公开(公告)号：US07904155B2

公开(公告)日：2011-03-08

申请号：US11549676

申请日：2006-10-16

申请人： Yinghong Yu ,  Jiang Ding ,  Qingsheng Zhu

发明人： Yinghong Yu ,  Jiang Ding ,  Qingsheng Zhu

IPC分类号： A61N1/365

CPC分类号： A61N1/36578 ,  A61N1/3627 ,  A61N1/36542 ,  A61N1/3684

摘要： Methods and devices are disclosed for employing mechanical measurements to synchronize contractions of ventricular wall locations. Accelerometers that may be placed within electrode leads are positioned at ventricular wall locations, such as the left ventricle free wall, right ventricle free wall, and the anterior wall/septum wall. The accelerometers produce signals in response to the motion of the ventricular wall locations. A processor may then compare the signals to determine a difference in the synchronization of the ventricular wall location contractions. The difference in synchronization can be determined in various ways such as computing a phase difference and/or amplitude difference between the accelerometer signals. One or more stimulation pulses may be provided per cardiac cycle to resynchronize the contractions as measured by the accelerometers to thereby constantly and automatically optimize the cardiac resynchronization therapy.

摘要翻译： 公开了用于采用机械测量来同步心室壁位置收缩的方法和装置。 可以放置在电极引线内的加速度计定位在心室壁位置，例如左心室游离壁，右心室游离壁和前壁/隔膜壁。 加速度计响应于心室壁位置的运动产生信号。 然后，处理器可以比较信号以确定心室壁位置收缩的同步的差异。 可以以各种方式确定同步差异，例如计算加速度计信号之间的相位差和/或振幅差。 可以在每个心动周期提供一个或多个刺激脉冲，以重新同步由加速度计测量的收缩，从而不断地和自动地优化心脏再同步治疗。

公开(公告)号：US07206634B2

公开(公告)日：2007-04-17

申请号：US10206131

申请日：2002-07-26

申请人： Jiang Ding ,  Yinghong Yu ,  Qingsheng Zhu

发明人： Jiang Ding ,  Yinghong Yu ,  Qingsheng Zhu

IPC分类号： A61N1/365

CPC分类号： A61N1/36542 ,  A61N1/36514 ,  A61N1/3682 ,  A61N1/3684

摘要： A cardiac rhythm and function management device configured to automatically adjust stimulation parameters used in delivering cardiac resynchronization therapy. Mechanical contraction intervals are measured using appropriately placed accelerometers and compared with optimum values. The stimulation parameters can then be adjusted accordingly in a manner that moves the mechanical contraction intervals toward their optimum values.

摘要翻译： 心律和功能管理装置被配置为自动调整用于递送心脏再同步治疗的刺激参数。 使用适当放置的加速度计测量机械收缩间隔，并与最佳值进行比较。 然后可以以使机械收缩间隔向其最佳值移动的方式相应地调节刺激参数。

公开(公告)号：US08792980B2

公开(公告)日：2014-07-29

申请号：US12980417

申请日：2010-12-29

申请人： Yinghong Yu ,  Jiang Ding ,  Qingsheng Zhu

发明人： Yinghong Yu ,  Jiang Ding ,  Qingsheng Zhu

IPC分类号： A61N1/368 ,  A61N1/365

CPC分类号： A61N1/36578 ,  A61N1/3627 ,  A61N1/36542 ,  A61N1/3684

摘要： Methods and devices are disclosed for employing mechanical measurements to synchronize contractions of ventricular wall locations. Accelerometers that may be placed within electrode leads are positioned at ventricular wall locations, such as the left ventricle free wall, right ventricle free wall, and the anterior wall/septum wall. The accelerometers produce signals in response to the motion of the ventricular wall locations. A processor may then compare the signals to determine a difference in the synchronization of the ventricular wall location contractions. The difference in synchronization can be determined in various ways such as computing a phase difference and/or amplitude difference between the accelerometer signals. One or more stimulation pulses may be provided per cardiac cycle to resynchronize the contractions as measured by the accelerometers to thereby constantly and automatically optimize the cardiac resynchronization therapy.

摘要翻译： 公开了用于采用机械测量来同步心室壁位置收缩的方法和装置。 可以放置在电极引线内的加速度计定位在心室壁位置，例如左心室游离壁，右心室游离壁和前壁/隔膜壁。 加速度计响应于心室壁位置的运动产生信号。 然后，处理器可以比较信号以确定心室壁位置收缩的同步的差异。 可以以各种方式确定同步差异，例如计算加速度计信号之间的相位差和/或振幅差。 可以在每个心动周期提供一个或多个刺激脉冲，以重新同步由加速度计测量的收缩，从而不断地和自动地优化心脏再同步治疗。

公开(公告)号：US07567838B2

公开(公告)日：2009-07-28

申请号：US11254344

申请日：2005-10-20

申请人： Nancy Yu ,  Jiang Ding ,  Qingsheng Zhu

发明人： Nancy Yu ,  Jiang Ding ,  Qingsheng Zhu

IPC分类号： A61N1/37

CPC分类号： A61N1/3627 ,  A61N1/36514 ,  A61N1/36542 ,  A61N2001/0585

摘要： Systems and methods for detecting and measuring cardiac contractile function of a heart using an acceleration sensor unit inserted within the heart, such as within a vein of the cardiac wall are disclosed. The systems and methods involve detecting the occurrence of electrical events within the patient's heart by inserting and positioning an implantable lead having an electrode near a cardiac wall as well as detecting mechanical events within the patient's heart by then inserting and positioning a cardiac motion sensor unit through the inner lumen of the implantable lead. Furthermore, the systems and methods do not require dedicated leads and may be used with preexisting implantable leads.

摘要翻译： 公开了使用插入心脏内的加速度传感器单元（例如在心脏壁的静脉内）来检测和测量心脏的心脏收缩功能的系统和方法。 该系统和方法涉及通过将具有电极靠近心脏壁的可植入引线插入和定位并且通过插入和定位心脏运动传感器单元来检测患者心脏内的机械事件来检测患者心脏内的电事件的发生 可植入引线的内腔。 此外，系统和方法不需要专用引线，并且可以与预先存在的可植入引线一起使用。

公开(公告)号：US20080015650A1

公开(公告)日：2008-01-17

申请号：US11776699

申请日：2007-07-12

申请人： Qingsheng Zhu ,  Julio Spinelli ,  Jiang Ding ,  Yinghong Yu

发明人： Qingsheng Zhu ,  Julio Spinelli ,  Jiang Ding ,  Yinghong Yu

IPC分类号： A61N1/372

CPC分类号： A61N1/3627 ,  A61N1/3682 ,  A61N1/3684 ,  A61N1/3688 ,  A61N1/371

摘要： A system and method for automatically selecting among a plurality of pacing modes based upon capture detection. Patients suffering from heart failure may be optimally treated with different resynchronization pacing modes or configurations. By detecting whether capture is being achieved by a particular configuration or mode, a device is able to automatically switch to one that is both optimal in treating the patient and is successful in capturing the heart with pacing pulses.

摘要翻译： 一种用于基于捕获检测在多个起搏模式之间自动选择的系统和方法。 患有心力衰竭的患者可以用不同的再同步起搏模式或配置进行最佳治疗。 通过检测是否通过特定配置或模式实现捕获，设备能够自动切换到在治疗患者时是最佳的并且成功地用起搏脉冲捕获心脏。

公开(公告)号：US06768924B2

公开(公告)日：2004-07-27

申请号：US10038225

申请日：2002-01-03

申请人： Jiang Ding ,  Yinghong Yu ,  Julio C. Spinelli ,  Qingsheng Zhu

发明人： Jiang Ding ,  Yinghong Yu ,  Julio C. Spinelli ,  Qingsheng Zhu

IPC分类号： A61N1362

CPC分类号： A61N1/3712 ,  A61N1/3684 ,  A61N1/3714

摘要： An implantable cardiac rhythm/function management device that automatically determines whether or not a pacing stimulus to the ventricles results in capture by detecting propagated depolarizations at stimulating and non-stimulating electrodes. The device of the present invention is suitable for use in either a single or multiple electrode pacing/sensing configuration and may be utilized to verify either atrial or ventricular capture of a heart having either normal or abnormal intrinsic AV conduction.

摘要翻译： 一种植入式心律/功能管理装置，其自动确定对心室的起搏刺激是否通过检测刺激和非刺激电极处的传播去极化而导致捕获。 本发明的装置适用于单电极或多电极起搏/感测配置，并且可用于验证具有正常或异常固有AV传导的心脏的心房或心室捕获。

公开(公告)号：US20070129781A1

公开(公告)日：2007-06-07

申请号：US11549676

申请日：2006-10-16

申请人： Yinghong Yu ,  Jiang Ding ,  Qingsheng Zhu

发明人： Yinghong Yu ,  Jiang Ding ,  Qingsheng Zhu

IPC分类号： A61N1/365

CPC分类号： A61N1/36578 ,  A61N1/3627 ,  A61N1/36542 ,  A61N1/3684

摘要： Methods and devices are disclosed for employing mechanical measurements to synchronize contractions of ventricular wall locations. Accelerometers that may be placed within electrode leads are positioned at ventricular wall locations, such as the left ventricle free wall, right ventricle free wall, and the anterior wall/septum wall. The accelerometers produce signals in response to the motion of the ventricular wall locations. A processor may then compare the signals to determine a difference in the synchronization of the ventricular wall location contractions. The difference in synchronization can be determined in various ways such as computing a phase difference and/or amplitude difference between the accelerometer signals. One or more stimulation pulses may be provided per cardiac cycle to resynchronize the contractions as measured by the accelerometers to thereby constantly and automatically optimize the cardiac resynchronization therapy.

摘要翻译： 公开了用于采用机械测量来同步心室壁位置收缩的方法和装置。 可以放置在电极引线内的加速度计定位在心室壁位置，例如左心室游离壁，右心室游离壁和前壁/隔膜壁。 加速度计响应于心室壁位置的运动产生信号。 然后，处理器可以比较信号以确定心室壁位置收缩的同步的差异。 可以以各种方式确定同步差异，例如计算加速度计信号之间的相位差和/或振幅差。 可以在每个心动周期提供一个或多个刺激脉冲，以重新同步由加速度计测量的收缩，从而不断地和自动地优化心脏再同步治疗。

公开(公告)号：US06937901B2

公开(公告)日：2005-08-30

申请号：US09999255

申请日：2001-10-31

申请人： Qingsheng Zhu ,  Julio C. Spinelli ,  Jiang Ding ,  Yinghong Yu

发明人： Qingsheng Zhu ,  Julio C. Spinelli ,  Jiang Ding ,  Yinghong Yu

IPC分类号： A61N1/362 ,  A61N1/368 ,  A61N1/37 ,  A61N1/18

CPC分类号： A61N1/3627 ,  A61N1/3682 ,  A61N1/3684 ,  A61N1/3688 ,  A61N1/371

摘要： A system and method for automatically selecting among a plurality of pacing modes based upon capture detection. Patients suffering from heart failure may be optimally treated with different resynchronization pacing modes or configurations. By detecting whether capture is being achieved by a particular configuration or mode, a device is able to automatically switch to one that is both optimal in treating the patient and is successful in capturing the heart with pacing pulses.

公开(公告)号：US06923772B2

公开(公告)日：2005-08-02

申请号：US10236714

申请日：2002-09-06

申请人： Yinghong Yu ,  Jiang Ding ,  Qingsheng Zhu

发明人： Yinghong Yu ,  Jiang Ding ,  Qingsheng Zhu

IPC分类号： A61B5/11 ,  A61B5/02

CPC分类号： A61B5/1107 ,  A61B5/6869 ,  A61B5/7242 ,  A61B2562/0219

摘要： A device for measuring a synchronicity of contraction of a heart to determine if an individual would be a responder to cardiac resynchronization therapy. The device may include a first electrode positioned at a first ventricular wall location to measure movement of the first ventricular wall location and generate a first signal, as well as a second electrode positioned at a second ventricular wall location to measure movement of the second ventricular wall location and generate a second signal. A processing module may process the first and second signals, for example, integrate the signals multiple times, and generate an output based on the processed signals. Based on this output, an individual can be labeled a responder or non-responder to cardiac resynchronization therapy. The electrodes may each include an accelerometer to measure acceleration of the heart wall.

摘要翻译： 用于测量心脏收缩的同步性的装置，以确定个体是否是心脏再同步治疗的应答​​者。 该装置可以包括位于第一心室壁位置处的第一电极，以测量第一心室壁位置的运动并产生第一信号，以及定位在第二心室壁位置处的第二电极，以测量第二心室壁的运动 位置并产生第二个信号。 处理模块可以处理第一和第二信号，例如，多次对信号进行积分，并且基于处理的信号生成输出。 基于该输出，个体可以被标记为心脏再同步治疗的应答​​者或非应答者。 电极可以各自包括用于测量心脏壁的加速度的加速度计。

公开(公告)号：US08352027B2

公开(公告)日：2013-01-08

申请号：US12048144

申请日：2008-03-13

申请人： Julio Spinelli ,  Qingsheng Zhu ,  Bruce H. Kenknight ,  Yinghong Yu ,  Jiang Ding

发明人： Julio Spinelli ,  Qingsheng Zhu ,  Bruce H. Kenknight ,  Yinghong Yu ,  Jiang Ding

IPC分类号： A61N1/36

CPC分类号： A61N1/3627

摘要： A cardiac rhythm management system for providing a plurality of therapy modalities. For example, the system may include a cardiac resynchronization therapy module for providing cardiac resynchronization therapy and a pacemaker module for providing bradycardia therapy, as well as a selector module coupled to the cardiac resynchronization therapy module and the bradycardia module. The selector module may select an operating mode from among a plurality of operating modes including the cardiac resynchronization therapy module and the pacemaker module. Various manual and automatic methods may be used to select the operating mode. In addition, a reversion management system may be included to assist the cardiac rhythm management system to recover in case of a disruption to the system.

摘要翻译： 一种用于提供多种治疗方式的心律管理系统。 例如，该系统可以包括用于提供心脏再同步治疗的心脏再同步治疗模块和用于提供心动过缓治疗的起搏器模块，以及耦合到心脏再同步治疗模块和心动过缓模块的选择器模块。 选择器模块可以从包括心脏再同步治疗模块和起搏器模块的多个操作模式中选择操作模式。 可以使用各种手动和自动方法来选择操作模式。 此外，还可以包括回归管理系统以帮助心律管理系统在系统中断的情况下恢复。