公开(公告)号：US20080226607A1

公开(公告)日：2008-09-18

申请号：US11929390

申请日：2007-10-30

申请人： Jiangchun Xu ,  John A. Stolk ,  Michael D. Kalos

发明人： Jiangchun Xu ,  John A. Stolk ,  Michael D. Kalos

IPC分类号： A61K39/00 ,  C07K4/00 ,  C07K14/00 ,  C07H21/04 ,  C12N5/00 ,  C12N5/02 ,  C12N15/00 ,  C07K16/00 ,  G01N33/574

CPC分类号： C07K14/005 ,  A01K2227/105 ,  A01K2267/0331 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2035/124 ,  A61K2039/505 ,  A61K2039/5156 ,  A61K2039/53 ,  A61K2039/55566 ,  C07K14/47 ,  C07K14/4748 ,  C07K14/705 ,  C07K16/3069 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2319/00 ,  C12N9/6424 ,  C12N2760/16222 ,  G01N33/57434

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.

摘要翻译： 公开了用于治疗和诊断癌症，特别是前列腺癌的组合物和方法。 说明性组合物包含一种或多种前列腺特异性多肽，其免疫原性部分，编码此类多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达此类多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是前列腺癌的诊断，预防和/或治疗。

公开(公告)号：US06720146B2

公开(公告)日：2004-04-13

申请号：US09970966

申请日：2001-10-02

申请人： John A. Stolk ,  David Alan Molesh ,  Steven P. Fling ,  Jiangchun Xu

发明人： John A. Stolk ,  David Alan Molesh ,  Steven P. Fling ,  Jiangchun Xu

IPC分类号： G01N3348

CPC分类号： C07K14/4748 ,  A61K38/00 ,  C07K14/47 ,  Y10S436/813 ,  Y10T436/143333

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.

公开(公告)号：US06617109B1

公开(公告)日：2003-09-09

申请号：US09713550

申请日：2000-11-14

申请人： Jiangchun Xu ,  John A. Stolk

发明人： Jiangchun Xu ,  John A. Stolk

IPC分类号： C07H2100

CPC分类号： C07K14/4748 ,  A61K38/00

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.

公开(公告)号：US06613515B1

公开(公告)日：2003-09-02

申请号：US09640173

申请日：2000-08-15

申请人： Jiangchun Xu ,  John A. Stolk

发明人： Jiangchun Xu ,  John A. Stolk

IPC分类号： G01N3353

CPC分类号： C07K14/4748 ,  A61K38/00 ,  Y10S436/813 ,  Y10T436/143333

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, portions thereof, polynucleotides that encode such portions or antibodies or immune system cells specific for such proteins. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Polypeptides and polynucleotides as provided herein may further be used for the detection and monitoring of ovarian cancer.

摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如卵巢癌。 组合物可以包含一种或多种卵巢癌蛋白，其部分，编码这种部分的多核苷酸或对这种蛋白质特异的抗体或免疫系统细胞。 这样的组合物可用于例如预防和治疗诸如卵巢癌的疾病。 本文提供的多肽和多核苷酸还可用于检测和监测卵巢癌。

公开(公告)号：US06710170B2

公开(公告)日：2004-03-23

申请号：US09825294

申请日：2001-04-03

申请人： Jiangchun Xu ,  John A. Stolk ,  Paul A. Algate ,  Steven P. Fling

发明人： Jiangchun Xu ,  John A. Stolk ,  Paul A. Algate ,  Steven P. Fling

IPC分类号： C07H2100

CPC分类号： C07K14/4748 ,  A61K38/00

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.

摘要翻译： 公开了用于治疗和诊断癌症，特别是卵巢癌的组合物和方法。 说明性组合物包含一个或多个卵巢肿瘤多肽，其免疫原性部分，编码此类多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达此类多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是卵巢癌的诊断，预防和/或治疗。