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21.发明申请公开(公告)号：US20100261752A1
公开(公告)日：2010-10-14
申请号：US12758631
申请日：2010-04-12
IPC分类号： A61K31/439 , A61K31/4545 , A61P25/28
CPC分类号： A61K31/46 , A61K31/445 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K45/06 , A61K2300/00
摘要： The invention provides methods for the treatment of cognitive disorders utilizing specific 5-HT4 receptor agonist compounds, in particular, methods utilizing these compounds in combination with other agents, specifically acetylcholinesterase inhibitors, for the treatment of Alzheimer's disease and other cognitive disorders.
摘要翻译： 本发明提供了使用特定的5-HT 4受体激动剂化合物治疗认知障碍的方法，特别是利用这些化合物与其它试剂，特别是乙酰胆碱酯酶抑制剂联合用于治疗阿尔茨海默氏病和其他认知障碍的方法。
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公开(公告)号：US20090107887A1
公开(公告)日：2009-04-30
申请号：US12335333
申请日：2008-12-15
CPC分类号： B01D3/22 , B01D3/14 , B01D3/38 , B01D3/4294 , C10G2400/20 , Y02P30/40
摘要： A vapor/liquid separation apparatus for treating a flow of vapor/liquid mixtures of hydrocarbons and steam comprises a vertical drum with a side inlet to introduce hydrocarbon/steam mixtures, an overhead vapor outlet, and a lower section in communication with a cylindrical boot of less diameter than the drum, the boot comprising sufficient gas-liquid contact surface, e.g., that provided by one or more sheds, baffles and/or distillation trays, to provide at least a partial theoretical distillation stage, and a lower portion for receiving liquid from the drum, a lower outlet for removing the liquid, and an inlet for introducing a stripping gas such as steam, hydrogen, light crackable hydrocarbon, and/or methane, below the distillation tray and preferably above the level of liquid in the boot.
摘要翻译： 用于处理烃和蒸汽的蒸汽/液体混合物流的蒸汽/液体分离装置包括具有侧入口以引入碳氢化合物/蒸气混合物的立式鼓，顶部蒸汽出口和与圆柱形套管 小于鼓的直径，靴子包括足够的气液接触表面，例如由一个或多个棚子，挡板和/或蒸馏塔板提供的，以提供至少部分理论蒸馏阶段的底部和用于接收液体的下部 从滚筒，用于除去液体的下部出口，以及用于在蒸馏托盘下方引入诸如蒸汽，氢气，轻质裂解烃和/或甲烷之类的汽提气体的入口，优选在引导器中的液体水平以上。
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公开(公告)号：US20060129012A1
公开(公告)日：2006-06-15
申请号：US11009661
申请日：2004-12-10
CPC分类号： B01D3/22 , B01D3/14 , B01D3/38 , B01D3/4294 , C10G2400/20 , Y02P30/40
摘要： A vapor/liquid separation apparatus for treating a flow of vapor/liquid mixtures of hydrocarbons and steam comprises a vertical drum with a side inlet to introduce hydrocarbon/steam mixtures, an overhead vapor outlet, and a lower section in communication with a cylindrical boot of less diameter than the drum, the boot comprising sufficient gas-liquid contact surface, e.g., that provided by one or more sheds, baffles and/or distillation trays, to provide at least a partial theoretical distillation stage, and a lower portion for receiving liquid from the drum, a lower outlet for removing the liquid, and an inlet for introducing a stripping gas, such as steam, hydrogen, light crackable hydrocarbon, and/or methane, below the distillation tray and preferably above the level of liquid in the boot.
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24.发明申请Benzothiazole derivatives having beta-2-adrenoreceptor agonist activity 审中-公开具有β-2-肾上腺素受体激动剂活性的苯并噻唑衍生物公开(公告)号：US20060106075A1
公开(公告)日：2006-05-18
申请号：US10522359
申请日：2003-08-08
申请人： Bernard Cuenoud , Robin Fairhurst , Roger Taylor , David Beattie
发明人： Bernard Cuenoud , Robin Fairhurst , Roger Taylor , David Beattie
IPC分类号： A61K31/428 , C07D277/68
CPC分类号： C07D417/12 , A61K31/428 , A61K31/454 , A61K31/4545 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D277/68
摘要： Compounds of formula (I) in free or salt or solvate form, wherein X has the meaning indicated in the specification, are useful for treating conditions that are prevented or alleviated by activation of the β2-adrenoreceptor. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
摘要翻译： 游离或盐或溶剂合物形式的式（I）化合物，其中X具有说明书中指出的含义，可用于治疗通过β2 - 肾上腺素受体激活而预防或缓解的病症。 还描述了含有化合物的药物组合物和用于制备化合物的方法。
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公开(公告)号：US20050153957A1
公开(公告)日：2005-07-14
申请号：US11074400
申请日：2005-03-07
申请人： Bernard Cuenoud , Ian Bruce , Robin Fairhurst , David Beattie
发明人： Bernard Cuenoud , Ian Bruce , Robin Fairhurst , David Beattie
IPC分类号： A61K31/137 , A61K31/167 , A61K31/18 , A61K31/222 , A61K31/4704 , A61P11/00 , A61P11/02 , A61P15/06 , A61P25/02 , A61P37/00 , A61P37/08 , A61P43/00 , C07C211/38 , C07C211/42 , C07C215/76 , C07C215/80 , C07C233/03 , C07C233/43 , C07C311/03 , C07C311/08 , C07D215/22 , C07D215/227 , C07D215/26 , C07D405/12 , A61K31/542 , A61K31/423 , A61K31/428 , A61K31/4706 , A61K31/538
CPC分类号： A61K31/4709 , A61K45/06 , C07C215/80 , C07C233/43 , C07C311/08 , C07C2602/08 , C07D215/227 , C07D215/26 , C07D405/12
摘要： Compounds of formula in free or salt or solvate form, where Ar is a group of formula Y is carbon or nitrogen and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n, p, q and r are as defined in the specification, their preparation and their use as pharmaceuticals, particularly for the treatment of obstructive or inflammatory airways diseases.
摘要翻译： 游离或盐或溶剂合物形式的化合物，其中Ar是式Y基团是碳或氮，R 1，R 2，R 3， R 4，R 5，R 6，R 7，R 8， R 0，R 9，R 10，X，n，p，q和r如说明书中所定义，它们的制备及其作为药物的用途，特别是 治疗阻塞性或炎症性气道疾病。
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公开(公告)号：US08283362B2
公开(公告)日：2012-10-09
申请号：US13295426
申请日：2011-11-14
申请人： Bernard Cuenoud , Ian Bruce , Robin A Fairhurst , David Beattie
发明人： Bernard Cuenoud , Ian Bruce , Robin A Fairhurst , David Beattie
IPC分类号： A61P11/00 , A61K31/395
CPC分类号： A61K31/4709 , A61K45/06 , C07C215/80 , C07C233/43 , C07C311/08 , C07C2602/08 , C07D215/227 , C07D215/26 , C07D405/12
摘要： Compounds of formula in free or salt or solvate form, where Ar is a group of formula Y is carbon or nitrogen and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n, p, q and r are as defined in the specification, their preparation and their use as pharmaceuticals, particularly for the treatment of obstructive or inflammatory airways diseases.
摘要翻译： 其中Ar为式Y的化合物为碳或氮，R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，X，n，p， q和r如说明书中所定义，它们的制备及其作为药物的用途，特别是用于治疗阻塞性或炎症性气道疾病。
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公开(公告)号：US20120077838A1
公开(公告)日：2012-03-29
申请号：US13295426
申请日：2011-11-14
IPC分类号： A61K31/46 , A61P11/00 , A61P29/00 , A61K31/4704
CPC分类号： A61K31/4709 , A61K45/06 , C07C215/80 , C07C233/43 , C07C311/08 , C07C2602/08 , C07D215/227 , C07D215/26 , C07D405/12
摘要： Compounds of formula in free or salt or solvate form, where Ar is a group of formula Y is carbon or nitrogen and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n, p, q and r are as defined in the specification, their preparation and their use as pharmaceuticals, particularly for the treatment of obstructive or inflammatory airways diseases.
摘要翻译： 其中Ar为式Y的化合物为碳或氮，R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，X，n，p， q和r如说明书中所定义，它们的制备及其作为药物的用途，特别是用于治疗阻塞性或炎症性气道疾病。
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公开(公告)号：US08067437B2
公开(公告)日：2011-11-29
申请号：US12885922
申请日：2010-09-20
申请人： Bernard Cuenoud , Ian Bruce , Robin A Fairhurst , David Beattie
发明人： Bernard Cuenoud , Ian Bruce , Robin A Fairhurst , David Beattie
IPC分类号： A61P11/00
CPC分类号： A61K31/4709 , A61K45/06 , C07C215/80 , C07C233/43 , C07C311/08 , C07C2602/08 , C07D215/227 , C07D215/26 , C07D405/12
摘要： Compounds of formula in free or salt or solvate form, where Ar is a group of formula Y is carbon or nitrogen and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n, p, q and r are as defined in the specification, their preparation and their use as pharmaceuticals, particularly for the treatment of obstructive or inflammatory airways diseases.
摘要翻译： 其中Ar为式Y的化合物为碳或氮，R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，X，n，p， q和r如说明书中所定义，它们的制备及其作为药物的用途，特别是用于治疗阻塞性或炎症性气道疾病。
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公开(公告)号：US20110034509A1
公开(公告)日：2011-02-10
申请号：US12885922
申请日：2010-09-20
IPC分类号： A61K31/4704 , A61P11/00
CPC分类号： A61K31/4709 , A61K45/06 , C07C215/80 , C07C233/43 , C07C311/08 , C07C2602/08 , C07D215/227 , C07D215/26 , C07D405/12
摘要： Compounds of formula in free or salt or solvate form, where Ar is a group of formula Y is carbon or nitrogen and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n, p, q and r are as defined in the specification, their preparation and their use as pharmaceuticals, particularly for the treatment of obstructive or inflammatory airways diseases.
摘要翻译： 其中Ar为式Y的化合物为碳或氮，R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，X，n，p， q和r如说明书中所定义，它们的制备及其作为药物的用途，特别是用于治疗阻塞性或炎症性气道疾病。
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公开(公告)号：US07767008B2
公开(公告)日：2010-08-03
申请号：US12335333
申请日：2008-12-15
IPC分类号： B01D19/00
CPC分类号： B01D3/22 , B01D3/14 , B01D3/38 , B01D3/4294 , C10G2400/20 , Y02P30/40
摘要： A vapor/liquid separation apparatus for treating a flow of vapor/liquid mixtures of hydrocarbons and steam comprises a vertical drum with a side inlet to introduce hydrocarbon/steam mixtures, an overhead vapor outlet, and a lower section in communication with a cylindrical boot of less diameter than the drum, the boot comprising sufficient gas-liquid contact surface, e.g., that provided by one or more sheds, baffles and/or distillation trays, to provide at least a partial theoretical distillation stage, and a lower portion for receiving liquid from the drum, a lower outlet for removing the liquid, and an inlet for introducing a stripping gas such as steam, hydrogen, light crackable hydrocarbon, and/or methane, below the distillation tray and preferably above the level of liquid in the boot.
摘要翻译： 用于处理烃和蒸汽的蒸汽/液体混合物流的蒸汽/液体分离装置包括具有侧入口以引入碳氢化合物/蒸气混合物的立式鼓，顶部蒸汽出口和与圆柱形套管 小于鼓的直径，靴子包括足够的气液接触表面，例如由一个或多个棚子，挡板和/或蒸馏塔板提供的，以提供至少部分理论蒸馏阶段的底部和用于接收液体的下部 从滚筒，用于除去液体的下部出口，以及用于在蒸馏托盘下方引入诸如蒸汽，氢气，轻质裂解烃和/或甲烷之类的汽提气体的入口，优选在引导器中的液体水平以上。
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