公开(公告)号：US07999079B2

公开(公告)日：2011-08-16

申请号：US12646705

申请日：2009-12-23

Applicant: James D. Marks ,  Peter Amersdorfer ,  Isin Geren ,  Jianlong Lou ,  Ali Razai ,  Maria Consuelo Garcia

Inventor： James D. Marks ,  Peter Amersdorfer ,  Isin Geren ,  Jianlong Lou ,  Ali Razai ,  Maria Consuelo Garcia

IPC: C07K16/00 ,  A61K39/395

CPC classification number: C07K16/1282 ,  A61K2039/507 ,  C07K2317/21 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92

Abstract: This invention provides antibodies that specifically bind to and neutralize botulinum neurotoxin type A (BoNT/A) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.

Abstract translation: 本发明提供了特异性结合并中和A型（BoNT / A）肉毒杆菌神经毒素和由这些抗体结合的表位的抗体。 特异性结合本文提供的中和表位的抗体及其衍生物和/或其他抗体可用于中和肉毒杆菌神经毒素，因此也可用于治疗肉毒中毒。

公开(公告)号：US07700738B2

公开(公告)日：2010-04-20

申请号：US11342271

申请日：2006-01-26

Applicant: James D. Marks ,  Isin Geren ,  Jianlong Lou

Inventor： James D. Marks ,  Isin Geren ,  Jianlong Lou

IPC: C07K16/00 ,  A61K39/395

CPC classification number: C07K16/1282 ,  A61K2039/507 ,  C07K2317/21 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92

Abstract: This invention provides antibodies that specifically bind to and neutralize botulinum neurotoxin type A (BoNT/A) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.

Abstract translation: 本发明提供了特异性结合并中和A型（BoNT / A）肉毒杆菌神经毒素和由这些抗体结合的表位的抗体。 特异性结合本文提供的中和表位的抗体及其衍生物和/或其他抗体可用于中和肉毒杆菌神经毒素，因此也可用于治疗肉毒中毒。

公开(公告)号：US07596578B1

公开(公告)日：2009-09-29

申请号：US09603601

申请日：2000-06-26

Applicant: James D. Marks

Inventor： James D. Marks

IPC: G06F17/00 ,  G06F7/00 ,  G06F9/46 ,  G05B19/418 ,  G06Q30/00 ,  G07G1/14

CPC classification number: G06Q30/02 ,  G06F19/00 ,  G06Q30/0217 ,  G06Q50/22 ,  Y10S707/99945 ,  Y10S707/99948

Abstract: A method and system, executed by a server, is disclosed for receiving questions from users regarding one or more topics and providing answers from a set of experts. Users can direct questions to one or more specific experts, who in turn can answer the questions, refer the questions to other experts, or both. The server automatically organizes and stores questions and answers in various for a dedicated to one or more topics, such as medical treatment for specific health conditions. Responses generated by the experts to the questions asked by the users may, in turn, be reviewed by peer review personnel. The system may be deployed at multiple network sites to provide a question and answer forum to users who visit different sites. Each network site in which the system is deployed may selectively decide whether to post at its network site the responses by experts and/or peer review personnel to questions originating from other network sites. In addition, each network site can selectively decide whether the responses by experts and/or peer review personnel to questions originating at their network site should be permitted to be posted on other network sites. Methods for funding a network site according to the present invention include the provision of advertising banners, receiving subscription payments or fees from user/subscribers for receiving expert opinions, and receiving payments from third party sponsors. Users who access the site may, in turn, receive benefits in exchange for soliciting such expert opinions.

Abstract translation: 公开了一种由服务器执行的方法和系统，用于从用户接收关于一个或多个主题的问题并从一组专家提供答案。 用户可以向一个或多个特定专家提出问题，反过来可以回答问题，将问题转交给其他专家或两者。 服务器自动组织和存储各种专门针对一个或多个主题的问题和答案，例如针对特定健康状况的医疗。 由专家对用户提出的问题产生的响应可以由同行评审人员进行审查。 该系统可以部署在多个网站，为访问不同站点的用户提供问答平台。 系统部署的每个网络站点可以选择性地决定是否在其网络站点发布专家和/或同行评审人员对来自其他网络站点的问题的响应。 此外，每个网络站点都可以选择性地决定是否允许专家和/或同行评审人员在其网站发起的问题的响应被发布在其他网站上。 根据本发明的为网站提供资金的方法包括提供广告横幅，从用户/订户接收订阅付款或收费以接收专家意见，以及从第三方赞助商接收付款。 进入该网站的用户反过来可以获得收益，以换取征求此类专家意见。

公开(公告)号：US07418437B1

公开(公告)日：2008-08-26

申请号：US10651490

申请日：2003-08-29

Applicant: James D. Marks

Inventor： James D. Marks

IPC: G06F17/30

CPC classification number: G06Q10/10 ,  Y10S707/99931 ,  Y10S707/99942 ,  Y10S707/99943

Abstract: A method and system, executed by a server, for receiving questions from users regarding one or more topics and providing answers from a set of experts. Users direct questions to one or more experts selected by the users, who in turn answer the questions and/or refer the questions to other experts. The system is deployed at multiple network sites that provide multiple question and answer forums, each directed to predetermined topics. An expert who answers a question presented at a forum on one network site is thereby able to post an answer to the forum on the one network site, and to selectively post the answer to another forum on another network site at which the question was not presented.

Abstract translation: 由服务器执行的用于从用户接收关于一个或多个主题的问题并从一组专家提供答案的方法和系统。 用户直接向用户选择的一个或多个专家提出问题，他们反过来回答问题和/或将问题转交给其他专家。 该系统部署在提供多个问题和答案论坛的多个网站上，每个都针对预定的主题。 因此，回答在一个网站上的论坛提出的问题的专家能够在一个网站上发布论坛的答案，并且有选择地将答案发布到另一个网站上，该问题不在此提出 。

公开(公告)号：US07244826B1

公开(公告)日：2007-07-17

申请号：US09250056

申请日：1999-02-12

Applicant: James D. Marks ,  Marie Alix Poul

Inventor： James D. Marks ,  Marie Alix Poul

IPC: C12P21/08 ,  C07K16/00 ,  A61K39/395

CPC classification number: A61K47/48823 ,  A61K9/0019 ,  A61K31/704 ,  A61K38/00 ,  A61K47/6809 ,  A61K47/6843 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6865 ,  A61K47/6913 ,  C07K16/2863 ,  C07K16/2881 ,  C07K16/3053 ,  C07K16/32 ,  C07K2317/10 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2319/02 ,  C12N15/86 ,  C12N2795/10043 ,  C12N2810/859 ,  Y10S424/812

Abstract: This invention provides novel erbB2-binding internalizing antibodies. The antibodies, designated F5 and C1, specifically bind to c-erbB2 antigen and, upon binding, are readily internalized into the cell bearing the c-erbB2 marker. Chimeric molecules comprising the F5 and/or C1 antibodies attached to one or more effector molecules are also provided.

Abstract translation: 本发明提供新的erbB2结合内化抗体。 称为F5和C1的抗体特异性结合c-erbB2抗原，并且在结合时容易内化到带有c-erbB2标记的细胞中。 还提供了包含与一个或多个效应分子相连的F5和/或C1抗体的嵌合分子。

公开(公告)号：US07045283B2

公开(公告)日：2006-05-16

申请号：US09981636

申请日：2001-10-16

Applicant: James D. Marks ,  Ulrik B. Nielson ,  Dimitri B. Kirpotin

Inventor： James D. Marks ,  Ulrik B. Nielson ,  Dimitri B. Kirpotin

IPC: C12Q1/00 ,  G01N33/53 ,  G01N33/566 ,  G01N33/573

CPC classification number: G01N33/5011 ,  C40B30/04 ,  G01N33/5008 ,  G01N33/5432 ,  G01N33/566 ,  G01N33/6845 ,  G01N33/6854 ,  G01N33/6863

Abstract: This invention provides methods of identifying ligands that are internalized into a cell. The methods typically involve i) contacting the cell with a reporter non-covalently coupled to a ligand; ii) dissociating the reporter from the ligand and removing dissociated reporter from the surface of the cell; and iii) detecting the reporter within said cell (if any is present) where the presence of the reporter within said cell indicates that the ligand binds to an internalizing receptor and is internalized.

公开(公告)号：US09220772B2

公开(公告)日：2015-12-29

申请号：US13810638

申请日：2011-07-22

Applicant: Yu Zhou ,  James D. Marks

Inventor： Yu Zhou ,  James D. Marks

IPC: A61K39/395 ,  C07K16/30 ,  C07K16/46 ,  C07K16/28 ,  C07K16/40

CPC classification number: C07K16/2866 ,  A61K39/39558 ,  A61K47/60 ,  C07K16/2884 ,  C07K16/30 ,  C07K16/40 ,  C07K16/464 ,  C07K2317/10 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/77 ,  C07K2317/92

Abstract: Antibodies that bind to tumor associated antigen CD44 or to tumor associated antigen EphA2, are disclosed herein, as well as related compositions and methods of use. Methods of use encompass cancer therapies, diagnostics, and screening methods.

Abstract translation: 与肿瘤相关抗原CD44或肿瘤相关抗原EphA2结合的抗体在本文中公开，以及相关的组合物和使用方法。 使用方法包括癌症治疗，诊断和筛选方法。

公开(公告)号：US08974792B2

公开(公告)日：2015-03-10

申请号：US13441651

申请日：2012-04-06

Applicant: James D. Marks ,  Marie Alix Poul

Inventor： James D. Marks ,  Marie Alix Poul

IPC: A61K39/44 ,  A61K39/395 ,  C07K16/30 ,  A61K47/48 ,  C07K16/28 ,  C07K16/32 ,  C12N15/86 ,  A61K31/704 ,  A61K38/00

CPC classification number: A61K47/48823 ,  A61K9/0019 ,  A61K31/704 ,  A61K38/00 ,  A61K47/6809 ,  A61K47/6843 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6865 ,  A61K47/6913 ,  C07K16/2863 ,  C07K16/2881 ,  C07K16/3053 ,  C07K16/32 ,  C07K2317/10 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2319/02 ,  C12N15/86 ,  C12N2795/10043 ,  C12N2810/859 ,  Y10S424/812

Abstract: This invention provides novel erbB2-binding internalizing antibodies. The antibodies, designated F5 and C1, specifically bind to c-erbB2 antigen and, upon binding, are readily internalized into the cell bearing the c-erbB2 marker. Chimeric molecules comprising the F5 and/or C1 antibodies attached to one or more effector molecules are also provided.

Abstract translation: 本发明提供新的erbB2结合内化抗体。 称为F5和C1的抗体特异性结合c-erbB2抗原，并且在结合时容易内化到带有c-erbB2标记的细胞中。 还提供了包含与一个或多个效应分子相连的F5和/或C1抗体的嵌合分子。

公开(公告)号：US08329873B2

公开(公告)日：2012-12-11

申请号：US11943367

申请日：2007-11-20

Applicant: Gregory P. Adams ,  Eva M. Horak ,  Louis M. Weiner ,  James D. Marks

Inventor： Gregory P. Adams ,  Eva M. Horak ,  Louis M. Weiner ,  James D. Marks

IPC: C07K16/00

CPC classification number: A61K39/395 ,  A61K51/109 ,  A61K2039/505 ,  C07K16/2863 ,  C07K16/32 ,  C07K2317/31 ,  C07K2317/622 ,  G01N2333/71

Abstract: Bispecific single chain antibody molecules are disclosed which may be used to advantage to treat various forms of cancer associated with the overexpression of members of the EGFR protein family.

Abstract translation: 公开了双特异性单链抗体分子，其可用于治疗与EGFR蛋白家族的成员的过表达相关的各种形式的癌症。

公开(公告)号：US08173424B2

公开(公告)日：2012-05-08

申请号：US12928792

申请日：2010-12-16

Applicant: James D. Marks ,  Marie Alix Poul

Inventor： James D. Marks ,  Marie Alix Poul

IPC: C12N5/16 ,  C07H21/02 ,  C07H21/04 ,  A61K39/395 ,  C12P21/08

CPC classification number: A61K47/48823 ,  A61K9/0019 ,  A61K31/704 ,  A61K38/00 ,  A61K47/6809 ,  A61K47/6843 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6865 ,  A61K47/6913 ,  C07K16/2863 ,  C07K16/2881 ,  C07K16/3053 ,  C07K16/32 ,  C07K2317/10 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2319/02 ,  C12N15/86 ,  C12N2795/10043 ,  C12N2810/859 ,  Y10S424/812

Abstract: This invention provides novel erbB2-binding internalizing antibodies. The antibodies, designated F5 and C1, specifically bind to c-erbB2 antigen and, upon binding, are readily internalized into the cell bearing the c-erbB2 marker. Chimeric molecules comprising the F5 and/or C1 antibodies attached to one or more effector molecules are also provided.

Abstract translation: 本发明提供新的erbB2结合内化抗体。 称为F5和C1的抗体特异性结合c-erbB2抗原，并且在结合时容易内化到带有c-erbB2标记的细胞中。 还提供了包含与一个或多个效应分子相连的F5和/或C1抗体的嵌合分子。