹理特征进一步相对于头部加速度和减速度的转向的方向定向，其在降低飞行高度，改善的滑动雪崩，减少的动态摩擦，降低的静摩擦和更好的磨损特性方面产生高性能。 纹理特征以各种图案形成，包括具有彼此接触的相邻特征的图案。 进一步的细化包括在最大高度区域的相对侧上形成具有基本不同斜率的特征。

公开(公告)号：US5901001A

公开(公告)日：1999-05-04

申请号：US660063

申请日：1996-06-03

申请人： Dallas W. Meyer ,  Subrahmanyan Nagarajan ,  Bo Wei

发明人： Dallas W. Meyer ,  Subrahmanyan Nagarajan ,  Bo Wei

IPC分类号： G01R33/12 ,  G11B21/21 ,  G11B27/36 ,  G11B33/10 ,  G11B5/02

CPC分类号： G01R33/1207 ,  G11B27/36 ,  G11B33/10 ,  G11B21/21

摘要： A tester for use in detecting asperities in a disc surface of a storage system includes a load arm having a proximal end and a distal end. The distal end of the load arm is positioned adjacent the disc surface. A slider is carried on the distal end of the load arm adjacent the disc surface. A thermal sensor is coupled to the slider and provides an electrical output in response to a thermal input due to interaction between the thermal sensor and asperity on the disc surface. Detection circuitry coupled to the thermal sensor detects the electrical output from the thermal sensor and responsively provides a detection output indicating the occurrence of an asperity on the disc surface.

摘要翻译： 用于检测存储系统的盘表面中的凹凸的测试器包括具有近端和远端的负载臂。 负载臂的远端位于盘表面附近。 滑块被承载在与盘表面相邻的负载臂的远端上。 热传感器耦合到滑块，并且由于热传感器和盘表面上的粗糙度之间的相互作用而响应于热输入而提供电输出。 耦合到热传感器的检测电路检测来自热传感器的电输出，并且响应地提供指示在盘表面上出现粗糙度的检测输出。