公开(公告)号：US06710170B2

公开(公告)日：2004-03-23

申请号：US09825294

申请日：2001-04-03

申请人： Jiangchun Xu ,  John A. Stolk ,  Paul A. Algate ,  Steven P. Fling

发明人： Jiangchun Xu ,  John A. Stolk ,  Paul A. Algate ,  Steven P. Fling

IPC分类号： C07H2100

CPC分类号： C07K14/4748 ,  A61K38/00

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.

摘要翻译： 公开了用于治疗和诊断癌症，特别是卵巢癌的组合物和方法。 说明性组合物包含一个或多个卵巢肿瘤多肽，其免疫原性部分，编码此类多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达此类多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是卵巢癌的诊断，预防和/或治疗。

公开(公告)号：US06720146B2

公开(公告)日：2004-04-13

申请号：US09970966

申请日：2001-10-02

申请人： John A. Stolk ,  David Alan Molesh ,  Steven P. Fling ,  Jiangchun Xu

发明人： John A. Stolk ,  David Alan Molesh ,  Steven P. Fling ,  Jiangchun Xu

IPC分类号： G01N3348

CPC分类号： C07K14/4748 ,  A61K38/00 ,  C07K14/47 ,  Y10S436/813 ,  Y10T436/143333

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.

公开(公告)号：US06699664B1

公开(公告)日：2004-03-02

申请号：US09667857

申请日：2000-09-20

申请人： Jennifer L. Mitcham ,  Gordon E. King ,  Paul A. Algate ,  Steven P. Fling ,  Marc W. Retter ,  Gary R. Fanger ,  Steven G. Reed ,  Thomas S. Vedvick ,  Darrick Carter

发明人： Jennifer L. Mitcham ,  Gordon E. King ,  Paul A. Algate ,  Steven P. Fling ,  Marc W. Retter ,  Gary R. Fanger ,  Steven G. Reed ,  Thomas S. Vedvick ,  Darrick Carter

IPC分类号： C12Q168

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C07K16/3069 ,  C07K2317/34 ,  C07K2319/00

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, polynucleotides that encode such portions or antibodies or immune system cells specific for such proteins. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Methods are further provided for identifying tumor antigens that are secreted from ovarian carcinomas and/or other tumors. Polypeptides and polynucleotides as provided herein may further be used for the diagnosis and monitoring of ovarian cancer.

摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如卵巢癌。 组合物可以包含一种或多种卵巢癌蛋白，其免疫原性部分，编码这种部分的多核苷酸或对这些蛋白质特异的抗体或免疫系统细胞。 这样的组合物可用于例如预防和治疗诸如卵巢癌的疾病。 还提供了用于鉴定从卵巢癌和/或其他肿瘤分泌的肿瘤抗原的方法。 本文提供的多肽和多核苷酸还可用于诊断和监测卵巢癌。

公开(公告)号：US07202334B1

公开(公告)日：2007-04-10

申请号：US09636801

申请日：2000-08-10

申请人： Jennifer L. Mitcham ,  Gordon E. King ,  Paul A. Algate ,  Steven P. Fling ,  Marc W. Retter ,  Gary R. Fanger ,  Steven G. Reed

发明人： Jennifer L. Mitcham ,  Gordon E. King ,  Paul A. Algate ,  Steven P. Fling ,  Marc W. Retter ,  Gary R. Fanger ,  Steven G. Reed

IPC分类号： A61K39/00

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00 ,  C07K14/70532 ,  C07K2319/00 ,  Y02A50/472 ,  Y10S436/813 ,  Y10S530/806 ,  Y10S530/828 ,  Y10S530/853

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, polynucleotides that encode such portions or antibodies or immune system cells specific for such proteins. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Methods are further provided for identifying tumor antigens that are secreted from ovarian carcinomas and/or other tumors. Polypeptides and polynucleotides as provided herein may further be used for the diagnosis and monitoring of ovarian cancer.

摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如卵巢癌。 组合物可以包含一种或多种卵巢癌蛋白，其免疫原性部分，编码这种部分的多核苷酸或对这些蛋白质特异的抗体或免疫系统细胞。 这样的组合物可用于例如预防和治疗诸如卵巢癌的疾病。 还提供了用于鉴定从卵巢癌和/或其他肿瘤分泌的肿瘤抗原的方法。 本文提供的多肽和多核苷酸还可用于诊断和监测卵巢癌。

公开(公告)号：US06432916B1

公开(公告)日：2002-08-13

申请号：US09556877

申请日：2000-04-19

申请人： Peter Probst ,  Ajay Bhatia ,  Yasir A. W. Skeiky ,  Steven P. Fling

发明人： Peter Probst ,  Ajay Bhatia ,  Yasir A. W. Skeiky ,  Steven P. Fling

IPC分类号： A61K3800

CPC分类号： C07K14/295 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/51 ,  C07K2319/00 ,  Y10S435/975

摘要： Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.

公开(公告)号：US20080226642A1

公开(公告)日：2008-09-18

申请号：US11929624

申请日：2007-10-30

申请人： Gary R. Fanger ,  Steven P. Fling

发明人： Gary R. Fanger ,  Steven P. Fling

IPC分类号： A61K39/395 ,  C07H21/04 ,  C12N15/00 ,  C12N5/00 ,  C12Q1/68 ,  A61K48/00 ,  C07K16/00 ,  G01N33/53 ,  C12N5/06

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K39/0011 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/3069 ,  C07K2317/34 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57449 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/25375 ,  Y10T436/255

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.

公开(公告)号：US20110150882A1

公开(公告)日：2011-06-23

申请号：US11929614

申请日：2007-10-30

申请人： Gary R. Fanger ,  Steven P. Fling

发明人： Gary R. Fanger ,  Steven P. Fling

IPC分类号： A61K39/395 ,  A61K39/00 ,  A61K35/26 ,  C12Q1/68 ,  G01N33/53 ,  C12N5/0783 ,  C12N15/63 ,  C12N5/02 ,  C12N5/10 ,  A61K38/00 ,  A61P35/00 ,  A61K31/7088 ,  C07K14/00 ,  C07K16/00 ,  C07H21/04

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K39/0011 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/3069 ,  C07K2317/34 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57449 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/25375 ,  Y10T436/255

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.

公开(公告)号：US07985843B2

公开(公告)日：2011-07-26

申请号：US11929595

申请日：2007-10-30

申请人： Gary R. Fanger ,  Steven P. Fling

发明人： Gary R. Fanger ,  Steven P. Fling

IPC分类号： A61K38/16 ,  C12K21/08 ,  C07K16/00 ,  C07K17/00 ,  C07K17/14

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K39/0011 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/3069 ,  C07K2317/34 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57449 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/25375 ,  Y10T436/255

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.

摘要翻译： 公开了用于治疗和诊断癌症，特别是卵巢癌的组合物和方法。 说明性组合物包含一个或多个卵巢肿瘤多肽，其免疫原性部分，编码此类多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达此类多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是卵巢癌的诊断，预防和/或治疗。

公开(公告)号：US20080233124A1

公开(公告)日：2008-09-25

申请号：US11929600

申请日：2007-10-30

申请人： Gary R. Fanger ,  Steven P. Fling

发明人： Gary R. Fanger ,  Steven P. Fling

IPC分类号： A61K39/395 ,  C07H21/04 ,  C12N15/00 ,  C12N5/00 ,  C12Q1/68 ,  A61K48/00 ,  C07K16/00 ,  G01N33/53 ,  C12N5/06

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K39/0011 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/3069 ,  C07K2317/34 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57449 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/25375 ,  Y10T436/255

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.

摘要翻译： 公开了用于治疗和诊断癌症，特别是卵巢癌的组合物和方法。 说明性组合物包含一个或多个卵巢肿瘤多肽，其免疫原性部分，编码此类多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达此类多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是卵巢癌的诊断，预防和/或治疗。

公开(公告)号：US20080226633A1

公开(公告)日：2008-09-18

申请号：US11929595

申请日：2007-10-30

申请人： Gary R. Fanger ,  Steven P. Fling

发明人： Gary R. Fanger ,  Steven P. Fling

IPC分类号： A61K35/12 ,  C07H21/04 ,  C07K14/46 ,  C12N15/63 ,  C12N5/16 ,  C12N5/08 ,  G01N33/574 ,  A61P35/00 ,  A61K39/395 ,  C07K16/00 ,  G01N33/53 ,  A61K38/17 ,  A61K31/7088

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K39/0011 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/3069 ,  C07K2317/34 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57449 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/25375 ,  Y10T436/255

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.