公开(公告)号：US4421688A

公开(公告)日：1983-12-20

申请号：US414032

申请日：1982-09-02

申请人： Masayuki Muroi ,  Makoto Kida

发明人： Masayuki Muroi ,  Makoto Kida

IPC分类号： C12P13/02 ,  A61K31/395 ,  A61P31/04 ,  A61P31/10 ,  C07D225/06 ,  C12P17/10 ,  C12R1/365 ,  C12R1/585

CPC分类号： C12R1/365 ,  C07D225/06 ,  C12P17/10 ,  C12R1/585 ,  Y10S435/872

摘要： Macbecin derivatives are produced by bringing Macbecins into contact with a microorganism, or its processed matter, of the genus Streptomyces or Nocardia. The Macbecin derivatives are useful as antibacterial, antifungal or antiprotozoal agent.

摘要翻译： 麦芽胨衍生物是通过使马可夫菌素与链霉菌属或诺卡氏菌属的微生物或其加工物质接触来制备的。 Macbecin衍生物可用作抗菌剂，抗真菌剂或抗原虫剂。

公开(公告)号：US5952463A

公开(公告)日：1999-09-14

申请号：US878546

申请日：1997-06-19

申请人： Yuji Shibano ,  Norihisa Kikuchi ,  Kohei Oda

发明人： Yuji Shibano ,  Norihisa Kikuchi ,  Kohei Oda

IPC分类号： C12N15/09 ,  C07H21/04 ,  C07K14/81 ,  C12N9/99 ,  C12N15/15 ,  C12P21/02 ,  C12R1/585 ,  A61K38/00 ,  C07K1/00

CPC分类号： C07K14/811

摘要： The present invention relates to a novel proteinase inhibitor useful as a medicine or pesticides and a gene coding for the inhibitor. A proteinase inhibitor (Kexstatin) having inhibitory activity against Kex2 proteinase family enzymes and having a molecular weight of 11,500; a gene coding for Kexstatin; and a method for producing Kexstatin using a microorganism belonging to the genus Streptomyces or transformed with Kexstatin gene are disclosed.

摘要翻译： 本发明涉及可用作药物或农药的新型蛋白酶抑制剂和编码该抑制剂的基因。 对Kex2蛋白酶家族酶具有抑制活性且分子量为11,500的蛋白酶抑制剂（Kexstatin）; 编码Kexstatin的基因; 并且公开了使用属于链霉菌属的微生物或用Kexstatin基因转化的Kexstatin的生产方法。

公开(公告)号：US5057536A

公开(公告)日：1991-10-15

申请号：US351391

申请日：1989-05-09

申请人： Michael J. Dawson ,  David Noble ,  Gordon C. Lawrence ,  Richard A. Fletton ,  Stephen J. Lane ,  Michael V. J. Ramsay ,  Oswy Z. Pereira ,  Derek R. Sutherland ,  Edward P. Tiley

发明人： Michael J. Dawson ,  David Noble ,  Gordon C. Lawrence ,  Richard A. Fletton ,  Stephen J. Lane ,  Michael V. J. Ramsay ,  Oswy Z. Pereira ,  Derek R. Sutherland ,  Edward P. Tiley

IPC分类号： C12P17/18 ,  A01N43/90 ,  A61K31/335 ,  A61K31/365 ,  A61P33/10 ,  C07D493/22 ,  C07H19/01 ,  C12R1/465 ,  C12R1/585 ,  C12R1/59 ,  C12R1/645

CPC分类号： C07H19/01 ,  A01N43/90

摘要： Compounds of formula (1) ##STR1## and salts thereof, wherein R.sup.1 represents a methyl, ethyl or isopropyl group;Y.sup.1 is --CH.sub.2 --, Y.sup.2 is --CH-- and X represents ##STR2## where R.sup.2 represents a hydrogen atom or a group OR.sup.8 (where OR.sup.8 is a hydroxyl group or a substituted hydroxyl group having up to 25 carbon atoms) and R.sup.3 represents a hydrogen atom, or R.sup.2 and R.sup.3 together with the carbon atom to which they are attached represent >C.dbd.O, >C.dbd.CH.sub.2 or >C.dbd.NOR.sup.9 (where R.sup.9 represents a hydrogen atom, a C.sub.1-8 alkyl group or a C.sub.3-8 alkenyl group) and the group >C.dbd.NOR.sup.9 is in the E configuration] or --Y.sup.1 --X--Y.sup.2 -- represents --CH.dbd.CH--CH-- or --CH.sub.2 --CH.dbd.C--;R.sup.4 represents a group OR.sup.8 as defined above and R.sup.5 represents a hydrogen atom, or R.sup.4 and R.sup.5 together with the carbon atom to which they are attached represent >C.dbd.O or >C.dbd.NOR.sup.9a (where R.sup.9a is as defined above for R.sup.9);R.sup.6 represents a hydrogen atom and R represents --CH.sub.2 OH, --CHO, --CO.sub.2 H or a carboxylic acid ester or amide group; or R.sup.6 represents a hydroxyl group and R represents a methyl group; andR.sup.7 represents a hydrogen atom or when R represents a group --CH.sub.2 OH then R.sup.7 may also represent a hydroxyl group.The compounds may be used to control nematode, acarine, insect or other pests.

公开(公告)号：US4671937A

公开(公告)日：1987-06-09

申请号：US626743

申请日：1984-07-02

申请人： Harumi Katsuyama ,  Fuminori Arai ,  Takushi Miyazako ,  Shigeru Nagatomo

发明人： Harumi Katsuyama ,  Fuminori Arai ,  Takushi Miyazako ,  Shigeru Nagatomo

IPC分类号： B32B7/02 ,  C12Q1/40 ,  G01N31/22 ,  G01N33/50 ,  G01N33/52 ,  C12R1/585 ,  C12R1/59 ,  C12R1/64

CPC分类号： C12Q1/40 ,  G01N33/525 ,  Y10S435/805 ,  Y10S436/81 ,  Y10S436/903 ,  Y10S436/904 ,  Y10S436/91

摘要： A multilayer analytical element for analysis of analyte in a liquid sample comprising a liquid sample-spreading layer, a reagent layer containing a diazonium salt, and a liquid-impermeable light-transmissive support, being laminated in this order, in which said reagent layer contains a sulfonic acid group-containing polymer having at least 10 molar % of a repeating unit selected from those consisting of a sulfoalkyl group and sulfophenyl group. The analytical element can be an element comprising a porous reagent layer containing a diazonium salt and the liquid-impermeable light-transmissive support, being laminated in this order.

摘要翻译： 用于分析液体样品中的分析物的多层分析元件，其包含液体样品扩散层，含有重氮盐的试剂层和不透液体的透光性载体，其中所述试剂层含有 具有至少10摩尔％的选自由磺基烷基和磺基苯基组成的重复单元的含磺酸基的聚合物。 分析元件可以是包含含有重氮盐的多孔试剂层和液体不可透过的透光性支撑体的元件，其顺序层叠。

公开(公告)号：US3907779A

公开(公告)日：1975-09-23

申请号：US47132274

申请日：1974-05-20

申请人： UPJOHN CO

发明人： DEBOER CLARENCE ,  BANNISTER BRIAN

IPC分类号： C12P19/38 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61K31/706 ,  A61P31/04 ,  C07H19/12 ,  C12N1/20 ,  C12P1/06 ,  C12R1/585

CPC分类号： C07H19/12 ,  Y10S435/903

摘要： New antibiotic U-44,590 and derivatives thereof, produced by the controlled fermentation of the new microorganism Streptomyces platensis var. clarensis var nova, NRRL 8035. This antibiotic and its derivatives are active against Gram-negative bacteria. Accordingly, they can be used in various environments to eradicate or control such bacteria.

摘要翻译： 新型抗生素U-44,590及其衍生物，通过新型微生物链霉菌Streptomyces platensis var。 这种抗生素及其衍生物对革兰氏阴性菌具有活性。 因此，它们可以用于各种环境中以消除或控制这些细菌。