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公开(公告)号：US20120238571A1
公开(公告)日：2012-09-20
申请号：US13513079
申请日：2010-12-03
申请人： Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Katherine Louise Jones , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Christian Alan Paul Smethurst
发明人： Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Katherine Louise Jones , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Christian Alan Paul Smethurst
IPC分类号： C07D417/14 , A61K31/437 , A61K31/4439 , A61K31/427 , C07D413/14 , C07D471/04 , A61P11/00 , A61P37/08 , A61P37/00 , A61P29/00 , A61P9/00 , A61P25/28 , A61P1/18 , A61P13/12 , A61P35/00 , A61P15/00 , A61P41/00 , A61P25/00 , A61P11/06 , A61P19/02 , A61P1/00 , A61P9/10 , A61K31/5377
CPC分类号： C07D417/14 , C07D417/12 , C07D471/04
摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.
摘要翻译： 本发明涉及某些新化合物。 具体地，本发明涉及式（I）的化合物及其盐。 本发明的化合物是PI3-激酶活性的抑制剂。
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公开(公告)号：US20120238559A1
公开(公告)日：2012-09-20
申请号：US13513048
申请日：2010-12-03
申请人： Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Juliet Kay Simpson , Christian Alan Paul Smethurst
发明人： Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Juliet Kay Simpson , Christian Alan Paul Smethurst
IPC分类号： A61K31/4439 , A61P37/08 , A61P37/06 , A61P29/00 , A61P9/00 , A61P25/28 , A61P13/12 , A61P7/02 , A61P35/00 , A61P15/00 , A61P9/10 , A61P19/02 , A61P11/06 , C07D401/14 , C07D471/04 , A61K31/437 , C07D413/14 , A61K31/422 , C07D403/14 , A61K31/416 , C07D417/14 , A61K31/427 , C07D491/048 , A61K31/4355 , A61K31/5377 , A61K31/541 , A61K31/4545 , A61P11/00
CPC分类号： C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/048
摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.
摘要翻译： 本发明涉及某些新化合物。 具体地，本发明涉及式（I）的化合物及其盐。 本发明的化合物是PI3-激酶活性的抑制剂。
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公开(公告)号：US20110178063A1
公开(公告)日：2011-07-21
申请号：US12994250
申请日：2009-06-03
申请人： Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Juliet Kay Simpson , Christian Alan Paul Smethurst
发明人： Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Juliet Kay Simpson , Christian Alan Paul Smethurst
IPC分类号： A61K31/553 , C07D413/14 , A61K31/5377 , C07D417/14 , A61K31/541 , A61K31/5386 , C07D401/14 , A61K31/454 , A61K31/427 , A61K31/496 , A61K31/4439 , C07D471/04 , A61K31/4985 , C07D487/04 , A61K31/519 , A61P11/00 , A61P37/08 , A61P9/00 , A61P19/02 , A61P25/28 , A61P1/00 , A61P7/02 , A61P29/00
CPC分类号： C07D231/56
摘要： The invention is directed to certain novel compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.
摘要翻译： 本发明涉及某些新的式（I）化合物及其盐。 本发明的化合物是PI3-激酶活性的抑制剂。
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公开(公告)号：US08658635B2
公开(公告)日：2014-02-25
申请号：US12994250
申请日：2009-06-03
申请人： Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Juliet Kay Simpson , Christian Alan Paul Smethurst
发明人： Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Juliet Kay Simpson , Christian Alan Paul Smethurst
IPC分类号： A61K31/55 , A61K31/5377 , A61K31/501 , A61K31/496 , A61K31/497 , A61K31/50 , A61K31/505 , A61K31/4523 , A61K31/4427 , A61K31/427 , A61K31/425 , C07D267/02 , C07D279/12 , C07D295/00 , C07D265/30 , C07D413/14 , C07D487/12 , C07D417/12 , C07D211/00 , C07D277/20 , C07D235/00 , C07D233/54 , C07D403/14
CPC分类号： C07D231/56
摘要： The invention is directed to certain novel compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.
摘要翻译： 本发明涉及某些新的式（I）化合物及其盐。 本发明的化合物是PI3-激酶活性的抑制剂。
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公开(公告)号：US20110118246A1
公开(公告)日：2011-05-19
申请号：US12994253
申请日：2009-06-03
申请人： Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , Juliet Kay Simpson , Christian Alan Paul Smethurst
发明人： Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , Juliet Kay Simpson , Christian Alan Paul Smethurst
IPC分类号： A61K31/4439 , C07D401/14 , C07D413/14 , A61K31/5377 , A61K31/4545 , A61K31/496 , C07D405/14 , C07D471/04 , A61K31/4985 , A61K31/444 , C07D417/14 , A61K31/541 , A61P11/00 , A61P11/06 , A61P25/28 , A61P35/00 , A61P37/06 , A61P29/00 , A61P9/10
CPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D471/04
摘要： The invention is directed to to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.
摘要翻译： 本发明涉及式（I）化合物及其盐。 本发明的化合物是PI3-激酶活性的抑制剂。
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26.发明申请公开(公告)号：US20110112070A1
公开(公告)日：2011-05-12
申请号：US12994246
申请日：2009-06-03
申请人： Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Katherine Louise Jones , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , Christian Alan Paul Smethurst , Yoshiaki Washio
发明人： Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Katherine Louise Jones , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , Christian Alan Paul Smethurst , Yoshiaki Washio
IPC分类号： A61K31/416 , C07D401/12 , C07D231/56 , C07D417/14 , C07D417/12 , C07D413/14 , A61K31/4439 , A61K31/427 , A61K31/5377 , A61K31/496 , A61K31/4545 , A61K31/541 , A61K31/553 , A61P11/00
CPC分类号： C07D231/56
摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of P13-kinase activity.
摘要翻译： 本发明涉及某些新化合物。 具体地，本发明涉及式（I）的化合物及其盐。 本发明的化合物是P13-激酶活性的抑制剂。
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公开(公告)号：US08536169B2
公开(公告)日：2013-09-17
申请号：US12994254
申请日：2009-06-03
申请人： Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Joelle Le , Nigel James Parr , Timothy John Ritchie , Juliet Kay Simpson , Christian Alan Paul Smethurst
发明人： Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Joelle Le , Nigel James Parr , Timothy John Ritchie , Juliet Kay Simpson , Christian Alan Paul Smethurst
IPC分类号： A61K31/5377 , A61K31/416 , A61K31/454 , A61K31/4439 , C07D401/14 , C07D403/04 , C07D413/14
CPC分类号： C07D403/04 , C07D401/14 , C07D403/14 , C07D413/14 , C07D471/04
摘要： The invention is directed to certain novel compounds directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.
摘要翻译： 本发明涉及针对式（I）化合物及其盐的某些新化合物。 本发明的化合物是PI3-激酶活性的抑制剂。
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公开(公告)号：US20090181950A1
公开(公告)日：2009-07-16
申请号：US12300832
申请日：2007-05-17
IPC分类号： A61K31/55 , C07D401/14 , A61P29/00 , A61P37/08
CPC分类号： C07D215/54 , C07D215/48
摘要： The present invention relates to compounds of formula (I), and salts thereof, processes for their preparation, to compositions containing them and to their use in the treatment of various disorders, such as allergic rhinitis.
摘要翻译： 本发明涉及式（I）化合物及其盐，其制备方法，含有它们的组合物及其在治疗各种疾病如过敏性鼻炎中的用途。
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公开(公告)号：US20120015932A1
公开(公告)日：2012-01-19
申请号：US13202139
申请日：2010-02-24
申请人： Heather Hobbs , Simon Teanby Hodgson , Yannick Maurice LaCroix , Deborah Needham , Nigel James Parr , Panayiotis Alexandrou Procopiou , Timothy John Ritchie , Michael David Woodrow
发明人： Heather Hobbs , Simon Teanby Hodgson , Yannick Maurice LaCroix , Deborah Needham , Nigel James Parr , Panayiotis Alexandrou Procopiou , Timothy John Ritchie , Michael David Woodrow
IPC分类号： A61K31/416 , C07D413/14 , C07D409/14 , A61K31/5377 , A61P29/00 , A61K31/496 , A61K31/422 , A61K31/4178 , A61P37/00 , C07D409/12 , A61K31/454
CPC分类号： C07D409/12 , C07D409/14 , C07D413/14
摘要： Indazole compounds, processes for their preparation, intermediates usable in these processes, pharmaceutical compositions containing such compounds and their use in therapy.
摘要翻译： 吲唑化合物，其制备方法，可用于这些方法的中间体，含有这些化合物的药物组合物及其在治疗中的用途。
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公开(公告)号：US08357716B2
公开(公告)日：2013-01-22
申请号：US13202139
申请日：2010-02-24
申请人： Heather Hobbs , Simon Teanby Hodgson , Yannick Maurice LaCroix , Deborah Needham , Nigel James Parr , Panayiotis Alexandrou Procopiou , Timothy John Ritchie , Michael David Woodrow
发明人： Heather Hobbs , Simon Teanby Hodgson , Yannick Maurice LaCroix , Deborah Needham , Nigel James Parr , Panayiotis Alexandrou Procopiou , Timothy John Ritchie , Michael David Woodrow
IPC分类号： A61K31/416 , C07D231/56
CPC分类号： C07D409/12 , C07D409/14 , C07D413/14
摘要： Indazole compounds, processes for their preparation, intermediates usable in these processes, pharmaceutical compositions containing such compounds and their use in therapy.
摘要翻译： 吲唑化合物，其制备方法，可用于这些方法的中间体，含有这些化合物的药物组合物及其在治疗中的用途。
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