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公开(公告)号：US20120294798A1
公开(公告)日：2012-11-22
申请号：US13535832
申请日：2012-06-28
IPC分类号： A61K38/20 , A61P35/02 , A61K51/08 , A61N5/00 , A61K38/21 , A61P37/04 , A61K39/00 , A61K39/395 , A61P35/00 , A61P37/02
CPC分类号： C07K14/54 , A61K38/193 , A61K38/20 , A61K38/2013 , A61K38/2026 , A61K38/2086 , A61K45/06 , C07K16/2878 , C07K2317/73 , Y02A50/463 , Y02A50/465 , Y02A50/475 , Y02A50/481
摘要： Methods for treating mammals with cancer using molecules that have an IL-21 functional activity are described. The molecules having IL-21 functional activities include polypeptides that have homology to the human IL-21 polypeptide sequence and proteins fused to a polypeptide with IL-21 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer therapeutics.
摘要翻译： 描述了使用具有IL-21功能活性的分子治疗具有癌症的哺乳动物的方法。 具有IL-21功能活性的分子包括与人IL-21多肽序列具有同源性的多肽和与具有IL-21功能活性的多肽融合的蛋白质。 分子可以用作单一疗法或与其他已知的癌症治疗剂组合使用。
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公开(公告)号：US20110189207A1
公开(公告)日：2011-08-04
申请号：US13021270
申请日：2011-02-04
申请人： Cindy A. Sprecher , Julia E. Novak , James W. West , Scott R. Presnell , Richard D. Holly , Andrew J. Nelson
发明人： Cindy A. Sprecher , Julia E. Novak , James W. West , Scott R. Presnell , Richard D. Holly , Andrew J. Nelson
IPC分类号： A61K39/395 , A61K38/17 , A61P29/00 , A61P3/10 , A61P25/00 , A61P37/06 , A61P11/06 , A61P19/02
CPC分类号： C07K16/2866 , A61K38/00 , C07K14/7155 , C07K2317/73 , C07K2319/00
摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for soluble zalpha11 receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block zalpha11 Ligand activity in vitro and in vivo, and may be used in conjunction with zalpha11 Ligand and other cytokines to selectively stimulate the immune system. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译： 公开了可用作新型细胞因子拮抗剂的可溶性zalpha11受体的新型多肽组合，编码多肽的多核苷酸以及相关组合物和方法，以及用于检测刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法 体外和体内。 配体结合受体多肽也可用于在体外和体内阻断zalpha11配体活性，并可与zalpha11配体和其他细胞因子结合使用以选择性刺激免疫系统。 本发明还包括生产蛋白质的方法，用途及其抗体。
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公开(公告)号：US20110086004A1
公开(公告)日：2011-04-14
申请号：US12947957
申请日：2010-11-17
申请人： Wayne R. Kindsvogel , Steven D. Hughes , Richard D. Holly , Christopher H. Clegg , Donald C. Foster , Rebecca A. Johnson , Mark D. Heipel , Pallavur V. Sivakumar
发明人： Wayne R. Kindsvogel , Steven D. Hughes , Richard D. Holly , Christopher H. Clegg , Donald C. Foster , Rebecca A. Johnson , Mark D. Heipel , Pallavur V. Sivakumar
CPC分类号： C07K16/32 , A61K38/20 , A61K39/395 , A61K39/39558 , C07K16/2818 , C07K16/2896 , C07K2317/732 , A61K2300/00
摘要： Methods for treating cancer by co-administering a therapeutic monoclonal antibody with IL-21 are described. Exemplary monoclonal antibodies that can be used are rituximab, trastuzumab and anti-CTLA-4 antibodies. The enhanced antitumor of the combination therapy is particularly useful for patient populations that are recalcitrant to monoclonal therapy, relapse after treatment with monoclonal antibodies or where the enhanced IL-21 antitumor effect reduces toxicities associated with treatment using the monoclonal antibodies.
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公开(公告)号：US20100316600A1
公开(公告)日：2010-12-16
申请号：US12771142
申请日：2010-04-30
CPC分类号： C07K14/54 , A61K38/193 , A61K38/20 , A61K38/2013 , A61K38/2026 , A61K38/2086 , A61K45/06 , C07K16/2878 , C07K2317/73 , Y02A50/463 , Y02A50/465 , Y02A50/475 , Y02A50/481
摘要： Methods for treating mammals with cancer using molecules that have an IL-21 functional activity are described. The molecules having IL-21 functional activities include polypeptides that have homology to the human IL-21 polypeptide sequence and proteins fused to a polypeptide with IL-21 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer therapeutics.
摘要翻译： 描述了使用具有IL-21功能活性的分子治疗具有癌症的哺乳动物的方法。 具有IL-21功能活性的分子包括与人IL-21多肽序列具有同源性的多肽和与具有IL-21功能活性的多肽融合的蛋白质。 分子可以用作单一疗法或与其他已知的癌症治疗剂组合使用。
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5.发明授权Method for expanding hematopoietic cells using cytokine zalpha11 ligand 有权使用细胞因子zalpha11配体扩增造血细胞的方法公开(公告)号：US07829075B2
公开(公告)日：2010-11-09
申请号：US11551127
申请日：2006-10-19
申请人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
发明人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
摘要翻译： 描述了与SEQ ID NO：2所示的包含zalpha11配体的序列的多肽和肽结合的抗体。 抗体可以结合162个氨基酸残基或其片段的全长序列，包括131个氨基酸残基的成熟多肽和较小的多肽和肽序列。 抗体可以包括多克隆，单克隆，鼠，人源化或中和的抗体。 还描述了产生抗体的方法。
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公开(公告)号：US07611699B2
公开(公告)日：2009-11-03
申请号：US11551349
申请日：2006-10-20
申请人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
发明人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
摘要翻译： 描述了与SEQ ID NO：2所示的包含zalpha11配体的序列的多肽和肽结合的抗体。 抗体可以结合162个氨基酸残基或其片段的全长序列，包括131个氨基酸残基的成熟多肽和较小的多肽和肽序列。 抗体可以包括多克隆，单克隆，鼠，人源化或中和的抗体。 还描述了产生抗体的方法。
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公开(公告)号：US07592425B2
公开(公告)日：2009-09-22
申请号：US11551362
申请日：2006-10-20
申请人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
发明人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
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公开(公告)号：US06686178B2
公开(公告)日：2004-02-03
申请号：US10295723
申请日：2002-11-15
申请人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
发明人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
IPC分类号： C12N1524
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： The present invention relates to zalpha11 Ligand polynucleotide and polypeptide molecules. The zalpha11 Ligand is a novel cytokine. The polypeptides may be used within methods for stimulating the proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译： 本发明涉及zalpha11配体多核苷酸和多肽分子。 zalpha11配体是一种新型细胞因子。 多肽可用于在体外和体内刺激造血细胞的增殖和/或发育的方法中。 本发明还包括生产蛋白质的方法，用途及其抗体。
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公开(公告)号：US06531576B1
公开(公告)日：2003-03-11
申请号：US09585228
申请日：2000-06-01
IPC分类号： C07K14475
CPC分类号： C07K14/47 , C07K14/475
摘要： This present invention is directed to polypeptide and polynucleotide molecules that encode a four-helical bundle cytokine. The cytokine has been designated zsig81, and has restricted expression in primarily heart, lung and liver. zsig81 has been shown to stimulate proliferation of hematopoietic cells and will be useful expansion of these cells, as well as conditions associated with hematopoietic cells. The invention is directed to antibodies and methods of making zsig81 polypeptides, as well.
摘要翻译： 本发明涉及编码四螺旋束细胞因子的多肽和多核苷酸分子。 细胞因子被指定为zsig81，并且主要限制在心脏，肺和肝中的表达。 已经显示zsig81刺激造血细胞的增殖，并且这些细胞的有用扩张以及与造血细胞相关的病症。 本发明还涉及制备zsig81多肽的抗体和方法。
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公开(公告)号：US08383775B2
公开(公告)日：2013-02-26
申请号：US13339639
申请日：2011-12-29
申请人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
发明人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
摘要翻译： 描述了与SEQ ID NO：2所示的包含zalpha11配体的序列的多肽和肽结合的抗体。 抗体可以结合162个氨基酸残基或其片段的全长序列，包括131个氨基酸残基的成熟多肽和较小的多肽和肽序列。 抗体可以包括多克隆，单克隆，鼠，人源化或中和的抗体。 还描述了产生抗体的方法。
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