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    System and method of rapid, comfortable parameter switching in spinal cord stimulation
    21.
    发明授权
    System and method of rapid, comfortable parameter switching in spinal cord stimulation 有权
    快速，舒适的脊髓刺激参数切换的系统和方法

    公开(公告)号：US07571001B2

    公开(公告)日：2009-08-04

    申请号：US11829742

    申请日：2007-07-27

    申请人： James R. Thacker ,  John D.H. King ,  Kerry Bradley

    发明人： James R. Thacker ,  John D.H. King ,  Kerry Bradley

    IPC分类号： A61N1/18

    CPC分类号： A61N1/36071 ,  A61N1/0551

    摘要： A system and method for rapidly switching stimulation parameters of a Spinal Cord Stimulation (SCS) system increases the number of stimulation parameter sets that may be tested during a fitting procedure, or alternatively, reduces the time required for the fitting procedure. The switching method comprises selecting a new stimulation parameter set, and setting the initial stimulation levels to levels at or just below an estimated perception threshold of the patient. The estimated perception level is based on previous stimulation results. The stimulation level is then increased to determine a minimum stimulation level for effective stimulation, and/or an optimal stimulation level, and/or a maximum stimulation level, based on patient perception.

    摘要翻译： 用于快速切换脊髓刺激（SCS）系统的刺激参数的系统和方法增加了在拟合过程期间可以测试的刺激参数集的数量，或者替代地减少了拟合过程所需的时间。 切换方法包括选择新的刺激参数集合，以及将初始刺激水平设置为等于或低于估计的患者感知阈值的水平。 估计的感知水平是基于以前的刺激结果。 然后根据患者的感知，增加刺激水平以确定有效刺激的最小刺激水平和/或最佳刺激水平和/或最大刺激水平。

    Neural stimulation system providing auto adjustment of stimulus output as a function of sensed impedance
    23.
    发明授权
    Neural stimulation system providing auto adjustment of stimulus output as a function of sensed impedance 有权
    神经刺激系统提供作为感测阻抗的函数的刺激输出的自动调整

    公开(公告)号：US08626312B2

    公开(公告)日：2014-01-07

    申请号：US13069143

    申请日：2011-03-22

    申请人： John D. H. King ,  James R. Thacker

    发明人： John D. H. King ,  James R. Thacker

    IPC分类号： A61N1/37

    CPC分类号： A61N1/36139 ,  A61N1/08 ,  A61N1/36071 ,  A61N1/3615

    摘要： A neural stimulation system automatically corrects or adjusts the stimulus magnitude (stimulation energy) in order to maintain a comfortable and effective stimulation therapy. Because the changes in impedance associated with the electrode-tissue interface can indicate obstruction of current flow and positional lead displacement, lead impedance can indicate the quantity of electrical stimulation energy that should be delivered to the target neural tissue to provide corrective adjustment. Hence, a change in impedance or morphology of an impedance curve may be used in a feedback loop to indicate that the stimulation energy needs to be adjusted and the system can effectively auto correct the magnitude of stimulation energy to maintain a desired therapeutic effect.

    摘要翻译： 神经刺激系统自动校正或调整刺激量值（刺激能量），以保持舒适有效的刺激治疗。 由于与电极 - 组织界面相关的阻抗变化可以指示电流和位置引线位移的阻塞，所以引线阻抗可以指示应该传送到目标神经组织的电刺激能量的量以提供校正调整。 因此，可以在反馈回路中使用阻抗曲线的阻抗或形态的变化，以指示需要调整刺激能量，并且系统能够有效地自动校正刺激能量的大小以维持所需的治疗效果。

    Neural stimulation lead fixation
    24.
    发明授权
    Neural stimulation lead fixation 失效
    神经刺激铅固定

    公开(公告)号：US08554342B2

    公开(公告)日：2013-10-08

    申请号：US13620138

    申请日：2012-09-14

    申请人： James R. Thacker ,  Michael S. Colvin ,  David K. L. Peterson ,  James P. McGivern

    发明人： James R. Thacker ,  Michael S. Colvin ,  David K. L. Peterson ,  James P. McGivern

    IPC分类号： A61N1/05

    CPC分类号： A61N1/0558 ,  A61M25/1002 ,  A61M25/1011

    摘要： An implantable lead having at least one electrode contact at or near its distal end prevents undesirable movement of the electrode contact from its initial implant location. One embodiment relates to a spinal cord stimulation (SCS) lead. A first injectable material is injected into the dura space to mechanically position the electrode array with respect to the spinal cord. Conjunctively for use with adhesives, or alternatively for use instead of the adhesives, a balloon may be positioned on the electrode lead array. The balloon is filled with air, liquid or a compliant material. When inflated, the balloon stabilizes the lead with respect to the spinal cord and holds the lead in place. An elastic aspect of the balloon serves as an internal contained relief valve to limit the pressure the balloon may place on the surrounding tissues when the epidural space is constrained.

    摘要翻译： 具有在其远端处或其远端处具有至少一个电极接触的可植入引线防止电极接触件从其初始植入位置的不期望的移动。 一个实施方案涉及脊髓刺激（SCS）引线。 将第一可注射材料注入硬脑膜空间以相对于脊髓机械地定位电极阵列。 结合使用粘合剂，或代替粘合剂代替使用，球囊可以位于电极引线阵列上。 气球充满空气，液体或柔顺材料。 当膨胀时，气囊相对于脊髓稳定铅，并将铅保持在适当位置。 气囊的弹性方面用作内部包含的安全阀，以限制当硬膜外腔被约束时球囊可能在周围组织上的压力。

    Sequenced and simultaneous stimulation for treating congestive heart failure
    27.
    发明授权
    Sequenced and simultaneous stimulation for treating congestive heart failure 有权
    有序和同时刺激治疗充血性心力衰竭

    公开(公告)号：US08301248B1

    公开(公告)日：2012-10-30

    申请号：US12163803

    申请日：2008-06-27

    申请人： James R. Thacker ,  Kelly H. McClure ,  Todd K. Whitehurst

    发明人： James R. Thacker ,  Kelly H. McClure ,  Todd K. Whitehurst

    IPC分类号： A61N1/36

    CPC分类号： A61N1/3627 ,  A61N1/3684

    摘要： A patient's ejection fraction is maximized through simultaneous sensing and stimulating across multiple electrodes. In one exemplary embodiment, a catheter or lead having multiple electrodes connected to a pulse generator is used. The pulse generator provides individual current control of the stimulus applied to each electrode, and further includes the ability to sense intrinsic and evoked depolarization through multiple electrodes. In another exemplary embodiment, a multiplicity of individual implantable microstimulators, each having its own current source and/or sensor and electrodes, cooperate in concert to provide multi-site stimulation and sensing.

    摘要翻译： 患者的射血分数通过同时感测和刺激跨多个电极而最大化。 在一个示例性实施例中，使用具有连接到脉冲发生器的多个电极的导管或引线。 脉冲发生器提供对施加到每个电极的刺激的单独电流控制，并且还包括通过多个电极感测固有和诱发去极化的能力。 在另一个示例性实施例中，多个单独的可植入微型激励器（各自具有其自身的电流源和/或传感器和电极）协同协作以提供多位点刺激和感测。