公开(公告)号：US5077011A

公开(公告)日：1991-12-31

申请号：US939856

申请日：1986-12-09

申请人： Yoshikazo Amano ,  Harumi Katsuyama

发明人： Yoshikazo Amano ,  Harumi Katsuyama

IPC分类号： G01N31/22 ,  C12Q1/00 ,  C12Q1/34 ,  C12Q1/40 ,  C12Q1/42 ,  G01N33/52 ,  G01N33/543

CPC分类号： C12Q1/40 ,  C12Q1/34 ,  C12Q1/42 ,  G01N33/526 ,  C12Q2334/10

摘要： A dry analytical element for use in the measurement of activity of enzyme in an aqueous liquid, such as, body fluid, having one or more water-retaining layers. The enzyme has an optimum pH in a in pH range within which the dissociation of p-nitrophenol is insufficient for color formation. The layers of the element comprise a self-developing substrate having p-nitrophenol group attached to the molecular structure through an ether or ester linkage and a cationic polymer, said self-developing substrate and said cationic polymer being incorporated separately in different water-retaining carriers which are arranged to allow the layers to have liquid contact with each other.

摘要翻译： 用于测量酶在水性液体（例如体液）中具有一个或多个保水层的活性的干燥分析元件。 该酶在pH范围内具有最佳pH，其中对硝基苯酚的解离不足以形成颜色。 元件的层包括具有通过醚或酯键连接到分子结构上的对硝基苯基的自显影底物和阳离子聚合物，所述自显影底物和所述阳离子聚合物分别并入不同的保水载体 其布置成允许层彼此液体接触。

公开(公告)号：USH791H

公开(公告)日：1990-06-05

申请号：US106906

申请日：1987-10-08

申请人： Harumi Katsuyama ,  Shigeki Kageyama ,  Shigeru Nagatomo

发明人： Harumi Katsuyama ,  Shigeki Kageyama ,  Shigeru Nagatomo

IPC分类号： G01N33/72 ,  G01N21/78

CPC分类号： G01N33/728

摘要： A multilayer analytical element for quantitative analysis of bilirubin in a liquid sample by a diazo method, which comprises a laminated structure consisting essentially of:(1) a porous reagent layer containing an acidic binder and a diazonium salt being reactive to bilirubin to produce azobilirubin;(2) an absorbent layer capable of absorbing an excessive liquid portion; and(3) a liquid-impermeable light-transmissive support.

公开(公告)号：US4839278A

公开(公告)日：1989-06-13

申请号：US866349

申请日：1986-05-22

申请人： Kaoru Terashima ,  Takushi Miyazako ,  Harumi Katsuyama

发明人： Kaoru Terashima ,  Takushi Miyazako ,  Harumi Katsuyama

IPC分类号： C12N15/02 ,  C12Q1/00 ,  C12Q1/42 ,  G01N31/22 ,  G01N33/52

CPC分类号： C12Q1/42 ,  G01N33/526 ,  C12Q2334/10 ,  Y10S435/805

摘要： An integral multilayer analytical element for the measurement of alkaline phosphatase activity, which comprises a porous spreading layer containing a self-developable substrate in response to contact with alkaline phosphatase, a buffer layer containing a diffusion-resistant base and a support in a laminated form.

摘要翻译： 一种用于测量碱性磷酸酶活性的整体多层分析元件，其包含响应于与碱性磷酸酶接触而含有可自发显影的底物的多孔扩散层，含有扩散抗性碱的缓冲层和层压形式的载体。

公开(公告)号：US4671937A

公开(公告)日：1987-06-09

申请号：US626743

申请日：1984-07-02

申请人： Harumi Katsuyama ,  Fuminori Arai ,  Takushi Miyazako ,  Shigeru Nagatomo

发明人： Harumi Katsuyama ,  Fuminori Arai ,  Takushi Miyazako ,  Shigeru Nagatomo

IPC分类号： B32B7/02 ,  C12Q1/40 ,  G01N31/22 ,  G01N33/50 ,  G01N33/52 ,  C12R1/585 ,  C12R1/59 ,  C12R1/64

CPC分类号： C12Q1/40 ,  G01N33/525 ,  Y10S435/805 ,  Y10S436/81 ,  Y10S436/903 ,  Y10S436/904 ,  Y10S436/91

摘要： A multilayer analytical element for analysis of analyte in a liquid sample comprising a liquid sample-spreading layer, a reagent layer containing a diazonium salt, and a liquid-impermeable light-transmissive support, being laminated in this order, in which said reagent layer contains a sulfonic acid group-containing polymer having at least 10 molar % of a repeating unit selected from those consisting of a sulfoalkyl group and sulfophenyl group. The analytical element can be an element comprising a porous reagent layer containing a diazonium salt and the liquid-impermeable light-transmissive support, being laminated in this order.

摘要翻译： 用于分析液体样品中的分析物的多层分析元件，其包含液体样品扩散层，含有重氮盐的试剂层和不透液体的透光性载体，其中所述试剂层含有 具有至少10摩尔％的选自由磺基烷基和磺基苯基组成的重复单元的含磺酸基的聚合物。 分析元件可以是包含含有重氮盐的多孔试剂层和液体不可透过的透光性支撑体的元件，其顺序层叠。

公开(公告)号：US4418037A

公开(公告)日：1983-11-29

申请号：US369718

申请日：1982-04-19

申请人： Harumi Katsuyama ,  Tadao Shishido

发明人： Harumi Katsuyama ,  Tadao Shishido

IPC分类号： G01N33/50 ,  C12Q1/00 ,  C12Q1/28 ,  G01N31/22 ,  G01N33/52 ,  G01N33/66

CPC分类号： C12Q1/28 ,  C12Q2326/00 ,  C12Q2326/50 ,  Y10S435/805 ,  Y10S436/904 ,  Y10T436/144444 ,  Y10T436/206664

摘要： In a multilayer analysis film for detecting hydrogen peroxide by dry process which comprises a support and a reagent layer having contained therein a color indicator composition comprising peroxidase and a substance capable of causing a optically detectable change in the presence of hydrogen peroxide and peroxidase, the color indicator composition is characterized by further containing specific pyrogallol derivatives. Such pyrogallol derivatives improve stability during storage of such a multilayer analysis film.

摘要翻译： 在用于通过干法检测过氧化氢的多层分析膜中，其包含载体和试剂层，其中含有包含过氧化物酶的颜色指示剂组合物和能够在过氧化氢和过氧化物酶存在下引起可光学检测的变化的物质，颜色 指标组合物的特征在于还含有特定的连苯三酚衍生物。 这种连苯三酚衍生物改善了在这种多层分析膜的储存期间的稳定性。

公开(公告)号：US4389474A

公开(公告)日：1983-06-21

申请号：US294644

申请日：1981-08-20

申请人： Kouichi Kawamura ,  Hideo Sato ,  Harumi Katsuyama

发明人： Kouichi Kawamura ,  Hideo Sato ,  Harumi Katsuyama

IPC分类号： C07D335/02 ,  G03G5/00 ,  G03G5/06 ,  G03G5/09 ,  G03G5/04 ,  G03G9/08

CPC分类号： G03G5/0637 ,  C07D335/02 ,  G03G5/067

摘要： A thiopyrylium compound having t-butyl groups at the 2- and 6-positions of the thiopyrylium nucleus, having a main absorption near the red region, i.e., 600 to 700 nm but substantially no side absorption near 400 nm, and useful as a sensitizer for a photoconductive composition.

摘要翻译： 在硫代吡喃核的2-和6-位具有叔丁基的硫代吡喃鎓化合物，在红色区域附近具有主吸收，即600-700nm，但在400nm附近基本上没有侧吸收，并且可用作敏化剂 用于光导组合物。

公开(公告)号：US3944556A

公开(公告)日：1976-03-16

申请号：US478498

申请日：1974-06-12

申请人： Harumi Katsuyama ,  Hisatake Ono

发明人： Harumi Katsuyama ,  Hisatake Ono

IPC分类号： G03C1/685 ,  G03C1/815 ,  G03G5/06 ,  C07D215/38

CPC分类号： G03G5/065 ,  G03C1/685 ,  G03C1/8155

摘要： Spiro-pyrazoline derivatives of the general formula ##SPC1##Where Z.sub.1, Z.sub.2, R.sub.1 to R.sub.4 are as defined hereinafter and methods for their preparation are disclosed. The compounds are useful as organic photoconductors, organic fluorescent materials and as additives for silver salt and non-silver salt photographic materials.

摘要翻译： 通式为Z 1，Z 2，R 1至R 4的螺 - 吡唑啉衍生物如下文所定义，并公开了其制备方法。 这些化合物可用作有机光电导体，有机荧光材料和用作银盐和非银盐照相材料的添加剂。

公开(公告)号：US3930851A

公开(公告)日：1976-01-06

申请号：US455797

申请日：1974-03-28

申请人： Hisatake Ono ,  Syu Watarai ,  Harumi Katsuyama

发明人： Hisatake Ono ,  Syu Watarai ,  Harumi Katsuyama

IPC分类号： G03G5/06 ,  G03G5/07 ,  G03G13/22

CPC分类号： G03G5/0661 ,  G03G5/065 ,  G03G5/071 ,  Y10S430/163

摘要： An electrophotographic member comprising a resin binder and an organic photoconductive composition and a process using the electrophotographic member, the composition consisting essentially of a compound of the formula (A), its dimeric compound or its polymeric compound: ##SPC1##Whereim R.sub.1 is hydrogen atom, halogen atom, alkyl group having 1 to 4 carbon atoms, alkoxy group having 1 to 4 carbon atoms, alkoxycarbonyl group having alkyl group 1 to 4 carbon atoms, nitro group, alkylene group having 1 to 3 carbon atoms which is capable of forming a bis-compound, or a bond which is capable of forming a bis-compound, R.sub.2 is hydrogen atom, hydroxyl group, alkoxycarbonyl group having alkyl group of 1 to 4 carbon atoms, cyano or phenyl group, R is substituted phenyl group (where substituted group is hydrogen atom, halogen atom, alkyl group having 1 to 4 carbon atoms, or alkoxy group having 1 to 4 carbon atoms), alkylene group having 1 to 3 carbon atoms which is capable of forming a bis-compound, phenylene group which is capable of forming a bis-compound, or a bond which is capable of forming a bis-compound, and m is an integer from 1 to 4.

公开(公告)号：USH930H

公开(公告)日：1991-06-04

申请号：US321977

申请日：1989-03-10

申请人： Keiko Kato ,  Fuminori Arai ,  Harumi Katsuyama

发明人： Keiko Kato ,  Fuminori Arai ,  Harumi Katsuyama

IPC分类号： G01N33/66 ,  C12Q1/54 ,  C12Q1/26 ,  C12Q1/28

CPC分类号： C12Q1/54

摘要： A dry-type quantitative glucose-analyzing element comprising a water-impermeable light-transmissive support having thereon a group of water-permeable layers comprising a reagent layer, an enzyme-containing layer, and a porous spreading layer which are laminated on said support in this order, and a hydrogen peroxide-detecting coloring composition comprising a hydrogen donor and a coupler; whereinsaid reagent layer contains at least said coupler;said enzyme-containing layer contains a glucose oxidase, a peroxidase and a mordant which immobilizes a dye formed by said coloring composition; andsaid hydrogen donor is contained in at least one water-permeable layer of said group. Using the element, quantitative determination of glucose of high concentration is possible with high accuracy.

公开(公告)号：US4916059A

公开(公告)日：1990-04-10

申请号：US876975

申请日：1986-06-20

申请人： Shigeki Kageyama ,  Harumi Katsuyama

发明人： Shigeki Kageyama ,  Harumi Katsuyama

IPC分类号： C12Q1/48 ,  G01N33/52

CPC分类号： G01N33/526 ,  C12Q1/48

摘要： A reagent sheet for the measurement of GGT (.gamma.-glutamyl transferase) activity comprising a porous sheet containing a cationic surfactant and a self-developable substrate upon contact with .gamma.-glutamyl transferase. An integral multilayer analytical element for the measurement of GGT activity, comprising a porous spreading layer containing a cationic surfactant and a self-developable substrate in response to contact with .gamma.-glutamyl transferase, a water-absorbing layer and a support in a laminated form. The substrate can be either .gamma.-glutamyl-p-nitroamilide or .gamma.-glutamyl-3-carboxy-4-nitroamilide.

摘要翻译： 用于测量GGT（γ-谷氨酰转移酶）活性的试剂片，其包含含有阳离子表面活性剂的多孔片材和与γ-谷氨酰转移酶接触时的自显影底物。 用于测量GGT活性的整体多层分析元件，包括响应于与γ-谷氨酰转移酶，吸水层和层叠形式的载体接触而含有阳离子表面活性剂和自显影底物的多孔扩散层。 底物可以是γ-谷氨酰 - 对 - 硝酰基苯胺或γ-谷氨酰基-3-羧基-4-硝基己酰苯胺。