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    Polynucleotides encoding soluble zalpha11 cytokine receptors
    28.
    发明授权
    Polynucleotides encoding soluble zalpha11 cytokine receptors 有权
    编码可溶性zalpha11细胞因子受体的多核苷酸

    公开(公告)号：US07629452B2

    公开(公告)日：2009-12-08

    申请号：US11538735

    申请日：2006-10-04

    申请人： Cindy A. Sprecher ,  Julia E. Novak ,  James W. West ,  Scott R. Presnell ,  Richard D. Holly ,  Andrew J. Nelson

    发明人： Cindy A. Sprecher ,  Julia E. Novak ,  James W. West ,  Scott R. Presnell ,  Richard D. Holly ,  Andrew J. Nelson

    IPC分类号： C07H21/04 ,  C12N15/63 ,  C12N15/85

    CPC分类号： C07K16/2866 ,  A61K38/00 ,  C07K14/7155 ,  C07K2317/73 ,  C07K2319/00

    摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for soluble zalpha11 receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block zalpha11 Ligand activity in vitro and in vivo, and may be used in conjunction with zalpha11 Ligand and other cytokines to selectively stimulate the immune system. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

    摘要翻译： 公开了可用作新型细胞因子拮抗剂的可溶性zalpha11受体的新型多肽组合，编码多肽的多核苷酸以及相关组合物和方法，以及用于检测刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法 体外和体内。 配体结合受体多肽也可用于在体外和体内阻断zalpha11配体活性，并可与zalpha11配体和其他细胞因子结合使用以选择性刺激免疫系统。 本发明还包括生产蛋白质的方法，用途及其抗体。

    POLYNUCLEOTIDES ENCODING SOLUBLE ZALPHA11 CYTOKINE RECEPTORS
    29.
    发明申请
    POLYNUCLEOTIDES ENCODING SOLUBLE ZALPHA11 CYTOKINE RECEPTORS 有权
    编码可溶性ZALPHA11细胞因子受体的多核苷酸

    公开(公告)号：US20080032333A1

    公开(公告)日：2008-02-07

    申请号：US11538735

    申请日：2006-10-04

    申请人： Cindy A. Sprecher ,  Julia E. Novak ,  James W. West ,  Scott R. Presnell ,  Richard D. Holly ,  Andrew J. Nelson

    发明人： Cindy A. Sprecher ,  Julia E. Novak ,  James W. West ,  Scott R. Presnell ,  Richard D. Holly ,  Andrew J. Nelson

    IPC分类号： C12N15/63 ,  C12N15/19 ,  C12P21/00

    CPC分类号： C07K16/2866 ,  A61K38/00 ,  C07K14/7155 ,  C07K2317/73 ,  C07K2319/00

    摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for soluble zalpha11 receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block zalpha11 Ligand activity in vitro and in vivo, and may be used in conjunction with zalpha11 Ligand and other cytokines to selectively stimulate the immune system. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

    摘要翻译： 公开了可用作新型细胞因子拮抗剂的可溶性zalpha11受体的新型多肽组合，编码多肽的多核苷酸以及相关组合物和方法，以及用于检测刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法 体外和体内。 配体结合受体多肽也可用于在体外和体内阻断zalpha11配体活性，并可与zalpha11配体和其他细胞因子结合使用以选择性刺激免疫系统。 本发明还包括生产蛋白质的方法，用途及其抗体。

    ANTIBODIES TO ZALPHA11 CYTOKINE RECEPTORS
    30.
    发明申请
    ANTIBODIES TO ZALPHA11 CYTOKINE RECEPTORS 审中-公开
    ZALPHA11细胞因子受体的抗体

    公开(公告)号：US20110003973A1

    公开(公告)日：2011-01-06

    申请号：US11538331

    申请日：2006-10-03

    申请人： Cindy A. Sprecher ,  Julia E. Novak ,  James W. West ,  Scott R. Presnell ,  Richard D. Holly ,  Andrew J. Nelson

    发明人： Cindy A. Sprecher ,  Julia E. Novak ,  James W. West ,  Scott R. Presnell ,  Richard D. Holly ,  Andrew J. Nelson

    IPC分类号： C07K16/28

    CPC分类号： C07K16/2866 ,  A61K38/00 ,  C07K14/7155 ,  C07K2317/73 ,  C07K2319/00

    摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for soluble zalpha11 receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block zalpha11 Ligand activity in vitro and in vivo, and may be used in conjunction with zalpha11 Ligand and other cytokines to selectively stimulate the immune system. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

    摘要翻译： 公开了可用作新型细胞因子拮抗剂的可溶性zalpha11受体的新型多肽组合，编码多肽的多核苷酸以及相关组合物和方法，以及用于检测刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法 体外和体内。 配体结合受体多肽也可用于在体外和体内阻断zalpha11配体活性，并可与zalpha11配体和其他细胞因子结合使用以选择性刺激免疫系统。 本发明还包括生产蛋白质的方法，用途及其抗体。