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公开(公告)号：US11408012B2
公开(公告)日：2022-08-09
申请号：US17588256
申请日：2022-01-29
Applicant: Inscripta, Inc.
Inventor： Andrew Garst , Ryan T. Gill , Tanya Elizabeth Warnecke Lipscomb
IPC: C12N15/90 , C12N9/22 , C12N15/70 , C12N15/81 , C12N15/85 , C12N15/11 , C12N15/10 , C12N15/63 , C12N15/113
Abstract: Disclosed herein are nucleic acid-guided nucleases, guide nucleic acids, and targetable nuclease systems, and methods of use. Disclosed herein are engineered non-naturally occurring nucleic acid-guided nucleases, guide nucleic acids, and targetable nuclease systems, and methods of use. Targetable nuclease systems can be used to edit genetic targets, including recursive genetic engineering and trackable genetic engineering methods.
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公开(公告)号：US20220162646A1
公开(公告)日：2022-05-26
申请号：US17588256
申请日：2022-01-29
Applicant: Inscripta, Inc.
Inventor： Andrew Garst , Ryan T. Gill , Tanya Elizabeth Warnecke Lipscomb
IPC: C12N15/90 , C12N9/22 , C12N15/70 , C12N15/81 , C12N15/85 , C12N15/11 , C12N15/10 , C12N15/63 , C12N15/113
Abstract: Disclosed herein are nucleic acid-guided nucleases, guide nucleic acids, and targetable nuclease systems, and methods of use. Disclosed herein are engineered non-naturally occurring nucleic acid-guided nucleases, guide nucleic acids, and targetable nuclease systems, and methods of use. Targetable nuclease systems can be used to edit genetic targets, including recursive genetic engineering and trackable genetic engineering methods.
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公开(公告)号：US11268061B2
公开(公告)日：2022-03-08
申请号：US17401362
申请日：2021-08-13
Applicant: Inscripta, Inc.
Inventor： Andrew Garst , Michael Graige , Richard Fox , Eileen Spindler , Amy Hiddessen , Phillip Belgrader , Don Masquelier , Bruce Chabansky
Abstract: The present disclosure provides automated modules and instruments for improved detection of nuclease genome editing of live cells. The disclosure provides improved modules—including high throughput modules—for screening cells that have been subjected to editing and identifying and selecting cells that have been properly edited.
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公开(公告)号：US20220025359A1
公开(公告)日：2022-01-27
申请号：US17300518
申请日：2021-07-27
Applicant: Inscripta, Inc.
Inventor： Tian Tian , Eileen Spindler , Clint Davis , Charles Johnson , Andrew Garst
Abstract: The present disclosure provides compositions of matter, methods, modules and automated multi-module instrumentation for performing editing of live cells followed by curing of editing and engine vectors from prior rounds of editing, followed by curing of the curing vector.
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公开(公告)号：US11220697B2
公开(公告)日：2022-01-11
申请号：US17387860
申请日：2021-07-28
Applicant: Inscripta, Inc.
Inventor： Andrew Garst , Ryan T. Gill , Tanya Elizabeth Warnecke Lipscomb
Abstract: Disclosed herein are nucleic acid-guided nucleases, guide nucleic acids, and targetable nuclease systems, and methods of use. Disclosed herein are engineered non-naturally occurring nucleic acid-guided nucleases, guide nucleic acids, and targetable nuclease systems, and methods of use. Targetable nuclease systems can be used to edit genetic targets, including recursive genetic engineering and trackable genetic engineering methods.
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Patent Agency Ranking
26.发明授权公开(公告)号：US11046928B2
公开(公告)日：2021-06-29
申请号：US17102414
申请日：2020-11-23
Applicant: Inscripta, Inc.
Inventor： Andrew Garst , Richard Fox , Phillip Belgrader , Don Masquelier
Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.
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公开(公告)号：US20210155912A1
公开(公告)日：2021-05-27
申请号：US16953253
申请日：2020-11-19
Applicant: Inscripta, Inc.
Inventor： Benjamin Mijts , Juhan Kim , Aamir Mir , Kyle Seamon , Andrew Garst
IPC: C12N9/22
Abstract: The present disclosure provides engineered RNA-guided enzymes for editing live cells.
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28.发明授权公开(公告)号：US11008557B1
公开(公告)日：2021-05-18
申请号：US17123067
申请日：2020-12-15
Applicant: Inscripta, Inc.
Inventor： Aamir Mir , Andrew Garst , Stephen Federowicz , Kyle Seamon
Abstract: The present disclosure relates to methods and compositions that allow one to identify in vivo edited cells when employing nucleic-acid guided editing. Additionally provided are automated multi-module instruments for performing editing and selection methods and using the compositions.
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29.发明授权公开(公告)号：US10954485B1
公开(公告)日：2021-03-23
申请号：US17101897
申请日：2020-11-23
Applicant: Inscripta, Inc.
Inventor： Phillip Belgrader , Don Masquelier , Andrew Garst , Richard Fox
Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.
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30.发明申请公开(公告)号：US20200346168A1
公开(公告)日：2020-11-05
申请号：US16928312
申请日：2020-07-14
Applicant: Inscripta, Inc.
Inventor： Phillip Belgrader , Don Masquelier , Matthew Estes , Bruce Chabansky , Andrew Garst , Richard Fox , Jorge Bernate
IPC: B01D63/08
Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.
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