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公开(公告)号：US06600999B2
公开(公告)日：2003-07-29
申请号：US09973903
申请日：2001-10-10
IPC分类号： B61K910
摘要： A railroad rail inspection system is provided for use in conjunction with a non-railbound vehicle having an equipment bay. The system comprises a detector carriage adapted for being propelled over a two-rail railroad track by the non-railbound vehicle. A magnetic induction sensor system adapted for magnetic induction inspection of at least one rail of the track is attached to the detector carriage. The system further comprises a data acquisition system in communication with the magnetic induction sensor system, the data acquisition system including at least one data processor adapted for processing induction data received from the magnetic induction sensor system. The system further comprises a power supply system adapted for supplying electrical power to the magnetic induction sensor system. The data acquisition system and the power supply system are configured for disposition and operation within the equipment bay of the non-railbound vehicle.
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公开(公告)号：US06476603B2
公开(公告)日：2002-11-05
申请号：US09997935
申请日：2001-11-30
申请人： Robin Clark , Douglas T. Main, Jr.
发明人： Robin Clark , Douglas T. Main, Jr.
IPC分类号： B61K910
摘要： A brush assembly for engaging and conducting electricity to or from a surface is provided. The brush assembly comprises a monolithic, electrically conductive bus block and a bristle holder removably attached to the bus block. The bristle holder is formed as a monolithic block having a plurality of parallel bristle holes formed therethrough. The brush assembly further comprises a plurality of bristle assemblies, each bristle assembly having an elongate, electrically conductive bristle and an electrically conductive bristle cap having a sleeve, the proximal end of the bristle being secured within the sleeve so that the bristle is in electrical communication with the sleeve. At least a portion of the bristle cap of each bristle assembly is removably disposed within an associated bristle hole so that the bristle of each bristle assembly extends through its associated bristle hole and downwardly away from the lower bristle holder surface. Each bristle cap is in electrical communication with the bus block.
摘要翻译： 提供了用于与表面接合和导电的刷组件。 电刷组件包括可拆卸地连接到总线块的整体式导电总线块和刷毛架。 刷毛保持器形成为具有穿过其形成的多个平行的刷毛孔的整体块。 刷子组件还包括多个刷毛组件，每个刷毛组件具有细长的导电刷毛和具有套筒的导电刷毛帽，刷毛的近端固定在套筒内，使得刷毛电连通 与袖子。 每个刷毛组件的刷毛帽的至少一部分可移除地设置在相关联的刷毛孔内，使得每个刷毛组件的刷毛延伸通过其相关联的刷毛孔并向下远离下部刷毛保持器表面。 每个刷毛盖与总线块电气通信。
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公开(公告)号：US5925516A
公开(公告)日：1999-07-20
申请号：US430521
申请日：1995-04-27
申请人： Michael R. Botchan , Robin Clark , Ian J. Mohr , Shaw Sun
发明人： Michael R. Botchan , Robin Clark , Ian J. Mohr , Shaw Sun
IPC分类号： G01N33/569 , A61K38/00 , A61K39/395 , A61P35/00 , C07K14/025 , C12Q1/18 , C12Q1/68 , C07H17/00 , C07K14/00
CPC分类号： C07K14/005 , C12Q1/18 , A61K38/00 , C12N2710/20022 , Y10S530/826
摘要： Medicaments, and methods of identifying the same, are described that are useful for treating papillomavirus diseases that have the characteristics of preventing, interfering with, or reversing the binding of the appropriate papillomavirus proteins E1 or E2 to a nucleotide sequence homologous to a nucleotide sequence present in the papillomavirus genome, or of the formation of a complex consisting of papillomavirus proteins E1 and E2, or the binding of the complex to the nucleotide sequence.
摘要翻译： 描述了用于治疗具有预防，干扰或逆转适当的乳头瘤病毒蛋白E1或E2与存在的核苷酸序列同源的核苷酸序列的结合的乳头瘤病毒疾病的药物及其鉴定方法 在乳头瘤病毒基因组中，或由乳头瘤病毒蛋白E1和E2组成的复合物的形成，或者复合物与核苷酸序列的结合。
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24.发明授权
公开(公告)号：US5464936A
公开(公告)日：1995-11-07
申请号：US632027
申请日：1990-12-21
申请人： Michael R. Botchan , Robin Clark , Ian J. Mohr , Shaw Sun
发明人： Michael R. Botchan , Robin Clark , Ian J. Mohr , Shaw Sun
IPC分类号： G01N33/569 , A61K38/00 , A61K39/395 , A61P35/00 , C07K14/025 , C12Q1/18 , A61K38/43 , A61K39/12 , C07K2/00 , C07K17/00
CPC分类号： C07K14/005 , C12Q1/18 , A61K38/00 , C12N2710/20022 , Y10S530/826
摘要： Medicaments, and methods of identifying the same, are described that are useful for treating papillomavirus diseases that have the characteristics of preventing, interfering with, or reversing the binding of the appropriate papillomavirus proteins E1 or E2 to a nucleotide sequence homologous to a nucleotide sequence present in the papillomavirus genome, or of the formation of a complex consisting of papillomavirus proteins E1 and E2, or the binding of the complex to the nucleotide sequence.
摘要翻译： 描述了用于治疗具有预防，干扰或逆转适当的乳头瘤病毒蛋白E1或E2与存在的核苷酸序列同源的核苷酸序列的结合的乳头瘤病毒疾病的药物及其鉴定方法 在乳头瘤病毒基因组中，或由乳头瘤病毒蛋白E1和E2组成的复合物的形成，或者复合物与核苷酸序列的结合。
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公开(公告)号：US4798787A
公开(公告)日：1989-01-17
申请号：US661909
申请日：1984-10-17
IPC分类号： A61K38/00 , C07K14/82 , G01N33/531 , B65D69/00 , C07K7/00
CPC分类号： C07K14/82 , G01N33/531 , A61K38/00 , Y10S435/81 , Y10S435/961 , Y10S436/808 , Y10S436/813
摘要： Antibodies exhibit specificity toward single amino acid differences between proteins. These antibodies may be produced by synthesizing a peptide of the appropriate amino acid sequence contained in the protein, immunizing a host with the peptide, and extracting sera from the host to obtain the antibodies. The antibodies and the desired protein are then immunoprecipitated under conditions of partial denaturation to expose the epitope of the protein. The antibodies may be used for diagnostic or therapeutic purposes.
摘要翻译： 抗体对蛋白质之间的单个氨基酸差异表现出特异性。 这些抗体可以通过合成蛋白质中包含的适当的氨基酸序列的肽，用肽免疫宿主和从宿主中提取血清得到抗体来产生。 然后将抗体和所需蛋白质在部分变性的条件下进行免疫沉淀以暴露蛋白质的表位。 抗体可用于诊断或治疗目的。
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公开(公告)号：US4762706A
公开(公告)日：1988-08-09
申请号：US661686
申请日：1984-10-17
申请人： Francis P. McCormick , Gail L. Wong , Robin Clark , Norman Arnheim , Danute E. Nitecki , James R. Feramisco
发明人： Francis P. McCormick , Gail L. Wong , Robin Clark , Norman Arnheim , Danute E. Nitecki , James R. Feramisco
IPC分类号： A61K38/00 , A61K39/395 , A61K45/00 , C07K7/08 , C07K16/32 , G01N33/531 , G01N33/574
CPC分类号： G01N33/5748 , C07K16/32 , C07K7/08 , G01N33/531 , A61K38/00
摘要： Antibodies exhibit specificity toward single amino acid differences between proteins. These antibodies may be produced by synthesizing a peptide of the appropriate amino acid sequence contained in the protein, immunizing a host with the peptide, and extracting sera from the host to obtain the antibodies. The antibodies and the desired protein are then immunoprecipitated under conditions of partial denaturation to expose the epitope of the protein. The antibodies may be used for diagnostic or therapeutic purposes.
摘要翻译： 抗体对蛋白质之间的单个氨基酸差异表现出特异性。 这些抗体可以通过合成蛋白质中包含的适当的氨基酸序列的肽，用肽免疫宿主和从宿主中提取血清得到抗体来产生。 然后将抗体和所需蛋白质在部分变性的条件下进行免疫沉淀以暴露蛋白质的表位。 抗体可用于诊断或治疗目的。
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公开(公告)号：US20120220565A1
公开(公告)日：2012-08-30
申请号：US13218809
申请日：2011-08-26
申请人： Robin Clark , Tony Johnson , Hazel Hunt , Ian McDonald
发明人： Robin Clark , Tony Johnson , Hazel Hunt , Ian McDonald
IPC分类号： A61K31/5383 , C07D471/14 , A61K31/437 , C07D498/04 , A61K31/5377 , A61K31/496
CPC分类号： C07D471/04
摘要： The present invention provides a novel class of pyridyl-amine fused azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators.
摘要翻译： 本发明提供了一类新颖的吡啶基 - 胺稠合的十九烷基化合物和使用该化合物作为糖皮质激素受体调节剂的方法。
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公开(公告)号：US20100292477A1
公开(公告)日：2010-11-18
申请号：US12777340
申请日：2010-05-11
申请人： Robin Clark , Doug Fry
发明人： Robin Clark , Doug Fry
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The present invention provides amorphous solid forms of the compound of Formula I, as well as methods for preparing the compound of Formula I by precipitation.
摘要翻译： 本发明提供了式I化合物的无定形固体形式，以及通过沉淀制备式I化合物的方法。
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公开(公告)号：US20070281928A1
公开(公告)日：2007-12-06
申请号：US10591884
申请日：2005-03-09
申请人： Robin Clark , Nicholas Ray , Paul Blaney , Christopher Hurley , Karen Williams
发明人： Robin Clark , Nicholas Ray , Paul Blaney , Christopher Hurley , Karen Williams
IPC分类号： A61K31/415 , A61K31/5377 , A61P43/00 , C07D401/02 , C07D413/14
CPC分类号： C07D471/04
摘要： The present invention provides a novel class of fused ring azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators.
摘要翻译： 本发明提供了一类新颖的稠环氮杂环丁烷化合物和使用该化合物作为糖皮质激素受体调节剂的方法。
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