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25 条记录 (耗时 0.072 秒)

    Mutant MT-SP1 proteases with altered substrate specificity or activity
    21.
    发明授权
    Mutant MT-SP1 proteases with altered substrate specificity or activity 有权
    具有改变的底物特异性或活性的突变体MT-SP1蛋白酶

    公开(公告)号：US08445245B2

    公开(公告)日：2013-05-21

    申请号：US13065182

    申请日：2011-03-15

    申请人： Sandra Waugh Ruggles ,  Jack Nguyen

    发明人： Sandra Waugh Ruggles ,  Jack Nguyen

    IPC分类号： C12N9/00

    CPC分类号： C12N9/50 ,  C12N9/6424

    摘要： MT-SP1 mutein proteases with altered specificity for the target molecules they cleave can be used to treat human diseases, such as cancer. Cleaving VEGF or VEGFR at certain substrate sequences with wild-type and mutein MT-SP1 proteases can be used to treat pathologies associated with angiogenesis.

    摘要翻译： 对其切割的靶分子具有特异性改变的MT-SP1突变蛋白酶可用于治疗人类疾病，如癌症。 用野生型和突变蛋白MT-SP1蛋白酶切割某些底物序列的VEGF或VEGFR可用于治疗与血管生成相关的病理学。

    Non-removable refill restrictor apparatus
    23.
    发明授权
    Non-removable refill restrictor apparatus 有权
    不可移动的再充装限流装置

    公开(公告)号：US07950412B2

    公开(公告)日：2011-05-31

    申请号：US11586395

    申请日：2006-10-25

    申请人： Jack Nguyen ,  Christopher Coppock

    发明人： Jack Nguyen ,  Christopher Coppock

    IPC分类号： F16K31/18

    CPC分类号： E03D1/32 ,  F16L33/20 ,  F16L37/098 ,  Y10S285/921 ,  Y10T137/3331 ,  Y10T137/7462 ,  Y10T137/9029

    摘要： A toilet refill restrictor apparatus includes an adapter interposed between a fill valve and a refill hose. The adapter is non-removably coupled to the fill valve and is configured with a larger proximal pathway, and a smaller distal metering pathway for restricting the refill flow rate. The adapter may be coupled to a shortened horizontal outlet formed at a top portion of the fill valve. The horizontal outlet is shortened to a length such that the refill hose cannot be connected directly to the outlet. The adapter may also be coupled to a fill valve without a horizontal outlet where an exit port is defined in the vertical conduit of the fill valve. The adapter includes a securing mechanism to prevent removal from the fill valve without excessive force or breaking the adapter.

    摘要翻译： 马桶再充装限流装置包括插入在填充阀和再填充软管之间的适配器。 适配器不可拆卸地联接到填充阀并且配置有较大的近端路径，以及用于限制再填充流量的较小远程计量路径。 适配器可以联接到形成在填充阀的顶部处的缩短的水平出口。 水平出口被缩短到使得补充软管不能直接连接到出口的长度。 适配器还可以连接到没有水平出口的填充阀，其中出口位于填充阀的垂直管道中。 适配器包括一个固定机构，用于防止从过滤器中取出而不用过大的力量或破坏适配器。

    Modified proteases that inhibit complement activation
    25.
    发明申请
    Modified proteases that inhibit complement activation 审中-公开
    抑制补体激活的修饰蛋白酶

    公开(公告)号：US20070093443A1

    公开(公告)日：2007-04-26

    申请号：US11584776

    申请日：2006-10-20

    申请人： Edwin Madison ,  Jack Nguyen ,  Sandra Ruggles ,  Christopher Thanos

    发明人： Edwin Madison ,  Jack Nguyen ,  Sandra Ruggles ,  Christopher Thanos

    IPC分类号： A61K48/00 ,  C12N15/09

    CPC分类号： A61K38/482 ,  A61K38/49 ,  C07K2319/00 ,  C12N9/6421 ,  C12N9/6424 ,  C12N9/6467 ,  C12Y304/21109

    摘要： Provided are methods for and compounds for modulating the complement system. In particular, compounds are provided that inhibit complement activation and compounds are provided that promote complement activation. The compounds are therapeutics by virtue of their effects on the complement system. Hence, the compounds that inhibit complement activation can be used for treatment of ischemic and reperfusion disorders, including myocardial infarction and stroke, sepsis, autoimmune diseases, inflammatory diseases and diseases with an inflammatory component, including Alzheimer's Disease and other neurodegenerative disorder.

    摘要翻译： 提供了用于调节补体系统的方法和化合物。 特别地，提供抑制补体活化的化合物，并提供促进补体活化的化合物。 这些化合物由于其对补体系统的作用而成为治疗剂。 因此，抑制补体活化的化合物可用于治疗缺血和再灌注障碍，包括心肌梗死和中风，败血症，自身免疫性疾病，炎性疾病和具有炎性成分的疾病，包括阿尔茨海默氏病和其他神经变性疾病。