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1.发明申请MICRONEEDLE DEVICE, AND METHOD FOR ENHANCING THE EFFICACY OF INFLUENZA VACCINE BY USING MICRONEEDLE DEVICE 有权MICRONEEDLE DEVICE，以及通过使用MICRONEEDLE装置来提高流感疫苗的效率的方法公开(公告)号：US20110112509A1
公开(公告)日：2011-05-12
申请号：US13001995
申请日：2009-05-22
申请人： Chikateru Nozaki , Kazuyoshi Kaminaka , Junichi Matsuda , Takaaki Terahara , Tetsuji Kuwahara , Seiji Tokumoto
发明人： Chikateru Nozaki , Kazuyoshi Kaminaka , Junichi Matsuda , Takaaki Terahara , Tetsuji Kuwahara , Seiji Tokumoto
IPC分类号： A61M5/00
CPC分类号： A61K39/145 , A61B17/205 , A61K39/12 , A61K2039/5252 , A61K2039/541 , A61K2039/545 , A61K2039/55511 , A61K2039/70 , A61M37/0015 , A61M2037/0046 , A61M2037/0061 , C12N2760/16134 , C12N2760/16234
摘要： The present invention provides a method for enhancing the immunogenicity using a microneedle device capable of enhancing the immunogenicity of an influenza vaccine. According to the method for enhancing the immunogenicity using the present microneedle device, a microneedle device having microneedles made of polylactic acid, coated with an influenza vaccine composed of an antigen having type A strain (H1N1), type A strain (H3N2), and type B strain as active ingredients is brought into direct contact with the skin so as to transcutaneously administer the aforementioned influenza vaccine. After the transcutaneous administration, lauryl alcohol is applied to the site of the skin where the microneedle device has been brought into direct contact.
摘要翻译： 本发明提供使用能够增强流感疫苗的免疫原性的微针装置增强免疫原性的方法。 根据使用本发明的微针装置的增强免疫原性的方法，将具有由聚乳酸制成的微针的微针装置涂敷于A型菌株（H1N1），A型菌株（H3N2）和A型菌株 作为活性成分的B菌株与皮肤直接接触，以便经皮施用上述流感疫苗。 在经皮给药之后，将月桂醇施用于已经与微针装置直接接触的皮肤部位。
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2.发明授权Microneedle device, and method for enhancing the efficacy of influenza vaccine by using microneedle device 有权微针装置以及通过使用微针装置增强流感疫苗的功效的方法公开(公告)号：US09028463B2
公开(公告)日：2015-05-12
申请号：US13001995
申请日：2009-05-22
申请人： Chikateru Nozaki , Kazuyoshi Kaminaka , Junichi Matsuda , Takaaki Terahara , Tetsuji Kuwahara , Seiji Tokumoto
发明人： Chikateru Nozaki , Kazuyoshi Kaminaka , Junichi Matsuda , Takaaki Terahara , Tetsuji Kuwahara , Seiji Tokumoto
IPC分类号： A61M31/00 , A61K39/145 , A61B17/20 , A61M37/00 , A61K39/00
CPC分类号： A61K39/145 , A61B17/205 , A61K39/12 , A61K2039/5252 , A61K2039/541 , A61K2039/545 , A61K2039/55511 , A61K2039/70 , A61M37/0015 , A61M2037/0046 , A61M2037/0061 , C12N2760/16134 , C12N2760/16234
摘要： The present invention provides a method for enhancing the immunogenicity using a microneedle device capable of enhancing the immunogenicity of an influenza vaccine. According to the method for enhancing the immunogenicity using the present microneedle device, a microneedle device having microneedles made of polylactic acid, coated with an influenza vaccine composed of an antigen having type A strain (H1N1), type A strain (H3N2), and type B strain as active ingredients is brought into direct contact with the skin so as to transcutaneously administer the aforementioned influenza vaccine. After the transcutaneous administration, lauryl alcohol is applied to the site of the skin where the microneedle device has been brought into direct contact.
摘要翻译： 本发明提供使用能够增强流感疫苗的免疫原性的微针装置增强免疫原性的方法。 根据使用本发明的微针装置的增强免疫原性的方法，将具有由聚乳酸制成的微针的微针装置涂敷于A型菌株（H1N1），A型菌株（H3N2）和A型菌株 作为活性成分的B菌株与皮肤直接接触，以便经皮施用上述流感疫苗。 在经皮给药之后，将月桂醇施用于已经与微针装置直接接触的皮肤部位。
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公开(公告)号：US20140065179A1
公开(公告)日：2014-03-06
申请号：US14004308
申请日：2012-03-09
IPC分类号： A61K39/39 , A61K39/145
CPC分类号： A61K39/39 , A61K39/0007 , A61K39/12 , A61K39/145 , A61K2039/55511 , A61K2039/55516 , A61K2039/575 , C12N2760/16134 , C12N2760/16171
摘要： A novel adjuvant composition is provided that is excellent in safety and convenience as compared to the conventional adjuvant such as Alum. An adjuvant composition comprising citrullines, which are water soluble substance present in the living body, and/or a salt thereof; a vaccine composition comprising said adjuvant composition and an antigen; a process for preparing said adjuvant composition and said vaccine composition; and a method for administering said adjuvant composition and said vaccine composition are provided.
摘要翻译： 提供与常规佐剂如Alum相比，安全性和便利性优异的新型佐剂组合物。 包含作为存在于生物体中的水溶性物质的瓜氨酸的佐剂组合物和/或其盐; 包含所述佐剂组合物和抗原的疫苗组合物; 一种制备所述佐剂组合物和所述疫苗组合物的方法; 并提供了用于施用所述佐剂组合物和所述疫苗组合物的方法。
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公开(公告)号：US20120244184A1
公开(公告)日：2012-09-27
申请号：US13392994
申请日：2010-08-23
CPC分类号： A61K39/145 , A61K39/00 , A61K39/12 , A61K2039/55505 , C07K14/005 , C12N2760/16122 , C12N2760/16134
摘要： A modified peptide derived from matrix protein 2 (hereinafter also referred to as “M2”), one of surface layer proteins of influenza virus, and a method for utilization of the modified peptide are provided. A peptide (hereinafter also referred to as “M2eC peptide”) that is made up by inserting cysteine residue(s) into a peptide (hereinafter also referred to as “M2e”) consisting of 23 amino acid residues of from positions No. 2 to No. 24 of M2 in influenza virus type A, a fusion protein consisting of said modified peptide and a polypeptide, an influenza vaccine comprising said modified peptide or said fusion protein as an active ingredient, a device which can be delivered into the body comprising said influenza vaccine, a nucleic acid fragment consisting of a nucleotide sequence encoding the amino acid sequence of said modified peptide or said fusion protein, an expression vector in which said nucleic acid fragment is incorporated, a host in which said expression vector is introduced, and an antibody that has a protective effect against influenza virus.
摘要翻译： 提供了衍生自基质蛋白2的修饰肽（以下也称为“M2”），流感病毒的表层蛋白之一和使用修饰肽的方法。 通过将半胱氨酸残基插入由位置2〜23的23个氨基酸残基组成的肽（以下也称为“M2e”）而构成的肽（以下也称为“M2eC肽” 流感病毒A型M2的第24号，由所述修饰肽和多肽组成的融合蛋白，包含所述修饰肽或所述融合蛋白作为活性成分的流感疫苗，可以递送到身体的装置，包括所述 流感疫苗，由编码所述修饰肽或所述融合蛋白质的氨基酸序列的核苷酸序列组成的核酸片段，其中加入所述核酸片段的表达载体，导入所述表达载体的宿主和 对流感病毒具有保护作用的抗体。
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5.发明授权Method for using inactivated Japanese encephalitis virus particles as adjuvant 有权使用灭活的日本脑炎病毒颗粒作为佐剂的方法公开(公告)号：US09114098B2
公开(公告)日：2015-08-25
申请号：US12996236
申请日：2009-05-27
CPC分类号： A61K39/00 , A61K2039/5252 , A61K2039/55588 , Y02A50/388 , Y02A50/39 , Y02A50/464 , Y02A50/466 , Y02A50/472 , Y02A50/484
摘要： A method for using inactivated Japanese encephalitis virus particles as an adjuvant of a vaccine is provided. A method for using inactivated Japanese encephalitis virus (JEV) particles as an adjuvant of various vaccines or a mixed vaccine, said JEV particles being obtained by inoculating JEV Beijing-1 strain to Vero cells, culturing said JEV-infected cells to give cultured cells or culture supernatant, purifying JEV particles from said cultured cells or culture supernatant and inactivating said JEV particles with formalin, a method for preparing a (mixed) vaccine which comprises a step of letting inactivated Japanese encephalitis virus be contained, and a mixed vaccine prepared by said method.
摘要翻译： 提供了使用灭活的日本脑炎病毒颗粒作为疫苗佐剂的方法。 使用灭活的日本脑炎病毒（JEV）颗粒作为各种疫苗或混合疫苗的佐剂的方法，所述JEV颗粒通过将JEV Beijing-1菌株接种到Vero细胞获得，培养所述JEV感染的细胞以产生培养的细胞或 培养上清液，从所述培养细胞或培养上清液中纯化JEV颗粒，并用福尔马林灭活所述JEV颗粒，制备包含使灭活的日本脑炎病毒的步骤的（混合）疫苗的方法，以及由所述 方法。
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公开(公告)号：US08106015B2
公开(公告)日：2012-01-31
申请号：US12596741
申请日：2008-04-18
IPC分类号： A61K38/17 , A61K39/00 , A61P25/00 , A61P37/04 , C07K14/435
CPC分类号： A61K39/0007 , A61K31/711 , C07K14/4711
摘要： An object of the present invention is to provide a safe and effective method for enhancing an immune response and a medicament for preventing or treating Alzheimer disease comprising amyloid β peptide that induces an enhanced immune response. An amyloid β peptide or a portion thereof with addition or insertion of cysteine and a method for enhancing an immune response using the peptide or a method for enhancing an immune response using the peptide together with an adjuvant. A medicament for preventing or treating Alzheimer disease comprising an amyloid β peptide or a portion thereof that induces an enhanced immune response. A DNA vaccine, that may have the same effect, comprising the gene encoding an amyloid β peptide or a portion thereof that induces an enhanced immune response with addition or insertion of cysteine.
摘要翻译： 本发明的目的是提供一种用于增强免疫应答的安全有效的方法和用于预防或治疗阿尔茨海默氏病的药物，其包括淀粉样蛋白 诱导增强的免疫应答的肽。 淀粉样蛋白 肽或其部分，其中加入或插入半胱氨酸，以及使用肽增强免疫应答的方法或使用肽与佐剂一起增强免疫应答的方法。 一种用于预防或治疗阿尔茨海默病的药物，其包含淀粉样蛋白 肽或其部分诱导增强的免疫应答。 可能具有相同作用的DNA疫苗，其包含编码淀粉样蛋白的基因; 肽或其部分，其通过加入或插入半胱氨酸诱导增强的免疫应答。
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公开(公告)号：US09381242B2
公开(公告)日：2016-07-05
申请号：US14004308
申请日：2012-03-09
IPC分类号： A61K45/00 , A61K39/145 , A61K39/39 , A61K39/12 , A61K39/00
CPC分类号： A61K39/39 , A61K39/0007 , A61K39/12 , A61K39/145 , A61K2039/55511 , A61K2039/55516 , A61K2039/575 , C12N2760/16134 , C12N2760/16171
摘要： A novel adjuvant composition is provided that is excellent in safety and convenience as compared to the conventional adjuvant such as Alum. An adjuvant composition comprising citrullines, which are water soluble substance present in the living body, and/or a salt thereof; a vaccine composition comprising said adjuvant composition and an antigen; a process for preparing said adjuvant composition and said vaccine composition; and a method for administering said adjuvant composition and said vaccine composition are provided.
摘要翻译： 提供与常规佐剂如Alum相比，安全性和便利性优异的新型佐剂组合物。 包含作为存在于生物体中的水溶性物质的瓜氨酸的佐剂组合物和/或其盐; 包含所述佐剂组合物和抗原的疫苗组合物; 一种制备所述佐剂组合物和所述疫苗组合物的方法; 并提供了用于施用所述佐剂组合物和所述疫苗组合物的方法。
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公开(公告)号：US20120107334A1
公开(公告)日：2012-05-03
申请号：US13220452
申请日：2011-08-29
IPC分类号： A61K39/00 , A61P25/28 , A61P37/04 , C07K14/435
CPC分类号： A61K39/0007 , A61K31/711 , C07K14/4711
摘要： An object of the present invention is to provide a safe and effective method for enhancing an immune response and a medicament for preventing or treating Alzheimer disease comprising amyloid β peptide that induces an enhanced immune response. An amyloid β peptide or a portion thereof with addition or insertion of cysteine and a method for enhancing an immune response using the peptide or a method for enhancing an immune response using the peptide together with an adjuvant. A medicament for preventing or treating Alzheimer disease comprising an amyloid β peptide or a portion thereof that induces an enhanced immune response. A DNA vaccine, that may have the same effect, comprising the gene encoding an amyloid peptide or a portion thereof that induces an enhanced immune response with addition or insertion of cysteine.
摘要翻译： 本发明的目的是提供一种用于增强免疫应答的安全有效的方法和用于预防或治疗阿尔茨海默氏病的药物，其包括淀粉样蛋白 诱导增强的免疫应答的肽。 淀粉样蛋白 肽或其部分，其中加入或插入半胱氨酸，以及使用肽增强免疫应答的方法或使用肽与佐剂一起增强免疫应答的方法。 一种用于预防或治疗阿尔茨海默病的药物，其包含淀粉样蛋白 肽或其部分诱导增强的免疫应答。 可以具有相同效果的DNA疫苗，其包含编码淀粉样肽或其部分的基因，其通过加入或插入半胱氨酸诱导增强的免疫应答。
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公开(公告)号：US20110268756A1
公开(公告)日：2011-11-03
申请号：US13124260
申请日：2009-10-16
CPC分类号： C07K14/4711 , A61K39/0007 , A61K2039/53
摘要： An object of the invention is to provide a peptide based on a sequence of an amyloid β peptide that may allow for induction of enhanced immune response and is safe and efficacious for prophylaxis and treatment of Alzheimer disease. An amyloid β peptide or a portion thereof with addition or insertion of cysteine or a cysteine analogue, and a method for enhancing immune response to amyloid β using said peptide, a medicament for prophylaxis and treatment of Alzheimer disease using said amyloid β peptide that induces an enhanced immune response, and a DNA vaccine comprising a gene coding for an amyloid β peptide or a sequence derived from an amyloid β peptide with addition or insertion of cysteine or a cysteine analogue, as expected to be similarly efficacious.
摘要翻译： 本发明的目的是提供一种基于淀粉样蛋白和bgr的序列的肽; 肽，其可以诱导增强的免疫应答，并且对阿尔茨海默病的预防和治疗是安全有效的。 淀粉样蛋白 肽或其部分加入或插入半胱氨酸或半胱氨酸类似物，以及增强对淀粉样蛋白的免疫应答的方法; 使用所述肽，使用所述淀粉样蛋白来预防和治疗阿尔茨海默病的药物; 诱导增强的免疫应答的肽，以及包含编码淀粉样蛋白的基因的DNA疫苗; 肽或衍生自淀粉样蛋白的序列; 具有加入或插入半胱氨酸或半胱氨酸类似物的肽，如预期类似地有效。
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公开(公告)号：US20100291122A1
公开(公告)日：2010-11-18
申请号：US12596741
申请日：2008-04-18
IPC分类号： A61K39/00 , C07K14/435 , A61K38/17 , A61P25/28 , A61P37/04
CPC分类号： A61K39/0007 , A61K31/711 , C07K14/4711
摘要： An object of the present invention is to provide a safe and effective method for enhancing an immune response and a medicament for preventing or treating Alzheimer disease comprising amyloid β peptide that induces an enhanced immune response. An amyloid β peptide or a portion thereof with addition or insertion of cysteine and a method for enhancing an immune response using the peptide or a method for enhancing an immune response using the peptide together with an adjuvant. A medicament for preventing or treating Alzheimer disease comprising an amyloid β peptide or a portion thereof that induces an enhanced immune response. A DNA vaccine, that may have the same effect, comprising the gene encoding an amyloid β peptide or a portion thereof that induces an enhanced immune response with addition or insertion of cysteine.
摘要翻译： 本发明的目的是提供一种用于增强免疫应答的安全有效的方法和用于预防或治疗阿尔茨海默氏病的药物，其包括淀粉样蛋白 诱导增强的免疫应答的肽。 淀粉样蛋白 肽或其部分，其中加入或插入半胱氨酸，以及使用肽增强免疫应答的方法或使用肽与佐剂一起增强免疫应答的方法。 一种用于预防或治疗阿尔茨海默病的药物，其包含淀粉样蛋白 肽或其部分诱导增强的免疫应答。 可能具有相同作用的DNA疫苗，其包含编码淀粉样蛋白的基因; 肽或其部分，其通过加入或插入半胱氨酸诱导增强的免疫应答。
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