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50 条记录 (耗时 0.026 秒)

    Transdermal Drug Administration Apparatus Having Microneedles
    21.
    发明申请
    Transdermal Drug Administration Apparatus Having Microneedles 有权
    具有微针的透皮药物管理装置

    公开(公告)号：US20090030365A1

    公开(公告)日：2009-01-29

    申请号：US12278483

    申请日：2007-02-07

    申请人： Seiji Tokumoto ,  Toshiyuki Matsudo ,  Tetsuji Kuwahara

    发明人： Seiji Tokumoto ,  Toshiyuki Matsudo ,  Tetsuji Kuwahara

    IPC分类号： A61N1/30 ,  A61M5/32 ,  A61N7/00 ,  A61L31/08

    CPC分类号： A61M37/0015 ,  A61M2037/0007 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0046 ,  A61N1/306

    摘要： It is intended to provide a transdermal drug administration apparatus having microneedles, which is capable of piercing the skin by a simple procedure in the transdermal administration of a biologically active substance (drug) and allows rapid absorption of the biologically active substance. The present apparatus comprises a microneedle device (50) comprising a microneedle substrate (53) having a plurality of microneedles (51) capable of piercing the skin, an absorbent (11) disposed thereon, the absorbent (11) comprising a material capable of absorbing a liquid, and a dissolving solution reservoir (18) disposed on the absorbent (11), the dissolving solution reservoir (18) containing a dissolving solution (16) for dissolving a drug and being capable of disrupting a diaphragm (20) provided the dissolving solution reservoir (18) and the absorbent (11) by pressing. A coating containing a dry drug is disposed on the microneedles (51) and/or the microneedle substrate (53).

    摘要翻译： 旨在提供具有微针的透皮给药装置，其能够通过简单的方法穿透皮肤给药生物活性物质（药物）并允许生物活性物质的快速吸收。 本发明的装置包括微针装置（50），其包括具有能够刺穿皮肤的多个微针（51）的微针基底（53），设置在其上的吸收体（11），所述吸收体（11）包括能吸收的材料 液体和设置在吸收剂（11）上的溶解溶液储存器（18），溶解液储存器（18）含有用于溶解药物的溶解溶液（16）并能够破坏隔膜（20） 溶液储存器（18）和吸收剂（11）。 将包含干药物的涂层设置在微针（51）和/或微针基片（53）上。

    ARRAY WITH FINE PROTRUSIONS
    25.
    发明申请
    ARRAY WITH FINE PROTRUSIONS 审中-公开
    阵列精美

    公开(公告)号：US20130084316A1

    公开(公告)日：2013-04-04

    申请号：US13699471

    申请日：2011-05-25

    申请人： Seiji Tokumoto ,  Shuji Ishitsuka ,  Yoshihiro Kodama ,  Nobumi Takemura

    发明人： Seiji Tokumoto ,  Shuji Ishitsuka ,  Yoshihiro Kodama ,  Nobumi Takemura

    IPC分类号： A61K9/00

    CPC分类号： A61K9/00 ,  A61M37/0015 ,  A61M2037/0038

    摘要： An array 1 with microprotrusions comprises a base 2 and tapered microprotrusions 3 each disposed on the base 2 and tapering down toward the tip from the bottom. Letting a distance from the tip to the bottom on an arbitrary side of each microprotrusion 3 as a and letting the length of a second line segment prepared by projecting a first line segment representing the distance a onto the base 2 as b, a relationship of 1.0

    摘要翻译： 具有微突起的阵列1包括基部2和锥形微突起3，每个突起3均设置在基部2上并且从底部向尖端向下逐渐变细。 将每个微注入器3的任意一侧的尖端到底部的距离设为a，并且通过将表示距离a的第一线段投影到基座2上而制备的第二线段的长度为b，关系为1.0 <（a / b）＆nlE; 7.5持有。

    MICRONEEDLE DEVICE
    26.
    发明申请
    MICRONEEDLE DEVICE 审中-公开
    MICRONEEDLE设备

    公开(公告)号：US20120004626A1

    公开(公告)日：2012-01-05

    申请号：US13147014

    申请日：2010-01-25

    申请人： Tetsuji Kuwahara ,  Seiji Tokumoto ,  Toshiyuki Matsudo

    发明人： Tetsuji Kuwahara ,  Seiji Tokumoto ,  Toshiyuki Matsudo

    IPC分类号： A61M5/32

    CPC分类号： A61L27/00 ,  A61K9/0021 ,  A61K38/1816 ,  A61K38/193 ,  A61K38/21 ,  A61K38/24 ,  A61K38/26 ,  A61K47/10 ,  A61K47/32 ,  A61M2037/0046

    摘要： The present invention aims to allow high molecular weight active ingredients to be contained in a coating agent substantially uniformly. For this purpose, a microneedle device 1 includes a microneedle base 2, and microneedles 3 capable of piercing a skin and being disposed on the microneedle base 2, wherein at least a part of a surface of the microneedles 3 and/or the microneedle base 2 is coated with a coating agent containing a high molecular weight active ingredient and a water-soluble polymer, and the content of the water-soluble polymer in the coating agent is 0.1 to 30% by weight, and the ratio of the content of the water-soluble polymer to the content of the high molecular weight active ingredient in the coating agent is 5:1 to 1:100.

    摘要翻译： 本发明的目的在于允许高分子量活性成分基本上均匀地包含在包衣剂中。 为此目的，微针装置1包括微针底座2和能够穿透皮肤并设置在微针底座2上的微针3，其中，微针3和/或微针底座2的表面的至少一部分 涂布含有高分子量活性成分和水溶性聚合物的涂布剂，涂布剂中的水溶性聚合物的含量为0.1〜30重量％，水的含量比例 可溶性聚合物与涂层剂中高分子量活性成分的含量为5:1-1:100。

    Applicator
    30.
    发明授权
    Applicator 有权
    申请人

    公开(公告)号：US09216252B2

    公开(公告)日：2015-12-22

    申请号：US14123523

    申请日：2012-07-13

    申请人： Makoto Ogura ,  Seiji Tokumoto

    发明人： Makoto Ogura ,  Seiji Tokumoto

    IPC分类号： A61M5/315 ,  A61M37/00

    CPC分类号： A61M5/31515 ,  A61M37/0015 ,  A61M2037/0023

    摘要： An applicator comprising a transmission member, a housing guiding a reciprocation of the transmission member, and a cap covering the housing. The transmission member is provided with a stopper extending in a direction orthogonal to an axial direction thereof. An upper end of the housing is formed with a projection sliding the stopper. The inside of the cap is formed with a lead part. The stopper is slid by the lead part to an end part of the projection when the cap is pushed and thereafter disengages from the projection when the cap is further pushed, so that the transmission member transmits the biasing force of an elastic member to a microneedle. This enables the microneedle to be applied to skin.

    摘要翻译： 一种涂抹器，包括传动构件，引导传动构件的往复运动的壳体和覆盖壳体的盖。 传动构件具有沿与其轴向正交的方向延伸的止动件。 壳体的上端形成有使塞子滑动的突起。 盖的内部形成有引线部分。 当盖被推动时，止动件被引导部分滑动到突起的端部，然后当帽被进一步推动时从突起脱离，从而传递构件将弹性构件的偏置力传递到微针。 这使得微针可以应用于皮肤。