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    Methods for accurately, substantially noninvasively determining pulmonary capillary blood flow, cardiac output, and mixed venous carbon dioxide content
    22.
    发明授权
    Methods for accurately, substantially noninvasively determining pulmonary capillary blood flow, cardiac output, and mixed venous carbon dioxide content 有权

    公开(公告)号：US07025731B2

    公开(公告)日：2006-04-11

    申请号：US10400717

    申请日：2003-03-27

    申请人： Joseph A. Orr ,  Kai Kück

    发明人： Joseph A. Orr ,  Kai Kück

    IPC分类号： A61B5/00

    CPC分类号： A61B5/0836 ,  A61B5/029 ,  G01N33/497 ,  G01N2001/2244

    摘要： A method for noninvasively determining the pulmonary capillary blood flow or cardiac output of a patient includes measurement of respiratory flow and carbon dioxide pressure of the patient's breathing. These measurements are used to calculate carbon dioxide elimination and an indicator of the carbon dioxide content of the patient's blood. A geometric relationship between the carbon dioxide elimination data and the data of the indicator of carbon dioxide content is determined. At least one set of the data is modified and at least one other determination of a geometric relationship between the data is made to find the most accurate data set. The data may be modified by filtering or clustering. A slope of at least a portion of the geometric relationship is then used to determine the pulmonary capillary blood flow or cardiac output of the patient.

    ALGORITHMS, SYSTEMS, AND METHODS FOR ESTIMATING CARBON DIOXIDE STORES, TRANSFORMING RESPIRATORY GAS MEASUREMENTS, AND OBTAINING ACCURATE NONINVASIVE PULMONARY CAPILLARY BLOOD FLOW AND CARDIAC OUTPUT MEASUREMENTS
    23.
    发明授权
    ALGORITHMS, SYSTEMS, AND METHODS FOR ESTIMATING CARBON DIOXIDE STORES, TRANSFORMING RESPIRATORY GAS MEASUREMENTS, AND OBTAINING ACCURATE NONINVASIVE PULMONARY CAPILLARY BLOOD FLOW AND CARDIAC OUTPUT MEASUREMENTS 有权
    用于估算二氧化碳储存库，改变呼吸气体测量和获得精确非侵入性血管毛细血管流量和心脏输出量度的算法，系统和方法

    公开(公告)号：US06955651B2

    公开(公告)日：2005-10-18

    申请号：US10121219

    申请日：2002-04-11

    申请人： Kai Kück ,  Joseph A. Orr ,  Lara Brewer

    发明人： Kai Kück ,  Joseph A. Orr ,  Lara Brewer

    IPC分类号： A61B5/026 ,  A61B5/08 ,  A61B5/083 ,  A61B5/087 ,  G01N1/22 ,  A61B5/00

    CPC分类号： A61B5/0836 ,  A61B5/029 ,  G01N33/497 ,  G01N2001/2244

    摘要： Methods for estimating the volume of the carbon dioxide stores of an individual's respiratory tract include determining a carbon dioxide store volume at which a correlation between corresponding signals of carbon dioxide elimination and an indicator of the content of carbon dioxide in blood of the individual is optimized. The estimate of the volume of carbon dioxide stores, which comprises a model of the respiratory tract, or lungs, of the individual, may be used as a transformation to improve the accuracy of one or both of the carbon dioxide elimination and carbon dioxide content signals. Transformation, or filtering, algorithms are also disclosed, as are systems in which the methods and algorithms may be used. The methods, algorithms, and systems may be used to accurately and noninvasively determine one or both of the pulmonary capillary blood flow and cardiac output of the individual.

    摘要翻译： 用于估计个体呼吸道二氧化碳储存体积的方法包括确定二氧化碳储存容积，其中二氧化碳消除的相应信号与个体血液中二氧化碳含量的指标被优化之间的相关性。 包括个人呼吸道或肺的模型的二氧化碳储存量的估算可以用作改善二氧化碳消除和二氧化碳含量信号中的一种或两种的准确性的转化 。 还公开了转换或滤波算法，以及可以使用方法和算法的系统。 方法，算法和系统可用于精确地和非侵入性地确定个体的肺毛细血管血流量和心输出量中的一个或两个。

    Method of continuously, non-invasively monitoring pulmonary capillary blood flow and cardiac output
    24.
    发明授权
    Method of continuously, non-invasively monitoring pulmonary capillary blood flow and cardiac output 有权
    方法连续，非侵入性地监测肺毛细血管血流量和心输出量

    公开(公告)号：US06217524B1

    公开(公告)日：2001-04-17

    申请号：US09150446

    申请日：1998-09-09

    申请人： Joseph A. Orr ,  Michael B. Jaffe ,  Kai Kück ,  Dinesh G. Haryadi

    发明人： Joseph A. Orr ,  Michael B. Jaffe ,  Kai Kück ,  Dinesh G. Haryadi

    IPC分类号： A61B502

    CPC分类号： A61B5/0836 ,  A61M16/021 ,  A61M2016/0036 ,  A61M2016/103

    摘要： A method of continuously, non-invasively determining the cardiac output of a patient. The method includes intermittently measuring the cardiac output, the volume of carbon dioxide exhaled by the patient per breath, and determining the arterial-venous gradient of the patient or a similar substantially constant value by dividing the volume of carbon dioxide exhaled by the measured cardiac output. The arterial-venous gradient or similar substantially constant value may then be employed to determine the cardiac output of the patient on a breath-by-breath basis. The carbon dioxide elimination, which is non-invasively measured as the volume of carbon dioxide exhaled by the patient per breath, is divided by the arterial-venous gradient or the substantially constant value to determine the cardiac output. The method may also include generating a signal to compensate for any non-metabolic changes in the carbon dioxide elimination, arterial-venous gradient, or other respiratory or blood gas profile measurements that may be caused by a change in ventilation or breathing of the patient. The compensatory signal may be employed to modify one or more of the respiratory or blood gas profile measurements in order to facilitate the accurate determination of cardiac output during or after changes in ventilation or breathing.

    摘要翻译： 一种连续，非侵入性地确定患者的心输出量的方法。 该方法包括间歇地测量心输出量，每次呼吸患者呼出的二氧化碳的体积，以及通过将所测量的心输出量呼出的二氧化碳的体积除以来确定患者的动脉 - 静脉梯度或类似的基本上恒定的值 。 然后可以采用动脉 - 静脉梯度或类似的基本上恒定的值来确定患者在呼吸基础上的心输出量。 二氧化碳消除，其被非侵入性地测量为每个呼吸患者呼出的二氧化碳的体积，除以动脉 - 静脉梯度或基本上恒定的值以确定心输出量。 该方法还可以包括产生信号以补偿二氧化碳消除，动脉 - 静脉梯度或可能由患者的通气或呼吸改变引起的其它呼吸或血气分布测量中的任何非代谢变化。 补偿信号可以用于修改呼吸或血气剖面测量中的一个或多个，以便于在通气或呼吸改变期间或之后准确确定心输出量。

    Differential pressure sensor for respiratory monitoring
    25.
    发明授权
    Differential pressure sensor for respiratory monitoring 失效
    差压传感器用于呼吸监测

    公开(公告)号：US5535633A

    公开(公告)日：1996-07-16

    申请号：US287665

    申请日：1994-08-09

    申请人： Scott A. Kofoed ,  Joseph A. Orr

    发明人： Scott A. Kofoed ,  Joseph A. Orr

    IPC分类号： A61B5/08 ,  A61B5/087 ,  G01F1/36 ,  G01F1/40 ,  G01F1/46 ,  G01F1/50

    CPC分类号： G01F1/363 ,  A61B5/087 ,  G01F1/40 ,  G01F1/46 ,  G01F1/50

    摘要： A differential pressure sensor for measuring respiratory gas flow including a tubular housing having a bore containing a diametrically-oriented, longitudinally extending strut containing first and second lumens having longitudinally spaced pressure ports at axially spaced locations of the strut, the ports being located on opposite sides of a bore restriction.

    摘要翻译： 一种用于测量呼吸气流的差压传感器，包括管状壳体，所述管状壳体具有包含径向定向的纵向延伸的支柱的孔，所述支柱包含第一和第二腔，所述第一和第二腔在所述支柱的轴向间隔开的位置处具有纵向隔开的压力端口，所述端口位于相对侧 的钻孔限制。

    Formable reusable enclosure
    26.
    发明授权
    Formable reusable enclosure 失效
    可重复使用的外壳

    公开(公告)号：US5102036A

    公开(公告)日：1992-04-07

    申请号：US540571

    申请日：1990-06-19

    申请人： Joseph A. Orr ,  John R. Orr

    发明人： Joseph A. Orr ,  John R. Orr

    IPC分类号： B65D59/04

    CPC分类号： B65D59/04 ,  Y02W30/807 ,  Y10S220/903

    摘要： A formable reusable enclosure is disclosed for use as a container wrap, a mailing tube, or the like. One specific embodiment of the enclosure comprises a pliable, elongated, substantially rectangular panel member having opposing ends and a tongue portion extending from one of the opposed ends. The panel member has an outer layer of bendable kraft board and an inner layer of corrugated paper adhered to the kraft board. The panel member is adapted to be formed into an enclosure by bending the panel member into the configuration of the peripheral wall of a container with the tongue portion overlapping the opposing end of the panel member. A slot is formed through the panel member adjacent to the end which is opposite to the tongue portion end. The slot has an engagement edge aligned parallel to the corrugations in the inner paper layer, enabling adjustment of the size of the enclosure by selecting a desired corrugation for engagement with the slot edge. The selected corrugation locks against the engagement edge when the tongue portion is inclined at an acute angle with respect to the outer kraft paper layer, thereby preventing the tongue portion form withdrawing from the slot.

    摘要翻译： 一种可成形的可重复使用的外壳被公开用作容器包装，邮寄管等。 外壳的一个具体实施例包括柔韧的，细长的基本上矩形的面板构件，其具有相对的端部和从相对的一个中的一个延伸的舌部。 面板构件具有可弯曲的牛皮纸板的外层和粘附到硫酸盐板的瓦楞纸的内层。 面板构件适于通过将面板构件弯曲成容器的周壁的构造而形成为外壳，其中舌部与面板构件的相对端重叠。 通过与舌部相对的端部相邻的面板构件形成槽。 狭槽具有与内纸层中的波纹平行排列的接合边缘，能够通过选择用于与槽边缘接合的所需波纹来调节外壳的尺寸。 当舌部相对于外部牛皮纸层倾斜成锐角时，所选择的波纹锁定在接合边缘上，从而防止舌部从槽中退出。

    Apparatus and method for non-invasively measuring cardiac output
    30.
    发明授权
    Apparatus and method for non-invasively measuring cardiac output 有权
    非侵入性测量心输出量的装置和方法

    公开(公告)号：US06648831B2

    公开(公告)日：2003-11-18

    申请号：US09767363

    申请日：2001-01-23

    申请人： Joseph A. Orr ,  Scott A. Kofoed ,  Dwayne Westenskow ,  Michael B. Jaffe

    发明人： Joseph A. Orr ,  Scott A. Kofoed ,  Dwayne Westenskow ,  Michael B. Jaffe

    IPC分类号： A61B0500

    CPC分类号： A61B5/029 ,  A61B5/0836 ,  A61M16/0045 ,  A61M16/0833 ,  A61M2016/0036 ,  A61M2230/432 ,  G01N33/004 ,  Y02A50/243

    摘要： Apparatus and methods for non-invasively determining cardiac output using partial re-breathing techniques are disclosed in which the apparatus is constructed with an instantaneously adjustable deadspace for accommodating differences in breathing capacities of various patients. The apparatus is constructed of inexpensive elements, including a single two-way valve which renders the apparatus very simple to use and inexpensive so that the unit may be readily disposable. The method of the invention provides a novel means of estimating cardiac output based on alveolar CO2 values rather than end-tidal CO2 values as previously practiced. A program for calculating cardiac output is also disclosed.

    摘要翻译： 公开了使用部分再呼吸技术非侵入性地确定心输出量的装置和方法，其中该装置构造有瞬时可调的死区，以适应各种患者的呼吸能力差异。 该设备由便宜的元件构成，包括单个双向阀，其使得该设备使用起来非常简单且便宜，使得该单元可以容易地被一次性使用。 本发明的方法提供了一种基于肺泡二氧化碳值估计心输出量的新方法，而不是如先前所述的潮汐CO 2值。 还公开了一种用于计算心输出量的程序。