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    DIAGNOSTIC DRUG AND DIAGNOSTIC METHOD FOR ALZHEIMER'S DISEASE
    1.
    发明申请
    DIAGNOSTIC DRUG AND DIAGNOSTIC METHOD FOR ALZHEIMER'S DISEASE 审中-公开
    诊断药物和阿尔茨海默病的诊断方法

    公开(公告)号：US20130280732A1

    公开(公告)日：2013-10-24

    申请号：US13997854

    申请日：2011-12-28

    申请人： Masakazu Hashimoto ,  Hiroyuki Nakagawa ,  Mikio Aoki ,  Lars O. Tjernberg ,  Bengt Winblad

    发明人： Masakazu Hashimoto ,  Hiroyuki Nakagawa ,  Mikio Aoki ,  Lars O. Tjernberg ,  Bengt Winblad

    IPC分类号： G01N33/68

    CPC分类号： G01N33/6896 ,  C07K16/18 ,  G01N2800/2821

    摘要： The present invention provides an agent for determining Alzheimer's disease, comprising an anti-S38AA antibody, a method of determining Alzheimer's disease in a test animal, comprising detecting an S38AA fragment in a sample collected from said animal, and a method of screening for a substance that treats or prevents Alzheimer's disease, comprising contacting a test substance with a cell permitting measurement of production of a S38AA fragment, measuring the production amount of the S38AA fragment in the cell, and comparing the production amount with that of the S38AA fragment in a control cell free of contact with the test substance, and selecting a test substance that down-regulates the production amount of the S38AA fragment as a substance capable of treating or preventing Alzheimer's disease, based on the comparison results.

    摘要翻译： 本发明提供了一种用于测定阿尔茨海默病的药剂，其包含抗S38AA抗体，测试动物中测定阿尔茨海默病的方法，包括检测从所述动物收集的样品中的S38AA片段，以及筛选物质的方法 治疗或预防阿尔茨海默病，包括使测试物质与允许测量S38AA片段生产的细胞接触，测量细胞中S38AA片段的产生量，并将生产量与对照组中的S38AA片段的产量进行比较 基于比较结果，选择与测试物质接触的细胞，并且根据比较结果选择下调S38AA片段的产生量的测试物质作为能够治疗或预防阿尔茨海默氏病的物质。

    Occupant protection device
    4.
    发明授权
    Occupant protection device 失效
    乘员保护装置

    公开(公告)号：US07207598B2

    公开(公告)日：2007-04-24

    申请号：US10874751

    申请日：2004-06-24

    申请人： Hiroyuki Tajima ,  Takahiko Sato ,  Akiyoshi Nagano ,  Masakazu Hashimoto ,  Toshikatsu Togawa ,  Osamu Fukawatase

    发明人： Hiroyuki Tajima ,  Takahiko Sato ,  Akiyoshi Nagano ,  Masakazu Hashimoto ,  Toshikatsu Togawa ,  Osamu Fukawatase

    IPC分类号： B60R21/045

    CPC分类号： B60R21/045 ,  B60R2021/0051

    摘要： In the occupant protection device according to the present invention, a restraint body joined with a driving mechanism is located near a target area of a seated occupant while being surrounded by an interior decoration member. Upon predicting a collision of the vehicle, the driving mechanism is actuated to protrude the restraint body from an opening in the interior decoration member for restraining the movement of the target area upon collision by its side facing the occupant, and when the collision is avoided, the driving mechanism returns the protruded restraint body in the opening of the interior decoration member. The restraint body is provided in the vicinity of its outer periphery with a retaining hole, a clip to be inserted in and retained by the retaining hole, and a guide surface for guiding the clip into the retaining hole for helping the restraint body to return in the opening of the interior decoration member. By this guide mechanism including the retaining hole, the clip and the guide surface, the restraint body is able to return to the opening of the interior decoration member smoothly without deteriorating the appearance.

    摘要翻译： 在根据本发明的乘员保护装置中，与驱动机构连接的约束体位于乘坐人员的目标区域附近，同时被室内装饰构件包围。 在预测车辆的碰撞时，驱动机构被致动以使约束体从内部装饰构件的开口突出，用于限制目标区域在碰撞时由其面向乘员的侧面的移动，并且当避免碰撞时， 驱动机构将突出的约束体返回到室内装饰构件的开口部。 约束体在其外周附近设置有保持孔，待插入并保持在保持孔中的夹子以及用于将夹子引导到保持孔中以帮助约束体返回的引导表面 室内装饰构件的开启。 通过这种引导机构，包括保持孔，夹子和引导面，约束体能平稳地返回到内部装饰构件的开口，而不会使外观恶化。

    Knee protection system
    5.
    发明申请
    Knee protection system 有权
    膝关节保护系统

    公开(公告)号：US20050218641A1

    公开(公告)日：2005-10-06

    申请号：US11085230

    申请日：2005-03-22

    申请人： Hiroyuki Tajima ,  Takahiko Sato ,  Akiyoshi Nagano ,  Masakazu Hashimoto ,  Osamu Fukawatase ,  Takeaki Kato ,  Hiroyoshi Yamaguchi ,  Tadanori Hisamoto ,  Shinichi Horibata

    发明人： Hiroyuki Tajima ,  Takahiko Sato ,  Akiyoshi Nagano ,  Masakazu Hashimoto ,  Osamu Fukawatase ,  Takeaki Kato ,  Hiroyoshi Yamaguchi ,  Tadanori Hisamoto ,  Shinichi Horibata

    IPC分类号： B60K37/00 ,  B60R21/00 ,  B60R21/02 ,  B60R21/045 ,  B60R21/08

    CPC分类号： B60R21/045 ,  B60R2021/0051 ,  B60R2021/0293

    摘要： In a knee protection system according to the present invention, a knee protection panel is driven from a standby position surrounded by an interior member to the vehicle rear side to a knee-protecting position in front of the knees of an occupant by a drive mechanism when the vehicle is crashing, whereby the knees moving forward are protected by the knee protection panel thus driven. The drive mechanism includes a holding portion for holding the knee protection panel in such a manner that the knee protection panel is moved rearward. Engagement portions are provided, respectively, at locations where the holding portion and the knee protection panel connect with each other in such a manner as to be brought into engagement with each other. These engagement portions are brought into engagement with each other when the holding portion is moved rearward due to the activation of the drive mechanism in such a manner as to prevent displacement of the knee protection panel relative to the holding portion while moving the knee protection panel rearward, as well as allowing the knee protection panel to be displaced vertically and horizontally relative to the holding portion prior to the activation of the drive mechanism. With the knee protection system according to the invention, the knee protection panel can be disposed at the standby position so as to have a visually attractive break with the surrounding interior member, without deteriorating mounting work efficiency.

    摘要翻译： 在根据本发明的膝盖保护系统中，膝部保护面板由从内部构件被车辆后侧包围的待机位置驱动到由驾驶机构在乘员的膝盖前方的膝盖保护位置， 车辆正在崩溃，由此向前移动的膝盖由被驱动的膝盖保护板保护。 驱动机构包括用于保持膝部保护面板的保持部，使得膝部保护面板向后方移动。 在保持部和膝部保护面板以彼此接合的方式彼此连接的位置处分别设置接合部。 当保持部分由于驱动机构的启动而向后移动时，这些接合部分彼此接合，以防止膝盖保护板相对于保持部分移动，同时将膝盖保护板向后移动 并且在激活驱动机构之前允许膝盖保护板相对于保持部分垂直和水平地移位。 根据本发明的膝盖保护系统，膝部保护面板可以设置在待机位置，以便与周围的内部构件具有视觉吸引力的断裂，而不会降低安装工作效率。

    Belt anchor incorporating seat track structure
    6.
    发明授权
    Belt anchor incorporating seat track structure 失效
    皮带锚固结合座轨道结构

    公开(公告)号：US4720072A

    公开(公告)日：1988-01-19

    申请号：US863423

    申请日：1986-05-15

    申请人： Tateo Kitano ,  Masakazu Hashimoto ,  Yuji Nishiyama

    发明人： Tateo Kitano ,  Masakazu Hashimoto ,  Yuji Nishiyama

    IPC分类号： B60N2/06 ,  B60N2/07 ,  B60N2/08 ,  B60N2/42 ,  B60N2/90 ,  B60R22/26 ,  F16M13/00 ,  B60R21/10

    CPC分类号： B60N2/0732 ,  B60N2/072 ,  B60N2/0825 ,  B60N2/0868 ,  B60R22/26

    摘要： A belt anchor incorporating seat track structure is employed in an occupant restraining seatbelt system for a vehicle and incorporates a seatbelt anchor for retaining a belt in the seatbelt system. The structure includes a lower rail which is rigidly secured to the vehicle and an upper rail which is movable along the lower rail in the longitudinal direction of the vehicle. A seat of the vehicle is rigidly secured to the upper rail through a lower arm. The structure further includes a lock pin which extends through the lower arm and the lower rail. The load which acts on the belt anchor is transmitted to the lower rail through the pin. In addition, one end portion of the upper rail extends so as to overlap one end portion of the lower rail, so that the load acting on the belt anchor is further transmitted to the lower rail through the overlapping portions. Accordingly, the load which acts on the belt anchor is transmitted to the lower rail while being dispersed and is supported thereby, so that the load is reliably supported by the lower rail even in an emergency situation of the vehicle.

    摘要翻译： 在用于车辆的乘员约束安全带系统中采用包括座椅轨道结构的带锚，并且包括用于将带保持在安全带系统中的安全带固定器。 该结构包括刚性地固定到车辆的下轨道和沿着车辆的纵向方向可沿下轨道移动的上轨道。 车辆的座椅通过下臂刚性地固定到上轨道。 该结构还包括延伸穿过下臂和下轨道的锁定销。 作用在带锚上的载荷通过销传递到下轨道。 此外，上轨道的一个端部延伸成与下轨道的一个端部重叠，使得作用在带锚上的负载通过重叠部分进一步传递到下轨道。 因此，作用在带锚上的负荷在被分散并被支撑的同时传递到下轨道，从而即使在车辆的紧急情况下也能够由下轨道可靠地支撑负载。

    Knee protecting airbag device
    8.
    发明授权
    Knee protecting airbag device 有权
    膝盖保护安全气囊装置

    公开(公告)号：US07370879B2

    公开(公告)日：2008-05-13

    申请号：US11016882

    申请日：2004-12-21

    申请人： Naoki Hotta ,  Atsushi Nagata ,  Masahiro Takimoto ,  Masakazu Hashimoto

    发明人： Naoki Hotta ,  Atsushi Nagata ,  Masahiro Takimoto ,  Masakazu Hashimoto

    IPC分类号： B60R21/16 ,  B60R21/20 ,  B60R21/205

    CPC分类号： B60R21/2171 ,  B60R21/206 ,  B60R21/26 ,  B60R21/261 ,  B60R2021/23169

    摘要： The knee protecting airbag device is assembled such that a retainer and an attachment bracket clamp the peripheral portion of a gas inlet opening of an airbag, bag holding wall parts of a case, and a gas providing inflator. This inflator is provided with a diffuser for covering the gas discharge port of a body. The retainer and the attachment bracket are connected by inserting bolts and connecting members through the airbag and the case, by retaining retaining portions on the retaining portions of the connecting members, and by inserting the bolts into through holes and fastening them with nuts. At this connecting time, guide portions of the retainer and the diffuser are fitted on each other to form a guide passage for guiding the gas into the airbag.

    摘要翻译： 膝盖保护安全气囊装置组装成使得保持器和附接支架夹紧气囊的气体入口的周边部分，壳体的保持壁部分和气体提供充气机的周边部分。 该充气机设置有用于覆盖主体的排气口的扩散器。 通过将螺栓和连接构件穿过气囊和壳体，通过将保持部分保持在连接构件的保持部分上并将螺栓插入通孔并用螺母紧固来将保持器和附接支架连接。 在此连接时，保持器和扩散器的引导部分彼此嵌合以形成用于将气体引导到气囊中的引导通道。

    Knee protection airbag apparatus
    9.
    发明授权
    Knee protection airbag apparatus 有权
    膝盖保护气囊装置

    公开(公告)号：US07232149B2

    公开(公告)日：2007-06-19

    申请号：US10942121

    申请日：2004-09-16

    申请人： Naoki Hotta ,  Masakazu Hashimoto ,  Atsushi Nagata ,  Yoshio Mizuno

    发明人： Naoki Hotta ,  Masakazu Hashimoto ,  Atsushi Nagata ,  Yoshio Mizuno

    IPC分类号： B60R21/16

    CPC分类号： B60R21/231 ,  B60R21/206 ,  B60R2021/0051 ,  B60R2021/0053 ,  B60R2021/23169

    摘要： A knee protection airbag apparatus of this invention has an airbag having a construction in which folded and accommodated below the area in front of the knees of a passenger who is seated, and inflates upward toward the rear of the vehicle so as to be capable of protecting the knees of the passenger, when an inflating gas is inserted. The airbag includes a knee protection inflation portion which is disposed on the upper side of the airbag after completion of inflation and which is capable of protecting both knees of the passenger, and a shin facing portion disposed below the knee protection inflation portion after completion of inflation, in an area extending substantially vertically so as to be at the position of both shins of the passenger. Gas flow paths are disposed within both right and left edge sides of the airbag and can cause the inflating gas flowing at the lower part of the airbag to flow towards the knee protection inflation portion while inhibiting the shin facing portion from greatly inflating in the initial stage of inflation of the airbag.

    摘要翻译： 本发明的膝盖保护气囊装置具有一种安全气囊，该安全气囊被折叠并容纳在座位的乘客的膝盖前面的区域的下方，并且朝向车辆的后方向上方膨胀，以便能够保护 当充气气体被插入时，乘客的膝盖。 气囊包括膝盖保护充气部，其在完成充气之后设置在气囊的上侧，并且能够保护乘客的膝盖，并且在完成充气之后设置在膝盖保护充气部下方的针对部分 在基本上垂直延伸的区域中，以便在乘客的两个肩部的位置。 气体流动路径设置在气囊的左右两侧边缘内，并且可以使气囊下部的气体流向膝盖保护充气部，同时在初始阶段抑制胫部面对部分的充气膨胀 的气囊膨胀。