公开(公告)号：US5866631A

公开(公告)日：1999-02-02

申请号：US894596

申请日：1997-08-22

申请人： Hiroyuki Nakagawa ,  Hideki Ohno

发明人： Hiroyuki Nakagawa ,  Hideki Ohno

IPC分类号： A61K6/00 ,  A61K6/083 ,  C08K5/55

CPC分类号： A61K6/0052 ,  A61K6/0073

摘要： There is provided a dental primer composition capable of obtaining high adhesive strength to both dentin and enamel, as a pretreatment material for a chemically polymerizable adhesive. This composition is a dental primer composition comprising a polymerizable monomer containing an acidic group, water, aryl borate and transition metal compound.

摘要翻译： PCT No.PCT / JP96 / 03739 Sec。 371日期1997年8月22日 102（e）日期1997年8月22日PCT 1996年12月20日PCT公布。 公开号WO97 / 23191 PCT 日期1997年7月3日提供了作为化学可聚合粘合剂的预处理材料能够获得牙本质和牙釉质的高粘合强度的牙科底漆组合物。 该组合物是包含含有酸性基团，水，芳基硼酸盐和过渡金属化合物的可聚合单体的牙科底漆组合物。

公开(公告)号：US08705208B2

公开(公告)日：2014-04-22

申请号：US12828073

申请日：2010-06-30

申请人： Hiroyuki Nakagawa ,  Reiko Arai ,  Ichiro Tamai ,  Kiwamu Tanahashi

发明人： Hiroyuki Nakagawa ,  Reiko Arai ,  Ichiro Tamai ,  Kiwamu Tanahashi

IPC分类号： G11B5/82

CPC分类号： G11B5/66 ,  G11B5/1278 ,  G11B5/65

摘要： According to one embodiment, a PMRM includes a substrate, a soft magnetic underlayer above the substrate, an underlayer above the soft magnetic underlayer, an oxide-containing magnetic layer above the underlayer, and a ferromagnetic layer above the magnetic layer having no oxides. The underlayer controls orientation and segregation of the magnetic layer. The oxide-containing magnetic layer comprises at least two or more magnetic layers, a Cr concentration of the magnetic layer adjacent to the ferromagnetic metal layer is between about 23 at. % and about 32 at. %, and a difference between the Cr concentration of the magnetic layer adjacent to the ferromagnetic metal layer and a magnetic layer having a lowest Cr concentration among the at least three magnetic layers is less than about 25 at. %, the magnetic layer with a lowest Cr concentration has a granular structure, and a nucleation field is greater than about 159.2 kA/m.

摘要翻译： 根据一个实施例，PMRM包括衬底，衬底上方的软磁性底层，软磁性底层上方的底层，底层上方的含氧化物的磁性层以及不含氧化物的磁性层上方的铁磁性层。 底层控制磁性层的取向和偏析。 含氧化物的磁性层包括至少两个或更多个磁性层，与强磁性金属层相邻的磁性层的Cr浓度在约23at。 ％和约32英寸。 ％，并且与所述强磁性金属层相邻的磁性层的Cr浓度与所述至少三个磁性层中具有最低Cr浓度的磁性层之间的差异小于约25at。 ％，具有最低Cr浓度的磁性层具有粒状结构，并且成核场大于约159.2kA / m。

公开(公告)号：US20130280732A1

公开(公告)日：2013-10-24

申请号：US13997854

申请日：2011-12-28

申请人： Masakazu Hashimoto ,  Hiroyuki Nakagawa ,  Mikio Aoki ,  Lars O. Tjernberg ,  Bengt Winblad

发明人： Masakazu Hashimoto ,  Hiroyuki Nakagawa ,  Mikio Aoki ,  Lars O. Tjernberg ,  Bengt Winblad

IPC分类号： G01N33/68

CPC分类号： G01N33/6896 ,  C07K16/18 ,  G01N2800/2821

摘要： The present invention provides an agent for determining Alzheimer's disease, comprising an anti-S38AA antibody, a method of determining Alzheimer's disease in a test animal, comprising detecting an S38AA fragment in a sample collected from said animal, and a method of screening for a substance that treats or prevents Alzheimer's disease, comprising contacting a test substance with a cell permitting measurement of production of a S38AA fragment, measuring the production amount of the S38AA fragment in the cell, and comparing the production amount with that of the S38AA fragment in a control cell free of contact with the test substance, and selecting a test substance that down-regulates the production amount of the S38AA fragment as a substance capable of treating or preventing Alzheimer's disease, based on the comparison results.

摘要翻译： 本发明提供了一种用于测定阿尔茨海默病的药剂，其包含抗S38AA抗体，测试动物中测定阿尔茨海默病的方法，包括检测从所述动物收集的样品中的S38AA片段，以及筛选物质的方法 治疗或预防阿尔茨海默病，包括使测试物质与允许测量S38AA片段生产的细胞接触，测量细胞中S38AA片段的产生量，并将生产量与对照组中的S38AA片段的产量进行比较 基于比较结果，选择与测试物质接触的细胞，并且根据比较结果选择下调S38AA片段的产生量的测试物质作为能够治疗或预防阿尔茨海默氏病的物质。

公开(公告)号：US20100093771A1

公开(公告)日：2010-04-15

申请号：US12311335

申请日：2007-09-28

申请人： Keiji Nakamura ,  Hiroyuki Nakagawa ,  Yoko Kan

发明人： Keiji Nakamura ,  Hiroyuki Nakagawa ,  Yoko Kan

IPC分类号： A61K31/519 ,  C07D471/04

CPC分类号： C07D471/04

摘要： The present invention relates to a bicyclic pyrimidine compound of the following formula (I) or a salt thereof. wherein R1 is lower alkyl, cyclic lower alkyl. etc.; R2 is H, lower alkyl, lower alkenyl, etc.; R3 is H, lower alkyl, lower alkenyl, etc.; X is O, S or —N(R4)—; R4 is H or lower, alkyl; or R2 and R4 may combine each other to form cyclic amino; Y is amido, keto, sulfonyl, etc.; R5 is H or lower alkyl; Z is O or S; m and n are 1 or 2. Said compound (I) or a salt thereof have MGAT inhibitory activity, and are useful as an agent for treatment or prophylaxis of adiposity, metabolic syndromes, hyperlipidemia, hyper neutral lipemia, hyper VLDL-mia, hyper fatty acidemia, diabetes mellitus, arteriosclerosis.

摘要翻译： 本发明涉及下式（I）的双环嘧啶化合物或其盐。 其中R1是低级烷基，环状低级烷基。 等等。; R2是H，低级烷基，低级烯基等; R3是H，低级烷基，低级烯基等; X是O，S或-N（R 4） - ; R4为H或更低，烷基; 或者R 2和R 4可以相互结合形成环状氨基; Y是酰胺基，酮基，磺酰基等; R5是H或低级烷基; Z是O或S; m和n为1或2.所述化合物（I）或其盐具有MGAT抑制活性，可用作治疗或预防肥胖，代谢综合征，高脂血症，高中性脂肪血症，超VLDL-mia，hyper 脂肪酸血症，糖尿病，动脉硬化。

公开(公告)号：US07625646B2

公开(公告)日：2009-12-01

申请号：US11354085

申请日：2006-02-15

申请人： Yoshiyuki Hirayama ,  Ichiro Tamai ,  Takayuki Ichihara ,  Hiroyuki Nakagawa ,  Hiroaki Nemoto ,  Mineaki Kodama ,  Ikuko Takekuma

发明人： Yoshiyuki Hirayama ,  Ichiro Tamai ,  Takayuki Ichihara ,  Hiroyuki Nakagawa ,  Hiroaki Nemoto ,  Mineaki Kodama ,  Ikuko Takekuma

IPC分类号： G11B5/66

CPC分类号： G11B5/65 ,  G11B5/656 ,  G11B5/66 ,  G11B5/667 ,  G11B5/732 ,  G11B5/7325 ,  G11B5/84

摘要： Disclosed are a perpendicular magnetic recording medium with lower medium noise, insusceptible to thermal fluctuation and high recording resolution and a method of manufacturing it. As the step of forming a metal layer at the time of forming a recording layer on a non-magnetic substrate via a plurality of underlayers and the step of forming an oxide layer with an average thickness of 0.2 nm or less are repeated, the crystal grains are magnetically isolated without disturbing the orientation of the crystal grain of the recording layer of the perpendicular magnetic recording medium or without degrading the magnetic characteristic of the crystal grain of the recording layer.

摘要翻译： 公开了一种具有较低介质噪声，不易受热波动和高记录分辨率的垂直磁记录介质及其制造方法。 作为通过多个底层在非磁性基板上形成记录层时形成金属层的步骤，重复平均厚度为0.2nm以下的氧化物层的工序，晶粒 磁性隔离，而不会干扰垂直磁记录介质的记录层的晶粒的取向，或不降低记录层的晶粒的磁特性。

公开(公告)号：US07618722B2

公开(公告)日：2009-11-17

申请号：US12079701

申请日：2008-03-27

申请人： Yoshiyuki Hirayama ,  Ikuko Takekuma ,  Hiroyuki Nakagawa ,  Yuzuru Hosoe

发明人： Yoshiyuki Hirayama ,  Ikuko Takekuma ,  Hiroyuki Nakagawa ,  Yuzuru Hosoe

IPC分类号： G11B5/66

CPC分类号： G11B5/7325 ,  G11B5/65 ,  G11B5/656

摘要： Embodiments of the invention provide a perpendicular magnetic recording medium that not only attains the magnetic isolation of crystal grains in a magnetic recording layer from one another in a region of the medium in which the thickness of an intermediate layer is equal to or smaller than about 20 nm but also exhibits excellent crystallographic texture and that exhibits small medium noise, excellent thermal stability, and high write-ability. In one embodiment, a perpendicular magnetic recording medium has at least a soft-magnetic underlayer, a first intermediate layer, a second intermediate layer, a third intermediate layer, and a magnetic recording layer successively formed on a substrate. The magnetic recording layer is composed of ferromagnetic crystal grains and oxides or nitrides, the third intermediate layer is composed of Ru or an Ru alloy, the second intermediate layer is composed of a metal or an alloy having the face-centered cubic lattice structure, and the first intermediate layer is composed of a metal or an alloy having the hexagonal close-packed structure.

摘要翻译： 本发明的实施例提供了一种垂直磁记录介质，其不仅在中间层的厚度等于或小于约20的介质的区域中彼此之间实现磁记录层中的晶粒的磁隔离 nm，但也具有优异的晶体学结构，表现出中等的中等噪声，优异的热稳定性和高的写入能力。 在一个实施例中，垂直磁记录介质至少具有在基板上依次形成的软磁性底层，第一中间层，第二中间层，第三中间层和磁记录层。 磁记录层由铁磁性晶粒和氧化物或氮化物构成，第三中间层由Ru或Ru合金构成，第二中间层由具有面心立方晶格结构的金属或合金构成， 第一中间层由具有六方密堆积结构的金属或合金构成。

公开(公告)号：US20070223142A1

公开(公告)日：2007-09-27

申请号：US11726099

申请日：2007-03-20

申请人： Ikuko Takekuma ,  Hiroyuki Nakagawa ,  Hiroaki Nemoto ,  Yoshiyuki Hirayama

发明人： Ikuko Takekuma ,  Hiroyuki Nakagawa ,  Hiroaki Nemoto ,  Yoshiyuki Hirayama

IPC分类号： G11B5/74 ,  G11B5/66

CPC分类号： G11B5/66 ,  G11B5/11 ,  G11B5/1278 ,  G11B5/3116 ,  G11B5/3146 ,  G11B5/315 ,  G11B5/3967 ,  G11B5/656

摘要： According to embodiments of the present invention, a shielded pole writer and a perpendicular magnetic recording medium suitable thereto are combined to provide high medium SNR and excellent OW characteristic simultaneously. A perpendicular magnetic recording medium of a magnetic storage apparatus mounting a shielded pole writer, including a perpendicular magnetic recording medium having a recording layer of a three layered structure is used. A first recording layer has a granular structure consisting of grain boundaries containing an oxide and columnar grains comprising a CoCrPt alloy, in which a second recording layer and a third recording layer formed thereabove comprise Co as a main ingredient, contain Cr and do not contain an oxide, and the Cr concentration in the second recording layer is lower than the Cr concentration in the third recording layer.

摘要翻译： 根据本发明的实施例，组合屏蔽极写入器和适合于其的垂直磁记录介质，以同时提供高中等信噪比和优异的OW特性。 使用安装屏蔽极写入器的磁存储装置的垂直磁记录介质，其包括具有三层结构的记录层的垂直磁记录介质。 第一记录层具有由包含氧化物的晶界和包含CoCrPt合金的柱状晶粒构成的粒状结构，其中形成在其上的第二记录层和第三记录层包含Co作为主要成分，并且不含有 并且第二记录层中的Cr浓度低于第三记录层中的Cr浓度。

公开(公告)号：US07235605B2

公开(公告)日：2007-06-26

申请号：US10606864

申请日：2003-06-27

申请人： Hiroyuki Nakagawa ,  Haruyasu Mizutani

发明人： Hiroyuki Nakagawa ,  Haruyasu Mizutani

IPC分类号： C08L67/02

CPC分类号： C08L51/08 ,  C08L15/00 ,  C08L51/00 ,  C08L51/003 ,  C08L51/06 ,  C08L51/085 ,  C08L67/00 ,  C08L67/02 ,  C08L67/04 ,  C08L2666/14 ,  C08L2666/02 ,  C08L2666/24

摘要： A crystalline biodegradable resin composition obtained by annealing a composition comprising an aliphatic polyester and a modified elastomer.

摘要翻译： 通过使包含脂肪族聚酯和改性弹性体的组合物退火而得到的结晶性生物降解性树脂组合物。

公开(公告)号：US07204281B2

公开(公告)日：2007-04-17

申请号：US10183158

申请日：2002-06-28

申请人： Hiroyuki Nakagawa

发明人： Hiroyuki Nakagawa

IPC分类号： B60C11/12

CPC分类号： B60C11/0302 ,  B60C11/12 ,  B60C2011/1213 ,  Y10S152/03

摘要： A studless tire which is provided in the tread portion with one or more circumferential portions provided with V-shaped sipes, the total width of the one or more circumferential portions is in a range of from 10 to 25% of the tread width, each V-shaped sipe is composed of two parts extending from its vertex located in a central region of the circumferential portion, and the V-shaped sipes in each circumferential portion are oriented towards the same direction and arranged at intervals in the tire circumferential direction.

摘要翻译： 一种在胎面部分设置有设置有V形刀槽花纹的一个或多个圆周部分的无钉防滑轮胎，一个或多个圆周部分的总宽度在胎面宽度的10至25％的范围内，每个V 形状的刀槽花纹由从位于圆周部分的中心区域的顶点延伸的两个部分组成，并且每个圆周部分中的V形刀槽花纹朝向相同的方向定向并且在轮胎周向方向上间隔设置。

公开(公告)号：US07033686B2

公开(公告)日：2006-04-25

申请号：US10701603

申请日：2003-11-06

申请人： Yoshiyuki Hirayama ,  Ichiro Tamai ,  Takayuki Ichihara ,  Hiroyuki Nakagawa ,  Hiroaki Nemoto ,  Mineaki Kodama ,  Ikuko Takekuma

发明人： Yoshiyuki Hirayama ,  Ichiro Tamai ,  Takayuki Ichihara ,  Hiroyuki Nakagawa ,  Hiroaki Nemoto ,  Mineaki Kodama ,  Ikuko Takekuma

IPC分类号： G11B5/66 ,  G11B5/70

CPC分类号： G11B5/65 ,  G11B5/656 ,  G11B5/66 ,  G11B5/667 ,  G11B5/732 ,  G11B5/7325 ,  G11B5/84

摘要： Disclosed are a perpendicular magnetic recording medium with lower medium noise, insusceptible to thermal fluctuation and high recording resolution and a method of manufacturing it. As the step of forming a metal layer at the time of forming a recording layer on a non-magnetic substrate via a plurality of underlayers and the step of forming an oxide layer with an average thickness of 0.2 nm or less are repeated, the crystal grains are magnetically isolated without disturbing the orientation of the crystal grain of the recording layer of the perpendicular magnetic recording medium or without degrading the magnetic characteristic of the crystal grain of the recording layer.