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公开(公告)号：US08554342B2
公开(公告)日：2013-10-08
申请号：US13620138
申请日：2012-09-14
IPC分类号： A61N1/05
CPC分类号： A61N1/0558 , A61M25/1002 , A61M25/1011
摘要： An implantable lead having at least one electrode contact at or near its distal end prevents undesirable movement of the electrode contact from its initial implant location. One embodiment relates to a spinal cord stimulation (SCS) lead. A first injectable material is injected into the dura space to mechanically position the electrode array with respect to the spinal cord. Conjunctively for use with adhesives, or alternatively for use instead of the adhesives, a balloon may be positioned on the electrode lead array. The balloon is filled with air, liquid or a compliant material. When inflated, the balloon stabilizes the lead with respect to the spinal cord and holds the lead in place. An elastic aspect of the balloon serves as an internal contained relief valve to limit the pressure the balloon may place on the surrounding tissues when the epidural space is constrained.
摘要翻译： 具有在其远端处或其远端处具有至少一个电极接触的可植入引线防止电极接触件从其初始植入位置的不期望的移动。 一个实施方案涉及脊髓刺激（SCS）引线。 将第一可注射材料注入硬脑膜空间以相对于脊髓机械地定位电极阵列。 结合使用粘合剂，或代替粘合剂代替使用，球囊可以位于电极引线阵列上。 气球充满空气，液体或柔顺材料。 当膨胀时，气囊相对于脊髓稳定铅，并将铅保持在适当位置。 气囊的弹性方面用作内部包含的安全阀，以限制当硬膜外腔被约束时球囊可能在周围组织上的压力。
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公开(公告)号：US07099718B1
公开(公告)日：2006-08-29
申请号：US10155146
申请日：2002-05-24
IPC分类号： A61N1/05
CPC分类号： A61N1/0558 , A61M25/10
摘要： An implantable lead having at least one electrode contact at or near its distal end prevents undesirable movement of the electrode contact from its initial implant location. One embodiment relates to a spinal cord stimulation (SCS) lead. A balloon may be positioned on the electrode lead array. The balloon is filled with air, liquid or a compliant material. When inflated, the balloon stabilizes the lead with respect to the spinal cord and holds the lead in place. The pressure of the balloon is monitored or otherwise controlled during the filling process in order to determine at what point the filling process should be discontinued. An elastic aspect of the balloon serves as a contained relief valve to limit the pressure the balloon may place on the surrounding tissues when the epidural space is constrained.
摘要翻译： 具有在其远端处或其远端处具有至少一个电极接触的可植入引线防止电极接触件从其初始植入位置的不期望的移动。 一个实施方案涉及脊髓刺激（SCS）引线。 气球可以位于电极引线阵列上。 气球充满空气，液体或柔顺材料。 当膨胀时，气囊相对于脊髓稳定铅，并将铅保持在适当位置。 在填充过程中监测或以其他方式控制气囊的压力，以便确定在何时应该停止填充过程。 气囊的弹性方面用作包含的安全阀，以限制当硬膜外腔被约束时球囊可能在周围组织上的压力。
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公开(公告)号：US08295945B1
公开(公告)日：2012-10-23
申请号：US11464109
申请日：2006-08-11
IPC分类号： A61N1/05
CPC分类号： A61N1/0558 , A61M25/1002 , A61M25/1011
摘要： An implantable lead having at least one electrode contact at or near its distal end prevents undesirable movement of the electrode contact from its initial implant location. One embodiment relates to a spinal cord stimulation (SCS) lead. A first injectable material is injected into the dura space to mechanically position the electrode array with respect to the spinal cord. Conjunctively for use with adhesives, or alternatively for use instead of the adhesives, a balloon may be positioned on the electrode lead array. The balloon is filled with air, liquid or a compliant material. When inflated, the balloon stabilizes the lead with respect to the spinal cord and holds the lead in place. An elastic aspect of the balloon serves as an internal contained relief valve to limit the pressure the balloon may place on the surrounding tissues when the epidural space is constrained.
摘要翻译： 具有在其远端处或其远端处具有至少一个电极接触的可植入引线防止电极接触件从其初始植入位置的不期望的移动。 一个实施方案涉及脊髓刺激（SCS）引线。 将第一可注射材料注入硬脑膜空间以相对于脊髓机械地定位电极阵列。 结合使用粘合剂，或代替粘合剂代替使用，球囊可以位于电极引线阵列上。 气球充满空气，液体或柔顺材料。 当膨胀时，气囊相对于脊髓稳定铅，并将铅保持在适当位置。 气囊的弹性方面用作内部包含的安全阀，以限制当硬膜外腔被约束时球囊可能在周围组织上的压力。
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公开(公告)号：US07983766B1
公开(公告)日：2011-07-19
申请号：US11464128
申请日：2006-08-11
IPC分类号： A61N1/00
CPC分类号： A61N1/0558 , A61M25/10
摘要： An implantable lead having at least one electrode contact at or near its distal end prevents undesirable movement of the electrode contact from its initial implant location. One embodiment relates to a spinal cord stimulation (SCS) lead. A first injectable material is injected into the dura space to mechanically position the electrode array with respect to the spinal cord. Conjunctively for use with adhesives, or alternatively for use instead of the adhesives, a balloon may be positioned on the electrode lead array. The balloon is filled with air, liquid or a compliant material. When inflated, the balloon stabilizes the lead with respect to the spinal cord and holds the lead in place. An elastic aspect of the balloon serves as an internal contained relief valve to limit the pressure the balloon may place on the surrounding tissues when the epidural space is constrained.
摘要翻译： 具有在其远端处或其远端处具有至少一个电极接触的可植入引线防止电极接触件从其初始植入位置的不期望的移动。 一个实施方案涉及脊髓刺激（SCS）引线。 将第一可注射材料注入硬脑膜空间以相对于脊髓机械地定位电极阵列。 结合使用粘合剂，或代替粘合剂代替使用，球囊可以位于电极引线阵列上。 气球充满空气，液体或柔顺材料。 当膨胀时，气囊相对于脊髓稳定铅，并将铅保持在适当位置。 气囊的弹性方面用作内部包含的安全阀，以限制当硬膜外腔被约束时球囊可能在周围组织上的压力。
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公开(公告)号：US07856277B1
公开(公告)日：2010-12-21
申请号：US11464137
申请日：2006-08-11
IPC分类号： A61N1/372
CPC分类号： A61N1/0558 , A61M25/10
摘要： An implantable lead having at least one electrode contact at or near its distal end prevents undesirable movement of the electrode contact from its initial implant location. One embodiment relates to a spinal cord stimulation (SCS) lead. A first injectable material is injected into the dura space to mechanically position the electrode array with respect to the spinal cord. Conjunctively for use with adhesives, or alternatively for use instead of the adhesives, a balloon may be positioned on the electrode lead array. The balloon is filled with air, liquid or a compliant material. When inflated, the balloon stabilizes the lead with respect to the spinal cord and holds the lead in place. An elastic aspect of the balloon serves as a contained relief valve to limit the pressure the balloon may place on the surrounding tissues when the epidural space is constrained.
摘要翻译： 具有在其远端处或其远端处具有至少一个电极接触的可植入引线防止电极接触件从其初始植入位置的不期望的移动。 一个实施方案涉及脊髓刺激（SCS）引线。 将第一可注射材料注入硬脑膜空间以相对于脊髓机械地定位电极阵列。 结合使用粘合剂，或代替粘合剂代替使用，球囊可以位于电极引线阵列上。 气球充满空气，液体或柔顺材料。 当膨胀时，气囊相对于脊髓稳定铅，并将铅保持在适当位置。 气囊的弹性方面用作包含的安全阀，以限制当硬膜外腔被约束时球囊可能在周围组织上的压力。
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公开(公告)号：US20130013044A1
公开(公告)日：2013-01-10
申请号：US13620138
申请日：2012-09-14
IPC分类号： A61N1/05
CPC分类号： A61N1/0558 , A61M25/1002 , A61M25/1011
摘要： An implantable lead having at least one electrode contact at or near its distal end prevents undesirable movement of the electrode contact from its initial implant location. One embodiment relates to a spinal cord stimulation (SCS) lead. A first injectable material is injected into the dura space to mechanically position the electrode array with respect to the spinal cord. Conjunctively for use with adhesives, or alternatively for use instead of the adhesives, a balloon may be positioned on the electrode lead array. The balloon is filled with air, liquid or a compliant material. When inflated, the balloon stabilizes the lead with respect to the spinal cord and holds the lead in place. An elastic aspect of the balloon serves as an internal contained relief valve to limit the pressure the balloon may place on the surrounding tissues when the epidural space is constrained.
摘要翻译： 具有在其远端处或其远端处具有至少一个电极接触的可植入引线防止电极接触件从其初始植入位置的不期望的移动。 一个实施方案涉及脊髓刺激（SCS）引线。 将第一可注射材料注入硬脑膜空间以相对于脊髓机械地定位电极阵列。 结合使用粘合剂，或代替粘合剂代替使用，球囊可以位于电极引线阵列上。 气球充满空气，液体或柔顺材料。 当膨胀时，气囊相对于脊髓稳定铅，并将铅保持在适当位置。 气囊的弹性方面用作内部包含的安全阀，以限制当硬膜外腔被约束时球囊可能在周围组织上的压力。
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公开(公告)号：US08934968B2
公开(公告)日：2015-01-13
申请号：US11779769
申请日：2007-07-18
CPC分类号： A61N1/36114 , A61M5/14276 , A61M2205/054 , A61M2205/3523 , A61M2205/8206 , A61M2230/06
摘要： A method for treating a patient may include treating coronary artery disease in combination with angina pectoris and/or the control of angina pain by delivering chemical and/or electrical stimulation pulses to the cardiac and/or nervous tissue of the patient in a coordinated manner. A system for treating a patient suffering from coronary artery disease and angina may include a stimulator that generates at least one pulse in accordance with prescribed parameters, a catheter, a lead, and/or a sensor.
摘要翻译： 用于治疗患者的方法可以包括通过以协调的方式将化学和/或电刺激脉冲递送到患者的心脏和/或神经组织来治疗与心绞痛联合的冠状动脉疾病和/或控制心绞痛。 用于治疗患有冠状动脉疾病和心绞痛的患者的系统可以包括根据规定参数产生至少一个脉冲的刺激器，导管，引线和/或传感器。
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公开(公告)号：US06970741B1
公开(公告)日：2005-11-29
申请号：US10246554
申请日：2002-09-17
申请人： Todd K. Whitehurst , James P. McGivern , Kelly H. McClure , Goran N. Marnfeldt , James R. Thacker
发明人： Todd K. Whitehurst , James P. McGivern , Kelly H. McClure , Goran N. Marnfeldt , James R. Thacker
CPC分类号： A61B5/413 , A61B5/053 , A61B5/0538 , A61B5/41 , A61B5/415 , A61B5/416 , A61B5/418 , A61B5/4244 , A61B2560/0219 , A61M5/14276 , A61M5/1723 , A61N1/30 , A61N1/32
摘要： An implantable system control unit (SCU) includes means for measuring tissue impedance or other condition to determine allograft health, in order to predict or detect allograft rejection. The SCU also includes at least two electrodes coupled to means for delivering electrical stimulation to a patient within whom the device is implanted, and may also include a reservoir for holding one or more drugs and a driver means for delivering the drug(s) to the patient. In certain embodiments, the system is capable of open- and closed-loop operation. In closed-loop operation, at least one SCU includes a sensor, and the sensed condition is used to adjust stimulation parameters. Alternatively, this sensory “SCU” sounds an alarm, communicates an alarm to an external device, and/or is responsive to queries regarding sensed information, such as tissue impedance.
摘要翻译： 可植入系统控制单元（SCU）包括用于测量组织阻抗或其他条件以确定同种异体移植物健康的装置，以便预测或检测同种异体移植排斥。 SCU还包括至少两个电极，其耦合到用于将电刺激递送到其中植入该装置的患者的装置，并且还可以包括用于容纳一种或多种药物的储存器和用于将药物递送至 患者。 在某些实施例中，系统能够进行开环和闭环操作。 在闭环操作中，至少一个SCU包括传感器，并且使用感测到的条件来调整刺激参数。 或者，该感官“SCU”发出警报，向外部设备通报警报，和/或响应关于感测信息（例如组织阻抗）的查询。
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9.发明授权Cavernous nerve stimulation via unidirectional propagation of action potentials 有权通过动作电位的单向传播进行海绵体神经刺激公开(公告)号：US08712547B2
公开(公告)日：2014-04-29
申请号：US13036278
申请日：2011-02-28
申请人： Todd K. Whitehurst , James P. McGivern , Rafael Carbunaru , Matthew I. Haller , Tom Xiaohai He , Kerry Bradley
发明人： Todd K. Whitehurst , James P. McGivern , Rafael Carbunaru , Matthew I. Haller , Tom Xiaohai He , Kerry Bradley
CPC分类号： A61N1/0556 , A61N1/0551 , A61N1/36071 , A61N1/37205
摘要： An implantable stimulation device includes a device body; at least one set of partitioned electrodes disposed on a portion of the device body and configured and arranged for application of electrical stimulation to adjacent tissue; and insulating material separating the partitioned electrodes from each other. Each set of partitioned electrodes includes a plurality of partitioned electrodes disposed around a circumference of the device body. The implantable stimulation device can be configured and arranged so that each of the partitioned electrodes is independently programmable.
摘要翻译： 可植入刺激装置包括装置主体; 至少一组分隔电极，其设置在所述装置主体的一部分上，并被配置和布置成用于对相邻组织施加电刺激; 以及将分隔电极彼此分离的绝缘材料。 每组分隔电极包括围绕装置主体的圆周设置的多个分隔电极。 可植入式刺激装置可以被配置和布置成使得每个分隔电极可独立编程。
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公开(公告)号：US08364278B2
公开(公告)日：2013-01-29
申请号：US10503281
申请日：2003-01-29
IPC分类号： A61N1/05
CPC分类号： H01R43/16 , A61N1/05 , H01R13/5224 , Y10T29/49204
摘要： A lead assembly for a small implantable medical device connects a remote electrode to a microdevice and inhibits fluid ingress into the connection. Microdevices may provide either or both tissue stimulation and sensing. Known microdevices include spaced apart electrodes on the outer surface of the microdevice. The lead assembly includes an insulated lead including a proximal end and a distal end, with at least one conductor therebetween; at least one electrode at the distal end of the lead and electrically connected to the at least one conductor, and a connector attached to the proximal end of the lead and adapted to be removably connectable to the microdevice. The connector includes at least one contact to electrically connect at least one device electrode on the microdevice to the at least one conductor. The lead assembly is configured to inhibit fluid ingress into the connector.
摘要翻译： 用于小型可植入医疗装置的引导组件将远程电极连接到微型装置并且阻止流体进入连接。 微器件可以提供组织刺激和感测之一或两者。 已知的微器件在微器件的外表面上包括间隔开的电极。 引线组件包括绝缘引线，其包括近端和远端，其间具有至少一个导体; 在所述引线的远端处的至少一个电极并且电连接到所述至少一个导体，以及连接到所述引线的近端并适于可移除地连接到所述微器件的连接器。 所述连接器包括至少一个接触件，以将所述微器件上的至少一个器件电极电连接到所述至少一个导体。 引线组件被配置为抑制流体进入连接器。
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