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公开(公告)号：US08952323B2
公开(公告)日：2015-02-10
申请号：US12092601
申请日：2006-11-10
CPC分类号： H01J49/004 , G01N27/622 , H01J49/0031 , H01J49/42
摘要： A mass spectrometer is disclosed comprising a first ion trap or ion guide (2), a single ion mobility spectrometer or separator stage (3) and a second ion trap or ion guide (4) arranged downstream of the ion mobility spectrometer or separator (3). In a mode of operation ions from the second ion trap or ion guide (4) are passed from the second ion trap or ion guide back upstream to the ion mobility spectrometer or separator (3).
摘要翻译： 公开了一种质谱仪，其包括第一离子阱或离子导向器（2），单离子迁移谱仪或分离器级（3）和设置在离子迁移谱仪或分离器（3）的下游的第二离子阱或离子导向器 ）。 在操作模式中，来自第二离子阱或离子导向器（4）的离子从第二离子阱或离子导向器返回到离子迁移谱仪或分离器（3）的上游。
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公开(公告)号：US08519328B2
公开(公告)日：2013-08-27
申请号：US13435877
申请日：2012-03-30
IPC分类号： H01J49/26
CPC分类号： H01J49/427 , H01J49/4235
摘要： An ion guide or ion trap is disclosed having an entrance electrode and an exit electrode. The potential of the exit electrode is periodically dropped for a relatively short period of time allowing some ions to escape from the ion guide or ion trap via an aperture in the exit electrode. The period of time that the potential of the exit electrode is dropped for is progressively increased and ions emerge from the ion guide or ion trap in a mass to charge ratio dependent manner. The ion guide or ion trap may be operated as a mass separator or low resolution mass analyzer.
摘要翻译： 公开了一种具有入口电极和出射电极的离子导向器或离子阱。 出口电极的电位周期性地下降相当短的时间段，允许一些离子通过出射电极的孔离开离子导向器或离子阱。 出口电极的电位下降的时间段逐渐增加，并且离子导向器或离子阱以质荷比依赖的方式出现离子。 离子导向器或离子阱可以作为质量分离器或低分辨率质量分析器来操作。
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23.发明申请公开(公告)号：US20130168546A1
公开(公告)日：2013-07-04
申请号：US13576344
申请日：2011-02-14
申请人： Richard Denny , Keith Richardson , Martin Raymond Green , Steven Derek Pringle , Anthony James Gilbert , John Skilling , Jason Lee Wildgoose
发明人： Richard Denny , Keith Richardson , Martin Raymond Green , Steven Derek Pringle , Anthony James Gilbert , John Skilling , Jason Lee Wildgoose
CPC分类号： H01J49/0036 , H01J49/40
摘要： A method of mass spectrometry is disclosed wherein a signal output from an ion detector is digitised by an Analogue to Digital Converter and is then deconvoluted to determine one or more ion arrival times and one more ion arrival intensities. The process of deconvoluting the ion signal involves determining a point spread function characteristic of an ion arriving at and being detected by the ion detector. A distribution of ion arrival times which produces a best fit to the digitised signal is then determined given that each ion arrival is assumed to produce a response given by the point spread function. A plurality of ion arrival times are then combined to produce a composite ion arrival time-intensity spectrum.
摘要翻译： 公开了一种质谱法，其中从离子检测器输出的信号被模拟数字转换器数字化，然后进行解卷积，以确定一个或多个离子到达时间和一个离子到达强度。 去卷积离子信号的过程涉及确定到达并被离子检测器检测的离子的点扩散函数特征。 因此，假设每个离子到达产生由点扩散函数给出的响应，则确定产生与数字化信号最佳拟合的离子到达时间的分布。 然后将多个离子到达时间组合以产生复合离子到达时间强度谱。
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公开(公告)号：US08426802B2
公开(公告)日：2013-04-23
申请号：US12518291
申请日：2007-12-12
CPC分类号： G01N27/622 , G01N27/624 , H01J49/062 , H01J49/4235
摘要： A mass spectrometer is disclosed comprising a device which is operable in a first mode of operation to separate ions temporally according to their ion mobility by applying a continuous axial electric field. The device is also operable in a second mode of operation wherein ions are separated temporally according to the their mass to charge ratio by pulsing an applied axial electric field ON and OFF.
摘要翻译： 公开了一种质谱仪，其包括可在第一操作模式中操作的装置，其通过施加连续的轴向电场根据其离子迁移率暂时分离离子。 该装置还可在第二操作模式中操作，其中通过脉冲施加的轴向电场ON和OFF，离子根据其质荷比暂时分离。
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公开(公告)号：US20110042565A1
公开(公告)日：2011-02-24
申请号：US12917720
申请日：2010-11-02
IPC分类号： H01J49/40
CPC分类号： G01N27/622 , H01J49/0027 , H01J49/0031 , H01J49/004 , H01J49/0045 , H01J49/02 , H01J49/062 , H01J49/065 , H01J49/066 , H01J49/40 , H01J49/401 , H01J49/42
摘要： A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator 4 and an ion guide 6 arranged downstream of the ion mobility spectrometer or separator 4. A plurality of axial potential wells are created in the ion guide 6 so that ions received from the ion mobility spectrometer or separator 4 become confined in separate axial potential wells. The potential wells maintain the fidelity and/or composition of ions received from the ion mobility spectrometer or separator 4. The potential wells are translated along the length of the ion guide 6.
摘要翻译： 公开了一种质谱仪，其包括离子迁移谱仪或分离器4和布置在离子迁移谱仪或分离器4下游的离子导向器6.在离子导向器6中产生多个轴向势阱，使得从离子迁移率 光谱仪或分离器4被限制在单独的轴向势阱中。 势阱保持从离子迁移谱仪或分离器4接收的离子的保真度和/或组成。势阱沿离子导向器6的长度平移。
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公开(公告)号：US07829841B2
公开(公告)日：2010-11-09
申请号：US11718213
申请日：2005-11-03
CPC分类号： G01N27/622 , H01J49/0027 , H01J49/0031 , H01J49/004 , H01J49/0045 , H01J49/02 , H01J49/062 , H01J49/065 , H01J49/066 , H01J49/40 , H01J49/401 , H01J49/42
摘要： A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator (4) and an ion guide (6) arranged downstream of the ion mobility spectrometer or separator (4). A plurality of axial potential wells are created in the ion guide (6) so that ions received from the ion mobility spectrometer or separator (4) become confined in separate axial potential wells. The potential wells maintain the fidelity and/or composition of ions received from the ion mobility spectrometer or separator (4). The potential wells are translated along the length of the ion guide (6).
摘要翻译： 公开了一种质谱仪，其包括离子迁移谱仪或分离器（4）和布置在离子迁移谱仪或分离器（4）的下游的离子导向器（6）。 在离子导向器（6）中产生多个轴向势阱，使得从离子迁移谱仪或分离器（4）接收的离子被限制在单独的轴向势阱中。 潜在的孔维持从离子迁移谱仪或分离器（4）接收的离子的保真度和/或组成。 潜在的井沿离子导向件（6）的长度平移。
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公开(公告)号：US20100065737A1
公开(公告)日：2010-03-18
申请号：US11721260
申请日：2005-12-08
申请人： Robert Harold Bateman , Kevin Giles , Jeffrey Mark Brown , Steven Derek Pringle , Jason Lee Wildgoose
发明人： Robert Harold Bateman , Kevin Giles , Jeffrey Mark Brown , Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： B01D59/44
CPC分类号： H01J49/062 , H01J49/004
摘要： A mass spectrometer is disclosed comprising a mass selective ion trap or mass analyser (4) arranged upstream of an ion guide (6). Ions are scanned out of the mass selective ion trap or mass analyser (4) and are received in one or more axial potential wells created or formed within the ion guide (6). One or more transient DC voltages or potentials are preferably applied to the ion guide (6) in order to create a plurality of axial potential wells which are translated along the length of the ion guide (6). Ions are released in packets from the exit of the ion guide (6) and are orthogonally accelerated into a drift or flight region of an orthogonal acceleration Time of Flight mass analyser (13) with a relatively high duty cycle.
摘要翻译： 公开了一种质谱仪，其包括布置在离子导向器（6）上游的质量选择性离子阱或质量分析器（4）。 从质量选择性离子阱或质量分析器（4）中扫描离子，并将其接收在离子导向器（6）内产生或形成的一个或多个轴向势阱中。 优选地将一个或多个瞬态DC电压或电位施加到离子导向器（6），以便产生沿离子导向件（6）的长度平移的多个轴向势阱。 从离子导向器（6）的出口以分组的形式释放离子，并以相对较高的占空比正交加速到正交加速时间飞行质量分析器（13）的漂移或飞行区域。
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公开(公告)号：US20090121123A1
公开(公告)日：2009-05-14
申请号：US11916438
申请日：2006-06-05
CPC分类号： H01J49/427 , H01J49/4235
摘要： An ion guide or ion trap (1) is disclosed having an entrance electrode (2) and an exit electrode (3). The potential of the exit electrode (3) is periodically dropped for a relatively short period of time allowing some ions to escape from the ion guide or ion trap (1) via an aperture in the exit electrode (3). The period of time that the potential of the exit electrode (3) is dropped for is progressively increased and ions emerge from the ion guide or ion trap (1) in a mass to charge ratio dependent manner. The ion guide or ion trap (1) may be operated as a mass separator or low resolution mass analyser.
摘要翻译： 公开了一种具有入口电极（2）和出口电极（3）的离子导向器或离子阱（1）。 出口电极（3）的电位周期性地下降相当短的时间段，允许一些离子通过出射电极（3）中的孔从离子导向器或离子阱（1）逸出。 退出电极（3）的电位下降的时间段逐渐增加，并且离子导向器或离子阱（1）以质荷比依赖的方式出现离子。 离子导向器或离子阱（1）可以作为质量分离器或低分辨率质量分析器来操作。
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公开(公告)号：US20080135746A1
公开(公告)日：2008-06-12
申请号：US11574554
申请日：2005-09-14
IPC分类号： B01D59/44
CPC分类号： H01J49/005
摘要： A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator (3) arranged upstream of a collision or fragmentation cell (5). Ions are separated according to their ion mobility within the ion mobility spectrometer or separator (3). The kinetic energy of the ions exiting the ion mobility spectrometer or separator (3) is increased substantially linearly with time in order to optimise the fragmentation energy of ions as they enter the collision or fragmentation cell (5).
摘要翻译： 公开了一种质谱仪，其包括设置在碰撞或破碎电池（5）的上游的离子迁移谱仪或分离器（3）。 离子在离子迁移谱仪或分离器（3）内根据其离子迁移率分离。 离子离子迁移谱仪或分离器（3）离子的动能随时间呈线性增加，以优化离子进入碰撞或破碎电池（5）时的碎裂能。
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公开(公告)号：US20140326867A1
公开(公告)日：2014-11-06
申请号：US14270433
申请日：2014-05-06
CPC分类号： H01J49/0036 , H01J49/40
摘要： A mass spectrometer is disclosed wherein an ion signal is split into a first and second signal. The first and second signals are multiplied by different gains and are digitised. Arrival time and intensity pairs are calculated for both digitised signals and the resulting time and intensity pairs are combined to form a high dynamic range spectrum. The spectrum is then combined with other corresponding spectra to form a summed spectrum.
摘要翻译： 公开了一种质谱仪，其中离子信号被分成第一和第二信号。 第一和第二信号乘以不同的增益并被数字化。 对于两个数字化信号计算到达时间和强度对，并且将所得到的时间和强度对组合以形成高动态范围谱。 然后将光谱与其他对应的光谱组合以形成相加光谱。
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