公开(公告)号：US10954284B2

公开(公告)日：2021-03-23

申请号：US15637276

申请日：2017-06-29

Applicant: Janssen Biotech, Inc.

Inventor： Mark Anderson ,  Ricardo Attar ,  Michael Diem ,  Linus Hyun ,  Steven Jacobs ,  Alastair King ,  Donna Klein ,  Sheri Moores ,  Karyn O'Neil ,  Kristen Picha

IPC: C07K14/705 ,  C07K14/78 ,  C07K14/71 ,  C07K16/28 ,  C07K14/47 ,  A61K45/06 ,  A61K39/00 ,  A61K38/00

Abstract: Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.

公开(公告)号：US10571472B2

公开(公告)日：2020-02-25

申请号：US15845657

申请日：2017-12-18

Applicant: Janssen Biotech, Inc.

Inventor： Michael Diem ,  Steven Jacobs

IPC: C40B40/10 ,  G01N33/68 ,  C12N15/10 ,  C40B40/08 ,  C40B50/06 ,  C40B30/04

Abstract: Protein scaffolds and scaffold libraries based on a fibronectin type III (FN3) repeat with an alternative binding surface design, isolated nucleic acids encoding the protein scaffolds, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.

公开(公告)号：US20180162928A1

公开(公告)日：2018-06-14

申请号：US15840281

申请日：2017-12-13

Applicant: Janssen Biotech, Inc.

Inventor： Michael Diem ,  Rebecca Hawkins ,  Steven Jacobs ,  Manuel Sepulveda

IPC: C07K14/78 ,  C07K14/705 ,  C12N15/85 ,  A61P35/00

Abstract: FN3 domains that specifically bind to PD-L1, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making and using them are useful in therapeutic and diagnostic applications.

公开(公告)号：US20170362301A1

公开(公告)日：2017-12-21

申请号：US15629090

申请日：2017-06-21

Applicant: Janssen Biotech, Inc.

Inventor： Mark Anderson ,  Ricardo Attar ,  Michael Diem ,  Linus Hyun ,  Alastair King ,  Steven Jacobs ,  Shalom Goldberg ,  Donna Klein ,  Sheri Moores ,  Karyn O'Neil ,  Kristen Picha

IPC: C07K14/78

Abstract: Cysteine engineered monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules comprising one or more free cysteine amino acids are prepared by mutagenizing a nucleic acid sequence of a parent molecule and replacing one or more amino acid residues by cysteine to encode the cysteine engineered FN3 domain containing monospecific or bispecific molecules; expressing the cysteine engineered FN3 domain containing molecules; and recovering the cysteine engineered FN3 domain containing molecule. Isolated cysteine engineered monospecific or bispecific FN3 domain containing molecules may be covalently attached to a detection label or a drug moiety and used therapeutically.

公开(公告)号：US20170305997A1

公开(公告)日：2017-10-26

申请号：US15637276

申请日：2017-06-29

Applicant: Janssen Biotech, Inc.

Inventor： Mark Anderson ,  Ricardo Attar ,  Michael Diem ,  Linus Hyun ,  Steven Jacobs ,  Alastair King ,  Donna Klein ,  Sheri Moores ,  Karyn O'Neil ,  Kristen Picha

IPC: C07K14/78 ,  A61K45/06 ,  C07K14/47 ,  C07K14/71 ,  C07K16/28 ,  C07K14/705 ,  A61K39/00 ,  A61K38/00

CPC classification number: C07K14/78 ,  A61K38/00 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/47 ,  C07K14/705 ,  C07K14/71 ,  C07K16/28 ,  C07K16/2863 ,  C07K2317/31 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2318/20 ,  C07K2319/70

Abstract: Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.

公开(公告)号：US12258385B2

公开(公告)日：2025-03-25

申请号：US17732420

申请日：2022-04-28

Applicant: JANSSEN BIOTECH, INC

Inventor： Michael Diem ,  Rebecca Hawkins ,  Steven Jacobs ,  Manuel Sepulveda

IPC: C07K14/78 ,  A61P35/00 ,  C07K14/705 ,  C12N15/85 ,  G01N33/53 ,  G01N33/566 ,  G01N33/574 ,  G01N33/68 ,  A61K38/39 ,  C07K14/71

Abstract: FN3 domains that specifically bind to CD137, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making and using them are useful in therapeutic and diagnostic applications.

公开(公告)号：US20240100129A1

公开(公告)日：2024-03-28

申请号：US18496397

申请日：2023-10-27

Applicant: Janssen Biotech, Inc.

Inventor： Michael Diem ,  Steven Jacobs ,  Karyn O'Neil ,  Thomas Rutkoski

IPC: A61K38/39 ,  A61K47/54 ,  C07K14/78 ,  C07K16/18 ,  C07K16/40 ,  G01N33/68

CPC classification number: A61K38/39 ,  A61K47/549 ,  C07K14/78 ,  C07K16/18 ,  C07K16/40 ,  G01N33/68 ,  A61K2039/505 ,  C07K2317/94

Abstract: Fibronectin type III domains (FN3) that specifically bind to serum albumin, related polynucleotides capable of encoding serum albumin-specific FN3 domains, cells expressing the FN3 domains, as well as associated vectors, detectably labeled FN3 domains and FN3 domains fused to a heterologous moiety are useful in extending the half-life of molecules in diagnostic and therapeutic applications.

公开(公告)号：US11447539B2

公开(公告)日：2022-09-20

申请号：US16801787

申请日：2020-02-26

Applicant: Janssen Biotech, Inc.

Inventor： Michael Diem ,  Rebecca Hawkins ,  Steven Jacobs ,  Manuel Sepulveda

IPC: C07K14/705 ,  C07K14/71 ,  C07K14/78 ,  A61P35/00 ,  C12N15/85 ,  C07K16/28 ,  A61K38/17 ,  A61K38/39

Abstract: FN3 domains that specifically bind to PD-L1, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making and using them are useful in therapeutic and diagnostic applications.

公开(公告)号：US11345739B2

公开(公告)日：2022-05-31

申请号：US16820844

申请日：2020-03-17

Applicant: Janssen Biotech, Inc.

Inventor： Michael Diem ,  Rebecca Hawkins ,  Steven Jacobs ,  Manuel Sepulveda

IPC: C07K14/78 ,  G01N33/53 ,  G01N33/574 ,  A61P35/00 ,  C12N15/85 ,  C07K14/705 ,  G01N33/68 ,  C07K14/71 ,  A61K38/39 ,  G01N33/566

Abstract: FN3 domains that specifically bind to CD137, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making and using them are useful in therapeutic and diagnostic applications.

公开(公告)号：US20210228688A1

公开(公告)日：2021-07-29

申请号：US17153229

申请日：2021-01-20

Applicant: Janssen Biotech, Inc.

Inventor： Michael Diem ,  Steven Jacobs ,  Karyn O'Neil ,  Thomas Rutkoski

IPC: A61K38/39 ,  A61K47/54 ,  C07K14/78 ,  C07K16/18 ,  C07K16/40

Abstract: Fibronectin type III domains (FN3) that specifically bind to serum albumin, related polynucleotides capable of encoding serum albumin-specific FN3 domains, cells expressing the FN3 domains, as well as associated vectors, detectably labeled FN3 domains and FN3 domains fused to a heterologous moiety are useful in extending the half-life of molecules in diagnostic and therapeutic applications.