公开(公告)号：US5135719A

公开(公告)日：1992-08-04

申请号：US607618

申请日：1990-10-23

申请人： Robert S. Hillman ,  Ian Gibbons

发明人： Robert S. Hillman ,  Ian Gibbons

IPC分类号： B01D39/06 ,  B01D39/20 ,  B01D61/18 ,  B01L3/00 ,  G01N33/49

CPC分类号： B01L3/502753 ,  B01D39/1692 ,  B01D39/18 ,  B01D39/2017 ,  B01D61/18 ,  G01N33/491 ,  B01D2239/1216 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0825 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L3/502723 ,  Y10S436/824 ,  Y10T436/25375

摘要： A method for separating plasma from red blood cells and a device utilizing the method in which a low-pressure filter is interposed in a pathway between an inlet port and a reaction area. The sole driving force for the movement of plasma from the filter to the reaction area is capillary force provided by a tubular capillary. The filter is selected from glass microfiber filters of specified characteristics, which can operate in the absence of agglutinins, and filters capable of separating agglutinated red cells from plasma, which require the use of an agglutinin.

摘要翻译： 一种用于从红细胞分离血浆的方法和利用其中低压过滤器插入在入口和反应区域之间的通路中的方法的装置。 用于将等离子体从过滤器移动到反应区域的唯一驱动力是由管状毛细管提供的毛细管力。 该过滤器选自具有特定特征的玻璃微纤维过滤器，其可在不存在凝集素的情况下操作，以及能够从需要使用凝集素的血浆中分离凝集的红细胞的过滤器。

公开(公告)号：US4868129A

公开(公告)日：1989-09-19

申请号：US90026

申请日：1987-08-27

申请人： Ian Gibbons ,  Robert S. Hillman ,  Channing R. Robertson

发明人： Ian Gibbons ,  Robert S. Hillman ,  Channing R. Robertson

IPC分类号： B01F13/00 ,  B01F13/08 ,  B01F15/04 ,  G01N1/38 ,  G01N33/04

CPC分类号： G01N1/38 ,  B01F13/0059 ,  B01F13/0818 ,  B01F15/04 ,  B01L3/5027 ,  G01N33/04 ,  Y10T436/25625 ,  Y10T436/2575

摘要： An apparatus for diluting a sample with a diluent, comprising a fixed volume measuring chamber, a fixed volume receiving chamber and fluid receiving relationship to the measuring chamber, a gas vent in the receiving chamber, a stop flow junction between the measuring chamber and the receiving chamber, a sample application site in fluid donating relationship to the measuring chamber, wherein the vertical height difference between the sample application site and the stop flow junction is insufficient to provide a hydrostatic pressure capable of overcoming backpressure at the stop flow junction when sample is applied to the sample application site, and the diluent application site and fluid donating relationship to the measuring chamber. Sample and diluent are added sequentially to the apparatus of the invention without requiring any intervening operations. Various means are provided for restarting flow, which causes diluent to wash the sample into the receiving chamber, where the two can be mixed.

摘要翻译： 一种用稀释剂稀释样品的装置，包括固定容积测量室，固定容积接收室和与测量室的流体接收关系，接收室中的气体通道，测量室和接收器之间的停止流动接合 室，与测量室的流体供应关系的样品施加部位，其中样品施加部位和止动流动接合点之间的垂直高度差不足以提供当施加样品时能够克服止动流动接合处的背压的静水压力 到样品应用场所，以及稀释剂施用部位和与测量室的流体供给关系。 样品和稀释剂依次添加到本发明的装置中，而不需要任何中间操作。 提供了重新启动流动的各种装置，这使得稀释剂将样品洗涤到接收室中，其中两个可以混合。