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43 条记录 (耗时 0.054 秒)

    Peroxisome proliferator activated receptor agonists
    22.
    发明授权
    Peroxisome proliferator activated receptor agonists 失效
    过氧化物酶体增殖物激活受体激动剂

    公开(公告)号：US07345070B2

    公开(公告)日：2008-03-18

    申请号：US11054226

    申请日：2005-02-09

    申请人： Dawn Alisa Brooks ,  Alexander Glenn Godfrey ,  Sarah Beth Jones ,  James Ray McCarthy ,  Christopher John Rito ,  Leonard Larry Winneroski ,  Yanping Xu

    发明人： Dawn Alisa Brooks ,  Alexander Glenn Godfrey ,  Sarah Beth Jones ,  James Ray McCarthy ,  Christopher John Rito ,  Leonard Larry Winneroski ,  Yanping Xu

    IPC分类号： A31K31/421 ,  C07D263/32

    CPC分类号： C07D413/04 ,  C07D263/32 ,  C07D413/06 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14

    摘要： Compounds represented by the following structural formula (I), and pharmaceutically acceptable salts, solvates and hydrates thereof, wherein: n is 2, 3, or 4 and W is CH2, CH(OH), C(O) or O; R1 is an unsubstituted or substituted aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aryl-alkyl, heteroaryl-alkyl, cycloalkyl-alkyl, or t-butyl; R2 is H, alkyl, haloalkyl or phenyl; Y is an unsubstituted or substituted thiophen-2,5-diyl or phenylene; R3 is alkyl or haloalkyl; R4 is a substituted or unsubstituted phenyl, naphthyl, 1,2,3,4-tetrahydronaphthyl, quinolyl, pyridyl or benzo[1,3]dioxol-5-yl group; and R5 is H, alkyl, or aminoalkyl; are useful for modulating a peroxisome proliferator activated receptor, particularly in the treatment of diabetes mellitus.

    摘要翻译： 由以下结构式（I）表示的化合物及其药学上可接受的盐，溶剂合物和水合物，其中：n为2,3或4，W为CH 2，CH（OH），C （O）或O; R 1是未取代或取代的芳基，杂芳基，环烷基，杂环烷基，芳基 - 烷基，杂芳基 - 烷基，环烷基 - 烷基或叔丁基; R2是H，烷基，卤代烷基或苯基; Y是未取代或取代的噻吩-2,5-二基或亚苯基; R3是烷基或卤代烷基; R4是取代或未取代的苯基，萘基，1,2,3,4-四氢萘基，喹啉基，吡啶基或苯并[1,3]二氧杂环戊烯-5-基; 并且R 5是H，烷基或氨基烷基; 可用于调节过氧化物酶体增殖物激活受体，特别是用于治疗糖尿病。

    Antimycobacterial agents
    26.
    发明授权
    Antimycobacterial agents 失效
    抗分枝杆菌药

    公开(公告)号：US06310058B1

    公开(公告)日：2001-10-30

    申请号：US09578973

    申请日：2000-05-25

    申请人： Marvin J. Miller ,  Yanping Xu

    发明人： Marvin J. Miller ,  Yanping Xu

    IPC分类号： A61K3155

    CPC分类号： C07D403/12 ,  C07D413/12

    摘要： Compounds represented by the formula [1] R1 is H or a substituent; R2 and R3 are C1-C3 alkyl; R4 is siderophore group e.g. CH3—(CH2)n—C(O)—N(OH)—(CH2)m— with n=10-22, m=2-6; X is O, S, or NH; X1 is O or NH; Y is H or alkyl; Z is H or substituted amino, e.g., t-BocNH or CbzNH, and r is 2-4; are useful in the method provided for treating tuberculosis. [1] is prepared by coupling [7], wherein HX1 is HO— or H2N—,  with [4] obtained as the free acid after saponification of the methyl ester.

    摘要翻译： 由式[1] R 1表示的化合物是H或取代基; R2和R3是C1-C3烷基; R4是铁载体基团 CH 3 - （CH 2）n -C（O）-N（OH） - （CH 2）m - ，其中n = 10-22，m = 2-6; X是O，S或NH; X1是O或NH; Y是H或烷基; Z是H或取代的氨基，例如t-BocNH或CbzNH，r是2-4; 可用于治疗结核病的方法。 [1]通过偶联[7]制备，其中HX1是HO-或H2N-，其中[4]在甲酯皂化后作为游离酸获得。

    Methods for Treating Inflammation and Oxidative Stress Related Diseases
    27.
    发明申请
    Methods for Treating Inflammation and Oxidative Stress Related Diseases 审中-公开
    治疗炎症和氧化应激相关疾病的方法

    公开(公告)号：US20130004477A1

    公开(公告)日：2013-01-03

    申请号：US13504286

    申请日：2010-10-22

    申请人： Zhe Lu ,  Yanping Xu

    发明人： Zhe Lu ,  Yanping Xu

    IPC分类号： A61K31/26 ,  A61K38/44 ,  A61P29/00 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P1/18 ,  A61K33/18 ,  A61P11/08

    CPC分类号： G01N33/84 ,  A23L33/10 ,  A61K8/23 ,  A61K31/26 ,  A61K31/275 ,  A61K38/44 ,  A61Q5/10 ,  A61Q19/08 ,  C12Y111/01007 ,  G01N2800/382 ,  A61K2300/00

    摘要： This invention provides compositions and methods for treating inflammation related diseases. Particularly, the present invention provides methods and compositions of administering thiocyanate to treat inflammation related diseases, such as cystic fibrosis, lung disease, lung cancer, asthma, bronchitis, pancreatic disease, digestive track disease, diabetes, neurological disorder, cardio-vascular disease, atherosclerosis, arthritis, nephritis, or stroke, and neurological disorders such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, or autism. The invention provides the use of thiocyanate to diagnose inflammation related diseases.

    摘要翻译： 本发明提供了治疗炎症相关疾病的组合物和方法。 特别地，本发明提供了硫氰酸盐治疗炎症相关疾病如囊性纤维化，肺部疾病，肺癌，哮喘，支气管炎，胰腺疾病，消化道疾病，糖尿病，神经障碍，心血管疾病， 动脉粥样硬化，关节炎，肾炎或中风，以及诸如阿尔茨海默病，帕金森病，多发性硬化或自闭症的神经障碍。 本发明提供了硫氰酸盐诊断炎症相关疾病的用途。